Aggressive childhood neuroblastomas do not express caspase-8: An important component of programmed cell death

Journal of Molecular Medicine

Volumn 79, Issue 8, 2001, Pages 428-436

  Teitz, Tal ^a   Lahti, Jill M ^a   Kidd, Vincent J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Apoptosis; Caspase 8; Methylation specific polymerase chain reaction; Neuroblastoma; Tumor suppressor

Indexed keywords

CASPASE 8; CASPASE 9; MESSENGER RNA;

APOPTOSIS; ARTICLE; CANCER INVASION; CHILDHOOD CANCER; DNA METHYLATION; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE SILENCING; NEURAL CREST; NEUROBLASTOMA; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

ANTIGENS, CD95; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 8; CASPASE 9; CASPASES; CHILD; CHROMOSOMES, HUMAN, PAIR 1; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; GENE AMPLIFICATION; HUMANS; LOSS OF HETEROZYGOSITY; NEUROBLASTOMA; PROTEINS;

EID: 0034886497     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090100233     Document Type: Article

References (47)

1. Neuroblastoma as a neurobiological disease
2. Neuroblastoma
3. Allelotype of neuroblastoma
4. A region of consistent deletion in neuroblastoma maps within 1p36.2-.3
5. Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification
6. Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: A pediatric oncology group study
7. Allelic loss of chromosome 1 and additional chromosome 17 material are both unfavorable prognostic markers in neuroblastoma
8. Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas
9. No CDKN2 mutations in neuroblastoma
10. Disruption of the cyclin D/cyclin-dependent kinase/INK4/pRb regulatory pathway in human neuroblastoma
11. Absence of p53 gene mutations in primary neuroblastomas
12. Caspase-8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
13. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex
14. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
15. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/α and caspase-8/β
16. Essential contribution of caspase-3/CPP32 to apoptosis and its associated nuclear changes
17. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
18. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
19. Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma
20. Structure and chromosome localization of the human CASP8 gene
21. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
22. Homozygous deletion at chromosome 2q33 in human small-cell lung carcinoma identified by arbitrarily primed PCR genomic fingerprinting
23. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
24. The TRAIL DISCussion: It is FADD and caspase-8!
25. Identification of the cytolinker plectin as a major early in vivo substrate for caspase-8 during CD95- and tumor necrosis factor receptor-mediated apoptosis
26. Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis
27. Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells
28. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis
29. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
30. BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
31. Alterations in DNA methylation: A fundamental aspect of neoplasia
32. Cancer epigenetics comes of age
33. A bird's eye view of global methylation
34. Cellular differentiation, cytidine analogs and DNA methylation
35. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
36. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
37. Resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression
38. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
39. The origins of the neural crest, embryonic induction
40. The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells
41. Biochemical pathways of caspase activation during apoptosis
42. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
43. Errors of homeostasis and deregulated apoptosis
44. Mechanisms of apoptosis avoidance in cancer
45. Apoptosis in cancer
46. Proteolytic regulation of apoptosis
47. Apoptosis in development