메뉴 건너뛰기




Volumn 8, Issue 4, 2012, Pages 510-519

Antimetabolites: Established cancer therapy

Author keywords

Antimetabolites; apoptosis; cell death; mitotic catastrophe; necrosis

Indexed keywords

ANTIMETABOLITE; AZACITIDINE; BGC 9331; CAPECITABINE; CISPLATIN; DOXORUBICIN; ETOPOSIDE; FLOXURIDINE; FLUDARABINE; FLUOROURACIL; PENTOSTATIN; PLEVITREXED; RALTITREXED; RAPAMYCIN; TAMOXIFEN; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VINBLASTINE;

EID: 84875538623     PISSN: 09731482     EISSN: 19984138     Source Type: Journal    
DOI: 10.4103/0973-1482.106526     Document Type: Review
Times cited : (44)

References (149)
  • 2
    • 0033118475 scopus 로고    scopus 로고
    • Apoptosis, p53, and tumor cell sensitivity to anticancer agents
    • Brown JM, Wouters BG. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 1999;59:1391-9.
    • (1999) Cancer Res , vol.59 , pp. 1391-1399
    • Brown, J.M.1    Wouters, B.G.2
  • 3
    • 0035135693 scopus 로고    scopus 로고
    • Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs
    • Tannock IF, Lee C. Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs. Br J Cancer 2001;84:100-5.
    • (2001) Br J Cancer , vol.84 , pp. 100-105
    • Tannock, I.F.1    Lee, C.2
  • 4
    • 1542472979 scopus 로고    scopus 로고
    • Apoptosis genes and resistance to cancer therapy
    • Brown M, Wilson G. Apoptosis genes and resistance to cancer therapy. Cancer Biol Ther 2003;2:477-90.
    • (2003) Cancer Biol Ther , vol.2 , pp. 477-490
    • Brown, M.1    Wilson, G.2
  • 5
    • 0037317521 scopus 로고    scopus 로고
    • The role of p53 in determining sensitivity to radiotherapy
    • Gudkov A, Komarova EA. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 2003;3:117-29.
    • (2003) Nat Rev Cancer , vol.3 , pp. 117-129
    • Gudkov, A.1    Komarova, E.A.2
  • 7
    • 0030584079 scopus 로고    scopus 로고
    • Apoptosis meets signal transduction: Elimination of a BAD influence
    • Gajewski TF, Thompson CB. Apoptosis meets signal transduction: Elimination of a BAD influence. Cell 1996;87:589-92.
    • (1996) Cell , vol.87 , pp. 589-592
    • Gajewski, T.F.1    Thompson, C.B.2
  • 8
    • 0031015454 scopus 로고    scopus 로고
    • Fluorouracil in colorectal cancer - A tale of two drugs: Implications for biochemical modulation
    • Sobrero AF, Aschele C, Bertino JR. Fluorouracil in colorectal cancer- A tale of two drugs: Implications for biochemical modulation. J Clin Oncol 1997;15:368-81.
    • (1997) J Clin Oncol , vol.15 , pp. 368-381
    • Sobrero, A.F.1    Aschele, C.2    Bertino, J.R.3
  • 9
    • 0032006318 scopus 로고    scopus 로고
    • Comparison of 5-fluoro-2?-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer
    • van Laar JA, Rustum YM, Ackland SP, van Groeningen CJ, Peters GJ. Comparison of 5-fluoro-2?-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer. Eur J Cancer1998;34:296-306.
    • (1998) Eur J Cancer , vol.34 , pp. 296-306
    • Van Laar, J.A.1    Rustum, Y.M.2    Ackland, S.P.3    Van Groeningen, C.J.4    Peters, G.J.5
  • 10
    • 0036023429 scopus 로고    scopus 로고
    • Modulation of the Fas signaling pathway by interferon-in therapy of colon cancer: Phase i trial and correlative studies of interferon, 5-fluorouracil andleucovorin
    • Schwartzberg L, Petak I, Stewart C, Turner PK, Ashley J, Tillman DM, et al. Modulation of the Fas signaling pathway by interferon-in therapy of colon cancer: Phase I trial and correlative studies of interferon, 5-fluorouracil andleucovorin. Clin Cancer Res 2002;8:2488-98.
    • (2002) Clin Cancer Res , vol.8 , pp. 2488-2498
    • Schwartzberg, L.1    Petak, I.2    Stewart, C.3    Turner, P.K.4    Ashley, J.5    Tillman, D.M.6
  • 11
    • 0028982818 scopus 로고
    • The ratio of dATP/dTTP influences the commitment ofhuman colon carcinoma cells to thymineless death
    • Houghton JA, Tillman DM, Harwood FG. The ratio of dATP/dTTP influences the commitment ofhuman colon carcinoma cells to thymineless death. Clin Cancer Res 1995;1:723-30.
    • (1995) Clin Cancer Res , vol.1 , pp. 723-730
    • Houghton, J.A.1    Tillman, D.M.2    Harwood, F.G.3
  • 12
    • 0018926733 scopus 로고
    • Regulation of RNA-and DNA-directedactions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells
    • Maybaum J, Ullman B, Mandel HG, Day JL, Sadee W. Regulation of RNA-and DNA-directedactions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells. Cancer Res 1980;40:4209-15.
    • (1980) Cancer Res , vol.40 , pp. 4209-4215
    • Maybaum, J.1    Ullman, B.2    Mandel, H.G.3    Day, J.L.4    Sadee, W.5
  • 13
    • 0033748796 scopus 로고    scopus 로고
    • P53-dependence of Fas induction and acute apoptosis inresponse to 5-fluorouracil-leucovorin in human colon carcinoma cell lines
    • Petak I, Tillman DM, Houghton JA. P53-dependence of Fas induction and acute apoptosis inresponse to 5-fluorouracil-leucovorin in human colon carcinoma cell lines. Clin Cancer Res 2000;6:4432-41.
    • (2000) Clin Cancer Res , vol.6 , pp. 4432-4441
    • Petak, I.1    Tillman, D.M.2    Houghton, J.A.3
  • 14
    • 0031691145 scopus 로고    scopus 로고
    • Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells
    • Parsels LA, Parsels JD, Wagner LM, Loney TL, Radany EH, Maybaum J. Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells. Cancer Chemother Pharmacol 1998;42:357-62.
    • (1998) Cancer Chemother Pharmacol , vol.42 , pp. 357-362
    • Parsels, L.A.1    Parsels, J.D.2    Wagner, L.M.3    Loney, T.L.4    Radany, E.H.5    Maybaum, J.6
  • 15
    • 0033770342 scopus 로고    scopus 로고
    • 5-Fluorouracil: Forty plus and still ticking A review of its preclinical and clinical development
    • Grem JL. 5-Fluorouracil: Forty plus and still ticking. A review of its preclinical and clinical development. Invest New Drugs 2000;18:299-313.
    • (2000) Invest New Drugs , vol.18 , pp. 299-313
    • Grem, J.L.1
  • 16
    • 0018744377 scopus 로고
    • Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine and 5-fluoro-2?-deoxyuridine
    • Houghton JA, Houghton PJ, Wooten RS. Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine and 5-fluoro-2?-deoxyuridine. Cancer Res 1979;39:2406-13.
    • (1979) Cancer Res , vol.39 , pp. 2406-2413
    • Houghton, J.A.1    Houghton, P.J.2    Wooten, R.S.3
  • 17
    • 12644291915 scopus 로고    scopus 로고
    • Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation
    • Pritchard DM, Watson AJM, Potten CS. Jackman AL, Hickman JA. Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation. Proc Natl Acad Sci USA 1997;94:1795-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1795-1799
    • Pritchard, D.M.1    Ajm, W.2    Potten, C.S.3    Jackman, A.L.4    Hickman, J.A.5
  • 18
    • 0033371602 scopus 로고    scopus 로고
    • New drugs in colorectal cancer: Preclinical studies
    • Rustum YM, Cao S. New drugs in colorectal cancer: Preclinical studies. Semin Oncol 1999;26:612-20.
    • (1999) Semin Oncol , vol.26 , pp. 612-620
    • Rustum, Y.M.1    Cao, S.2
  • 19
    • 0033783056 scopus 로고    scopus 로고
    • Mechanism of action of fluoropyrimidines: Elevance to the new developments in colorectal cancer chemotherapy
    • Sobrero A, Guglielmi A, Grossi F, Puglisi F, Aschele C. Mechanism of action of fluoropyrimidines: Elevance to the new developments in colorectal cancer chemotherapy. Semin Oncol 2000;27(5 Suppl 10):72-7.
