Engagement of α4β1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine

Journal of Leukocyte Biology

Volumn 71, Issue 3, 2002, Pages 495-502

  De La Fuente, Ma Teresa ^a   Casanova, Benito ^a   Moyano, José V ^a   Garcia Gila, Mercedes ^a   Sanz, Laura ^a   Garcia Marco, José ^b   Silva, Augusto ^a   Garcia Pardo, Angeles ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

Apoptosis; Bcl xL; Drug resistance; Integrin signaling

Indexed keywords

FIBRONECTIN; FLUDARABINE; INTEGRIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; POLYLYSINE; PROTEIN BCL XL; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; ANTINEOPLASTIC AGENT; BCL2L1 PROTEIN, HUMAN; DRUG DERIVATIVE; HOMING RECEPTOR; PEPTIDE FRAGMENT; PROTEIN BCL 2; PROTEIN BCL X; VIDARABINE;

ADULT; AGED; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CANCER RESISTANCE; CELL ADHESION; CELL CULTURE; CELL SURVIVAL; CELL VIABILITY; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN INTERACTION; DRUG EFFECT; DRUG RESISTANCE; METABOLISM; MIDDLE AGED; PATHOLOGY;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; DRUG RESISTANCE, NEOPLASM; FEMALE; FIBRONECTINS; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; LEUKEMIA, B-CELL, CHRONIC; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, LYMPHOCYTE HOMING; TUMOR CELLS, CULTURED; VIDARABINE;

