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Volumn 17, Issue 5, 1999, Pages 1364-1374

Analysis of the p53/BAX pathway in colorectal cancer: Low BAX is a negative prognostic factor in patients with resected liver metastases

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; COLORECTAL CANCER; FEMALE; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; LIVER METASTASIS; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS;

EID: 0344348993     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.5.1364     Document Type: Article
Times cited : (162)

References (53)
  • 1
    • 0021821903 scopus 로고
    • Involvement of the bcl-2 gene in human follicular lymphoma
    • Tsujimoto Y, Cossman J, Jaffe E, et al: Involvement of the bcl-2 gene in human follicular lymphoma. Science 228:1440-1443, 1985
    • (1985) Science , vol.228 , pp. 1440-1443
    • Tsujimoto, Y.1    Cossman, J.2    Jaffe, E.3
  • 2
    • 0026053958 scopus 로고
    • Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)
    • McDonnell TJ, Korsmeyer SJ: Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature 349:254-256, 1991
    • (1991) Nature , vol.349 , pp. 254-256
    • McDonnell, T.J.1    Korsmeyer, S.J.2
  • 3
    • 0024454762 scopus 로고
    • Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell
    • Tsujimoto Y: Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell. Oncogene 4:1331-1336, 1989
    • (1989) Oncogene , vol.4 , pp. 1331-1336
    • Tsujimoto, Y.1
  • 4
    • 9044225527 scopus 로고    scopus 로고
    • BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy
    • Reed JC, Miyashita T, Takayama S, et al: BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 60:23-32, 1996
    • (1996) J Cell Biochem , vol.60 , pp. 23-32
    • Reed, J.C.1    Miyashita, T.2    Takayama, S.3
  • 5
    • 0028982183 scopus 로고
    • Expression of bcl-xL can confer a multidrug resistance phenotype
    • Minn AJ, Rudin CM, Boise LH, et al: Expression of bcl-xL can confer a multidrug resistance phenotype. Blood 86:1903-1910, 1995
    • (1995) Blood , vol.86 , pp. 1903-1910
    • Minn, A.J.1    Rudin, C.M.2    Boise, L.H.3
  • 6
    • 0028944271 scopus 로고
    • Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis
    • Bargou RC, Daniel PT, Mapara MY, et al: Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int J Cancer 60:854-859, 1995
    • (1995) Int J Cancer , vol.60 , pp. 854-859
    • Bargou, R.C.1    Daniel, P.T.2    Mapara, M.Y.3
  • 7
    • 8944230657 scopus 로고    scopus 로고
    • Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice
    • Bargou RC, Wagener C, Bommert K, et al: Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest 97:2651-2659, 1996
    • (1996) J Clin Invest , vol.97 , pp. 2651-2659
    • Bargou, R.C.1    Wagener, C.2    Bommert, K.3
  • 8
    • 0030062205 scopus 로고    scopus 로고
    • Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis
    • Wagener C, Bargou RC, Daniel PT, et al: Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int J Cancer 67:138-141, 1996
    • (1996) Int J Cancer , vol.67 , pp. 138-141
    • Wagener, C.1    Bargou, R.C.2    Daniel, P.T.3
  • 9
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • Yin C, Knudson CM, Korsmeyer SJ, et al: Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385:637-640, 1997
    • (1997) Nature , vol.385 , pp. 637-640
    • Yin, C.1    Knudson, C.M.2    Korsmeyer, S.J.3
  • 10
    • 0029045784 scopus 로고
    • Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
    • Krajewski S, Blomqvist C, Franssila K, et al: Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 55:4471-4478, 1995
    • (1995) Cancer Res , vol.55 , pp. 4471-4478
    • Krajewski, S.1    Blomqvist, C.2    Franssila, K.3
  • 11
    • 0031052731 scopus 로고    scopus 로고
    • Liver resection for colorectal metastases
    • Fong Y, Cohen AM, Fortner JG, et al: Liver resection for colorectal metastases. J Clin Oncol 15:938-946, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 938-946
    • Fong, Y.1    Cohen, A.M.2    Fortner, J.G.3
  • 12
    • 0029881854 scopus 로고    scopus 로고
    • Surgical resection of colorectal carcinoma metastases to the liver: A prognostic scoring system to improve case selection, based on 1568 patients - Association Francaise de Chirurgie
    • Nordlinger B, Guiguet M, Vaillant JC, et al: Surgical resection of colorectal carcinoma metastases to the liver: A prognostic scoring system to improve case selection, based on 1568 patients - Association Francaise de Chirurgie. Cancer 77:1254-1262, 1996
    • (1996) Cancer , vol.77 , pp. 1254-1262
