-
1
-
-
0036883940
-
Pancreatic cancer biology and genetics
-
Bardeesy N, Depinho RA. Pancreatic cancer biology and genetics. Nature Rev 2002;2:897-909.
-
(2002)
Nature Rev
, vol.2
, pp. 897-909
-
-
Bardeesy, N.1
Depinho, R.A.2
-
3
-
-
0033805783
-
Molecular prognostic markers in pancreatic cancer
-
Coppola D. Molecular prognostic markers in pancreatic cancer. Cancer Control 2000;7:421-7.
-
(2000)
Cancer Control
, vol.7
, pp. 421-427
-
-
Coppola, D.1
-
4
-
-
0037103069
-
New application of gemcitabine and future directions in the management of pancreatic cancer
-
Abbruzzese JL. New application of gemcitabine and future directions in the management of pancreatic cancer. Cancer (Phila.) 2002;95:941-5.
-
(2002)
Cancer (Phila.)
, vol.95
, pp. 941-945
-
-
Abbruzzese, J.L.1
-
5
-
-
0036681993
-
The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a ras-dependent manner
-
Chakravarti A, Chakladar A, Dekaney MA, Lathman DE, Loeffler JS. The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a ras-dependent manner. Cancer Res 2002; 62:4307-15.
-
(2002)
Cancer Res
, vol.62
, pp. 4307-4315
-
-
Chakravarti, A.1
Chakladar, A.2
Dekaney, M.A.3
Lathman, D.E.4
Loeffler, J.S.5
-
7
-
-
0034212763
-
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
-
Bruns CJ, Solorzano CC, Harbison MT, et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 2000;60:2926-35.
-
(2000)
Cancer Res
, vol.60
, pp. 2926-2935
-
-
Bruns, C.J.1
Solorzano, C.C.2
Harbison, M.T.3
-
8
-
-
0036531923
-
Blockade of vascular growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer
-
Baker CH, Solorzano CC, Fidler IJ. Blockade of vascular growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. Cancer Res 2002;62: 1996-2003.
-
(2002)
Cancer Res
, vol.62
, pp. 1996-2003
-
-
Baker, C.H.1
Solorzano, C.C.2
Fidler, I.J.3
-
9
-
-
0027293748
-
Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
-
Yamanaka Y, Friess H, Kobrin MS, et al. Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 1993; 13:565-9.
-
(1993)
Anticancer Res
, vol.13
, pp. 565-569
-
-
Yamanaka, Y.1
Friess, H.2
Kobrin, M.S.3
-
10
-
-
0034194348
-
Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent
-
Perugini RA, McDade TP, Vittimberga FJ, Callery MP. Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent. J Surg Res 2000;90:29-44.
-
(2000)
J Surg Res
, vol.90
, pp. 29-44
-
-
Perugini, R.A.1
McDade, T.P.2
Vittimberga, F.J.3
Callery, M.P.4
-
11
-
-
0036185848
-
The protein kinase B/Akt signaling pathway in human malignancy
-
Nicholson KM, Anderson NG. The protein kinase B/Akt signaling pathway in human malignancy. Cell Signal 2002;14:381-95.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
12
-
-
0036031772
-
Therapeutics targeting signal transduction for patients with colorectal carcinoma
-
De Bono JS, Rowinsky EK. Therapeutics targeting signal transduction for patients with colorectal carcinoma. Br Med Bull 2002;64: 227-54.
-
(2002)
Br Med Bull
, vol.64
, pp. 227-254
-
-
De Bono, J.S.1
Rowinsky, E.K.2
-
13
-
-
0038786580
-
Apoptosis-targeted therapies for cancer
-
Reed JC. Apoptosis-targeted therapies for cancer. Cancer Cell 2003;3:17-22.
-
(2003)
Cancer Cell
, vol.3
, pp. 17-22
-
-
Reed, J.C.1
-
14
-
-
0035990924
-
Inhibition of protein kinase B/Akt: Implication for cancer therapy
-
Hill MM, Hemmings BA. Inhibition of protein kinase B/Akt: implication for cancer therapy. Pharmacol Ther 2002;93:243-51.
