ABC transporters in yeast - Drug resistance and stress response in a nutshell

Yeast as a Tool in Cancer Research

Volumn , Issue , 2007, Pages 289-314

  Kuchler, Karl ^a   Schüller, Christoph ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

ABC protein; antifungal resistance; detoxification; drug screening; stress response; Yeast

Indexed keywords

EID: 84875230884     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4020-5963-6_11     Document Type: Chapter

References (159)

1. Ahn, J., J. T. Wong, and R. S. Molday. 2000. The effect of lipid environment and retinoids on the ATPase activity of ABCR, the photoreceptor ABC transporter responsible for Stargardt macular dystrophy. J. Biol. Chem. 275:20399-20405
2. Akache, B., and B. Turcotte. 2002. New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J. Biol. Chem. 277:21254-21260
3. Allen, J., H. M. Davey, D. Broadhurst, J. K. Heald, J. J. Rowland, S. G. Oliver, and D. B. Kell. 2003. High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat. Biotechnol. 21:692-696
4. Allikmets, R., W. H. Raskind, A. Hutchinson, N. D. Schueck, M. Dean, and D. M. Koeller. 1999. Mutation of a putative mitochondrial iron transporter gene (ABC7) in Xlinked sideroblastic anemia and ataxia (XLSA/A). Hum. Mol. Genet. 8:743-749
5. Almashanu, S., and D. Valle. 2003. Peroxisomal ABC transporters, pp. 497-513. In ABC Proteins: From Bacteria to Man, Susan P. C. Cole, I. Barry Holland, Karl Kuchler, and Christopher F. Higgins (eds.), Academic Press Elsevier Science, Amsterdam.
6. Anderson, J. B., C. Sirjusingh, A. B. Parsons, C. Boone, C. Wickens, L. E. Cowen, and L. M. Kohn. 2003. Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 163:1287-1298
7. Bader, G. D., A. Heilbut, B. Andrews, M. Tyers, T. Hughes, and C. Boone. 2003. Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol. 13:344-356
8. Balzi, E., W. Chen, S. Ulaszewski, E. Capieaux, and A. Goffeau. 1987. The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J. Biol. Chem. 262:16871-16879
9. Balzi, E., M. Wang, S. Leterme, L. Van Dyck, and A. Goffeau. 1994. PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J. Biol. Chem. 269:2206-2214
10. Bauer, B. E., C. Schüller, and K. Kuchler. 2003. Fungal ABC proteins in clinical drug resistance and cellular detoxification, pp. 295-316. In ABC Proteins: From Bacteria to Man, Susan P. C. Cole, I. Barry Holland, Karl Kuchler, and Christopher F. Higgins (ed.), Academic Press Elsevier Science, Amsterdam.
11. Bauer, B. E., H. Wolfger, and K. Kuchler. 1999. Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim. Biophys. Acta 1461:217-236
12. Bekri, S., G. Kispal, H. Lange, E. Fitzsimons, J. Tolmie, R. Lill, and D. F. Bishop. 2000. Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood 96:3256-3264
13. Bissinger, P. H., and K. Kuchler. 1994. Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J. Biol. Chem. 269:4180-4186
14. Borst, P., and R. O. Elferink. 2002. Mammalian ABC transporters in health and disease. Annu. Rev. Biochem. 71:537-592
15. Borst, P., A. H. Schinkel, J. J. Smit, E. Wagenaar, L. Van Deemter, A. J. Smith, E. W. Eijdems, F. Baas, and G. J. Zaman. 1993. Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals. Pharmacol. Ther. 60:289-299
16. Cai, J., and P. Gros. 2003. Overexpression, purification, and functional characterization of ATP-binding cassette transporters in the yeast, Pichia pastoris. Biochim. Biophys. Acta 1610:63-76
17. Carvajal, E., H. B. van den Hazel, A. Cybularz-Kolaczkowska, E. Balzi, and A. Goffeau. 1997. Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes. Mol. Gen. Genet. 256:406-415
18. Castrillo, J. I., and S. G. Oliver. 2004. Yeast as a touchstone in post-genomic research: strategies for integrative analysis in functional genomics. J. Biochem. Mol. Biol. 37:93-106
19. Chloupkova, M., L. S. LeBard, and D. M. Koeller. 2003. MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress. J. Mol. Biol. 331:155-165
20. Cresswell, P., N. Bangia, T. Dick, and G. Diedrich. 1999. The nature of the MHC class I peptide loading complex. Immunol. Rev. 172:21-28
21. Cui, Z., D. Hirata, E. Tsuchiya, H. Osada, and T. Miyakawa. 1996. The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions. J. Biol. Chem. 271:14712-14716
22. Cui, Z., T. Shiraki, D. Hirata, and T. Miyakawa. 1998. Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Mol. Microbiol. 29:1307-1315
23. Daleke, D. L. 2003. Regulation of transbilayer plasma membrane phospholipid asymmetry. J. Lipid Res. 44:233-242
24. Dassa, E. 2003. Phylogenetic and functional classification of ABC (ATP-binding cassette) systems, pp. 3-35. In ABC Proteins: From Bacteria to Man, Susan P. C. Cole, I. Barry Holland, Karl Kuchler, and Christopher F. Higgins (ed.), Academic Press Elsevier Science, Amsterdam.