    • Nordlinger, B.1    Guiguet, M.2    Vaillant, J.C.3
  • 13
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299, 1995
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 14
    • 0027158031 scopus 로고
    • Clues to the pathogenesis of familial colorectal cancer
    • Aaltonen LA, Peltomaki P, Leach FS, et al: Clues to the pathogenesis of familial colorectal cancer. Science 260:812-816, 1993
    • (1993) Science , vol.260 , pp. 812-816
    • Aaltonen, L.A.1    Peltomaki, P.2    Leach, F.S.3
  • 15
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonie carcinogenesis
    • Ionov Y, Peinado MA, Malkhosyan S, et al: Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonie carcinogenesis. Nature 363:558-561, 1993
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3
  • 16
    • 0029903534 scopus 로고    scopus 로고
    • Cancer of the microsatellite mutator phenotype
    • Perucho M: Cancer of the microsatellite mutator phenotype. Biol Chem 377:675-684, 1996
    • (1996) Biol Chem , vol.377 , pp. 675-684
    • Perucho, M.1
  • 17
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N, Yamamoto H, Ionov Y, et al: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275:967-969, 1997
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3
  • 18
    • 0032032682 scopus 로고    scopus 로고
    • Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer
    • Yamamoto H, Sawai H, Weber TK, et al: Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. Cancer Res 58:997-1003, 1998
    • (1998) Cancer Res , vol.58 , pp. 997-1003
    • Yamamoto, H.1    Sawai, H.2    Weber, T.K.3
  • 19
    • 0031940209 scopus 로고    scopus 로고
    • Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas
    • Yagi OK, Akiyama Y, Nomizu T, et al: Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas. Gastroenterology 114:268-274, 1998
    • (1998) Gastroenterology , vol.114 , pp. 268-274
    • Yagi, O.K.1    Akiyama, Y.2    Nomizu, T.3
  • 20
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260:816-819, 1993
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 21
    • 0030048977 scopus 로고    scopus 로고
    • Ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas
    • Weyrer K, Feichtinger H, Haun M, et al: p53, Ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas. Lab Invest 74:279-289, 1996
    • (1996) Lab Invest , vol.74 , pp. 279-289
    • Weyrer, K.1    Feichtinger, H.2    Haun, M.3
  • 22
    • 0032532553 scopus 로고    scopus 로고
    • Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers
    • Simms LA, Radford-Smith G, Biden KG, et al: Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers. Oncogene 17:2003-2008, 1998
    • (1998) Oncogene , vol.17 , pp. 2003-2008
    • Simms, L.A.1    Radford-Smith, G.2    Biden, K.G.3
  • 23
    • 0031927982 scopus 로고    scopus 로고
    • BAX protein expression and clinical outcome in epithelial ovarian cancer
    • Tai YT, Lee S, Niloff E, et al: BAX protein expression and clinical outcome in epithelial ovarian cancer [see comments]. J Clin Oncol 16:2583-2590, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 2583-2590
    • Tai, Y.T.1    Lee, S.2    Niloff, E.3
  • 24
    • 0030814361 scopus 로고    scopus 로고
    • Prognostic significance of Bax protein expression in diffuse aggressive non-Hodgkin's lymphoma
    • Gascoyne RD, Krajewska M, Krajewski S, et al: Prognostic significance of Bax protein expression in diffuse aggressive non-Hodgkin's lymphoma. Blood 90:3173-3178, 1997
    • (1997) Blood , vol.90 , pp. 3173-3178
    • Gascoyne, R.D.1    Krajewska, M.2    Krajewski, S.3
  • 25
    • 0031436251 scopus 로고    scopus 로고
    • Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells
    • Zha H, Reed JC: Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells. J Biol Chem 272:31482-31488, 1997
    • (1997) J Biol Chem , vol.272 , pp. 31482-31488
    • Zha, H.1    Reed, J.C.2
  • 26
    • 0029906828 scopus 로고    scopus 로고
    • BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
    • Xiang J, Chao DT, Korsmeyer SJ: BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci U S A 93:14559-14563, 1996
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14559-14563
    • Xiang, J.1    Chao, D.T.2    Korsmeyer, S.J.3
  • 27
    • 0030779846 scopus 로고    scopus 로고
    • Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
    • Schlesinger PH, Gross A, Yin XM, et al: Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A 94:11357-11362, 1997
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 11357-11362
    • Schlesinger, P.H.1    Gross, A.2    Yin, X.M.3
  • 28