EID: 0036489442     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Jurlander, J. (1998) The cellular biology of B-cell chronic lymphocytic leukemia. Crit. Rev. Oncol. Hematol. 27, 29-52.
2. Bannerji, R., Byrd, J. C. (2000) Update on the biology of chronic lymphocytic leukemia. Curr. Opin. Oncol. 12, 22-29.
3. Kroft, S. H., Finn, W. G., LoAnn, C., Peterson, C. (1995) The pathology of the chronic lymphoid leukaemias. Blood Rev. 9, 234-250.
4. Aguilar-Santelises, M., Rottenberg, M. E., Mellstedt, N. H., Jondal, M. (1996) Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression. Int. J. Cancer 69, 114-119.
5. Collins, R. J., Verschuer, L. A., Harmon, B. V., Prentice, R. L., Pope, J. L., Kerr, J. F. R. (1989) Spontaneous programmed cell death of B-chronic lymphocytic leukemia cells following their culture in vitro. Br. J. Haematol. 71, 343-350.
6. Robertson, L. E., Chubb, S., Meyn, R. E., Story, M., Ford, R., Hittelman, W. N., Plunkett, W. (1993) Induction of apoptosis cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-β-D-arabinosyl-2-fluoroadenine. Blood 81, 143-150.
7. Gross, A., McDonnell, J. M., Korsmeyer, S. (1999) Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13, 1899-1911.
8. Oltvai, Z. N., Milliman, C. L., Korsmeyer, S. J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-619.
9. Hanada, M., Delia, D., Aiello, A., Stadtmauer, E., Reed, J. C. (1993) Bcl-2 gene hypomethylation and high level expression in B-cell chronic lymphocytic leukemia. Blood 82, 1820-1828.
10. McConkey, D. J., Chandra, J., Wright, S., Plunkett, W., McDonnel, T. J., Reed, J. C., Keating, M. (1996) Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relatively expression of Bcl-2 and Bax. J. Immunol. 156, 2624-2630.
11. Thomas, A., El Rouby, S., Reed, J. C., Krajewski, S., Silber, R., Potmesil, M., Newcomb, E. W. (1996) Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene 12, 1055-1062.
12. Stoetzer, O., Pogrebniak, A., Scholz, M., Pelka-Fleischer, R., Gullis, E., Darsow, M., Nussler, V., Wilmanns, W. (1999) Drug-induced apoptosis in chronic lymphocytic leukemia. Leukemia 13, 1873-1880.
13. Kitada, S., Andersen, J., Akar, S., Zaparta, J. M., Takayama, S., Krajewski, S., Wang, H. G., Zhang, X., Bullrich, F., Croce, C. M., Rai, K., Hines, J., Reed, J. C. (1998) Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood 91, 3379-3389.
14. Kitada, S., Zapata, J. M., Andreff, M., Reed, J. C. (1999) Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukemia. Br. J. Haematol. 106, 995-1004.
15. Bellosillo, B., Villamor, N., Colomer, D., Pons, G., Montserrat, E., Gil, J. (1999) In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 94, 2836-2843.
16. Meredith Jr., J. E., Schwartz, M. A. (1997) Integrins and adhesion in apoptosis. Trends Cell Biol. 7, 146-150.
17. Long, B. W., Witte, P. L., Abraham, G. N., Gregory, S. A., Plate, J. M. D. (1995) Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells. Proc. Natl. Acad. Sci. USA 92, 1416-1420.
18. Panayiotidis, P., Jones, D., Ganeshaguru, K., Foroni, L., Hoffbrand, A. V. (1996) Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukemia cells in vitro. Br. J. Haematol. 92, 97-103.
19. Lagneaux, L., Delforge, A., Bron, D., De Bruyn, C., Stryckmans, P. (1998) Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 91, 2387-2396.
20. de la Fuente, M. T., Casanova, B., Garcia-Gila, M., Silva, A., Garcia-Pardo, A. (1999) Fibronectin interaction with α4β1 integrin prevents apoptosis in B-cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax. Leukemia 13, 266-274.
21. Zaitseva, M. B., Mojcik, C. F., Salomon, D. R., Shevach, E. M., Goldine, H. (1998) Co-ligation of alpha4beta1 integrin and TCR rescues human thymocytes from steroid-induced apoptosis. Int. Immunol. 10, 1551-1561.
22. Taylor, S. T, Hickman, J. A., Dive, C. (1999) Survival signals within the tumor microenvironment suppress drug-induced apoptosis: lessons learned from B lymphomas. Endocr. Relat. Cancer 6, 21-23.
23. Damiano, J. S., Cress, A. E., Hazlehurst, L. A., Shtil, A. A., Dalton, W. S. (1999) Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 93, 1658-1667.
24. Mudry, R. E., Fortney, J. E., York, T., Hall, B. M., Gibson, L. F. (2000) Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy. Blood 96, 1926-1932.
25. Rai, K. R., Sawitsky, A., Cronkite, E. P., Chanana, A. D., Levy, R. N., Pasternack, B. S. (1975) Clinical staging of chronic lymphocytic leukemia. Blood 46, 219-234.
26. Binet, J. L., Auquier, A., Dighiero, G., Chastang, C., Piguet, H., Goasguen, J., Vaugier, G., Potron, G., Colona, P., Oberling, F., Thomas, M., Tchernia, G., Jacquillat, C., Boivin, P., Lesty, C., Duault, M. T., Monconduit, M., Belabbes, S., Gremy, F. (1981) A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate analysis. Cancer 48, 198-206.
27. Saltman, D., Bansal, N. S., Ross, F. M., Ross, J. A., Turner, G., Guy, K. (1990) Establishment of a karyotypically normal B-chronic lymphocytic leukemia cell line: evidence of leukemic origin by immunoglobulin gene rearrangement. Leuk. Res. 14, 381-387.
28. Wayner, E. A, Garcia-Pardo, A., Humphries, M. J., McDonald, J. A., Carter, W. G. (1989) Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J. Cell Biol. 109, 1321-1330.
29. Guan, J-L., Hynes, R. O. (1990) Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1. Cell 60, 53-61.
30. Mould, A. P., Askari, J. A., Craig, S. E., Garrat, A. N., Clements, J., Humphries, M. J. (1994) Integrin α4β1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin. J. Biol. Chem. 269, 27224-27230.
31. Vincent, A. M., Cawley, J. C., Burthem, J. (1996) Integrin function in chronic lymphocytic leukemia. Blood 87, 4780-4788.
32. Gimond, C., Sonnenberg, A. (1997) Activation states of integrins. In Integrin-Ligand Interaction (J. A. Eble, K. Kühn, eds.), Heidelberg, Germany, Springer-Verlag, 219-240.
33. Sembries, S., Pahl, H., Stilgenbauer, S., Dohner, H., Schriever, F. (1999) Reduced expression of adhesion molecules and cell signaling receptors by chronic lymphocytic leukemia cells with 11q deletion. Blood 93, 624-631.
34. Johnston, J. B., Daeninck, P., Verburg, L., Lee, K., Williams, G., Israels, L. G., Mowat, M. R., Bedgleiter, A. (1997) p53, mdm-2, Bax and Bcl-2 and drug resistance in chronic lymphocytic leukemia. Leuk. Lymphoma 26, 435-449.
35. Klein, A., Miera, O., Bauer, O., Golfier, S., Schriever, F. (2000) Chemosensitivity of B cell chronic lymphocytic leukemia and correlated expression of proteins regulating apoptosis, cell cycle and DNA repair. Leukemia 14, 40-46.
36. Tuscano, J. M., Druey, K. M., Riva, A., Pena, J., Thompson, C. B., Kehrl, J. H. (1996) Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center. Blood 15, 1359-1364.
37. Ghia, P., Boussiotis, V. A., Schultze, J. L., Cardoso, A. A., Dorfman, D. M., Gribben, J. G., Freedman, A. S., Nadler, L. M. (1998) Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood 91, 244-251.
38. Hayashida, K., Shimaoka, Y., Ochi, T., Lipsky, P. E. (2000) Rheumatoid arthritis synovial stromal cells inhibit apoptosis and up-regulate Bcl-xL expression by B cells in a CD49/CD29-CD106-dependent mechanism. J. Immunol. 164, 1110-1116.