25. Dean, M., R. Allikmets, B. Gerrard, C. Stewart, A. Kistler, B. Shafer, S. Michaelis, and J. Strathern. 1994. Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily. Yeast 10:377-383
26. Decottignies, A., and A. Goffeau. 1997. Complete inventory of the yeast ABC proteins. Nat. Genet. 15:137-145
27. Delahodde, A., T. Delaveau, and C. Jacq. 1995. Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance. Mol. Cell. Biol. 15:4043-4051
28. Delaunay, A., D. Pflieger, M. B. Barrault, J. Vinh, and M. B. Toledano. 2002. A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation. Cell 111:471-481
29. Delaveau, T., A. Delahodde, E. Carvajal, J. Subik, and C. Jacq. 1994. PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol. Gen. Genet. 244:501-511
30. DeRisi, J., B. van den Hazel, P. Marc, E. Balzi, P. Brown, C. Jacq, and A. Goffeau. 2000. Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants. FEBS Lett. 470:156-160
31. Des Etages, S. A., D. Saxena, H. L. Huang, D. A. Falvey, D. Barber, and M. C. Brandriss. 2001. Conformational changes play a role in regulating the activity of the proline utilization pathway-specific regulator in Saccharomyces cerevisiae. Mol. Microbiol. 40:890-899
32. Devaux, F., E. Carvajal, S. Moye-Rowley, and C. Jacq. 2002. Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast. FEBS Lett. 515:25-28
33. Devaux, P. F., and R. Morris. 2004. Transmembrane asymmetry and lateral domains in biological membranes. Traffic 5:241-246
34. Dolinski, K., C. A. Ball, S. A. Chervitz, S. S. Dwight, M. A. Harris, S. Roberts, T. Roe, J. M. Cherry, and D. Botstein. 1998. Expanding yeast knowledge online. Yeast 14:1453-1469
35. Egner, R., F. E. Rosenthal, A. Kralli, D. Sanglard, and K. Kuchler. 1998. Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter. Mol. Biol. Cell 9:523-543
36. Estruch, F., and M. Carlson. 1993. Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol. Cell. Biol. 13:3872-3881
37. Fernandes, L., C. Rodrigues-Pousada, and K. Struhl. 1997. Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol. Cell. Biol. 17:6982-6993
38. Ferreira-Pereira, A., S. Marco, A. Decottignies, J. Nader, A. Goffeau, and J. L. Rigaud. 2003. Three-dimensional reconstruction of the Saccharomyces cerevisiae multidrug resistance protein Pdr5p. J. Biol. Chem. 278:11995-11999
39. Fitzgerald, M. L., K. J. Moore, and M. W. Freeman. 2002. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J. Mol. Med. 80:271-281
40. Forsburg, S. L. 2001. The art and design of genetic screens: yeast. Nat. Rev. Genet. 2:659-668
41. Gaber, R. F., D. M. Copple, B. K. Kennedy, M. Vidal, and M. Bard. 1989. The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Mol. Cell Biol. 9:3447-3456
42. Gaedeke, N., M. Klein, U. Kolukisaoglu, et al. 2001. The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement. EMBO J. 20:1875-1887
43. Gasch, A. P., P. T. Spellman, C. M. Kao, O. Carmel-Harel, M. B. Eisen, G. Storz, D. Botstein, and P. O. Brown. 2000. Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell 11:4241-4257
44. Gavin, A. C., M. Bosche, R. Krause, et al. 2002. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415:141-147
45. Ghaemmaghami, S., W. K. Huh, K. Bower, R. W. Howson, A. Belle, N. Dephoure, E. K. O'Shea, and J. S. Weissman. 2003. Global analysis of protein expression in yeast. Nature 425:737-741
46. Ghosh, M., J. Shen, and B. P. Rosen. 1999. Pathways of As(III) detoxification in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 96:5001-5006
47. Giaever, G., A. M. Chu, L. Ni, et al. 2002. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418:387-391
48. Golin, J., S. V. Ambudkar, M. M. Gottesman, A. D. Habib, J. Sczepanski, W. Ziccardi, and L. May. 2003. Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux. J. Biol. Chem. 278:5963-5969
