The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: A novel target for the transcription factors Pdr1 and Pdr3

Molecular Microbiology

Volumn 20, Issue 1, 1996, Pages 109-117

  Mahé, Yannick ^a   Parle McDermott, Anne ^a   Nourani, Amine ^b   Delahodde, Agnès ^b   Lamprecht, Andrea ^a   Kuchler, Karl ^a  

^a University and Biocenter of Vienna   (Austria)

^b ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; CYCLOHEXIMIDE; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; DNA FOOTPRINTING; IMMUNOBLOTTING; MULTIDRUG RESISTANCE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE;

4-NITROQUINOLINE-1-OXIDE; ANTIBIOTICS, ANTIFUNGAL; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; CYCLOHEXIMIDE; DNA-BINDING PROTEINS; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; FUNGAL PROTEINS; GLYCOPROTEINS; MEMBRANE PROTEINS; MUTAGENS; MUTATION; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0029868238     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.1996.tb02493.x     Document Type: Article

References (42)

1. Alani, E., Cao, L., and Kleckner, N. (1987) A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics 116: 541-545.
2. Allikmets, R., Gerrard, B., Glavac, D., Ravnik-Glavac, M., Jenkins, N.A., Gilbert, D.B., Copeland, N.G., Modi, W., and Dean, M. (1995) Characterization and mapping of three new mammalian ATP binding transporter genes. Mamm Genome 6: 114-117.
3. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (1987) In Current Protocols in Molecular Biology. Greene Publishing Associates, New York.
4. Balzi, E., and Goffeau, A. (1994) Genetics and biochemistry of yeast multidrug resistance. Biochim Biophys Acta 1187: 152-162.
5. Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., and Goffeau, A. (1987) The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem 262: 16871-16879.
6. Balzi, E., Wang, M., Leterme, S., Van Dyck, L., and Goffeau, A. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269: 2206-2214.
7. Baum, P., Thorner, J., and Honig, L. (1978) Identification of tubulin from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 75: 4962-4966.
8. Bissinger, P.H., and Kuchler, K. (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269: 4180-4186.
9. Boeke, J.D., Trueheart, J., Natsoulis, G., and Fink, G.R. (1987) 5-Fluoro-orotic acid as a selective agent in yeast molecular genetics. Methods Enzymol 154: 164-175.
10. Cole, S.P., Bhardwaj, G., Gerlach, J.H., Mackie, J.E., Grant, C.E., Almquist, K.C., Stewart, A.J., Kurz, E.U., Duncan, A.M., and Deeley, R.G. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654.
11. Decottignies, A., Lambert, L., Catty, P., Degand, H., Epping, E.A., Moye-Rowley, W.S., Balzi, E., and Goffeau, A. (1995) Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J Biol Chem 270: 18150-18157.
12. Delahodde, A., Delaveau, T., and Jacq, C. (1995) Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance. Mol Cell Biol 15: 4043-4051.
13. Delaveau, T., Delahodde, A., Carvajal, E., Subik, J., and Jacq, C. (1994) PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol Gen Genet 244: 501-511.
14. Egner, R., Mahé, Y., Pandjaitan, R., Huter, V., Lamprecht, A., and Kuchler, K. (1995a) ATP binding cassette transporters in yeast: from mating to multidrug resistance. In Membrane Protein Transport. Vol. 2. Rothman, S. (ed.). Greenwich: JAI Press Inc., pp. 57-96.
15. Egner, R., Mahé, Y., Pandjaitan, R., and Kuchler, K. (1995b) Endocytosis and vacuolar degradation of the plasma membrane localized Pdr5 ATP binding cassette multidrug transporter. Mol Cell Biol 15: 5879-5887.
16. Gallwitz, D., and Sures, I. (1980) Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 77: 2546-2550.
17. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
18. Higgins, C.F. (1992) ABC-transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67-113.
