Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

Nature Biotechnology

Volumn 22, Issue 1, 2004, Pages 62-69

  Parsons, Ainslie B ^a,b   Brost, Renée L ^b   Ding, Huiming ^b   Li, Zhijian ^a,b   Zhang, Chaoying ^a   Sheikh, Bilal ^b   Brown, Grant W ^a   Kane, Patricia M ^c   Hughes, Timothy R ^a,b   Boone, Charles ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; GENES; GENETIC ENGINEERING; MUTAGENESIS; PROTEINS; YEAST;

BIOACTIVE COMPOUNDS; GENETIC INTERACTION DATA;

BIOTECHNOLOGY;

BENOMYL; CAFFEINE; CAMPTOTHECIN; CYCLOHEXIMIDE; CYCLOSPORIN A; FLUCONAZOLE; HYDROXYUREA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RAPAMYCIN; SULFOMETURON METHYL; TACROLIMUS; TUNICAMYCIN; WORTMANNIN;

ARTICLE; CELL VACUOLE; CHEMICAL GENETICS; CONTROLLED STUDY; DELETION MUTANT; DRUG HYPERSENSITIVITY; DRUG MECHANISM; GENE; GENE INTERACTION; HAPLOIDY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; TARGET CELL DESTRUCTION; YEAST;

BIOTECHNOLOGY; CLUSTER ANALYSIS; DRUG INDUSTRY; DRUG RESISTANCE; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION; MUTATION; PHARMACOGENETICS; PROTON-TRANSLOCATING ATPASES; SACCHAROMYCES CEREVISIAE; SOFTWARE;

MAMMALIA;

EID: 0347473810     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt919     Document Type: Article

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