    • (2000) Semin Oncol , vol.27 , Issue.5 SUPPL. 10 , pp. 72-77
    • Sobrero, A.1    Guglielmi, A.2    Grossi, F.3    Puglisi, F.4    Aschele, C.5
  • 20
    • 4344644911 scopus 로고    scopus 로고
    • P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase (TS) inhibitors in colorectal carcinoma cells
    • Geller JI, Szekely-Szucs K, Petak I, Doyle B, Houghton JA. P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase (TS) inhibitors in colorectal carcinoma cells. Cancer Res 2004;64:6296-303.
    • (2004) Cancer Res , vol.64 , pp. 6296-6303
    • Geller, J.I.1    Szekely-Szucs, K.2    Petak, I.3    Doyle, B.4    Houghton, J.A.5
  • 21
    • 10244226744 scopus 로고    scopus 로고
    • The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines
    • Eisold S, Linnebacher M, Ryschich E, Antolovic D, Hinz U, Klar E, et al. The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines. World J Gastroenterol 2004;10:3583-9.
    • (2004) World J Gastroenterol , vol.10 , pp. 3583-3589
    • Eisold, S.1    Linnebacher, M.2    Ryschich, E.3    Antolovic, D.4    Hinz, U.5    Klar, E.6
  • 22
    • 2942520695 scopus 로고    scopus 로고
    • Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil
    • de Angelis PM, Fjell B, Kravik KL, Haug T, Tunheim SH, Reichelt W, et al. Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. Int J Oncol 2004;24:1279-88.
    • (2004) Int J Oncol , vol.24 , pp. 1279-1288
    • De Angelis, P.M.1    Fjell, B.2    Kravik, K.L.3    Haug, T.4    Tunheim, S.H.5    Reichelt, W.6
  • 23
    • 0030610390 scopus 로고    scopus 로고
    • Overexpressioin of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells
    • Li WW, Fan J, Hochhauser D, Bertino JR. Overexpressioin of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. Cancer Res 1997;57:2193-9.
    • (1997) Cancer Res , vol.57 , pp. 2193-2199
    • Li, W.W.1    Fan, J.2    Hochhauser, D.3    Bertino, J.R.4
  • 24
    • 4644318236 scopus 로고    scopus 로고
    • 5-Fluoro-2-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells
    • Parsels LA, Parsels JD, Tai DC-H, Coughlin DJ, Maybaum J. 5-Fluoro-2-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells. Cancer Res 2004;64:6588-94.
    • (2004) Cancer Res , vol.64 , pp. 6588-6594
    • Parsels, L.A.1    Parsels, J.D.2    Dc-H, T.3    Coughlin, D.J.4    Maybaum, J.5
  • 25
    • 14844315930 scopus 로고    scopus 로고
    • A novel mechanism of checkpoint abrogation conferred by chk1 downregulation
    • Xiao Z, Xue J, Sowin TJ, Rosenberg SH, Zhang H. A novel mechanism of checkpoint abrogation conferred by chk1 downregulation. Oncogene 2005;24:1403-11.
    • (2005) Oncogene , vol.24 , pp. 1403-1411
    • Xiao, Z.1    Xue, J.2    Sowin, T.J.3    Rosenberg, S.H.4    Zhang, H.5
  • 26
    • 0034699353 scopus 로고    scopus 로고
    • Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis
    • Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, et al. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 2000;19:4563-73.
    • (2000) Oncogene , vol.19 , pp. 4563-4573
    • Engels, I.H.1    Stepczynska, A.2    Stroh, C.3    Lauber, K.4    Berg, C.5    Schwenzer, R.6
  • 27
    • 0033449456 scopus 로고    scopus 로고
    • Apoptosis of colorectal adenocarcinoma induced by 5-FU and/or IFNgamma through caspase 3 and caspase 8
    • Adachi Y, Taketani S, Oyaizu H, Ikebukuro K, Tokunaga R, Ikehara S. Apoptosis of colorectal adenocarcinoma induced by 5-FU and/or IFNgamma through caspase 3 and caspase 8. Int J Oncol 1999;15:1191-6.
    • (1999) Int J Oncol , vol.15 , pp. 1191-1196
    • Adachi, Y.1    Taketani, S.2    Oyaizu, H.3    Ikebukuro, K.4    Tokunaga, R.5    Ikehara, S.6
  • 28
    • 0035409326 scopus 로고    scopus 로고
    • Activation of caspase-3 in renal cell carcinoma cells by anthracyclines or 5-fluorouracil
    • Wu XX, Kakehi Y, Mizutani Y, Lu J, Terachi T, Ogawa O. Activation of caspase-3 in renal cell carcinoma cells by anthracyclines or 5-fluorouracil. Int J Oncol 2001;19:19-24.
    • (2001) Int J Oncol , vol.19 , pp. 19-24
    • Wu, X.X.1    Kakehi, Y.2    Mizutani, Y.3    Lu, J.4    Terachi, T.5    Ogawa, O.6
  • 29
    • 0034657911 scopus 로고    scopus 로고
    • Fas-dependent and-independent mechanisms of cell death following DNA damage in human colon carcinoma cells
    • Petak I, Tillman DM, Harwood FG, Houghton JA. Fas-dependent and-independent mechanisms of cell death following DNA damage in human colon carcinoma cells. Cancer Res 2000;60:2643-50.
    • (2000) Cancer Res , vol.60 , pp. 2643-2650
    • Petak, I.1    Tillman, D.M.2    Harwood, F.G.3    Houghton, J.A.4
  • 30
    • 0034088892 scopus 로고    scopus 로고
    • Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor ralitrexed
    • Peters GJ, van Triest B, Backus HH, Kuiper CM, van der Wilt CL, Pinedo HM. Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor ralitrexed. Eur J Cancer 2000;36:916-24.
    • (2000) Eur J Cancer , vol.36 , pp. 916-924
    • Peters, G.J.1    Van Triest, B.2    Backus, H.H.3    Kuiper, C.M.4    Van Der Wilt, C.L.5    Pinedo, H.M.6
  • 31
    • 0346431866 scopus 로고    scopus 로고
    • Interferon-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the IAP survivin
    • Geller J, Petak I, Szekely Szucs K, Nagy K, Tillman DM, Houghton JA. Interferon-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the IAP survivin. Clin Cancer Res 2003;9:6504-15.
    • (2003) Clin Cancer Res , vol.9 , pp. 6504-6515
    • Geller, J.1    Petak, I.2    Szekely Szucs, K.3    Nagy, K.4    Tillman, D.M.5    Houghton, J.A.6
  • 32
    • 0038126261 scopus 로고    scopus 로고
    • Killers or clean-up crew: How central are the central mechanisms of apoptosis
    • Hickman JA, Dive C, editors Totowa, NJ: Humana PressInc
    • Green DR, Beere HM. Killers or clean-up crew: How central are the central mechanisms of apoptosis. In: Hickman JA, Dive C, editors. Apoptosis and cancer therapy. Totowa, NJ: Humana PressInc.; 1999. p. 157-74.
    • (1999) Apoptosis and Cancer Therapy , pp. 157-174
    • Green, D.R.1    Beere, H.M.2
  • 33
    • 0031033274 scopus 로고    scopus 로고
    • Inhibition of ced-3/ICErelated proteases doesnot prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
    • McCarthy NJ, Whyte MK, Gilbert CS, Evan GI. Inhibition of ced-3/ICErelated proteases doesnot prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J Cell Biol 1997;136:215-27.
    • (1997) J Cell Biol , vol.136 , pp. 215-227
    • McCarthy, N.J.1    Whyte, M.K.2    Gilbert, C.S.3    Evan, G.I.4
  • 34
    • 0030808385 scopus 로고    scopus 로고
    • Thymineless death in colon carcinoma cells is mediatedvia Fas signaling
    • Houghton JA, Harwood FG, Tillman DM. Thymineless death in colon carcinoma cells is mediatedvia Fas signaling. Proc Natl Acad Sci USA 1997;94:8144-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8144-8149
    • Houghton, J.A.1    Harwood, F.G.2    Tillman, D.M.3
  • 35
    • 0033044686 scopus 로고    scopus 로고
    • A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells
    • Tillman DM, Petak I, Houghton JA. A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells. Clin Cancer Res 1999;5:425-30.
    • (1999) Clin Cancer Res , vol.5 , pp. 425-430
    • Tillman, D.M.1    Petak, I.2    Houghton, J.A.3
  • 36
    • 0033796587 scopus 로고    scopus 로고
    • A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs
    • Eichhorst ST, Muller M, Li-Weber M, Schulze-Bergkamen H, Angel P, Krammer PH. A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol Cell Biol 2000;20:7826-37.