49. Gray, N. S., L. Wodicka, A. M. Thunnissen, et al. 1998. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281:533-538
50. Guo, H., and G. B. Kohlhaw. 1996. Regulation of transcription in mammalian cells by yeast Leu3p and externally supplied inducer. FEBS Lett. 390:191-195
51. Hallström, T. C., L. Lambert, S. Schorling, E. Balzi, A. Goffeau, and W. S. Moye- Rowley. 2001. Coordinate control of sphingolipid biosynthesis and multidrug resistance in Saccharomyces cerevisiae. J. Biol. Chem. 276:23674-23680
52. Hallström, T. C., and W. S. Moye-Rowley. 1998. Divergent transcriptional control of multidrug resistance genes in Saccharomyces cerevisiae. J. Biol. Chem. 273:2098-2104
53. Hallström, T. C., and W. S. Moye-Rowley. 2000. Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J. Biol. Chem. 275:37347-37356
54. Hellauer, K., B. Akache, S. MacPherson, E. Sirard, and B. Turcotte. 2002. Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter. J. Biol. Chem. 277:17671-17676
55. Hemenway, C. S., and J. Heitman. 1996. Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. J. Biol. Chem. 271:18527-18534
56. Hikkel, I., A. Lucau-Danila, T. Delaveau, P. Marc, F. Devaux, and C. Jacq. 2003. A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. J. Biol. Chem. 278:11427-11432
57. Hirata, D., K. Yano, K. Miyahara, and T. Miyakawa. 1994. Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance. Curr. Genet. 26:285-294
58. Hughes, T., B. Andrews, and C. Boone. 2004. Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets. Cell 116:5-7
59. Julien, M., S. Kajiji, R. H. Kaback, and P. Gros. 2000. Simple purification of highly active biotinylated P-glycoprotein: enantiomer-specific modulation of drug-stimulated ATPase activity. Biochemistry 39:75-85
60. Katzmann, D. J., P. E. Burnett, J. Golin, Y. Mahé, and W. S. Moye-Rowley. 1994. Transcriptional control of the yeast PDR5 gene by the PDR3 gene product. Mol. Cell. Biol. 14:4653-4661
61. Katzmann, D. J., T. C. Hallström, Y. Mahé, and W. S. Moye-Rowley. 1996. Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J. Biol. Chem. 271:23049-23054
62. Katzmann, D. J., T. C. Hallström, M. Voet, W. Wysock, J. Golin, G. Volckaert, and W. S. Moye-Rowley. 1995. Expression of an ATP-binding cassette transporterencoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol. Cell. Biol. 15:6875-6883
63. Kean, L. S., A. M. Grant, C. Angeletti, Y. Mahé, K. Kuchler, R. S. Fuller, and J. W. Nichols. 1997. Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. J. Cell Biol. 138:255-270
64. Kiser, G. L., M. Gentzsch, A. K. Kloser, E. Balzi, D. H. Wolf, A. Goffeau, and J. R. Riordan. 2001. Expression and degradation of the cystic fibrosis transmembrane conductance regulator in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 390:195-205
65. Kispal, G., P. Csere, C. Prohl, and R. Lill. 1999. The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J. 18:3981-3989
66. Klein, M., Y. M. Mamnun, T. Eggmann, C. Schüller, H. Wolfger, E. Martinoia, and K. Kuchler. 2002. The ATP-binding cassette (ABC) transporter Bpt1p mediates vacuolar sequestration of glutathione conjugates in yeast. FEBS Lett. 520:63-67
67. Klett, E. L., K. Lu, A. Kosters, et al. 2004. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2:5
68. Kolaczkowska, A., and A. Goffeau. 1999. Regulation of pleiotropic drug resistance in yeast. Drug Res. Updates 2:403-414
69. Kolaczkowski, M., A. Kolaczowska, J. Luczynski, S. Witek, and A. Goffeau. 1998. In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network. Microb. Drug Resist. 4:143-158
70. Kralli, A., S. P. Bohen, and K. R. Yamamoto. 1995. LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones. Proc. Natl. Acad. Sci. USA 92:4701-4705