-
(2002)
Pharmacol Ther
, vol.93
, pp. 243-251
-
-
Hill, M.M.1
Hemmings, B.A.2
-
15
-
-
0033628571
-
Phosphatidylinositol-3 kinase dependent pathways: The role in control of cell growth, survival, and malignant transformation
-
Krasilnikov MA. Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry 2000;65:59-67.
-
(2000)
Biochemistry
, vol.65
, pp. 59-67
-
-
Krasilnikov, M.A.1
-
16
-
-
0034307305
-
Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
-
Ng SSW, Tsao M-S, Chow S, Hedley DW. Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res 2000;60:5451-5.
-
(2000)
Cancer Res
, vol.60
, pp. 5451-5455
-
-
Ng, S.S.W.1
Tsao, M.-S.2
Chow, S.3
Hedley, D.W.4
-
17
-
-
0034792844
-
Wortmannin inhibits PKB/Akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
-
Ng SSW, Tsao M-S, Nicklee T, Hedley DW. Wortmannin inhibits PKB/Akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res 2001;7:3269-75.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3269-3275
-
-
Ng, S.S.W.1
Tsao, M.-S.2
Nicklee, T.3
Hedley, D.W.4
-
18
-
-
0041338049
-
Inhibition of the phosphatidylinositol 3′-kinase-Akt pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
-
Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB, McConkey DJ. Inhibition of the phosphatidylinositol 3′-kinase-Akt pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther 2002;1:989-97.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 989-997
-
-
Bondar, V.M.1
Sweeney-Gotsch, B.2
Andreeff, M.3
Mills, G.B.4
McConkey, D.J.5
-
19
-
-
0032943591
-
The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
-
Wang W, Abbruzzese JJ, Evans DB, et al. The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999;5:119-27.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 119-127
-
-
Wang, W.1
Abbruzzese, J.J.2
Evans, D.B.3
-
21
-
-
0030995558
-
Prevention of endotoxemia-induced acute respiratory distress syndrome-like lung injury in rabbit by monoclonal antibody to IL-8
-
Yokoi K, Mukaida N, Harada A, Watanabe Y, Matsushima K. Prevention of endotoxemia-induced acute respiratory distress syndrome-like lung injury in rabbit by monoclonal antibody to IL-8. Lab Investig 1997;76:375-84.
-
(1997)
Lab Investig
, vol.76
, pp. 375-384
-
-
Yokoi, K.1
Mukaida, N.2
Harada, A.3
Watanabe, Y.4
Matsushima, K.5
-
22
-
-
0032712997
-
Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
-
Shi Q, Abbruzzese JL, Huang S, et al. Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res 1999;5:3711-21.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 3711-3721
-
-
Shi, Q.1
Abbruzzese, J.L.2
Huang, S.3
-
23
-
-
0034792393
-
Expression of interleukin-8 and its receptor in human colon carcinoma cells with different metastatic potentials
-
Li A, Varney ML, Singh RK. Expression of interleukin-8 and its receptor in human colon carcinoma cells with different metastatic potentials. Clin Cancer Res 2001;7:3298-304.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3298-3304
-
-
Li, A.1
Varney, M.L.2
Singh, R.K.3
-
24
-
-
0036359548
-
Hypoxia: A key regulatory factor in tumor growth
-
Harris AL. Hypoxia: a key regulatory factor in tumor growth. Nature Rev 2002;2:38-47.
-
(2002)
Nature Rev
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
25
-
-
1842471663
-
Responding to hypoxia: Lessons from a model cell line
-
Seta KA, Spicer Z, Yuan Y, Lu G, Millhorn DE. Responding to hypoxia: lessons from a model cell line. Science (Wash. DC) 2002; 146:1-16.
-
(2002)
Science (Wash. DC)
, vol.146
, pp. 1-16
-
-
Seta, K.A.1
Spicer, Z.2
Yuan, Y.3
Lu, G.4
Millhorn, D.E.5
-
26
-
-
0035866784
-
Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/ Akt pathway that results in glycogen synthase kinase-3 inactivation
-
Chen EY, Mazure NM, Cooper JA, Giaccia A. Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/ Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Res 2001;61:2429-33.