    • (2000) Mol Cell Biol , vol.20 , pp. 7826-7837
    • Eichhorst, S.T.1    Muller, M.2    Li-Weber, M.3    Schulze-Bergkamen, H.4    Angel, P.5    Krammer, P.H.6
  • 37
    • 2542496862 scopus 로고    scopus 로고
    • The roles of thymidylate synthase and p53 in regulating Fasmediated apoptosis in response to antimetabolites
    • Longley DB, Allen WL, McDermott U, Wilson TR, LAtif T, Boyer J, et al. The roles of thymidylate synthase and p53 in regulating Fasmediated apoptosis in response to antimetabolites. Clin Cancer Res 2004;10:3562-71.
    • (2004) Clin Cancer Res , vol.10 , pp. 3562-3571
    • Longley, D.B.1    Allen, W.L.2    McDermott, U.3    Wilson, T.R.4    Latif, T.5    Boyer, J.6
  • 38
    • 0035134514 scopus 로고    scopus 로고
    • The chemotherapeutic drug 5-fluorouracil induces apoptosis in mouse thymocytes in vivo via activation of the CD95(APO-1/Fas) system
    • Eichhorst ST, Muerkoster S, Weigand MA, Krammer PH. The chemotherapeutic drug 5-fluorouracil induces apoptosis in mouse thymocytes in vivo via activation of the CD95(APO-1/Fas) system. Cancer Res 2001;61:243-48.
    • (2001) Cancer Res , vol.61 , pp. 243-248
    • Eichhorst, S.T.1    Muerkoster, S.2    Weigand, M.A.3    Krammer, P.H.4
  • 39
    • 20244384661 scopus 로고    scopus 로고
    • Transmission of apoptosis in human colorectal tumor cells exposed to capecitabine, xeloda, is mediated via Fas
    • Ciccolini J, Fina F, Bezulier K, Giacometti S, Roussel M, Evrard A, et al. Transmission of apoptosis in human colorectal tumor cells exposed to capecitabine, xeloda, is mediated via Fas. Mol Cancer Ther 2002;1:923-7.
    • (2002) Mol Cancer Ther , vol.1 , pp. 923-927
    • Ciccolini, J.1    Fina, F.2    Bezulier, K.3    Giacometti, S.4    Roussel, M.5    Evrard, A.6
  • 40
    • 0028246885 scopus 로고
    • Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium
    • Moller P, Koretz K, Leithauser F, Bruderlein S, Henne C, Quentmeier A, et al. Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int J Cancer 1994;57:371-7.
    • (1994) Int J Cancer , vol.57 , pp. 371-377
    • Moller, P.1    Koretz, K.2    Leithauser, F.3    Bruderlein, S.4    Henne, C.5    Quentmeier, A.6
  • 41
    • 0027420929 scopus 로고
    • Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells
    • Leithauser F, Dhein J, Mechtersheimer G, Koretz K, Bruderlein S, Henne C, et al. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest 1993;69:415-29.
    • (1993) Lab Invest , vol.69 , pp. 415-429
    • Leithauser, F.1    Dhein, J.2    Mechtersheimer, G.3    Koretz, K.4    Bruderlein, S.5    Henne, C.6
  • 42
    • 0041592448 scopus 로고    scopus 로고
    • Enhanced susceptibility of oral squamous cell carcinoma cell lines to FASmediated apoptosis by cisplatin and 5-fluorouracil
    • Iwase M, Watanabe H, kondo G, Ohashi M, Nagumo M. Enhanced susceptibility of oral squamous cell carcinoma cell lines to FASmediated apoptosis by cisplatin and 5-fluorouracil. Int J Cancer 2003;106:619-25.
    • (2003) Int J Cancer , vol.106 , pp. 619-625
    • Iwase, M.1    Watanabe, H.2    Kondo, G.3    Ohashi, M.4    Nagumo, M.5
  • 43
    • 4344607589 scopus 로고    scopus 로고
    • Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitization of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
    • Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, et al. Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitization of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ 2004;11:S86-96.
    • (2004) Cell Death Differ , vol.11
    • Ganten, T.M.1    Haas, T.L.2    Sykora, J.3    Stahl, H.4    Sprick, M.R.5    Fas, S.C.6
  • 44
    • 0037468930 scopus 로고    scopus 로고
    • Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells
    • Lacour S, Micheau O, Hammann A, Drouineaud V, Tschopp J, Solary E, et al. Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. Oncogene 2003;22:1807-16.
    • (2003) Oncogene , vol.22 , pp. 1807-1816
    • Lacour, S.1    Micheau, O.2    Hammann, A.3    Drouineaud, V.4    Tschopp, J.5    Solary, E.6
  • 45
    • 0037108712 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice
    • Naka T, Sugamura K, Hylander BL, Widmer MB, Rustum YM, Repasky EA. Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice. Cancer Res 2002;62:5800-6.
    • (2002) Cancer Res , vol.62 , pp. 5800-5806
    • Naka, T.1    Sugamura, K.2    Hylander, B.L.3    Widmer, M.B.4    Rustum, Y.M.5    Repasky, E.A.6
  • 46
    • 9744276046 scopus 로고    scopus 로고
    • Partial contribution of tumor necrosis factor-related apootosisinducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against hepatocellular carcinoma
    • Yamamoto T, Nagano H, Sakon M, Wada H, Eguchi H, Kondo M, et al. Partial contribution of tumor necrosis factor-related apootosisinducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5- fluorouracil against hepatocellular carcinoma. Clin Cancer Res 2004;10:7884-95.
    • (2004) Clin Cancer Res , vol.10 , pp. 7884-7895
    • Yamamoto, T.1    Nagano, H.2    Sakon, M.3    Wada, H.4    Eguchi, H.5    Kondo, M.6
  • 47
    • 4644245083 scopus 로고    scopus 로고
    • Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil
    • Wang S, El-Deiry WS. Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil. Cancer Res 2004;64:6666-72.
    • (2004) Cancer Res , vol.64 , pp. 6666-6672
    • Wang, S.1    El-Deiry, W.S.2
  • 48
    • 0037463238 scopus 로고    scopus 로고
    • Constitutive nuclear factor-kappa B m RNA, protein overexpression and enhanced DNA-binding activity in thymidylaye synthase inhibitor-resistant tumour cells
    • Wang W, Cassidy J. Constitutive nuclear factor-kappa B m RNA, protein overexpression and enhanced DNA-binding activity in thymidylaye synthase inhibitor-resistant tumour cells. Br J Cancer 2003;88:624-9.
    • (2003) Br J Cancer , vol.88 , pp. 624-629
    • Wang, W.1    Cassidy, J.2
  • 49
    • 0037457481 scopus 로고    scopus 로고
    • Disulfiram-mediated inhibition of NF-B activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines
    • Wang W, McLeod HL, Cassidy J. Disulfiram-mediated inhibition of NF-B activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer 2003;104:504-11.
    • (2003) Int J Cancer , vol.104 , pp. 504-511
    • Wang, W.1    McLeod, H.L.2    Cassidy, J.3
  • 50
    • 3042511585 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer
    • Voboril R, Hochwald SN, Li J, Brank A, Weberova J, Wessels F, et al. Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer. J Surg Res 2004;120:178-88.
    • (2004) J Surg Res , vol.120 , pp. 178-188
    • Voboril, R.1    Hochwald, S.N.2    Li, J.3    Brank, A.4    Weberova, J.5    Wessels, F.6
  • 51
    • 0042663849 scopus 로고    scopus 로고
    • Inhibition of inducible NF-kappaB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell line
    • Uetsuka H, Haisa M, Kimura M, Gunduz M, Kaneda Y, Ohkawa T, et al. Inhibition of inducible NF-kappaB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell line. Exp Cell Res 2003;10:27-35.
    • (2003) Exp Cell Res , vol.10 , pp. 27-35
    • Uetsuka, H.1    Haisa, M.2    Kimura, M.3    Gunduz, M.4    Kaneda, Y.5    Ohkawa, T.6
  • 52
    • 3142671271 scopus 로고    scopus 로고
    • Chemosensitization of breast carcinoma cells with the use of bcl-2 antisense oligonucleotide
    • Yang JH, Fenf F, Qian H, Cheng H. Chemosensitization of breast carcinoma cells with the use of bcl-2 antisense oligonucleotide. Breast 2004;13:227-31.
    • (2004) Breast , vol.13 , pp. 227-231
    • Yang, J.H.1    Fenf, F.2    Qian, H.3    Cheng, H.4
  • 53
    • 0033982752 scopus 로고    scopus 로고
    • Overexpression of Bax enhances antitumor activity of chemotherapeutic agents in human head and neck squamous cell carcinoma
    • Guo B, Cao S, Toth K, Azrak RG, Rustum YM. Overexpression of Bax enhances antitumor activity of chemotherapeutic agents in human head and neck squamous cell carcinoma. Clin Cancer Res 2000;6:718-24.
