Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: Quinone oxidoreductase 1 by alkylating keap1

Chemical Research in Toxicology

Volumn 21, Issue 10, 2008, Pages 1939-1948

  Dietz, Birgit M ^a   Liu, Donating ^a   Hagos, Ghenet K ^a   Yao, Ping ^a   Schinkovitz, Andreas ^a   Pro, Samuel M ^b   Deng, Shixin ^a   Farnsworth, Norman R ^a   Pauli, Guido F ^a   Van Breemen, Richard B ^a   Bolton, Judy L ^a  

^a Department of Medicinal Chemistry and Pharmacognosy

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGELICA SINENSIS EXTRACT; CHLOROFORM; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LIGUSTILIDE; NADPH:QUINONE OXIDOREDUCTASE 1; OXIDOREDUCTASE; PETROLEUM; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANGELICA SINENSIS; ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN;

4-BUTYROLACTONE; ALKYLATION; ANGELICA SINENSIS; ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; GLUTATHIONE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR STRUCTURE; NAD(P)H DEHYDROGENASE (QUINONE); PLANT EXTRACTS; TANDEM MASS SPECTROMETRY;

ANGELICA SINENSIS; APIACEAE; PANAX GINSENG;

EID: 55949128500     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx8001274     Document Type: Article

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