Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux

Journal of Biological Chemistry

Volumn 278, Issue 8, 2003, Pages 5963-5969

  Golin, John ^a   Ambudkar, Suresh V ^b   Gottesman, Michael M ^b   Habib, Asif Dominic ^c   Sczepanski, John ^a   Ziccardi, William ^a   May, Leopold ^a  

^a CATHOLIC UNIVERSITY OF AMERICA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c University of Wisconsin Milwaukee at Waukesha   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROPHOBICITY; IONIZATION; STRUCTURE (COMPOSITION); SUBSTRATES;

ELECTRON PAIR DONORS;

BIOCHEMISTRY;

ANTINEOPLASTIC AGENT; CHLORAMPHENICOL; DOXORUBICIN; GLYCOPROTEIN P; IMIDAZOLE DERIVATIVE; ORGANOTIN COMPOUND; XENOBIOTIC AGENT; ABC TRANSPORTER; ANTIFUNGAL AGENT; PDR5 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; ASSAY; BINDING SITE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; HYDROPHOBICITY; IONIZATION; MOLECULAR MODEL; MOLECULAR SIZE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MICROBIOLOGICAL EXAMINATION; STRUCTURE ACTIVITY RELATION;

MAMMALIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

ANTIFUNGAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; MICROBIAL SENSITIVITY TESTS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; XENOBIOTICS;

EID: 0037458550     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210908200     Document Type: Article

References (15)

1. Leppert, G., McDevitt, R., Falco, S. C., Van Dyk, T. K., Ficke, M. B., and Golin, J. (1990) Genetics 125, 13-20
2. Meyers, S., Schauer, W., Balzi, E., Wagner, M., Goffeau, A., and Golin, J. (1992) Curr. Genet. 21, 431-436
3. Kolaczkowski, M., Vanderest, M., Cybularz-Kolaczkowski, A., Soumilluion, J., Konings, W., and Goffeau, A. (1996) J. Biol. Chem. 271, 31543-31548
4. Egner, R. F., Rosenthal, A., Kralli, D., Sanglard, D., and Kuchler, K. (1998) Mol. Biol. Cell 9, 523-543
5. Leonard, P., Rathod, P., and Golin, J. (1994) Antimicrob. Agents Chemother. 38, 2492-2494
6. Golin, J., Barkatt, A., Cronin, S., Eng, G., and May, L. (2000) Antimicrob. Agents Chemother. 44, 134-138
7. Seelig, A. (1998) Int. J. Clin. Pharmacol. Ther. 36, 50-54
8. Seelig, A., and Landwojtowicz, E. (2000) Eur. J. Pharm. Sci. 1, 31-40
9. Aldabbagh, F., and Bowman, W. R. (1999) Tetrahedron 55, 4109-4122
10. Katzmann, D., Burnett, P. E., Golin, J., Mahe, Y., and Moye-Rowley, W. S. (1994) Mol. Cell. Biol. 14, 4653-4661
11. Rogers, B., Decottignies, A., Kolaczkowski, M., Carvajal, E., Balzi, E., and Goffeau, A. (2001) J. Mol. Microbiol. Biotechnol. 3, 207-214
12. Loo, T., and Clarke, D. (2001) J. Biol. Chem. 276, 36877-36880
13. Salerno, M., Przewloka, T., Fokt, I., Priebe, W., and Garnier-Suillerot, A. (2002) Biochem. Pharmacol. 63, 1471-1479
14. Ambudkar, S., Dey, S., Hrycyna, C., Ramachandra, M., Pastan, I., and Gottesman, M. (1999) Annu. Rev. Pharmacol. Toxicol. 39, 361-398
15. Mealy, K., Barhoumi, R., Burghardt, R., Safe, S., and Kochevar, D., (2002) Antimicrob. Agents Chemother. 46, 755-761