    • (2000) Clin Cancer Res , vol.6 , pp. 718-724
    • Guo, B.1    Cao, S.2    Toth, K.3    Azrak, R.G.4    Rustum, Y.M.5
  • 54
    • 0036092840 scopus 로고    scopus 로고
    • Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents
    • Xu ZW, Freiss H, Buchler MW, Solioz M. Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents. Cancer Chemother Pharmacol 2002;49:504-10.
    • (2002) Cancer Chemother Pharmacol , vol.49 , pp. 504-510
    • Xu, Z.W.1    Freiss, H.2    Buchler, M.W.3    Solioz, M.4
  • 55
    • 0034632668 scopus 로고    scopus 로고
    • Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine
    • Pritchard DM, Print C, O'Reilly L, Adams JM, Potten CS, Hickman JA. Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine. Oncogene 2000;19:3955-9.
    • (2000) Oncogene , vol.19 , pp. 3955-3959
    • Pritchard, D.M.1    Print, C.2    O'Reilly, L.3    Adams, J.M.4    Potten, C.S.5    Hickman, J.A.6
  • 56
    • 0033145416 scopus 로고    scopus 로고
    • Caspase activity sows the seeds of neuronal death
    • Yuan J, Yanker BA. Caspase activity sows the seeds of neuronal death. Nat Cell Biol 1999;1:E44-5.
    • (1999) Nat Cell Biol , vol.1
    • Yuan, J.1    Yanker, B.A.2
  • 57
    • 0037077254 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway
    • Rao RV, Castro-Obregon S, Frankowski H, Schuler M, Stoka V, Del Rio G, et al. Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem 2002;277:21836-42.
    • (2002) J Biol Chem , vol.277 , pp. 21836-21842
    • Rao, R.V.1    Castro-Obregon, S.2    Frankowski, H.3    Schuler, M.4    Stoka, V.5    Del Rio, G.6
  • 58
    • 0037072937 scopus 로고    scopus 로고
    • An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12
    • Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 2002;277:34287-94.
    • (2002) J Biol Chem , vol.277 , pp. 34287-34294
    • Morishima, N.1    Nakanishi, K.2    Takenouchi, H.3    Shibata, T.4    Yasuhiko, Y.5
  • 59
    • 13644257039 scopus 로고    scopus 로고
    • Fluorouracil or gemcitabine combined with adenoviralmediated reintroduction of p16INK4A greatly enhanced cytotoxicityt in Panc-1 pancreatic adenocarcinoma cells
    • Halloran CM, Ghaneh P, Shore S, Greenhalf W, Zumstein L, Wilson D, et al. %-Fluorouracil or gemcitabine combined with adenoviralmediated reintroduction of p16INK4A greatly enhanced cytotoxicityt in Panc-1 pancreatic adenocarcinoma cells. J Gene Med 2004;6:514-25.
    • (2004) J Gene Med , vol.6 , pp. 514-525
    • Halloran, C.M.1    Ghaneh, P.2    Shore, S.3    Greenhalf, W.4    Zumstein, L.5    Wilson, D.6
  • 60
    • 2942674265 scopus 로고    scopus 로고
    • The HPV16 E6/E7 oncogene sensitizes human ovarian surface epithelial cells to low-dose but not high-dose 5-FU and 5-FUdR
    • Hsu LC, Lee RM, White RL. The HPV16 E6/E7 oncogene sensitizes human ovarian surface epithelial cells to low-dose but not high-dose 5-FU and 5-FUdR. Biochem Biophys Res Commun 2004;320:249-55.
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 249-255
    • Hsu, L.C.1    Lee, R.M.2    White, R.L.3
  • 61
    • 0036275624 scopus 로고    scopus 로고
    • E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells
    • Elliott MJ, Farmer MR, Atienza C, Stilwell A, Dong YB, Yang HL, et al. E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells. Tumour Biol 2002;23:76-86.
    • (2002) Tumour Biol , vol.23 , pp. 76-86
    • Elliott, M.J.1    Farmer, M.R.2    Atienza, C.3    Stilwell, A.4    Dong, Y.B.5    Yang, H.L.6
  • 63
    • 0036479901 scopus 로고    scopus 로고
    • Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts
    • Modrak DE, Rodriguez MD, Goldenberg DM, Lew W, Blumenthal RD. Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts. Int J Oncol 2002;20:379-84.
    • (2002) Int J Oncol , vol.20 , pp. 379-384
    • Modrak, D.E.1    Rodriguez, M.D.2    Goldenberg, D.M.3    Lew, W.4    Blumenthal, R.D.5
  • 64
    • 0042564487 scopus 로고    scopus 로고
    • Haras overexpression mediated cell apoptosis in the presence of 5-fluorouracil
    • Tseng YS, Tzeng CC, Chiu AW, Lin CH, Won SJ, Wu IC, et al. Haras overexpression mediated cell apoptosis in the presence of 5-fluorouracil. Exp Cell Res 2003;288:403-14.
    • (2003) Exp Cell Res , vol.288 , pp. 403-414
    • Tseng, Y.S.1    Tzeng, C.C.2    Chiu, A.W.3    Lin, C.H.4    Won, S.J.5    Wu, I.C.6
  • 65
    • 0041343273 scopus 로고    scopus 로고
    • Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells
    • Jin W, Wu L, Liang K, Liu B, Lu Y, Fan Z. Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells. Br J Cancer 2003;89:185-91.
    • (2003) Br J Cancer , vol.89 , pp. 185-191
    • Jin, W.1    Wu, L.2    Liang, K.3    Liu, B.4    Lu, Y.5    Fan, Z.6
  • 66
    • 0036829336 scopus 로고    scopus 로고
    • Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells
    • Sun Y, Tang XM, Half E, Kuo MT, Sinicrope FA. Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res 2002;62:6323-8.
    • (2002) Cancer Res , vol.62 , pp. 6323-6328
    • Sun, Y.1    Tang, X.M.2    Half, E.3    Kuo, M.T.4    Sinicrope, F.A.5
  • 67
    • 1842427479 scopus 로고    scopus 로고
    • Sequence-dependent effect of a cyclooxygenase-2 inhibitor on topoisomerase i inhibitor and 5-fluorouracil-induced cytotoxicity of colon cancer cells
    • Chen WS, Liu JH, Liu JM, Lin JK. Sequence-dependent effect of a cyclooxygenase-2 inhibitor on topoisomerase I inhibitor and 5-fluorouracil- induced cytotoxicity of colon cancer cells. Anticancer Drugs 2004;15:287-94.
    • (2004) Anticancer Drugs , vol.15 , pp. 287-294
    • Chen, W.S.1    Liu, J.H.2    Liu, J.M.3    Lin, J.K.4
  • 68
    • 0035392965 scopus 로고    scopus 로고
    • Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine- mediated cell death and cell cycle responses
    • Meyers M, Wagner MW, Hwang H-S, Kinsella TJ, Boothman DA. Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Cancer Res 2001;61:5193-201.
    • (2001) Cancer Res , vol.61 , pp. 5193-5201
    • Meyers, M.1    Wagner, M.W.2    Hwang, H.-S.3    Kinsella, T.J.4    Boothman, D.A.5
  • 69
    • 7444221823 scopus 로고    scopus 로고
    • Special section: Impact of the environment on colon cancer (II): Roles of DNA mismatch repair in apoptotic responses to therapeutic agents
    • Meyers M, Hwang A, Wagner MW, Boothman DA. Special section: Impact of the environment on colon cancer (II): Roles of DNA mismatch repair in apoptotic responses to therapeutic agents. Environ Mol Mutagen 2004;44:249-64.
    • (2004) Environ Mol Mutagen , vol.44 , pp. 249-264
    • Meyers, M.1    Hwang, A.2    Wagner, M.W.3    Boothman, D.A.4
  • 71
    • 0035793799 scopus 로고    scopus 로고
    • Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer
    • Paradiso A, Simone G, Lena MD, Leone B, Vallejo C, Lacava J, et al. Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer. Br J Cancer 2001;84:651-8.
    • (2001) Br J Cancer , vol.84 , pp. 651-658
    • Paradiso, A.1    Simone, G.2    Lena, M.D.3    Leone, B.4    Vallejo, C.5    Lacava, J.6
  • 72
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997;275:967-9.
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3    Li, Y.4    Sawai, H.5    Reed, J.C.6
  • 73
    • 0031895510 scopus 로고    scopus 로고
    • The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium
    • Ouyang H, Furukawa T, Abe T, Kato Y, Horii A. The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium. Clin Cancer Res 1998;4:1071-4.