71. Kren, A., Y. M. Mamnun, B. E. Bauer, et al. 2003. War1p, a novel transcription factor controlling weak acid stress response in yeast. Mol. Cell. Biol. 23:1775-1785
72. Kuchler, K. 1993. Unusual routes of protein secretion: the easy way out. Trends Cell Biol. 3:421-426
73. Kuchler, K., R. E. Sterne, and J. Thorner. 1989. Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells. EMBO J. 8:3973-3984
74. Kuchler, K., and J. Thorner. 1992. Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 89:2302-2306
75. Lee, M. H., K. Lu, S. Hazard, et al. 2001. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat. Genet. 27:79-83
76. Lee, S. H., and G. A. Altenberg. 2003. Expression of functional multidrug-resistance protein 1 in Saccharomyces cerevisiae: effects of N- and C-terminal affinity tags. Biochem. Biophys. Res. Commun. 306:644-649
77. Lee, S. H., and G. A. Altenberg. 2003. Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1). Biochem. J. 370:357-360
78. Lee, T. I., N. J. Rinaldi, F. Robert, et al. 2002. Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 298:799-804
79. Leighton, J., and G. Schatz. 1995. An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J. 14:188-195
80. Lerner-Marmarosh, N., K. Gimi, I. L. Urbatsch, P. Gros, and A. E. Senior. 1999. Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins. J. Biol. Chem. 274:34711-34718
81. Levy, S., and M. Alekshun. 1999. The mar regulon: multiple resistance to antibiotics and other toxic chemicals. Trends Microbiol. 7:410-413
82. Li, Z. S., M. Szczypka, Y. P. Lu, D. J. Thiele, and P. A. Rea. 1996. The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J. Biol. Chem. 271:6509-6517
83. Lill, R., and G. Kispal. 2003. ABC transporters in mitochondria, pp. 515-531. In ABC Proteins: From Bacteria to Man, Susan P. C. Cole, I. Barry Holland, Karl Kuchler, and Christopher F. Higgins (ed.), Academic Press Elsevier Science, Amsterdam.
84. Litman, T., T. E. Druley, W. D. Stein, and S. E. Bates. 2001. From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cell Mol. Life Sci. 58:931-959
85. Liu, G., R. Sanchez-Fernandez, Z. S. Li, and P. A. Rea. 2001. Enhanced multispecificity of arabidopsis vacuolar multidrug resistance-associated protein-type ATP-binding cassette transporter, AtMRP2. J. Biol. Chem. 276:8648-8656
86. Lucau-Danila, A., T. Delaveau, G. Lelandais, F. Devaux, and C. Jacq. 2003. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. J. Biol. Chem. 278:52641-52650
87. Lum, P. Y., C. D. Armour, S. B. Stepaniants, et al. 2004. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 116:121-137
88. Mahé, Y., Y. Lemoine, and K. Kuchler. 1996. The ATP-binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J. Biol. Chem. 271:25167-25172
89. Mahé, Y., A. Parle-McDermott, A. Nourani, A. Delahodde, A. Lamprecht, and K. Kuchler. 1996. The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3. Mol. Microbiol. 20:109-117
90. Mamnun, Y. M., R. Pandjaitan, Y. Mahé, A. Delahodde, and K. Kuchler. 2002. The yeast zinc finger regulators Pdr1p and Pdr3p control pleiotropic drug resistance (PDR) as homo- and heterodimers in vivo. Mol. Microbiol. 46:1429-1440
91. Mamnun, Y. M., C. Schüller, and K. Kuchler. 2004. Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett. 559:111-117
92. Mangelsdorf, D. J., and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-850
93. Marmorstein, R., M. Carey, M. Ptashne, and S. C. Harrison. 1992. DNA recognition by GAL4: structure of a protein-DNA complex. Nature 356:408-414
94. Martens, J. A., J. Genereaux, A. Saleh, and C. J. Brandl. 1996. Transcriptional activation by yeast PDR1p is inhibited by its association with NGG1p/ADA3p. J. Biol. Chem. 271:15884-15890
