c-myb heterozygous mice are hypersensitive to 5-fluorouracil and ionizing radiation

Molecular Cancer Research

Volumn 2, Issue 6, 2004, Pages 354-361

  Ramsay, Robert G ^a   Micallef, Suzanne ^b   Lightowler, Sally ^a   Mucenski, Michael L ^c   Mantamadiotis, Theo ^a   Bertoncello, Ivan ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; GAMMA RADIATION; GENE FUNCTION; GENE MUTATION; HETEROZYGOSITY; IONIZING RADIATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIOSENSITIVITY; STEM CELL;

ANIMALS; APOPTOSIS; BONE MARROW; CELL PROLIFERATION; COLON; FLUOROURACIL; GENES, MYB; HEMATOPOIETIC STEM CELLS; HETEROZYGOTE; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-MYB; RADIATION, IONIZING;

ANIMALIA;

EID: 3543082269     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Mucenski ML, McLain K, Kier AB, et al. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 1991;65:677-89.
2. Zorbas M, Sicurella C, Bertoncello I, et al. c-Myb is critical for murine colon development. Oncogene 1999;18:5821-30.
3. Weston K. Myb proteins in life, death and differentiation. Curr Opin Genet Dev 1998;8:76-81.
4. Allen RD 3rd, Bender TP, Siu G. c-Myb is essential for early T cell development. Genes Dev 1999;13:1073-8.
5. Bender TP, Thompson CB, Kuehl WM. Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation. Science 1987;237:1473-6.
6. Emambokus N, Vegiopoulos A, Harman B, Jenkinson E, Anderson G, Frampton J. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J 2003;22:4478-88.
7. Fu SL, Lipsick JS. Constitutive expression of full-length c-Myb transforms avian cells characteristic of both the monocytic and granulocytic lineages. Cell Growth & Differ 1997;8:35-45.
8. Gonda TJ, Ramsay RG, Johnson GR. Murine myeloid cell lines derived by in vitro infection with recombinant c-myb retroviruses express myb from rearranged vector proviruses. EMBO J 1989;8:1767-75.
9. Gonda TJ, Buckmaster C, Ramsay RG. Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro. EMBO J 1989;8:1777-83.
10. Thompson MA, Rosenthal MA, Ellis SL, et al. c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression. Cancer Res 1998;58:5168-75.
11. Alexander RJ, Buxbaum JN, Raicht RF. Oncogene alterations in rat colon tumors induced by N-methy-N-nitrosourea. Am J Med Sci 1992;303:16-24.
12. Rosenthal MA, Thompson MA, Ellis S, Whitehead RH, Ramsay RG. Colonic expression of c-myb is initiated in utero and continues throughout adult life. Cell Growth & Differ 1996;7:961-7.
13. Thompson MA, Ramsay RG. Myb: an old oncoprotein with new roles. BioEssays 1995;17:341-50.
14. Torelli G, Venturelli D, Colo A, et al. Expression of c-myb protooncogene and other cell cycle-related genes in normal and neoplastic human colonic mucosa. Cancer Res 1987;47:5266-9.
15. Alitalo K, Winqvist R, Lin CC, de la Chapelle A, Schwab M, Bishop JM. Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma. Proc Natl Acad Sci USA 1984;81:4534-8.
16. Kanei-Ishii C, Yasukawa T, Morimoto RI, Ishii S. c-Myb-induced transactivation mediated by heat shock elements without sequence-specific DNA binding of c-Myb. J Biol Chem 1994;269:15768-75.
17. Baird MC, Hendry JH, Dexter MT, Testa NG. The radiosensitivity of populations of murine hemopoietic colony-forming cells that respond to combinations of growth factors. Exp Hematol 1991;19:282-7.
18. Alexander RJ, Buxbaum JN, Raicht RF. Enhanced expression of oncogene-encoded mRNA in a rat model of colon cancer. Am J Med Sci 1991;301: 238-45.
19. Ramsay RG, Thompson MA, Hayman JA, Reid G, Gonda TJ, Whitehead RH. Myb expression is higher in malignant human colonic carcinoma and premalignant adenomatous polyps than in normal mucosa. Cell Growth & Differ 1992;3:723-30.
20. Brabender J, Lord RV, Danenberg KD, et al. Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. J Surg Res 2001;99:301-6.
21. Biroccio A, Benassi B, D'Agnano I, et al. c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: clinical and experimental findings. Am J Pathol 2001;158:1289-99.
22. Potten CS, Grant HK. The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine. Br J Cancer 1998; 78:993-1003.
23. Pritchard DM, Print C, O'Reilly L, Adams JM, Porten CS, Hickman JA. Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine. Oncogene 2000;19:3955-9.
24. Merritt AJ, Potten CS, Watson AJ, Loh DY, Nakayama K, Hickman JA. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J Cell Sci 1995;108:2261-71.
25. Potten CS. Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos Trans R Soc Lond B Biol Sci 1998;353:821-30.
26. Pritchard DM, Potten CS, Korsmeyer SJ, Roberts S, Hickman JA. Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 1999;18:7287-93.
27. Neben S, Redfearn WJ, Parra M, Brecher G, Pallavicini MG. Short- and long-term repopulation of lethally irradiated mice by bone marrow stem cells enriched on the basis of light scatter and Hoechst 33342 fluorescence. Exp Hematol 1991;19:958-67.
28. Hodgson GS, Bradley TR. Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: evidence for a pre-CFU-S cell? Nature 1979; 281:381-2.
29. Bertoncello I, Bradford GB. Surrogate assays for hematopoietic stem cell activity. In: Garand J, Quesenberry P, Hilton D, editors. Colony-stimulating factors. 2nd ed. New York: Marcel Dekker, Inc.; 1997. p. 35-47.
30. Kamada S, Shimono A, Shinto Y, et al. bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res 1995;55:354-9.
31. Churilla AM, Braciale TJ, Braciale VL. Regulation of T lymphocyte proliferation. Interleukin 2-mediated induction of c-myb gene expression is dependent on T lymphocyte activation state. J Exp Med 1989;170:105-21.
32. Gewirtz AM, Anfossi G, Venturelli D, Valpreda S, Sims R, Calabretta, B. G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb. Science 1989;245:180-3.
33. Stern JB, Smith KA. Interleukin-2 induction of T-cell G1 progression and c-myb expression. Science 1986;233:203-6.
34. Sumner R, Crawford A, Mucenski M, Frampton J. Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factor. Oncogene 2000;19:3335-42.
35. Sicurella C, Freeman R, Micallef S, Mucenski ML, Bertoncello I, Ramsay RG. Defective stem cell factor expression in c-myb null fetal liver stroma. Blood Cells Mol Dis 2001;27:470-8.
36. Bradford GB, Williams B, Rossi R, Bertoncello I. Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment. Exp Hematol 1997;25:445-53.