    • (1998) Clin Cancer Res , vol.4 , pp. 1071-1074
    • Ouyang, H.1    Furukawa, T.2    Abe, T.3    Kato, Y.4    Horii, A.5
  • 74
    • 0034718591 scopus 로고    scopus 로고
    • Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution
    • Ionov Y, Yamamoto H, Krajewski S, Reed JC, Perucho M. Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. Proc Natl Acad Sci USA 2000;97:10872-7.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10872-10877
    • Ionov, Y.1    Yamamoto, H.2    Krajewski, S.3    Reed, J.C.4    Perucho, M.5
  • 75
    • 0036605086 scopus 로고    scopus 로고
    • Analysis of P53/BAX in primary colorectal carcinoma: Low BAX protein expression is a negative prognostic factor in UICC stage III tumors
    • Schelwies K, Sturm I, Grabowski P, Scherubl H, Schindler I, Hermann S, et al. Analysis of P53/BAX in primary colorectal carcinoma: Low BAX protein expression is a negative prognostic factor in UICC stage III tumors. Int J Cancer 2002;99:589-96.
    • (2002) Int J Cancer , vol.99 , pp. 589-596
    • Schelwies, K.1    Sturm, I.2    Grabowski, P.3    Scherubl, H.4    Schindler, I.5    Hermann, S.6
  • 76
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995;80:293-9.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 77
    • 0344348993 scopus 로고    scopus 로고
    • Analysis of the p53/BAX pathway in colorectal cancer: Low BAX is a negative prognostic factor in patients with resected liver metastases
    • Sturm I, Kohne C-H, Wolff G, Petrowsky H, Hillebrand T, Hauptmann S, et al. Analysis of the p53/BAX pathway in colorectal cancer: Low BAX is a negative prognostic factor in patients with resected liver metastases. J Clin Oncol 1999;17:1364-74.
    • (1999) J Clin Oncol , vol.17 , pp. 1364-1374
    • Sturm, I.1    Kohne, C.-H.2    Wolff, G.3    Petrowsky, H.4    Hillebrand, T.5    Hauptmann, S.6
  • 78
    • 0035011885 scopus 로고    scopus 로고
    • Immunohistochemical detection of the anti-apoptosis protein, survivin, predicts survival after curative resection of stage II colorectal carcinomas
    • Sarela A, Scott N, Ramsdale J, Markham AF, Guilou PJ. Immunohistochemical detection of the anti-apoptosis protein, survivin, predicts survival after curative resection of stage II colorectal carcinomas. Ann Surg Oncol 2001;8:305-10.
    • (2001) Ann Surg Oncol , vol.8 , pp. 305-310
    • Sarela, A.1    Scott, N.2    Ramsdale, J.3    Markham, A.F.4    Guilou, P.J.5
  • 79
    • 0036338868 scopus 로고    scopus 로고
    • High survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection
    • Rodel F, Hoffmann J, Grabenbauer GG, Papadopoulos T, Weiss C, Gunther K, et al. High survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection. Strahlenther Onkol 2002;178:426-35.
    • (2002) Strahlenther Onkol , vol.178 , pp. 426-435
    • Rodel, F.1    Hoffmann, J.2    Grabenbauer, G.G.3    Papadopoulos, T.4    Weiss, C.5    Gunther, K.6
  • 80
    • 0032533494 scopus 로고    scopus 로고
    • Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer
    • Kawasaki H, Altieri DC, Lu CD, Toyoda M, Tenjo T, Tanigawa N. Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res 1998;58:5071-4.
    • (1998) Cancer Res , vol.58 , pp. 5071-5074
    • Kawasaki, H.1    Altieri, D.C.2    Lu, C.D.3    Toyoda, M.4    Tenjo, T.5    Tanigawa, N.6
  • 83
    • 0342657718 scopus 로고    scopus 로고
    • A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cells to chemotherapy
    • Olie RA, Simoes-Wust AP, Baumann B, Leech SH, Fabbro D, Stahel RA, et al. A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cells to chemotherapy. Cancer Res 2000;60:2805-9.
    • (2000) Cancer Res , vol.60 , pp. 2805-2809
    • Olie, R.A.1    Simoes-Wust, A.P.2    Baumann, B.3    Leech, S.H.4    Fabbro, D.5    Stahel, R.A.6
  • 84
    • 0021282176 scopus 로고
    • Relationships among Ara-CTP pools, formation of (Ara-C) DNA, and cytotoxicity of human leukemic cells
    • Kufe D, Spriggs D, Egan EM, Munroe D. Relationships among Ara-CTP pools, formation of (Ara-C) DNA, and cytotoxicity of human leukemic cells. Blood 1984;64;54-8.
    • (1984) Blood , vol.64 , pp. 54-58
    • Kufe, D.1    Spriggs, D.2    Egan, E.M.3    Munroe, D.4
  • 85
    • 0034799510 scopus 로고    scopus 로고
    • Cross-resistance to cytosine arabinoside in a multidrug-resistant human promyelocytic cell line selected for resistance to doxorubicin: Implications for combination chemotherapy
    • Mansson E, Paul A, Lofgren C, Ullberg K, Paul C, Eriksson S, et al. Cross-resistance to cytosine arabinoside in a multidrug-resistant human promyelocytic cell line selected for resistance to doxorubicin: Implications for combination chemotherapy. Br J Haematol 2001:114:557-65.
    • (2001) Br J Haematol , vol.114 , pp. 557-565
    • Mansson, E.1    Paul, A.2    Lofgren, C.3    Ullberg, K.4    Paul, C.5    Eriksson, S.6
  • 86
    • 5044225419 scopus 로고    scopus 로고
    • Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
    • Aciwa H, Oguri T, Sato S, Maeda H, Niimi T, Ueda R. Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer. Cancer Sci 2004;95:753-7.
    • (2004) Cancer Sci , vol.95 , pp. 753-757
    • Aciwa, H.1    Oguri, T.2    Sato, S.3    Maeda, H.4    Niimi, T.5    Ueda, R.6
  • 87
    • 2642535305 scopus 로고    scopus 로고
    • Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene
    • Galmarini CM, Clrke ML, Jordheim L, Santos CL, Cros E, Mackey JR, et al. Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene. BMC Pharmacol 2004;4:8.
    • (2004) BMC Pharmacol , vol.4 , pp. 8
    • Galmarini, C.M.1    Clrke, M.L.2    Jordheim, L.3    Santos, C.L.4    Cros, E.5    MacKey, J.R.6
  • 88
    • 1542742114 scopus 로고    scopus 로고
    • RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine
    • Duxbury MS, Hiromichi I, Zinner MJ, Ashley SW, Whang EE. RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene 2004;23:1539-48.
    • (2004) Oncogene , vol.23 , pp. 1539-1548
    • Duxbury, M.S.1    Hiromichi, I.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 89
    • 4043050908 scopus 로고    scopus 로고
    • Susceptibility to cytosine arabinoside (Ara-C)-induced cytotoxicity in human leukemia cell lines
    • Kanno S, Higurashi A, Watanabe Y, Shouji A, Asou K, Ishikawa M. Susceptibility to cytosine arabinoside (Ara-C)-induced cytotoxicity in human leukemia cell lines. Toxicol Lett 2004;152:149-58.
    • (2004) Toxicol Lett , vol.152 , pp. 149-158
    • Kanno, S.1    Higurashi, A.2    Watanabe, Y.3    Shouji, A.4    Asou, K.5    Ishikawa, M.6
  • 90
    • 0034100255 scopus 로고    scopus 로고
    • The role of p53 in gemcitabinemediated cytotoxicity and radio sensitization
    • Chen M, Hough AM, Lawrence TS. The role of p53 in gemcitabinemediated cytotoxicity and radio sensitization. Cancer Chemother Pharmacol 2000;45:369-74.
    • (2000) Cancer Chemother Pharmacol , vol.45 , pp. 369-374
    • Chen, M.1    Hough, A.M.2    Lawrence, T.S.3
  • 91
    • 1242319394 scopus 로고    scopus 로고
    • Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis
    • Schniewind B, Christgen M, Kurdow R, Haye S, Kremer B, Kalthoff H. Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis. Int J Cancer 2004;109:182-8.