19. Hirata, D., Yano, K., Miyahara, K., and Miyakawa, T. (1994) Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance. Curr Genet 26: 285-294.
20. Kane, S.E. (1996) Multidrug resistance of cancer cells. In Advances in Drug Research. Vol. 2. Testa, B., and Meyer, U.A. (eds). San Diego: Academic Press, in press.
21. Katzmann, D.J., Burnett, P.E., Golin, J., Mahé, Y., and Moye-Rowley, W.S. (1994) Transcriptional control of the yeast PDR5 gene by the PDR3 gene product. Mol Cell Biol 14: 4653-4661.
22. Katzmann, D.J., Hallstrom, T.C., Voet, M., Wysock, W., Golin, J., Volckaert, G., and Moye-Rowley, W.S. (1995) Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol 15: 6875-6883.
23. Köiling, R., and Hollenberg, C.P. (1994) The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants. EMBO J 13: 3261-3271.
24. Kralli, A., Bohen, S.P., and Yamamoto, K.R. (1995) LEM1, an ATP-binding cassette transporter, selectively modulates the biological potency of steroid hormones. Proc Natl Acad Sci USA 92: 4701-4705.
25. Kuchler, K., Sterne, R.S., and Thorner, J. (1989) Saccharomyces cerevisae STE6 gene product: a novel pathway for protein export in eukaryotic cells. EMBO J 8: 3973-3984.
26. Kuchler, K., Göransson, M., Visnawathan, M., and Thorner, J. (1992) Dedicated transporters for peptide export and intercompartmental traffic in yeast. CSH Symp Quant Biol 57: 579-592.
27. Kuchler, K., Dohlman, H., and Thorner, J. (1993) The a-factor transporter (STE6 gene product) and cell polarity in Saccharomyces cerevisiae. J Cell Biol 120: 1203-1215.
28. Leppert, G., McDevitt, R., Falco, S.C., Van Dyk, T.K., Ficke, M.B., and Golin, J. (1990) Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces. Genetics 125: 13-20.
29. Luciani, M.F., Denizot, F., Savary, S., Mattel, G.M., and Chimini, G. (1994) Cloning of two novel ABC transporters mapping on human chromosome 9. Genomics 21: 150-159.
30. McGrath, J.P., and Varshavsky, A. (1989) The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature 340: 400-404.
31. Meyers, S., Schauer, W., Balzi, E., Wagner, M., Goffeau, A., and Golin, J. (1992) Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5. Curr Genet 21: 431-436.
32. Moye-Rowley, W.S., Harshman, K.D., and Parker, C.S. (1989) Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins. Genes Dev 3: 283-292.
33. Rose, M.D., Winston, F., and Hieter, P. (1990) Methods in Yeast Genetics. A Laboratory Course Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
34. Rothstein, R. (1991) Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Meth Enzymol 194: 281-301.
35. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
36. Sanglard, D., Kuchler, K., Ischer, F., Pagani, J.-L., Monod, M., and Bille, J. (1995) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother 39: 2378-2386.
37. Sathe, G.M., O'Brien, S., McLaughlin, M.M., Watson, F., and Livi, G.P. (1991) Use of polymerase chain reaction for rapid detection of gene insertions in whole yeast cells. Nucl Acids Res 19: 4775-4781.
38. Schmitt, M.E., Brown, T.A., and Trumpower, B.L. (1990) A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucl Acids Res 18: 3091-3092.
39. Servos, J., Haase, E., and Brendel, M. (1993) Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases. Mol Gen Genet 236: 214-218.
40. Towbin, H., Staehelin, T., and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354.
41. Vieira, A., Elkin, R.G., and Kuchler, K. (1994) Western blotting and ligand blotting using enhanced chemiluminescence (ECL) and radio-iodine detection. In Cell Biology: A Laboratory Handbook. Vol. 2. Celis, J.E. (ed.). San Diego: Academic Press, pp. 314-321.
42. Zaman, G.J., Flens, M.J., van Leusden, M.R., de Haas, M., Mulder, H.S., Lankelma, J., Pinedo, H.M., Scheper, R.J., Baas, F., Broxterman, H.J., and Borst, P. (1994) The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci USA 91: 8822-8826.