Paradox of sonic hedgehog (SHH) transcriptional regulation: Alternative transcription initiation overrides the effect of downstream promoter DNA methylation

Epigenetics

Volumn 6, Issue 4, 2011, Pages 465-477

  ten Haaf, Anette ^a   Franken, Laura ^a   Heymann, Caroline ^a   von Serenyi, Sonja ^a   Cornelissen, Christian ^a   de Hoon, Joep P J ^b   Veeck, Jürgen ^b   Lüscher, Bernhard ^a   Knüchel, Ruth ^a   Dahl, Edgar ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Cancer; Expression; Hedgehog; Methylation; Oncogene; SHH

Indexed keywords

MESSENGER RNA; SONIC HEDGEHOG PROTEIN; ISOPROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CHROMOSOME 7Q; CPG ISLAND; DNA METHYLATION; EXON; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENETIC REGULATION; HELA CELL; HUMAN; HUMAN CELL; PROMOTER REGION; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; TUMOR CELL LINE;

ERINACEIDAE;

CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HEDGEHOG PROTEINS; HUMANS; MODELS, GENETIC; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; RNA, MESSENGER; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 79954508252     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.6.4.14952     Document Type: Article

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