    • (2004) Int J Cancer , vol.109 , pp. 182-188
    • Schniewind, B.1    Christgen, M.2    Kurdow, R.3    Haye, S.4    Kremer, B.5    Kalthoff, H.6
  • 92
    • 0036225876 scopus 로고    scopus 로고
    • Brostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-xL
    • Wang Z, Wang S, Dai Y, Grant S. Brostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-xL. J Pharmacol Exp Ther 2002;301:568-77.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 568-577
    • Wang, Z.1    Wang, S.2    Dai, Y.3    Grant, S.4
  • 93
    • 0034670161 scopus 로고    scopus 로고
    • Potentiation of 1-beta-Darabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells(U937) overexpressing Bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01)
    • Tang L, Boise LH, Dent P, Grant S. Potentiation of 1-beta- Darabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing Bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01). Biochem Pharmacol 2000;60:1445-56.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1445-1456
    • Tang, L.1    Boise, L.H.2    Dent, P.3    Grant, S.4
  • 94
    • 0030843575 scopus 로고    scopus 로고
    • Overexpression of Bcl-x (L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis
    • Kim CN, Wang X, Huang Y, Ibrado AM, Liu L, Fang G, et al. Overexpression of Bcl-x(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res 1997;57:3115-20.
    • (1997) Cancer Res , vol.57 , pp. 3115-3120
    • Kim, C.N.1    Wang, X.2    Huang, Y.3    Ibrado, A.M.4    Liu, L.5    Fang, G.6
  • 95
    • 5044240387 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway
    • Chang GC, Hsu SL, Tsai JR, Wu WJ, Chen CY, Sheu GT. Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol 2004;502:169-83.
    • (2004) Eur J Pharmacol , vol.502 , pp. 169-183
    • Chang, G.C.1    Hsu, S.L.2    Tsai, J.R.3    Wu, W.J.4    Chen, C.Y.5    Sheu, G.T.6
  • 96
    • 0035888180 scopus 로고    scopus 로고
    • Bcl-x(L) antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine
    • Xu Z, Freiss H, Solioz M, Aebi S, Korc M, Kleef J, et al. Bcl-x(L) antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine. Int J Cancer 2001;94:268-74.
    • (2001) Int J Cancer , vol.94 , pp. 268-274
    • Xu, Z.1    Freiss, H.2    Solioz, M.3    Aebi, S.4    Korc, M.5    Kleef, J.6
  • 97
    • 0034660068 scopus 로고    scopus 로고
    • Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins
    • Konopleva M, Tari AM, Estrov Z, Harris D, Xie Z, Zhao S, et al. Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins. Blood 2001;95:3929-38.
    • (2001) Blood , vol.95 , pp. 3929-3938
    • Konopleva, M.1    Tari, A.M.2    Estrov, Z.3    Harris, D.4    Xie, Z.5    Zhao, S.6
  • 98
    • 0036468529 scopus 로고    scopus 로고
    • An MCL-1-overexpressing Burkitt lymphoma subline exhibits enhanced survival on nexpopsure to serum deprivation, topoisomerase inhibitors, or staurosporine but remains sensitive to 1-beta-D-arabinofuranosylcytosine
    • Vrana JA, Bieszczad CK, Cleveland ES, Ma Y, Park JP, Mohandas TK, et al. An MCL-1-overexpressing Burkitt lymphoma subline exhibits enhanced survival on nexpopsure to serum deprivation, topoisomerase inhibitors, or staurosporine but remains sensitive to 1-beta-D-arabinofuranosylcytosine. Cancer Res 2002;62:892-900.
    • (2002) Cancer Res , vol.62 , pp. 892-900
    • Vrana, J.A.1    Bieszczad, C.K.2    Cleveland, E.S.3    Ma, Y.4    Park, J.P.5    Mohandas, T.K.6
  • 99
    • 0036057585 scopus 로고    scopus 로고
    • Acquired resistance of pancreatic cancer cells towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes
    • Shi X, Liu S, Kleeff J, Freiss H, Buchler MW. Acquired resistance of pancreatic cancer cells towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes. Oncology 2002;62:354-62.
    • (2002) Oncology , vol.62 , pp. 354-362
    • Shi, X.1    Liu, S.2    Kleeff, J.3    Freiss, H.4    Buchler, M.W.5
  • 100
    • 0029664942 scopus 로고    scopus 로고
    • Dual modes of cell death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival
    • Lock RB, Stribinskene L. Dual modes of cell death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Cancer Res 1996;56:4006-12.
    • (1996) Cancer Res , vol.56 , pp. 4006-4012
    • Lock, R.B.1    Stribinskene, L.2
  • 102
    • 0034307305 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositide 3-kinase enhances gencitabine-induced apoptosis in human pancreatic cancer cells
    • Ng SS, Tsao MS, Chow S, Hadley DW. Inhibition of phosphatidylinositide 3-kinase enhances gencitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res 2000;60:5451-5.
    • (2000) Cancer Res , vol.60 , pp. 5451-5455
    • Ng, S.S.1    Tsao, M.S.2    Chow, S.3    Hadley, D.W.4
  • 103
    • 0034792844 scopus 로고    scopus 로고
    • Wortmannin inhibits pkb/akt phosphorylation and promotes gencitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
    • Ng SS, Tsao MS, Nicklee T, Hedley DW. Wortmannin inhibits pkb/akt phosphorylation and promotes gencitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res 2001;7:3269-75.
    • (2001) Clin Cancer Res , vol.7 , pp. 3269-3275
    • Ng, S.S.1    Tsao, M.S.2    Nicklee, T.3    Hedley, D.W.4
  • 104
    • 1842583652 scopus 로고    scopus 로고
    • Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine
    • Yokoi K, Fidler IJ. Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. Clin Cancer Res 2004;10:2299-306.
    • (2004) Clin Cancer Res , vol.10 , pp. 2299-2306
    • Yokoi, K.1    Fidler, I.J.2
  • 105
    • 0034806012 scopus 로고    scopus 로고
    • MEK1/2 inhibitors promote Ara-Cinduced apoptosis but not loss in m in HL-60 cells
    • Yu C, Wang Z, Dent P, Grant S. MEK1/2 inhibitors promote Ara-Cinduced apoptosis but not loss in m in HL-60 cells. Biochem Biophys Res Commun 2001;286:1011-8.
    • (2001) Biochem Biophys Res Commun , vol.286 , pp. 1011-1018
    • Yu, C.1    Wang, Z.2    Dent, P.3    Grant, S.4
  • 106
    • 0034823632 scopus 로고    scopus 로고
    • Therapeutic targeting of the MEKK/MAPK signal transduction module in acute myeloid leukemia
    • Milella M, Kornblau SM, Estrov Z, Carter BZ, Lapillonne H, Harris D, et al. Therapeutic targeting of the MEKK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 2001;108:851-9.
    • (2001) J Clin Invest , vol.108 , pp. 851-859
    • Milella, M.1    Kornblau, S.M.2    Estrov, Z.3    Carter, B.Z.4    Lapillonne, H.5    Harris, D.6
  • 107
    • 1542285510 scopus 로고    scopus 로고
    • Involvement of p38 mitogen-activated protein kinase in gemcitabineinduced apoptosis in human pancreatic cancer cells
    • Habiro A, Tanno S, Koizumi K, Izawa T, Nakano Y, Osanai M, et al. Involvement of p38 mitogen-activated protein kinase in gemcitabineinduced apoptosis in human pancreatic cancer cells. Biochem Biophys Res Commun 2004;316:71-7.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 71-77
    • Habiro, A.1    Tanno, S.2    Koizumi, K.3    Izawa, T.4    Nakano, Y.5    Osanai, M.6
  • 108
    • 0031785213 scopus 로고    scopus 로고
    • Evidence of involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-D- arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling
    • Jarvis WD, Fornari FA, Tombes RM, Erukulla RK, Bittman R, Schwartz GK, et al. Evidence of involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-D- arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. Mol Pharmacol 1998;54:844-56.
    • (1998) Mol Pharmacol , vol.54 , pp. 844-856
    • Jarvis, W.D.1    Fornari, F.A.2    Tombes, R.M.3    Erukulla, R.K.4    Bittman, R.5    Schwartz, G.K.6
  • 109
    • 1642551021 scopus 로고    scopus 로고
    • Inhibition of Src tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Inhibition of Src tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin Cancer Res 2004;10:2307-18.
    • (2004) Clin Cancer Res , vol.10 , pp. 2307-2318
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 110
    • 2942607458 scopus 로고    scopus 로고
    • SiRNA directed against s-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. SiRNA directed against s-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity. J Am Coll Surg 2004;198:953-9.
    • (2004) J Am Coll Surg , vol.198 , pp. 953-959
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 111
    • 0038621384 scopus 로고    scopus 로고
    • Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    • Arlt A, Gehrz A, Muerkoster S, Vorndamm J, Kruse ML, Folsch UR, et al. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003;22:3243-51.