95. Martinoia, E., M. Klein, M. Geisler, L. Bovet, C. Forestier, U. Kolukisaoglu, B. Muller-Rober, and B. Schulz. 2002. Multifunctionality of plant ABC transportersmore than just detoxifiers. Planta 214:345-355
96. Mason, D. L., M. P. Mallampalli, G. Huyer, and S. Michaelis. 2003. A region within a lumenal loop of Saccharomyces cerevisiae Ycf1p directs proteolytic processing and substrate specificity. Eukaryot. Cell 2:588-598
97. McGrath, J. P., and A. Varshavsky. 1989. The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature 340:400-404
98. Meyers, S., W. Schauer, E. Balzi, M. Wagner, A. Goffeau, and J. Golin. 1992. Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5. Curr. Genet. 21:431-436
99. Miyahara, K., D. Hirata, and T. Miyakawa. 1996. yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr. Genet. 29:103-105
100. Miyahara, K., M. Mizunuma, D. Hirata, E. Tsuchiya, and T. Miyakawa. 1996. The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett. 399:317-320
101. Moye-Rowley, W. S., K. D. Harshman, and C. S. Parker. 1989. Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins. Genes Dev. 3:283-292
102. Munder, T., and A. Hinnen. 1999. Yeast cells as tools for target-oriented screening. Appl. Microbiol. Biotechnol. 52:311-320
103. Nakamura, K., M. Niimi, K. Niimi, A. R. Holmes, J. E. Yates, A. Decottignies, B. C. Monk, A. Goffeau, and R. D. Cannon. 2001. Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters. Antimicrob. Agents Chemother. 45:3366-3374
104. Nourani, A., M. Wesolowski-Louvel, T. Delaveau, C. Jacq, and A. Delahodde. 1997. Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters. Mol. Cell. Biol. 17:5453-5460
105. Ortiz, D. F., M. V. St Pierre, A. Abdulmessih, and I. M. Arias. 1997. A yeast ATPbinding cassette-type protein mediating ATP-dependent bile acid transport. J. Biol. Chem. 272:15358-15365
106. Ouellette, M., and D. Légaré. 2003. Drug resistance mediated by ABC transporters in parasites of humans, pp. 317-333. In ABC Proteins: From Bacteria to Man, Susan P. C. Cole, I. Barry Holland, Karl Kuchler, and Christopher F. Higgins (ed.), Academic Press Elsevier Science, Amsterdam.
107. Paddon, C., D. Loayza, L. Vangelista, R. Solari, and S. Michaelis. 1996. Analysis of the localization of STE6/CFTR chimeras in a Saccharomyces cerevisiae model for the cystic fibrosis defect CFTR delta F508. Mol. Microbiol. 19:1007-1017
108. Parsons, A. B., R. L. Brost, H. Ding, et al. 2004. Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat. Biotechnol. 22:62-69
109. Pascolo, L., S. Petrovic, F. Cupelli, C. V. Bruschi, P. L. Anelli, V. Lorusso, M. Visigalli, F. Uggeri, and C. Tiribelli. 2001. Abc protein transport of MRI contrast agents in canalicular rat liver plasma vesicles and yeast vacuoles. Biochem. Biophys. Res. Commun. 282:60-66
110. Petrovic, S., L. Pascolo, R. Gallo, F. Cupelli, J. D. Ostrow, A. Goffeau, C. Tiribelli, and C. V. Bruschi. 2000. The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Yeast 16:561-571
111. Piper, P., Y. Mahé, S. Thompson, R. Pandjaitan, C. Holyoak, R. Egner, M. Mühlbauer, P. Coote, and K. Kuchler. 1998. The Pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast. EMBO J. 17:4257-4265
112. Prasad, R., P. De Wergifosse, A. Goffeau, and E. Balzi. 1995. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet. 27:320-329
113. Prendergast, J. A., R. A. Singer, N. Rowley, A. Rowley, G. C. Johnston, M. Danos, B. Kennedy, and R. F. Gaber. 1995. Mutations sensitizing yeast cells to the start inhibitor nalidixic acid. Yeast 11:537-547
114. Raggers, R. J., A. van Helvoort, R. Evers, and G. van Meer. 1999. The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane. J. Cell Sci. 112:415-422
115. Raymond, M., P. Gros, M. Whiteway, and D. Y. Thomas. 1992. Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene. Science 256:232-234
