Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis

International Journal of Cancer

Volumn 109, Issue 2, 2004, Pages 182-188

  Schniewind, Bodo ^a   Christgen, Matthias ^a   Kurdow, Roland ^a   Haye, Sieglinde ^a   Kremer, Bernd ^a   Kalthoff, Holger ^a,b   Ungefroren, Hendrik ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Bax; Bcl xL; c FLIP; Caspases; Chemotherapy; Death receptor; Drug resistance

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; CARRIER PROTEIN; CASPASE; CASPASE 8; CASPASE 9; CYTOCHROME C; DEOXYCYTIDINE; DRUG DERIVATIVE; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; FLIP (CELLULAR); GEMCITABINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ONCOPROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN BCL XL; PROTEIN BID; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CANCER SURVIVAL; CELL CULTURE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG RESISTANCE; DRUG SENSITIVITY; FEMALE; GENE OVEREXPRESSION; GENETICS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE POTENTIAL; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; PANCREAS CANCER; PANCREAS TUMOR; PATHOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RETROVIRUS; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR REGRESSION;

ANIMALS; ANTIGENS, CD95; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CASPASE 9; CASPASES; CYTOCHROMES C; DEOXYCYTIDINE; DRUG RESISTANCE, NEOPLASM; FEMALE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE POTENTIALS; MICE; MICE, INBRED BALB C; MICE, SCID; MITOCHONDRIA; PANCREATIC NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROVIRIDAE; TUMOR CELLS, CULTURED;

EID: 1242319394     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11679     Document Type: Article

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