    • (2003) Oncogene , vol.22 , pp. 3243-3251
    • Arlt, A.1    Gehrz, A.2    Muerkoster, S.3    Vorndamm, J.4    Kruse, M.L.5    Folsch, U.R.6
  • 112
    • 0036164423 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation
    • Jones DR, Broad RM, Comeau LD, Parsons SJ, Mayo MW. Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation. J Thorac Cardiovasc Surg 2002;123:310-7.
    • (2002) J Thorac Cardiovasc Surg , vol.123 , pp. 310-317
    • Jones, D.R.1    Broad, R.M.2    Comeau, L.D.3    Parsons, S.J.4    Mayo, M.W.5
  • 113
    • 0033929398 scopus 로고    scopus 로고
    • Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B-Rel-specific decoy oligodeoxynucleotides
    • Romano MF, Lamberti A, Bisogni R, Tassone P, Pagnini D, Storti G, et al. Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B-Rel-specific decoy oligodeoxynucleotides. Gene Ther 2000;7:1234-7.
    • (2000) Gene Ther , vol.7 , pp. 1234-1237
    • Romano, M.F.1    Lamberti, A.2    Bisogni, R.3    Tassone, P.4    Pagnini, D.5    Storti, G.6
  • 114
    • 4644316230 scopus 로고    scopus 로고
    • Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis
    • Denlinger CE, Rundall BK, Keller MD, Jones DR. Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis. Ann Thorac Surg 2004;78:1207-14.
    • (2004) Ann Thorac Surg , vol.78 , pp. 1207-1214
    • Denlinger, C.E.1    Rundall, B.K.2    Keller, M.D.3    Jones, D.R.4
  • 115
    • 2442549643 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-B mutations or activation of the CD30 CD40, and RANK receptors
    • Zheng B, Georgakis GV, Li Y, Bharti A, McConkey D, Aggarwal BB, et al. Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-B mutations or activation of the CD30, CD40, and RANK receptors. Clin Cancer Res 2004;10:3207-15.
    • (2004) Clin Cancer Res , vol.10 , pp. 3207-3215
    • Zheng, B.1    Georgakis, G.V.2    Li, Y.3    Bharti, A.4    McConkey, D.5    Aggarwal, B.B.6
  • 116
    • 4444235841 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo
    • Kamat AM, Karashima T, Davis DW, Lashinger L, Bar-Eli M, Millikan R, et al. The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo. Mol Cancer Ther 2004;3:279-90.
    • (2004) Mol Cancer Ther , vol.3 , pp. 279-290
    • Kamat, A.M.1    Karashima, T.2    Davis, D.W.3    Lashinger, L.4    Bar-Eli, M.5    Millikan, R.6
  • 118
    • 0033971809 scopus 로고    scopus 로고
    • Drug-induced apoptosis in lung cancer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway
    • Ferreira CG, Tolis C, Span SW, Peters GJ, van Lopik T, Kummer AJ, et al. Drug-induced apoptosis in lung cancer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway. Clin Cancer Res 2000;6:203-12.
    • (2000) Clin Cancer Res , vol.6 , pp. 203-212
    • Ferreira, C.G.1    Tolis, C.2    Span, S.W.3    Peters, G.J.4    Van Lopik, T.5    Kummer, A.J.6
  • 119
    • 0034914110 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines
    • Liu W, Bodle E, Chen JY, Gao M, Rosen GD, Broaddus VC. Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines. Am J Respir Cell Mol Biol 2001;25:111-8.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 111-118
    • Liu, W.1    Bodle, E.2    Chen, J.Y.3    Gao, M.4    Rosen, G.D.5    Broaddus, V.C.6
  • 120
    • 0344393732 scopus 로고    scopus 로고
    • Strategies for reversing drug resistance
    • Fojo T, Bates S. Strategies for reversing drug resistance. Oncogene 2003;22:7512-23.
    • (2003) Oncogene , vol.22 , pp. 7512-7523
    • Fojo, T.1    Bates, S.2
  • 122
    • 0031045307 scopus 로고    scopus 로고
    • Pharmacological approach for optimization of the dose schedule of 5-aza-2-deoxycytidine (decitabine) for the therapy of leukemia
    • Momparler RL, Cote S, Eliopoulos N. Pharmacological approach for optimization of the dose schedule of 5-aza-2-deoxycytidine (decitabine) for the therapy of leukemia. Leukemia 1997;11:175-80.
    • (1997) Leukemia , vol.11 , pp. 175-180
    • Momparler, R.L.1    Cote, S.2    Eliopoulos, N.3
  • 123
    • 0032933747 scopus 로고    scopus 로고
    • Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes
    • Durant ST, Morris MM, Illand M, McKay HJ, McCormick C, Hirst GL, et al. Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes. Curr Biol 1999;9:51-4.
    • (1999) Curr Biol , vol.9 , pp. 51-54
    • Durant, S.T.1    Morris, M.M.2    Illand, M.3    McKay, H.J.4    McCormick, C.5    Hirst, G.L.6
  • 124
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2-deoxy-5-azacytidineinduced demethylation of the hMLH1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. Reversal of drug resistance in human tumor xenografts by 2-deoxy-5-azacytidineinduced demethylation of the hMLH1 gene promoter. Cancer Res 2000;60:6039-44.
    • (2000) Cancer Res , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 125
    • 0033535612 scopus 로고    scopus 로고
    • A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
    • Strathdee G, MacKean MJ, Illand M, Brown R. A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene 1999;18:2335-41.
    • (1999) Oncogene , vol.18 , pp. 2335-2341
    • Strathdee, G.1    MacKean, M.J.2    Illand, M.3    Brown, R.4
  • 126
    • 0034886497 scopus 로고    scopus 로고
    • Aggressive childhood neuroblastomas do not express caspase-8: An important component of programmed cell death
    • Teitz T, Lahti JM, Kidd VJ. Aggressive childhood neuroblastomas do not express caspase-8: An important component of programmed cell death. J Mol Med (Berl) 2001;79:428-36.
    • (2001) J Mol Med (Berl) , vol.79 , pp. 428-436
    • Teitz, T.1    Lahti, J.M.2    Kidd, V.J.3
  • 127
    • 0035866396 scopus 로고    scopus 로고
    • Resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression
    • Eggert A, Grotzer MA, Zuzak TJ, Wiewrodt BR, Ho R, Ikegaki N, et al. Resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Cancer Res 2001;61:1314-9.
    • (2001) Cancer Res , vol.61 , pp. 1314-1319
    • Eggert, A.1    Grotzer, M.A.2    Zuzak, T.J.3    Wiewrodt, B.R.4    Ho, R.5    Ikegaki, N.6
  • 129
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor-or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • Fulda S, Kufer MU, Meyer E, van Halen F, Dockhorn-Dworniczak B, Debatin K-M. Sensitization for death receptor-or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 2001;20:5865-77.
    • (2001) Oncogene , vol.20 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    Van Halen, F.4    Dockhorn-Dworniczak, B.5    Debatin, K.-M.6
  • 130
    • 0034699330 scopus 로고    scopus 로고
    • Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression
    • Grotzer MA, Eggert A, Zuzak TJ, Janss AJ, Marwaha S, Wiewrodt BR, et al. Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression. Oncogene 2000;19:4604-10.
    • (2000) Oncogene , vol.19 , pp. 4604-4610
    • Grotzer, M.A.1    Eggert, A.2    Zuzak, T.J.3    Janss, A.J.4    Marwaha, S.5    Wiewrodt, B.R.6
  • 131
    • 4644275854 scopus 로고    scopus 로고
    • 5-Aza-2-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells
    • Gomyo Y, Sasaki J, Branch C, Roth JA, Mukhopadhyay T. 5-Aza-2-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells. Oncogene 2004;23:6779-87.
    • (2004) Oncogene , vol.23 , pp. 6779-6787
    • Gomyo, Y.1    Sasaki, J.2    Branch, C.3    Roth, J.A.4    Mukhopadhyay, T.5
  • 132
    • 0035283740 scopus 로고    scopus 로고
    • Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo
    • Ueki T, Takeuchi T, Nishimatsu H, Kajiwara T, Moriyama N, Narita Y, et al. Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo. Int J Cancer 2001;91:673-9.
    • (2001) Int J Cancer , vol.91 , pp. 673-679
    • Ueki, T.1    Takeuchi, T.2    Nishimatsu, H.3    Kajiwara, T.4    Moriyama, N.5    Narita, Y.6
  • 133
    • 0002875089 scopus 로고    scopus 로고
    • Clinical development of 2deoxycoformycin
    • Cheson BD, Keating MJ, Plunket W, editors New York Marcel Dekker
    • Cheson BD, Grever MR. Clinical development of 2deoxycoformycin. In:Cheson BD, Keating MJ, Plunket W, editors. Nucleoside analogs in cancer therapy. New York: Marcel Dekker; 1997. p. 95-112.
