Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

Cell

Volumn 116, Issue 1, 2004, Pages 121-137

  Lum, Pek Yee ^a   Armour, Christopher D ^a   Stepaniants, Sergey B ^a   Cavet, Guy ^a   Wolf, Maria K ^c   Butler, J Scott ^c   Hinshaw, Jerald C ^e   Garnier, Philippe ^e   Prestwich, Glenn D ^e   Leonardson, Amy ^a   Garrett Engele, Philip ^a   Rush, Christopher M ^d   Bard, Martin ^d   Schimmack, Greg ^a   Phillips, John W ^b   Roberts, Christopher J ^a   Shoemaker, Daniel D ^a  

^a ROSETTA INPHARMATICS   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d INDIANA UNIVERSITY   (United States)

^e UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; AMPHOTERICIN B; ANTIANGINA PECTORIS AGENT; ATENOLOL; CAFFEINE; CAMPTOTHECIN; CARBENDAZIM; CHLORPROMAZINE; CISPLATIN; CLOMIPRAMINE; CLOTRIMAZOLE; CYCLOHEXIMIDE; DACTINOMYCIN; DAUNORUBICIN; DESIPRAMINE; DILTIAZEM; DIMETHYL SULFOXIDE; DOXORUBICIN; DOXYCYCLINE; EFAVIRENZ; FLOXURIDINE; FLUCYTOSINE; FLUOROURACIL; HYPOCHOLESTEROLEMIC AGENT; LANOSTEROL SYNTHASE; MOLSIDOMINE; OXYBUPROCAINE; RIBOSOME RNA; UNINDEXED DRUG; ZIDOVUDINE;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; GENOME; GENOME ANALYSIS; GROWTH INHIBITION; HETEROZYGOTE; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RNA PROCESSING; SACCHAROMYCES CEREVISIAE; SCREENING; VALIDATION PROCESS; YEAST;

FUNGI; MYXOGASTRIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 10744225364     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(03)01035-3     Document Type: Article

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