Molecular and phenotypic: Characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes

Molecular and General Genetics

Volumn 256, Issue 4, 1997, Pages 406-415

  Carvajal, E ^a,b   Van Den Hazel, H B ^a   Cybularz Kolaczkowska, A ^a   Balzi, E ^a   Goffeau, A ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Multidrug resistance; PDR1; Saccharomyces cerevisiae; Transcriptional regulator

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ABC TRANSPORTER; CYCLOHEXIMIDE; KETOCONAZOLE; MESSENGER RNA; NUCLEOSIDE TRIPHOSPHATASE; OLIGOMYCIN; TRANSCRIPTION FACTOR;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL GENETICS; FUNGUS MUTANT; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

ALLELES; ATP-BINDING CASSETTE TRANSPORTERS; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENOME, FUNGAL; MEMBRANE PROTEINS; MUTAGENESIS; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0030671457     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050584     Document Type: Article

References (48)

1. Balzi E, Goffeau A (1991) Multiple or pleiotropic drug resistance in yeast. Biochim Biophys Acta 1073:241-252
2. Balzi E, Chen W, Ulaszewski S, Capiaux E, Goffeau A (1987) The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem 262:16871-16879
3. Balzi E, Wang M, Leterme S, Van Dijck L, Goffeau A (1994) PDR5, a novel yeast multidrug resistance-conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269:2206-2214
4. Brent R, Ptashne M (1985) A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell 43:729-736
5. Clavilier L (1976) Mitochondrial genetics. XII. An oligomycin-resistant mutant localized at a new mitochondrial locus in Saccharomyces cerevisiae. Genetics 83:227-243
6. Decottignies A, Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nature Genet 15:137-145
7. Decottignies A, Kolaczkowski M, Balzi E, Goffeau A (1994) Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide trisphosphatase of yeast. J Biol Chem 269:12797-12803
8. Decottignies A, Lambert L, Catty P, Degand H, Epping EA, Moye-Rowley WS, Balzi E, Goffeau A (1995) Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J Biol Chem 270:18150-18157
9. Delahodde A, Delaveau T, Jacq C (1995) Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance. Mol Cell Biol 15:4043-4051
10. Delaveau T, Delahodde A, Carvajal E, Subik J, Jacq C (1994) PDK3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol Gen Genet. 244:501-512
11. Dexter D, Moye-Rowley WS, Wu A, Golin J (1994) Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter-encoding gene, PDR5. Genetics 136:505-515
12. Emr SD, Vassarotti A, Garret J, Geller BC, Takeda M, Douglas MG (1986) The amino-terminus of the yeast F1-ATPase beta-subunit precursor functions as a mitochondrial import signal. J Cell Biol. 102:523-533
13. Gilbert DM, Heery DM, Losson R, Chambon P, Lemoine Y (1993) Estradiol-inducible squelching and cell growth arrest by a chimeric VP16-estrogen receptor expressed in Saccharomyres cerevisiae: suppression by an allele of PDR1. Mol Cell Biol 13:462-472
14. Gill G, Ptashne M (1987) Mutants of GAL4 protein altered in an activation function. Cell 51:121-126
15. Goffeau A, Dufour JP (1988) Plasma membrane ATPase from the yeast Saccharomyces cerevisiae. Methods Enzymol 157:528-533
16. Goffeau A, Park J, Paulsen IT, Jonniaux JL, Dinh T, Mordant P, Saier M (1997) Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames within the Major Facilitators Superfamily. Yeast 13:43-54
17. Guérineau M, Slonimski PP, Avner PR (1974) Yeast episome: oligomycin resistance associated with a small covalently closed non-mitochondrial DNA. Biochem Biophys Res Commun 61:462-469
18. Guthrie C, Fink GR (1991) Yeast genetic nomenclature. Methods Enzymol 194:8-11
19. Ito H, Fukuda Y, Murata K, Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153:163-168
20. Katzmann DJ, Burnett PE, Golin J, Mahé Y, Moye-Rowley WS (1994) Transcriptional control of the yeast PDR5 gene by the PDR3 gene product. Mol Cell Biol 14:4653-4661
