Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome C and other perturbations that activate the molecular cascade of apoptosis

Cancer Research

Volumn 57, Issue 15, 1997, Pages 3115-3120

  Kim, Caryn Naekyung ^a   Wang, Xiaodong ^b   Huang, Yue ^a   Ibrado, Ana Maria ^a   Liu, Linda ^a   Fang, Guofu ^a   Bhalla, Kapil ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; CYTARABINE; CYTOCHROME C; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL MEMBRANE POTENTIAL; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL;

APOPTOSIS; ARAC TRANSCRIPTION FACTOR; BACTERIAL PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; CYTOCHROME C GROUP; CYTOSOL; DNA FRAGMENTATION; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; REPRESSOR PROTEINS; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 0030843575     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. L overexpression inhibits progression of molecular events leading to paclitaxel-induccd apoptosis of human AML HL-60 cells. Cancer Res., 57; 1109-1115, 1997.
2. Chen, Z., Nailo, M., Mashima, T., and Tsuruo, T. Activation of actin-cleavable interleukin lβ-converting enzyme (ICE) family protease CPP-32 during chemotherapeutic agent-induced apoptosis in ovarian carcinoma cells. Cancer Res., 56: 5224-5229, 1996.
3. L inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Cancer Res., 56: 4743-4748,1996.
4. AInemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thomberry, N. A., Wong, W. W., and Yuan, J. Human ICE/CED-3 protease nomenclature (Letter). Cell, 87: 171, 1996.
5. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, S., Beidler, D. R., Poirier, G. G., Salvesen, G. S., and Dixit, V. M. Yama/CPP32β, a mammalian homolog of Ced-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81: 801-809, 1995.
6. Lazebnik, Y. A., Takahashi, A., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., and Eamshaw, W. C. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc. Natl. Acad. Sei. USA, 92; 9042-9046, 1995.
7. Bolwell, B. J., Cassileth, P. A., and Gale, R. P. High dose cytarabine: a review. Leukemia (Baltimore), 4: 790-796, 1990.
8. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86: 147-157, 1996.
9. Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B., and Kroemer, G. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med., 182: 367-377, 1995.
10. Zamzami, N., Susin, S. A., Marchetti, P., Hirsch, T., Gómez-Monterrey, I., Castedo, M., and Kroemer, G. Mitochondrial control of nuclear apoptosis. J. Exp. Med., 183: 1533-1544, 1996.
11. Yang, E., and Korsmeyer, S. J. Molecular thanatopsis: A discourse on the BCL2 family and cell death. Blood, 88: 386-401, 1996.
12. Boise, L., Gonzalez-Garcia, M., Postema, C., Ding, L., Lindsten, T., Turka, L., Mao, X., Nunez, G., and Thompson, C. bcl-x, a bcl-2-reIated gene that functions as a dominant regulator of apoptotic cell death. Cell, 74: 597-608, 1993.
13. González-García, M., García, I., Ding, L., O'Shea, S., Boise, L. H., Thompson, C. B., and Nunez, G. bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc. Nail. Acad. Sei. USA, 92:4304-4308, 1995.
14. Gottschalk, A. R., Boise, L. H., Thompson, C. B., and Quintans, J. Identification of immnosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not Bcl-2. Proc. Natl. Acad. Sei. USA, 91: 7350-7354, 1994.
15. Decaudin, D., Geley, S., Hirsch, T., Castedo, M., Marchetti, P., Macho, A., Kofler, R., and Kroemer, G. Bcl-2 and Bcl-xL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res., 57: 62-67, 1997.
16. L function upstream of the CED-3-like apoptotic proteases. J. Biol. Chem., 271: 4573-4576, 1996.