Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia

Development

Volumn 134, Issue 6, 2007, Pages 1231-1242

  Moraes, Ricardo C ^a   Zhang, Xiaomei ^a   Harrington, Nikesha ^a   Fung, Jennifer Y ^a   Wu, Meng Fen ^a   Hilsenbeck, Susan G ^a   Allred, D Craig ^a   Lewis, Michael T ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Ductal carcinoma in situ; Hedgehog signaling; Invacive breast cancer; Progenitor cell; Stem cell

Indexed keywords

MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN PATCHED 1; PROTEIN SMOOTHENED; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST DYSPLASIA; BREAST EPITHELIUM; CANCER INVASION; CARCINOMA IN SITU; CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CELL TYPE; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; HETEROZYGOSITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; APOPTOSIS; CASPASE 3; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; FIBROCYSTIC BREAST DISEASE; HEDGEHOG PROTEINS; HUMANS; KI-67 ANTIGEN; MAMMARY GLANDS, ANIMAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; TRANSGENES;

ERINACEIDAE; MOUSE MAMMARY TUMOR VIRUS; MUS; MUS MUSCULUS;

EID: 34247398806     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.02797     Document Type: Article

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