    • 0032571294 scopus 로고    scopus 로고
    • The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition
    • Pastorino JG, Chen ST, Tafani M, et al: The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 273:7770-7775, 1998
    • (1998) J Biol Chem , vol.273 , pp. 7770-7775
    • Pastorino, J.G.1    Chen, S.T.2    Tafani, M.3
  • 29
    • 0032574761 scopus 로고    scopus 로고
    • Bax directly induces release of cytochrome c from isolated mitochondria
    • Jürgensmeier JM, Xie ZH, Deveraux Q, et al: Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 95:4997-5002, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4997-5002
    • Jürgensmeier, J.M.1    Xie, Z.H.2    Deveraux, Q.3
  • 30
    • 0031974274 scopus 로고    scopus 로고
    • Mitochondria in chemotherapy-induced apoptosis: A prospective novel target of cancer therapy
    • Decaudin D, Marzo I, Brenner C, et al: Mitochondria in chemotherapy-induced apoptosis: A prospective novel target of cancer therapy. Int J Oncol 12:141-152, 1998
    • (1998) Int J Oncol , vol.12 , pp. 141-152
    • Decaudin, D.1    Marzo, I.2    Brenner, C.3
  • 31
    • 0030916417 scopus 로고    scopus 로고
    • DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
    • Liu X, Zou H, Slaughter C, et al: DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175-184, 1997
    • (1997) Cell , vol.89 , pp. 175-184
    • Liu, X.1    Zou, H.2    Slaughter, C.3
  • 32
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. Elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H, Henzel WJ, Liu X, et al: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90:405-413, 1997
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3
  • 34
    • 0026318356 scopus 로고
    • Participation of p53 protein in the cellular response to DNA damage
    • Kastan MB, Onyekwere O, Sidransky D, et al: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304-6311, 1991
    • (1991) Cancer Res , vol.51 , pp. 6304-6311
    • Kastan, M.B.1    Onyekwere, O.2    Sidransky, D.3
  • 35
    • 0028901054 scopus 로고
    • De novo vs. Adenoma-carcinoma sequence
    • Hasegawa H, Ueda M, Furukawa K, et al: p53 gene mutations in early colorectal carcinoma. De novo vs. adenoma-carcinoma sequence. Int J Cancer 64:47-51, 1995
    • (1995) Int J Cancer , vol.64 , pp. 47-51
    • Hasegawa, H.1    Ueda, M.2    Furukawa, K.3
  • 36
    • 0031046787 scopus 로고    scopus 로고
    • WAF1 expression and p53 mutations in human colorectal cancers
    • Wang A, Yoshimi N, Ino N, et al: WAF1 expression and p53 mutations in human colorectal cancers. J Cancer Res Clin Oncol 123:118-123, 1997
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 118-123
    • Wang, A.1    Yoshimi, N.2    Ino, N.3
  • 37
    • 0030934802 scopus 로고    scopus 로고
    • Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma
    • Pricolo VE, Finkelstein SD, Hansen K, et al: Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma. Arch Surg 132:371-374, 1997
    • (1997) Arch Surg , vol.132 , pp. 371-374
    • Pricolo, V.E.1    Finkelstein, S.D.2    Hansen, K.3
  • 38
    • 0031929626 scopus 로고    scopus 로고
    • TP53 and long-term prognosis in colorectal cancer: Mutations in the L3 zinc-binding domain predict poor survival
    • Borresen-Dale AL, Lothe RA, Meling GI, et al: TP53 and long-term prognosis in colorectal cancer: Mutations in the L3 zinc-binding domain predict poor survival. Clin Cancer Res 4:203-210, 1998
    • (1998) Clin Cancer Res , vol.4 , pp. 203-210
    • Borresen-Dale, A.L.1    Lothe, R.A.2    Meling, G.I.3
  • 39
    • 0028088897 scopus 로고
    • Association of p53 mutations with short survival in colorectal cancer
    • Hamelin R, Laurent PP, Olschwang S, et al: Association of p53 mutations with short survival in colorectal cancer. Gastroenterology 106:42-48, 1994
    • (1994) Gastroenterology , vol.106 , pp. 42-48
    • Hamelin, R.1    Laurent, P.P.2    Olschwang, S.3
  • 40
    • 0026784607 scopus 로고
    • Increased p53 protein content of colorectal tumours correlates with poor survival
    • Remvikos Y, Tominaga O, Hammel P, et al: Increased p53 protein content of colorectal tumours correlates with poor survival. Br J Cancer 66:758-764, 1992
    • (1992) Br J Cancer , vol.66 , pp. 758-764
    • Remvikos, Y.1    Tominaga, O.2    Hammel, P.3
  • 41
    • 0027170898 scopus 로고
    • p53 immunoreaction in endoscopie biopsy specimens of colorectal cancer, and its prognostic significance
    • Yamaguchi A, Nakagawara G, Kurosaka Y, et al: p53 immunoreaction in endoscopie biopsy specimens of colorectal cancer, and its prognostic significance. Br J Cancer 68:399-402, 1993
