A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

Oncogene

Volumn 24, Issue 8, 2005, Pages 1403-1411

  Xiao, Zhan ^a   Xue, John ^a   Sowin, Thomas J ^a   Rosenberg, Saul H ^a   Zhang, Haiying ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

5 fluorouracil (5 FU); Antimetabolites; Chk1; Mitotic catastrophe; Phospho histone H2A.X; Premature chromosomal condensation (PCC)

Indexed keywords

CAMPTOTHECIN; CASPASE 3; CASPASE 8; CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; FLUOROURACIL; PROTEIN CDC25A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CHROMOSOME CONDENSATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; DNA SYNTHESIS; DRUG EFFICACY; DRUG SENSITIVITY; ENZYME INHIBITION; FLUORESCENCE ACTIVATED CELL SORTING; GENOTOXICITY; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASES; CELL CYCLE; CELL NUCLEUS; DNA; DNA DAMAGE; DNA REPLICATION; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; HELA CELLS; HUMANS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASES; RNA, SMALL INTERFERING;

EID: 14844315930     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208309     Document Type: Article

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