116. Raymond, M., S. Ruetz, D. Y. Thomas, and P. Gros. 1994. Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520. Mol. Cell. Biol. 14:277-286
117. Reid, R. J., E. A. Kauh, and M. A. Björnsti. 1997. Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast. J. Biol. Chem. 272:12091-12099
118. Riordan, J. R., and X. B. Chang. 1992. CFTR, a channel with the structure of a transporter. Biochim. Biophys. Acta 1101:221-222
119. Rogers, B., A. Decottignies, M. Kolaczkowski, E. Carvajal, E. Balzi, and A. Goffeau. 2001. The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J. Mol. Microbiol. Biotechnol. 3:207-214
120. Ruetz, S., and P. Gros. 1994. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77:1071-1081
121. Saleh, A., V. Lang, R. Cook, and C. J. Brandl. 1997. Identification of native complexes containing the yeast coactivator/repressor proteins NGG1/ADA3 and ADA2. J. Biol. Chem. 272:5571-5578
122. Sanglard, D., F. Ischer, M. Monod, and J. Bille. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143:405-416
123. Sanglard, D., K. Kuchler, F. Ischer, J. L. Pagani, M. Monod, and J. Bille. 1995. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39:2378-2386
124. Schuetz, E. G., S. Strom, K. Yasuda, et al. 2001. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J. Biol. Chem. 276:39411-39418
125. Schuetzer-Muehlbauer, M., B. Willinger, R. Egner, G. Ecker, and K. Kuchler. 2003. Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast. Int. J. Antimicrob. Agents 22:291-300
126. Schuetzer-Muehlbauer, M., B. Willinger, G. Krapf, S. Enzinger, E. Presterl, and K. Kuchler. 2003. The Candida albicans Cdr2p ATP-binding cassette (ABC) transporter confers resistance to caspofungin. Mol. Microbiol. 48:225-235
127. Schüller, C., B. E. Bauer, and K. Kuchler. 2003. Inventory and evolution of fungal ABC protein genes, pp. 279-293. In ABC Proteins: From Bacteria to Man, Susan P. C. Cole, I. Barry Holland, Karl Kuchler, and Christopher F. Higgins (ed.), Academic Press Elsevier Science, Amsterdam.
128. Schüller, C., Y. M. Mamnun, M. Mollapour, G. Krapf, M. Schuster, B. E. Bauer, P. W. Piper, and K. Kuchler. 2004. Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Mol. Biol. Cell 15:706-720
129. Servos, J., E. Haase, and M. Brendel. 1993. Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases. Mol. Gen. Genet. 236:214-218
130. Shah, N., and R. D. Klausner. 1993. Brefeldin A reversibly inhibits secretion in Saccharomyces cerevisiae. J. Biol. Chem. 268:5345-5348
131. Shani, N., P. A. Watkins, and D. Valle. 1995. PXA1, a possible Saccharomyces cerevisiae ortholog of the human adrenoleukodystrophy gene. Proc. Natl. Acad. Sci. USA 92:6012-6016
132. Sharma, K. G., D. L. Mason, G. Liu, P. A. Rea, A. K. Bachhawat, and S. Michaelis. 2002. Localization, regulation, and substrate transport properties of Bpt1p, a Saccharomyces cerevisiae MRP-type ABC transporter. Eukaryot. Cell 1:391-400
133. Simonics, T., Z. Kozovska, D. Michalkova-Papajova, A. Delahodde, C. Jacq, and J. Subik. 2000. Isolation and molecular characterization of the carboxy-terminal pdr3 mutants in Saccharomyces cerevisiae. Curr. Genet. 38:248-255
134. Smriti, S. K., B. L. Dixit, C. M. Gupta, S. Milewski, and R. Prasad. 2002. ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators. Yeast 19:303-318
135. Smriti, S. K., and R. Prasad. 1999. Membrane fluidity affects functions of Cdr1p, a multidrug ABC transporter of Candida albicans. FEMS Microbiol. Lett. 173:475-481
136. Swartzman, E. E., M. N. Viswanathan, and J. Thorner. 1996. The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae. J. Cell Biol. 132:549-563
137. Szczypka, M. S., J. A. Wemmie, W. S. Moye-Rowley, and D. J. Thiele. 1994. A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J. Biol. Chem. 269:22853-22857