    • (1993) Br J Cancer , vol.68 , pp. 399-402
    • Yamaguchi, A.1    Nakagawara, G.2    Kurosaka, Y.3
  • 42
    • 8544267897 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 and p53 associated with disease recurrence in colorectal adenocarcinoma
    • Maeda K, Chung YS, Kang SM, et al: Overexpression of cyclin D1 and p53 associated with disease recurrence in colorectal adenocarcinoma. Int J Cancer 74:310-315, 1997
    • (1997) Int J Cancer , vol.74 , pp. 310-315
    • Maeda, K.1    Chung, Y.S.2    Kang, S.M.3
  • 43
    • 0026032511 scopus 로고
    • p53 in colorectal cancer: Clinicopathological correlation and prognostic significance
    • Scott N, Sagar P, Stewart J, et al: p53 in colorectal cancer: Clinicopathological correlation and prognostic significance. Br J Cancer 63:317-319, 1991
    • (1991) Br J Cancer , vol.63 , pp. 317-319
    • Scott, N.1    Sagar, P.2    Stewart, J.3
  • 44
    • 0030453230 scopus 로고    scopus 로고
    • p53 and PCNA expression in advanced colorectal cancer: Response to chemotherapy and long-term prognosis
    • Paradiso A, Rabinovich M, Vallejo C, et al: p53 and PCNA expression in advanced colorectal cancer: Response to chemotherapy and long-term prognosis. Int J Cancer 69:437-441, 1996
    • (1996) Int J Cancer , vol.69 , pp. 437-441
    • Paradiso, A.1    Rabinovich, M.2    Vallejo, C.3
  • 45
    • 0031012326 scopus 로고    scopus 로고
    • p53 and Rb1 protein expression: Are they prognostically useful in colorectal cancer?
    • Poller DN, Baxter KJ, Shepherd NA: p53 and Rb1 protein expression: Are they prognostically useful in colorectal cancer? Br J Cancer 75:87-93, 1997
    • (1997) Br J Cancer , vol.75 , pp. 87-93
    • Poller, D.N.1    Baxter, K.J.2    Shepherd, N.A.3
  • 46
    • 0029738119 scopus 로고    scopus 로고
    • p53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases
    • Belluco C, Guillem JG, Kemeny N, et al: p53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases. J Clin Oncol 14:2696-2701, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 2696-2701
    • Belluco, C.1    Guillem, J.G.2    Kemeny, N.3
  • 47
    • 0029125551 scopus 로고
    • Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression
    • Kastrinakis WV, Ramchurren N, Rieger KM, et al: Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression. Oncogene 11:641-652, 1995
    • (1995) Oncogene , vol.11 , pp. 641-652
    • Kastrinakis, W.V.1    Ramchurren, N.2    Rieger, K.M.3
  • 48
    • 0028294605 scopus 로고
    • WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
    • El-Deiry W, Harper JW, O'Connor PM, et al: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54:1169-1174, 1994
    • (1994) Cancer Res , vol.54 , pp. 1169-1174
    • El-Deiry, W.1    Harper, J.W.2    O'Connor, P.M.3
  • 49
    • 0031036934 scopus 로고    scopus 로고
    • Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells
    • Ogretmen B, Safa AR: Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells. Oncogene 14:499-506, 1997
    • (1997) Oncogene , vol.14 , pp. 499-506
    • Ogretmen, B.1    Safa, A.R.2
  • 50
    • 16044375068 scopus 로고    scopus 로고
    • Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas
    • Soong R, Robbins PD, Dix BR, et al: Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum Pathol 27:1050-1505, 1996
    • (1996) Hum Pathol , vol.27 , pp. 1050-1505
    • Soong, R.1    Robbins, P.D.2    Dix, B.R.3
  • 51
    • 0028129236 scopus 로고
    • Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas
    • Dix B, Robbins P, Carrello S, et al: Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas. Br J Cancer 70:585-590, 1994
    • (1994) Br J Cancer , vol.70 , pp. 585-590
    • Dix, B.1    Robbins, P.2    Carrello, S.3
  • 52
    • 0028093479 scopus 로고
    • A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma
    • Cripps KJ, Purdie CA, Carder PJ, et al: A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma. Oncogene 9:2739-2743, 1994
    • (1994) Oncogene , vol.9 , pp. 2739-2743
    • Cripps, K.J.1    Purdie, C.A.2    Carder, P.J.3
  • 53
    • 0029787441 scopus 로고    scopus 로고
    • Correlation between p53 immunostaining patterns and gene sequence mutations in breast carcinoma
    • Visscher DW, Sarkar FH, Shimoyama RK, et al: Correlation between p53 immunostaining patterns and gene sequence mutations in breast carcinoma. Diagn Mol Pathol 5:187-193, 1996
    • (1996) Diagn Mol Pathol , vol.5 , pp. 187-193
    • Visscher, D.W.1    Sarkar, F.H.2    Shimoyama, R.K.3


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