Mechanism of action of sulforaphane: Inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells

Cancer Research

Volumn 66, Issue 17, 2006, Pages 8804-8813

  Keum, Young Sam ^a   Yu, Siwang ^a   Chang, Peter Pil Jae ^a   Yuan, Xiaoling ^a   Kim, Jung Hwan ^a   Xu, Changjiang ^a   Han, Jiahuai ^b   Agarwal, Anupam ^c   Kong, Ah Ng Tony ^a  

^a RUTGERS UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; HEME OXYGENASE 1; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; SULFORAPHANE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR KEAP1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL NUCLEUS; CELL STRAIN HEPG2; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENHANCER REGION; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO SELECTION; KERATINOCYTE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TRANSPORT; TRANSCRIPTION INITIATION;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELLS, CULTURED; EMBRYONIC STRUCTURES; ENHANCER ELEMENTS (GENETICS); FIBROBLASTS; GENES, REPORTER; HEME OXYGENASE-1; HUMANS; ISOENZYMES; KERATINOCYTES; LIVER NEOPLASMS; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; THIOCYANATES;

EID: 33749019130     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3513     Document Type: Article

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