-
(2001)
Cancer Res
, vol.61
, pp. 2429-2433
-
-
Chen, E.Y.1
Mazure, N.M.2
Cooper, J.A.3
Giaccia, A.4
-
27
-
-
18844473781
-
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms
-
Bruns CJ, Harbison MT, Davis DW, et al. Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin Cancer Res 2000; 6:1936-48.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1936-1948
-
-
Bruns, C.J.1
Harbison, M.T.2
Davis, D.W.3
-
28
-
-
0034788453
-
Tyrosine kinase inhibitors: From rational design to clinical trials
-
Traxler P, Bold G, Buchdunger E, et al. Tyrosine kinase inhibitors: from rational design to clinical trials. Med Res Rev 2001;21: 499-512.
-
(2001)
Med Res Rev
, vol.21
, pp. 499-512
-
-
Traxler, P.1
Bold, G.2
Buchdunger, E.3
-
29
-
-
0033571167
-
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells
-
Xu L, Xie K, Mukaida N, Matsushima K, Fidler IJ. Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells. Cancer Res 1999;59:5822-9.
-
(1999)
Cancer Res
, vol.59
, pp. 5822-5829
-
-
Xu, L.1
Xie, K.2
Mukaida, N.3
Matsushima, K.4
Fidler, I.J.5
-
30
-
-
0036298180
-
Activation of Erk1/2 and Akt in astrocytes under ischemia
-
Jiang Z, Zhang Y, Chen X, et al. Activation of Erk1/2 and Akt in astrocytes under ischemia. Biochem Biophys Res Commun 2002;294:726-33.
-
(2002)
Biochem Biophys Res Commun
, vol.294
, pp. 726-733
-
-
Jiang, Z.1
Zhang, Y.2
Chen, X.3
-
31
-
-
0035933726
-
Hypoxia induced the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells
-
Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, et al. Hypoxia induced the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells. J Biol Chem 2001;276:22368-74.
-
(2001)
J Biol Chem
, vol.276
, pp. 22368-22374
-
-
Alvarez-Tejado, M.1
Naranjo-Suarez, S.2
Jimenez, C.3
-
32
-
-
0034677776
-
HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-κB pathway
-
Zhou BP, Hu MC-T, Miller SA, et al. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-κB pathway. J Biol Chem 2000;275:8027-31.
-
(2000)
J Biol Chem
, vol.275
, pp. 8027-8031
-
-
Zhou, B.P.1
Hu, M.C.-T.2
Miller, S.A.3
-
33
-
-
0037036365
-
Herstain, an auto-inhibitor of the human epidermal growth factor receptor 2 tyrosine kinase, modulates epidermal growth factor signaling pathway resulting in growth arrest
-
Quincey AJ, Clinton GM. Herstain, an auto-inhibitor of the human epidermal growth factor receptor 2 tyrosine kinase, modulates epidermal growth factor signaling pathway resulting in growth arrest. J Biol Chem 2002;277:20618-24.
-
(2002)
J Biol Chem
, vol.277
, pp. 20618-20624
-
-
Quincey, A.J.1
Clinton, G.M.2
-
34
-
-
0030795612
-
The erbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
-
Alroy I, Yarden Y. The erbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 1997;410:83-6.
-
(1997)
FEBS Lett
, vol.410
, pp. 83-86
-
-
Alroy, I.1
Yarden, Y.2
-
35
-
-
0034644539
-
Cell signaling receptor tyrosine kinases
-
Schlessinger J. Cell signaling receptor tyrosine kinases. Cell 2000; 103:211-25.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
36
-
-
0036258332
-
Receptor-specific regulation of phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2
-
Zhang SQ, Tsiaras WG, Araki T, et al. Receptor-specific regulation of phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2. Mol Cell Biol 2002;22:4062-72.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4062-4072
-
-
Zhang, S.Q.1
Tsiaras, W.G.2
Araki, T.3
-
37
-
-
0037067454
-
Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein shc in endothelial cells
-
Jung F, Haendeler J, Hoffmann J, et al. Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein shc in endothelial cells. Circ Res 2002;91:38-45.
-
(2002)
Circ Res
, vol.91
, pp. 38-45
-
-
Jung, F.1
Haendeler, J.2
Hoffmann, J.3
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