21. Katzmann DJ, Hallstrom TC, Voet M, Wysock W, Golin J, Volckaert G, Moye-Rowley WS (1995) Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol 15:6875-6883
22. Katzmann D, Hallstrom TC, Mahé Y, Moye-Rowley WS (1996) Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J Biol Chem 271:23049-23054
23. Keegan L, Gill G, Ptashne M (1986) Separation of DNA binding from the transcription-activation function of a eukaryotic regulatory protein. Science 231:699-704
24. Kolaczkowski M, van der Rest M, Cybularz-Kolaczkowska A, Soumillion J-P, Konings WN, Goffeau A (1996) Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p. J Biol Chem 271:31543-31548
25. Laughon A, Gesteland RF (1984) Primary structure of the Saccharomyces cerevisiae GAL4 gene. Mol Cell Biol 4:260-267
26. Ma J, Ptashne M (1987a) Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48:847-853
27. Ma J, Ptashne M (1987b) The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80. Cell 50:137-142
28. Mahé Y, Parle-McDermott AM. Nourani A, Delahodde A, Lamprecht A, Kuchler K (1996) The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3. Mol Microbiol 20:109-117
29. Marmorstein R, Carey M, Ptashne M, Harrison SC (1992) DNA recognition by GAL4: structure of a protein-DNA complex. Nature 356:408-414
30. McGuire T, Carvajal E, Katzmann D, Wagner M, Moye-Rowley S, Goffeau A, Golin J (1995) Analysis of second-site mutations that suppress the multiple drug resistance phenotype of the yeast PDR1-7 allele. Gene 167:151-155
31. Meyers S, Schauer W, Balzi E, Wagner M, Goffeau A, Golin J (1992) Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5. Curr Genet 21:431-436
32. Miller JH (1972) Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
33. Nass G, Poralla K (1976) Genetics of borrelidin resistant mutants of Saccharomyces cerevisiae and properties of their threonyl-tRNA-synthetase. Mol Gen Genet 147:39-43
34. Poch O (1996) Conservation of a putative inhibitory domain in the GAL4 family members. Gene 184:229-235
35. Rank GH, Bech-Hansen NT (1973) Single nuclear gene-inherited cross resistance and collateral sensitivity to 17 inhibitors of mitochondrial function in Saccharomyces cerevisiae. Mol Gen Genet 126:93-102
36. Rank GH, Gerlach JH, Robertson AJ (1976) Some physiological alterations associated with pleiotropic drug resistance and collateral sensitivity in Saccharomyces cerevisiae. Mol Gen Genet 152:13-18
37. Salmeron JM, Leuther KK, Jonston SA (1990) GAL4 mutations that separate the transcriptional activation and GAL80-interactive functions of the GAL4 protein. Genetics 125:21-27
38. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual (2nd edn) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
39. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain termination inhibitors. Proc Natl Acad Sci USA 74:5463-5467
40. Saunders, GW and Rank, GH (1982) Allelism of pleiotropic drug resistance in Saccharomyces cerevisiae. Can. J. Genet. Cytol. 24, 493-503
41. Schjerling P, Holmberg S (1996) Comparative amino acid sequence analysis of the C6 zinc cluster family of transcriptional regulators. Nucleic Acids Res 24:4599-4607
42. Schmitt ME, Brown TA, Trumpower BL (1990) A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res 18:3091
43. Sherman F (1981) Genetic nomenclature. In: Strathern JN, Jones EW, Broach JR (eds) The molecular biology of the yeast Saccharomyces, vol 1. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp 639-640
44. Sherman F, Fink GR, Hicks JB (1986) Laboratory course manual for methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
45. Sikorski RS, Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27
46. Stone G, Sadowski I (1993) GAL4 is regulated by a glucose-responsive functional domain. EMBO J 12:1375-1385
47. Thierry A, Fairhead C, Dujon B (1990) The complete sequence of the 8.2 kb segment left of MAT on chromosome III reveals five ORFs, including a gene for a yeast ribokinase. Yeast 6:521-534
48. Wallis JW, Chrebet G, Brodsky G, Rolfe M, Rothstein R (1989) A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase. Cell 58:409-419