138. Taglicht, D., and S. Michaelis. 1998. Saccharomyces cerevisiae ABC proteins and their relevance to human health and disease. Methods Enzymol. 292:130-162
139. Teem, J. L., H. A. Berger, L. S. Ostedgaard, D. P. Rich, L. C. Tsui, and M. J. Welsh. 1993. Identification of revertants for the cystic fibrosis delta F508 mutation using STE6-CFTR chimeras in yeast. Cell 73:335-346
140. Tommasini, R., R. Evers, E. Vogt, C. Mornet, G. J. Zaman, A. H. Schinkel, P. Borst, and E. Martinoia. 1996. The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1. Proc. Natl. Acad. Sci. USA 93:6743-6748
141. Tong, A. H., G. Lesage, G. D. Bader, et al. 2004. Global mapping of the yeast genetic interaction network. Science 303:808-813
142. Ueda, K., A. M. Shimabuku, H. Konishi, Y. Fujii, S. Takebe, K. Nishi, M. Yoshida, T. Beppu, and T. Komano. 1993. Functional expression of human P-glycoprotein in Schizosaccharomyces pombe. FEBS Lett. 330:279-282
143. Urban, M., T. Bhargava, and J. E. Hamer. 1999. An ATP-driven efflux pump is a novel pathogenicity factor in rice blast disease. EMBO J. 18:512-521
144. Urlinger, S., K. Kuchler, T. H. Meyer, S. Uebel, and R. Tampé. 1997. Intracellular location, complex formation, and function of the transporter associated with antigen processing in yeast. Eur. J. Biochem. 245:266-272
145. Vik, A., and J. Rine. 2001. Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 21:6395-6405
146. Volkman, S. K., A. F. Cowman, and D. F. Wirth. 1995. Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 92:8921-8925
147. Wang, D., F. Zheng, S. Holmberg, and G. B. Kohlhaw. 1999. Yeast transcriptional regulator Leu3p. Self-masking, specificity of masking, and evidence for regulation by the intracellular level of Leu3p. J. Biol. Chem. 274:19017-19024
148. Wemmie, J. A., M. S. Szczypka, D. J. Thiele, and W. S. Moye-Rowley. 1994. Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1. J. Biol. Chem. 269:32592-32597
149. Wendler, F., H. Bergler, K. Prutej, H. Jungwirth, G. Zisser, K. Kuchler, and G. Högenauer. 1997. Diazaborine resistance in the yeast Saccharomyces cerevisiae reveals a link between YAP1 and the pleiotropic drug resistance genes PDR1 and PDR3. J. Biol. Chem. 272:27091-27098
150. Wilcox, L. J., D. A. Balderes, B. Wharton, A. H. Tinkelenberg, G. Rao, and S. L. Sturley. 2002. Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J. Biol. Chem. 277:32466-32472
151. Wolfger, H., Y. Mahé, A. Parle-McDermott, A. Delahodde, and K. Kuchler. 1997. The yeast ATP-binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett. 418:269-274
152. Wolfger, H., Y. M. Mamnun, and K. Kuchler. 2001. Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification. Res. Microbiol. 152:375-389
153. Wolfger, H., Y. M. Mamnun, and K. Kuchler. 2004. The yeast Pdr15p ATP-binding cassette (ABC) protein is a general stress response factor implicated in cellular detoxification. J. Biol. Chem. 279:11593-11599
154. Yano, K., and T. Fukasawa. 1997. Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 94:1721-1726
155. Young, L., K. Leonhard, T. Tatsuta, J. Trowsdale, and T. Langer. 2001. Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science 291:2135-2138
156. Zgurskaya, H. I., and H. Nikaido. 2002. Mechanistic parallels in bacterial and human multidrug efflux transporters. Curr. Protein Pept. Sci. 3:531-540
157. Zhang, X., Z. Cui, T. Miyakawa, and W. S. Moye-Rowley. 2001. Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. J. Biol. Chem. 276:8812-8819
158. Zhu, H., J. F. Klemic, S. Chang, et al. 2000. Analysis of yeast protein kinases using protein chips. Nat. Genet. 26:283-289
159. Zhu, H., and M. Snyder. 2003. Protein chip technology. Curr. Opin. Chem. Biol. 7:55-63.