    • (1997) Nucleoside Analogs in Cancer Therapy , pp. 95-112
    • Cheson, B.D.1    Grever, M.R.2
  • 134
    • 0034994444 scopus 로고    scopus 로고
    • Nucleoside analogues: Mechanisms of drug resistance and reveral strategies
    • Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues: Mechanisms of drug resistance and reveral strategies. Leukemia 2001;15:875-90.
    • (2001) Leukemia , vol.15 , pp. 875-890
    • Galmarini, C.M.1    MacKey, J.R.2    Dumontet, C.3
  • 135
    • 0038509118 scopus 로고    scopus 로고
    • Mechanism of action of purine analogues in chronic lymphocytic leukaemia
    • Pettitt A. mechanism of action of purine analogues in chronic lymphocytic leukaemia. Br J Hematol 2003;121:692-702.
    • (2003) Br J Hematol , vol.121 , pp. 692-702
    • Pettitt, A.1
  • 136
    • 0027525929 scopus 로고
    • Relationship of deoxycytidine kinase and cytoplasmic 5-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine
    • Kawasaki H, Carrera CJ, Piro LD, Saven A, Kipps TJ, Carson DA. Relationship of deoxycytidine kinase and cytoplasmic 5-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine. Blood 1993;81:597-601.
    • (1993) Blood , vol.81 , pp. 597-601
    • Kawasaki, H.1    Carrera, C.J.2    Piro, L.D.3    Saven, A.4    Kipps, T.J.5    Carson, D.A.6
  • 137
    • 0022003367 scopus 로고
    • Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
    • Seto S, CArrera CJ, Kubota M, Wasson DB, Carson DA. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J Clin Invest 1985;75:377-83.
    • (1985) J Clin Invest , vol.75 , pp. 377-383
    • Seto, S.1    Carrera, C.J.2    Kubota, M.3    Wasson, D.B.4    Carson, D.A.5
  • 138
    • 0027505303 scopus 로고
    • Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine
    • Robertson LE, Chubb S, Meyn RE, Story M, Ford R, Hittelman WN, et al. Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine. Blood 1993;81:143-50.
    • (1993) Blood , vol.81 , pp. 143-150
    • Robertson, L.E.1    Chubb, S.2    Meyn, R.E.3    Story, M.4    Ford, R.5    Hittelman, W.N.6
  • 139
    • 0029060757 scopus 로고
    • Fludarabine-and gemcitabine-induced apoptosis: Incorporation of analogs into DNA as a critical event
    • Huang P, Plunkett W. Fludarabine-and gemcitabine-induced apoptosis: Incorporation of analogs into DNA as a critical event. Cancer Chemther Pharmacol 1995;36:181-8.
    • (1995) Cancer Chemther Pharmacol , vol.36 , pp. 181-188
    • Huang, P.1    Plunkett, W.2
  • 140
    • 0029150180 scopus 로고
    • High molecular weight DNA fragmentation: A critical event in nucleoside analogue-induced apoptosis in leukemia cells
    • Huang P, Robertson LE, Wright LS, Plunkett W. High molecular weight DNA fragmentation: A critical event in nucleoside analogue-induced apoptosis in leukemia cells. Clin Cancer Res 1995;1:1005-13.
    • (1995) Clin Cancer Res , vol.1 , pp. 1005-1013
    • Huang, P.1    Robertson, L.E.2    Wright, L.S.3    Plunkett, W.4
  • 141
    • 0030841329 scopus 로고    scopus 로고
    • Biochemical characterization of the protein activity responsible for high molecular weight DNA fragmentation during drug-induced apoptosis
    • Huang P, Ballal K, Plunkett W. Biochemical characterization of the protein activity responsible for high molecular weight DNA fragmentation during drug-induced apoptosis. Cancer Res 1997;57:3407-14.
    • (1997) Cancer Res , vol.57 , pp. 3407-3414
    • Huang, P.1    Ballal, K.2    Plunkett, W.3
  • 142
    • 0030905543 scopus 로고    scopus 로고
    • Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells
    • Belosillo B, Dalmau M, Colomer D, Gil J. Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells. Blood 1997;89:3378-84.
    • (1997) Blood , vol.89 , pp. 3378-3384
    • Belosillo, B.1    Dalmau, M.2    Colomer, D.3    Gil, J.4
  • 143
    • 0033866737 scopus 로고    scopus 로고
    • Caspases influence the mode but not the extent of cell death induced by purine analogues in chronic lymphocytic leukaemia
    • Pettitt AR, Cawley JC. Caspases influence the mode but not the extent of cell death induced by purine analogues in chronic lymphocytic leukaemia. Br J Haematol 2000;109:800-4.
    • (2000) Br J Haematol , vol.109 , pp. 800-804
    • Pettitt, A.R.1    Cawley, J.C.2
  • 144
    • 0036799354 scopus 로고    scopus 로고
    • Role of caspases and apoptosis-inducing factor (AIF) in cladribineinduced apoptosis of B cell chronic lymphocytic leukemia
    • Pérez-Galán P, Marzo I, Giraldo P, Rubio-Félix D, Lasierra P, Larrad L, et al. Role of caspases and apoptosis-inducing factor (AIF) in cladribineinduced apoptosis of B cell chronic lymphocytic leukemia. Leukemia 2002;16:2106-14.
    • (2002) Leukemia , vol.16 , pp. 2106-2114
    • Pérez-Galán, P.1    Marzo, I.2    Giraldo, P.3    Rubio-Félix, D.4    Lasierra, P.5    Larrad, L.6
  • 145
    • 0033708423 scopus 로고    scopus 로고
    • The role of c-Jun kinase in the apoptotic response to nucleoside analogue induced DNA damage
    • Sampath D, Plunkett W. The role of c-Jun kinase in the apoptotic response to nucleoside analogue induced DNA damage. Cancer Res 2000;60:6408-15.
    • (2000) Cancer Res , vol.60 , pp. 6408-6415
    • Sampath, D.1    Plunkett, W.2
  • 146
    • 0035893389 scopus 로고    scopus 로고
    • Interaction of p53 and DNA-PK in response to nucleoside analogues: Potential role as a sensor complex for DNA damage
    • Achanta G, Pelicano H, Feng L, Plunkett W, Huang P. Interaction of p53 and DNA-PK in response to nucleoside analogues: Potential role as a sensor complex for DNA damage. Cancer Res 2001;61:8723-9.
    • (2001) Cancer Res , vol.61 , pp. 8723-8729
    • Achanta, G.1    Pelicano, H.2    Feng, L.3    Plunkett, W.4    Huang, P.5
  • 147
    • 0033621706 scopus 로고    scopus 로고
    • CD40 and B chronic lymphocytic leukemia cell response to fludarabine: The influence of NF-kappaB/Rel transcription factors on chemotherapy induced apoptosis
    • Romano MF, Lamberti A, Turco MC, Venuta S. CD40 and B chronic lymphocytic leukemia cell response to fludarabine: The influence of NF-kappaB/Rel transcription factors on chemotherapy induced apoptosis. Leuk Lymphoma 2000;36:255-62.
    • (2000) Leuk Lymphoma , vol.36 , pp. 255-262
    • Romano, M.F.1    Lamberti, A.2    Turco, M.C.3    Venuta, S.4
  • 148
    • 0036489442 scopus 로고    scopus 로고
    • Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine
    • de la Fuente MT, Casanove B, Moyano JV, Garcia-Gila M, Sanz L, Garcia-Marco J, et al. Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine. J Leukoc Biol 2002;71:495-502.
    • (2002) J Leukoc Biol , vol.71 , pp. 495-502
    • De La Fuente, M.T.1    Casanove, B.2    Moyano, J.V.3    Garcia-Gila, M.4    Sanz, L.5    Garcia-Marco, J.6
  • 149
    • 0032877142 scopus 로고    scopus 로고
    • Pleiotropic drug resistance in B-cell chronic lymphocytic leukaemia: The role of Bcl-2 family dysregulation
    • Pepper C, Thomas A, Hidalgo de Quintana J, Davies S, Hoy T, Bentley P. Pleiotropic drug resistance in B-cell chronic lymphocytic leukaemia: The role of Bcl-2 family dysregulation. Leuk Res 1999;23:1007-14.
    • (1999) Leuk Res , vol.23 , pp. 1007-1014
    • Pepper, C.1    Thomas, A.2    Hidalgo De Quintana, J.3    Davies, S.4    Hoy, T.5    Bentley, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.