P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells

Cancer Research

Volumn 64, Issue 17, 2004, Pages 6296-6303

  Geller, James I ^a   Szekely Szucs, Kinga ^a   Petak, Istvan ^b   Doyle, Belinda ^a   Houghton, Janet A ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; FLUOROURACIL; FOLINIC ACID; GAMMA INTERFERON; PLEVITREXED; PROTEIN P21; ROSCOVITINE; THYMIDINE DERIVATIVE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; ENZYME INHIBITOR; FAS ANTIGEN; PURINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

APOPTOSIS; ARTICLE; CDK1 GENE; CDK2 GENE; CELL CYCLE; CELL CYCLE S PHASE; CELL SURVIVAL; CLONOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYCLIN E GENE; CYTOTOXICITY; DNA DAMAGE; DNA MICROARRAY; DRUG ACCUMULATION; DRUG EXPOSURE; DRUG MECHANISM; DRUG POTENTIATION; GENE; HUMAN; HUMAN CELL; MITOSIS; P21 CIP1 GENE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRESS; UPREGULATION; BIOSYNTHESIS; CELL CYCLE G1 PHASE; CELL STRAIN HCT116; CELL STRAIN HT29; COLORECTAL TUMOR; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY;

ANTIGENS, CD95; APOPTOSIS; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DRUG SYNERGISM; ENZYME INHIBITORS; G1 PHASE; HCT116 CELLS; HT29 CELLS; HUMANS; INTERFERON TYPE II; PURINES; QUINAZOLINES; S PHASE; THYMIDYLATE SYNTHASE;

EID: 4344644911     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0863     Document Type: Article

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