Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1)

Biochemical Journal

Volumn 370, Issue 1, 2003, Pages 357-360

  Lee, Sung H ^a   Altenberg, Guillermo A ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

ATP binding cassette (ABC) protein; Cys less; Cystic fibrosis transmembrane conductance regulator (CFTR); MRP; Multidrug resistance; Nucleotide binding domain

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOCHEMICAL ENGINEERING; BIOLOGICAL MEMBRANES; DRUG DOSAGE; SPECTROSCOPIC ANALYSIS; SUBSTRATES; YEAST;

MULTIDRUG RESISTANCE;

PROTEINS;

ADENOSINE TRIPHOSPHATE; CYSTEINE; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN 1; RECOMBINANT PROTEIN; GLYCOPROTEIN P;

ARTICLE; BIOCHEMISTRY; CELL MEMBRANE; CONTROLLED STUDY; LIPID TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; WESTERN BLOTTING; GENETICS; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

BIOLOGICAL TRANSPORT; LEUKOTRIENE C4; P-GLYCOPROTEIN; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 0037440563     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021452     Document Type: Article

References (19)

1. Hipfner, D. R., Deeley, R. G. and Cole, S. P. C. (1999) Structural, mechanistic and clinical aspects of MRP1. Biochim. Biophys. Acta 1461, 359-376
2. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I. and Gottesman, M. M. (1999) Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39, 361-398
3. Borst, P., Evers, R., Kool, M. and Wijnholds J. (2000) The multidrug resistance protein family. Biochim. Biophys. Acta 1461, 347-357
4. Leslie, E. M., Deeley, R. G. and Cole, S. P. C. (2001) Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters. Toxicology 167, 3-23
5. Renes, J., DeVries, E. G., Jansen, P. L. M. and Muller, M. (2000) The (patho)physiological functions of the MRP family. Drug Resist. Updates 3, 289-302
6. Bakos, E., Evers, R., Szákacs, G., Tusnády, G. E., Welker, E., Szabó, K., Dehaas, M., Vandeemter, L., Borst, P., Váradi, A. and Sarkadi, B. (1998) Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. J. Biol. Chem. 273, 32167-32175
7. Chang, G. and Roth, C. B. (2001) Structure of MsbA from E-coli: A homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science 293, 1793-1800
8. Locher, K. P., Lee, A. T. and Rees, D. C. (2002) The E. coli BtuCD structure: A framework for ABC transporter architecture and mechanism. Science 296, 1091-1098
9. Higgins, C. F. and Linton, K. J. (2001) The xyz of ABC transporters. Science 293, 1782-1783
10. Davidson, A. L. (2002) Not just another ABC transporter. Science 296, 1038-1040
11. Yang, Y., Chen, Q. and Zhang, J.-T (2002) Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistanceassociated protein 1. J. Biol. Chem. 277, 44268-44277
12. Figler, R. A., Omote, H., Nakamoto, R. K. and Al-shawi, M. K. (2000) Use of chemical chaperones in the yeast Saccharomyces cerevisiae to enhance heterologous membrane protein expression: High-yield expression and purification of human P-glycoprotein. Arch. Biochem. Biophys. 376, 34-46
13. Zaman, G. J., Flens, M. J., van Leusden, M. R., de Haas, M., Mulder, H. S., Lankelma, J., Pinedo, H. M., Scheper, R. J., Baas, F., Broxterman, H. J. and Borst, P. (1994) The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc. Natl. Acad. Sci. U.S.A. 91, 8822-8826
14. Loo, T. W. and Clarke, D. M. (1999) Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques. Biochim. Biophys. Acta 1461, 315-325
15. Morello, J. P., Petaja-Repo, U. E., Bichet, D. G. and Bouvier, M. (2000) Pharmacological chaperones: a new twist on receptor folding. Trends Pharmacol. Sci. 21, 466-469
16. Han, E. S., Vanoye, C. G., Altenberg, G. A. and Reuss, L. (1996) P-glycoprotein-associated chloride currents revealed by specific block by an anti-P-glycoprotein antibody. Am. J. Physiol. 270, C1370-C1378
17. Loe, D. W., Almquist, K. C., Deeley, R. G. and Cole, S. P. (1998) Multidrug resistance protein (MRP)-mediated transport of leukotriene C-4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J. Biol. Chem. 271, 9675-9682
18. Leier, I., Jedlitschky, G., Buchholz, U., Cole, S. P., Deeley, R. G. and Keppler, D. (1994) The MRP gene encodes an ATP-dependent export pump for leukotriene C-4, and structurally related conjugates. J. Bio. Chem. 269, 27807-27810
19. Cai, J., Daoud, R., Georges, E. and Gros, P. (2001) Functional expression of multidrug resistance protein 1 in Pichia pastoris. Biochemistry 40, 8307-8316