Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2

Molecular Microbiology

Volumn 29, Issue 5, 1998, Pages 1307-1315

  Cui, Zhifeng ^a   Shiraki, Toshiyuki ^a   Hirata, Dai ^a   Miyakawa, Tokichi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ABC TRANSPORTER; AMINO ACID; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; MUTANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENOME; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION; YEAST;

4-NITROQUINOLINE-1-OXIDE; AMINO ACID SEQUENCE; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, NORTHERN; CLONING, MOLECULAR; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTAGENS; PHENOTYPE; PYRANS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SPIRO COMPOUNDS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; ZINC FINGERS;

SACCHAROMYCES CEREVISIAE;

EID: 0031655755     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1998.01027.x     Document Type: Article

References (29)

1. Balzi, E., and Goffeau, A. (1995) Yeast multidrug resistance: the PDR network. J Bioenerg Biomembr 27: 71-76.
2. Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., and Goffeau, A. (1987) The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem 262: 16871-16879.
3. Balzi, E., Wang, M., Leterme, S., Dyck, L.V., and Goffeau, A. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269: 2206-2214.
4. Bissinger, P.H., and Kuchler, K. (1994) Molecular cloning and expression of the Sacchammyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269: 4180-4186.
5. Cole, S.P.C., Bhardwaj, G., Gerlach, J.H., Mackie, J.E., Grant, C.E., Almquist, K.C., et al. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654.
6. Cui, Z., Hirata, D., Tsuchiya, E., Osada, H., and Miyakawa, T. (1996) The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Sacchammyces cerevisiae is important for the tolerance to a broad range of organic anions. J Biol Chem 271: 14712-14716.
7. Decottignies, A., Lambert, L., Catty, P., Degand, H., Epping, E.A., Moye-Rowley, W.S., et al. (1995) Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J Biol Chem 270: 18150-18157.
8. Decottignies, A., Gramt, A.M., Nichols, J.W., Wet, H., McIntosh, D.B., and Goffeau, A. (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem 273: 12612-12622.
9. Delahodde, A., Delaveau, T., and Jacq, C. (1995) Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance. Mol Cell Biol 15: 4043-4051.
10. Delaveau, T., Delahodde, A., Carvajal, E., Subik, J., and Jacq, C. (1994) PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol Gen Genet 244: 501-511.
11. Gottesman, M.M., and Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427.
12. Grunstein, M., and Hogness, D.S. (1975) Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc Natl Acad Sci USA 72: 3961-3965.
13. Hallstrom, T.C., and Moye-Rowley, W.S. (1998) Divergent transcriptional control of multidrug resistance genes in Saccharomyces cerevisiae. J Biol Chem 273: 2098-2104.
14. Higgins, C.F. (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67-113.
15. Hirata, D., Yano, K., Miyahara, K., and Miyakawa, T. (1994) Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance. Curr Genet 26: 285-294.
16. Horio, M., Gottesman, M.M., and Pastan, I. (1988) ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci USA 85: 3580-3584.
17. Katzmann, D.J., Burnett, P.E., Golin, J., Mahe, Y., and Moye-Rowley, W.S. (1994) Transcriptional control of the yeast PDR5 gene by the PDR3 gene product. Mol Cell Biol 14: 4653-4661.
18. Katzmann, D.J., Hallstrom, T.C., Voet, M., Wysock, W., Golin, J., Volckaert, G., et al. (1995) Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol 15: 6875-6883.
19. Katzmann, D.J., Hallstrom, T.C., Mahe, Y., and Moye-Rowley, W.S. (1996) Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J Biol Chem 271: 23049-23054.
20. Mahe, Y., Parle-McDermott, A., Nourani, A., Delahodde, A., Lamprecht, A., and Kuchler, K. (1996) The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3. Mol Microbiol 20: 109-117.
21. Maniatis, T., Fritsch; E.F., and Sambrook, J (1982) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
22. Meyers, S., Schauer, W., Balzi, E., Wagner, M., Goffeau, A., and Golin, J. (1992) Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5. Curr Genet 21: 431-436.
23. Muller, M., Meijer, C., Zaman, G.J.R., Borst, P., Scheper, R.J., Mulder, N.H., et al. (1994) Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91: 13033-13037.
24. 6 binuclear cluster. Proc Natl Acad Sci USA 87: 2077-2081.
25. Sanger, F., Nicklen, S., and Coulson, A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467.
26. Scherman, F., Fink, G.R., and Hicks, J.B. (1983) Methods in Yeast Genetics Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
27. Schmitt, M.E., Brown, T.A., and Trumpower, B.L. (1990) A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res 18: 3091-3092.
28. Servos, J., Haase, E., and Brendel, M. (1993) Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases. Mol Gen Genet 236: 214-218.
29. Szczypka, M.S., Wemmie, J.A., Moye-Rowley, W.S., and Thiele, D.J. (1994) A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J Biol Chem 269: 22853-22857.