Expression of Indian Hedgehog signaling molecules in breast cancer

Journal of Cancer Research and Clinical Oncology

Volumn 135, Issue 2, 2009, Pages 235-240

  Xuan, Yanhua ^a   Lin, Zhenhua ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

Breast cancer; Gli; Hedgehog; Patched; Smoothened

Indexed keywords

CELL SURFACE RECEPTOR; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; IHH PROTEIN, HUMAN; KI 67 ANTIGEN; PATCHED RECEPTORS; PROGESTERONE RECEPTOR; SMO PROTEIN, HUMAN; SONIC HEDGEHOG PROTEIN;

ADULT; AGED; ARTICLE; BREAST; BREAST TUMOR; CANCER INVASION; CYTOLOGY; DISEASE COURSE; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY; PHYSIOLOGY;

ADULT; AGED, 80 AND OVER; BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL; DISEASE PROGRESSION; FEMALE; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MIDDLE AGED; NEOPLASM INVASIVENESS; RECEPTORS, CELL SURFACE; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PROGESTERONE;

EID: 65849506662     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-008-0451-x     Document Type: Article

References (20)

1. Bale AE, Yu KP (2001) The hedgehog pathway and basal cell carcinomas. Hum Mol Genet 10(7):757-762. doi:10.1093/hmg/10.7.757
2. Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425(6960):846-851
3. Denef N, Neubuser D, Perez L, Cohen SM (2000) Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102(4):521-531
4. Goodrich LV, Scott MP (1998) Hedgehog and patched in neural development and disease. Neuron 21(6):1243-1257. doi:10.1016/S0896-6273(00)80645-5
5. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG et al (2002) American Joint Committee on Cancer Staging Manual, 6th edn edn. Springer, Heidelberg, pp 139-144
6. Hammerschmidt M, Brook A, McMahon AP (1997) The world according to hedgehog. Trends Genet 13(1):14-21. doi:10.1016/S0168-9525(96)10051-2
7. Kubo M, Nakamura M, Tasaki A, Yamanaka N, Nakashima H, Nomura M et al (2004) Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 64(17):6071-6074. doi:10.1158/0008-5472.CAN-04-0416
8. Lewis MT, Ross S, Strickland PA, Sugnet CW, Jimenez E, Hui C et al (2001) The Gli2 transcription factor is required for normal mouse mammary gland development. Dev Biol 238(1):133-144. doi:10.1006/dbio.2001.0410
9. Ma XL, Chen K, Huang S, Zhang X, Adegboyega PA, Evers BM et al (2005) Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 26(10):1698-1705. doi:10.1093/carcin/bgi130
10. Matise P, Joyner AL (1999) Gli genes in development and cancer. Oncogene 18(55):7852-7859. doi:10.1038/sj.onc.1203243
11. Oniscu A, James RM, Morris RG, Bader S, Malcomson RD, Harrison DJ (2004) Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. J Pathol 203(4):909-917. doi:10.1002/path.1591
12. Pasca di Magliano M, Hebrok M (2003) Hedgehog signaling in cancer formation and maintenance. Nat Rev Cancer 3(12):903-911. doi:10.1038/nrc1229
13. Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, Therond PP (2003) Stability and association of Smoothened, Costal2 and fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol 5(10):907-913. doi:10.1038/ncb1052
14. Ruizi Altaba A (1999) Gli proteins and hedgehog signaling in development and cancer. Trends Genet 15(10):418-425. doi:10.1016/S0168-9525(99)01840-5
15. Ruizi Altaba A, Sanchez P, Dahmane N (2002) Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2(5):361-372. doi:10.1038/nrc796
16. Sinicrope FA, Ruan SB, Cleary KB, Stephens LC, Lee JJ, Levin B (1995) bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 55(2):237-241
17. Toftgard R (2000) Hedgehog signalling in cancer. Cell Mol Life Sci 57(12):1720-1731. doi:10.1007/PL00000654
18. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB (2003) Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer. Nature 422(6929):313-317. doi:10.1038/nature01493
19. Wechsler-Reya R, Scott MP (2001) The developmental biology of brain tumors. Annu Rev Neurosci 24:385-428. doi:10.1146/annurev.neuro.24.1.385
20. Xuan YH, Jung HS, Choi YL, Shin YK, Kim HJ, Kim KH et al (2006) Enhanced expression of hedgehog signaling molecules in squamous cell carcinoma of uterine cervix and its precursor lesions. Mod Pathol 19(6):825-834