Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced Apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression

Cancer Research

Volumn 61, Issue 4, 2001, Pages 1314-1319

  Eggert, Angelika ^a   Grotzer, Michael A ^a   Zuzak, Tycho J ^a   Wiewrodt, Barbara R ^a   Ho, Ruth ^a   Ikegaki, Naohiko ^a   Brodeur, Garrett M ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CASPASE; CASPASE 10; CASPASE 18; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; FLICE INHIBITORY PROTEIN; MESSENGER RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; DNA METHYLATION; DOSE TIME EFFECT RELATION; DRUG SENSITIVITY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; NEUROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AZACITIDINE; CASPASE 10; CASPASE 8; CASPASE 9; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; METHYLATION; NEUROBLASTOMA; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR DECOY RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035866396     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Induction of apoptosis by Apo-2 ligand, a new member of tumor necrosis factor cytokine family
2. Lethal effect of the anti-Fas antibody in mice
3. Apoptosis control by death and decoy receptors
4. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
5. An antagonist decoy receptor and a death domain-containing receptor for TRAIL
6. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
7. Identification and characterisation of a new member of the TNF family that induces apoptosis
8. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signaling
9. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex
10. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kB
11. Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes
12. Inhibition of death receptor signals by cellular FLIP
13. A relative quantitative RT-PCR protocol for TrkB expression in neuroblastoma using GAPD as an internal control
14. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
15. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
16. Fas/Apo-1 gene transfer for human malignant glioma
17. The CD95 (Apo1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells
18. Structure and chromosome location of the human CASP8 gene
19. Alterations in DNA methylation: A fundamental aspect of neoplasia
20. Targeted disruption of the mouse caspase-8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
21. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
22. Molecular determinants of response to TRAIL in killing of normal and cancer cells
23. The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
24. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma
25. Involvement of the CD95 (Apo-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
26. Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia
27. Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia