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Volumn 1763, Issue 12, 2006, Pages 1767-1775

Pexophagy: Autophagic degradation of peroxisomes

Author keywords

ATG gene; Autophagy; Peroxin; Pexophagy; Sequestration; Vacuole

Indexed keywords

AMINO ACID; GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; RAB PROTEIN; SCAFFOLD PROTEIN; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; UBIQUITIN CONJUGATING ENZYME;

EID: 33845298622     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2006.08.023     Document Type: Review
Times cited : (191)

References (60)
  • 1
    • 0033280667 scopus 로고    scopus 로고
    • Vacuolar import of proteins and organelles from the cytoplasm
    • Klionsky D.J., and Ohsumi Y. Vacuolar import of proteins and organelles from the cytoplasm. Annu. Rev. Cell Dev. Biol. 15 (1999) 1-32
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 1-32
    • Klionsky, D.J.1    Ohsumi, Y.2
  • 3
    • 0020772844 scopus 로고
    • Degradation and turnover of peroxisomes in the yeast Hansenula polymorpha induced by selective inactivation of peroxisomal enzymes
    • Veenhuis M., Douma A., Harder W., and Osumi M. Degradation and turnover of peroxisomes in the yeast Hansenula polymorpha induced by selective inactivation of peroxisomal enzymes. Arch. Microbiol. 134 (1983) 193-203
    • (1983) Arch. Microbiol. , vol.134 , pp. 193-203
    • Veenhuis, M.1    Douma, A.2    Harder, W.3    Osumi, M.4
  • 4
    • 0027207680 scopus 로고
    • Selective autophagy of peroxisomes in methylotrophic yeasts
    • Tuttle D.L., Lewin A.S., and Dunn Jr. W.A. Selective autophagy of peroxisomes in methylotrophic yeasts. Eur. J. Cell Biol. 60 (1993) 283-290
    • (1993) Eur. J. Cell Biol. , vol.60 , pp. 283-290
    • Tuttle, D.L.1    Lewin, A.S.2    Dunn Jr., W.A.3
  • 5
    • 0141964578 scopus 로고    scopus 로고
    • Modification of a ubiquitin-like protein Paz2 conducted micropexophagy through formation of a novel membrane structure
    • Mukaiyama H., Baba M., Osumi M., Aoyagi S., Kato N., Ohsumi Y., and Sakai Y. Modification of a ubiquitin-like protein Paz2 conducted micropexophagy through formation of a novel membrane structure. Mol. Biol. Cell 15 (2004) 58-70
    • (2004) Mol. Biol. Cell , vol.15 , pp. 58-70
    • Mukaiyama, H.1    Baba, M.2    Osumi, M.3    Aoyagi, S.4    Kato, N.5    Ohsumi, Y.6    Sakai, Y.7
  • 8
    • 0035733932 scopus 로고    scopus 로고
    • Glucose-induced and nitrogen-starvation-induced peroxisome degradation are distinct processes in Hansenula polymorpha that involve both common and unique genes
    • Bellu A.R., Kram A.M., Kiel J.A.K.W., Veenhuis M., and van der Klei I.J. Glucose-induced and nitrogen-starvation-induced peroxisome degradation are distinct processes in Hansenula polymorpha that involve both common and unique genes. FEMS Yeast Res. 1 (2001) 23-31
    • (2001) FEMS Yeast Res. , vol.1 , pp. 23-31
    • Bellu, A.R.1    Kram, A.M.2    Kiel, J.A.K.W.3    Veenhuis, M.4    van der Klei, I.J.5
  • 10
    • 0033490110 scopus 로고    scopus 로고
    • Peroxisome degradation in Saccharomyces cerevisiae is dependent on machinery of macroautophagy and the Cvt pathway
    • Hutchins M.U., Veenhuis M., and Klionsky D.J. Peroxisome degradation in Saccharomyces cerevisiae is dependent on machinery of macroautophagy and the Cvt pathway. J. Cell Sci. 112 (1999) 4079-4087
    • (1999) J. Cell Sci. , vol.112 , pp. 4079-4087
    • Hutchins, M.U.1    Veenhuis, M.2    Klionsky, D.J.3
  • 12
    • 0032907514 scopus 로고    scopus 로고
    • Selective peroxisome degradation in Yarrowia lipolytica after a shift of cells from acetate/oleate/ethylamine into glucose/ammonium sulfate-containing media
    • Gunkel K., van der Klei I.J., Barth G., and Veenhuis M. Selective peroxisome degradation in Yarrowia lipolytica after a shift of cells from acetate/oleate/ethylamine into glucose/ammonium sulfate-containing media. FEBS Lett. 451 (1999) 1-4
    • (1999) FEBS Lett. , vol.451 , pp. 1-4
    • Gunkel, K.1    van der Klei, I.J.2    Barth, G.3    Veenhuis, M.4
  • 13
    • 14844360712 scopus 로고    scopus 로고
    • Observation of the Yarrowia lipolytica peroxisome-vacuole dynamics by fluorescence microscopy with a single filter set
    • Nazarko T.Y., Nicaud J.M., and Sibirny A.A. Observation of the Yarrowia lipolytica peroxisome-vacuole dynamics by fluorescence microscopy with a single filter set. Cell Biol. Int. 29 (2005) 65-70
    • (2005) Cell Biol. Int. , vol.29 , pp. 65-70
    • Nazarko, T.Y.1    Nicaud, J.M.2    Sibirny, A.A.3
  • 15
    • 0038263977 scopus 로고    scopus 로고
    • Peroxisome degradation requires catalytically active sterol glucosyltransferase with a GRAM domain
    • Oku M., Warnecke D., Noda T., Muller F., Heinz E., Mukaiyama H., Kato N., and Sakai Y. Peroxisome degradation requires catalytically active sterol glucosyltransferase with a GRAM domain. EMBO J. 22 (2003) 3231-3241
    • (2003) EMBO J. , vol.22 , pp. 3231-3241
    • Oku, M.1    Warnecke, D.2    Noda, T.3    Muller, F.4    Heinz, E.5    Mukaiyama, H.6    Kato, N.7    Sakai, Y.8
  • 16
    • 33845345128 scopus 로고    scopus 로고
    • Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae
    • Nazarko T.Y., Huang J., Nicaud J.M., Klionsky D.J., and Sibirny A.A. Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae. Autophagy 1 (2005) 37-45
    • (2005) Autophagy , vol.1 , pp. 37-45
    • Nazarko, T.Y.1    Huang, J.2    Nicaud, J.M.3    Klionsky, D.J.4    Sibirny, A.A.5
  • 17
    • 0038558137 scopus 로고    scopus 로고
    • Degradation of normal and proliferated peroxisomes in rat hepatocytes: regulation of peroxisomes quantity in cells
    • Yokota S. Degradation of normal and proliferated peroxisomes in rat hepatocytes: regulation of peroxisomes quantity in cells. Microsc. Res. Tech. 61 (2003) 151-160
    • (2003) Microsc. Res. Tech. , vol.61 , pp. 151-160
    • Yokota, S.1
  • 19
    • 0032895859 scopus 로고    scopus 로고
    • Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein
    • Yuan W., Stromhaug P.E., and Dunn Jr. W.A. Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. Mol. Biol. Cell 10 (1999) 1353-1366
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1353-1366
    • Yuan, W.1    Stromhaug, P.E.2    Dunn Jr., W.A.3
  • 21
    • 2442581274 scopus 로고    scopus 로고
    • Transcriptional down-regulation of peroxisome numbers affects selective peroxisome degradation in Hansenula polymorpha
    • Leão-Helder A.N., Krikken A.M., van der Klei I.J., Kiel J.A.K.W., and Veenhuis M. Transcriptional down-regulation of peroxisome numbers affects selective peroxisome degradation in Hansenula polymorpha. J. Biol. Chem. 278 (2003) 40749-40756
    • (2003) J. Biol. Chem. , vol.278 , pp. 40749-40756
    • Leão-Helder, A.N.1    Krikken, A.M.2    van der Klei, I.J.3    Kiel, J.A.K.W.4    Veenhuis, M.5
  • 23
    • 0037044768 scopus 로고    scopus 로고
    • Removal of Pex3p is an important stage in selective peroxisome degradation in Hansenula polymorpha
    • Bellu A.R., Salomons F.A., Kiel J.A.K.W., Veenhuis M., and van der Klei I.J. Removal of Pex3p is an important stage in selective peroxisome degradation in Hansenula polymorpha. J. Biol. Chem. 277 (2002) 42875-42880
    • (2002) J. Biol. Chem. , vol.277 , pp. 42875-42880
    • Bellu, A.R.1    Salomons, F.A.2    Kiel, J.A.K.W.3    Veenhuis, M.4    van der Klei, I.J.5
  • 24
    • 0033618147 scopus 로고    scopus 로고
    • The Hansenula polymorpha PDD1 gene product, essential for the selective degradation of peroxisomes, is a homologue of Saccharomyces cerevisiae Vps34p
    • Kiel J.A.K.W., Rechinger K.B., van der Klei I.J., Salomons F.A., Titorenko V.I., and Veenhuis M. The Hansenula polymorpha PDD1 gene product, essential for the selective degradation of peroxisomes, is a homologue of Saccharomyces cerevisiae Vps34p. Yeast 15 (1999) 741-754
    • (1999) Yeast , vol.15 , pp. 741-754
    • Kiel, J.A.K.W.1    Rechinger, K.B.2    van der Klei, I.J.3    Salomons, F.A.4    Titorenko, V.I.5    Veenhuis, M.6
  • 26
    • 0036668807 scopus 로고    scopus 로고
    • Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes
    • Hazra P.P., Suriapranata I., Snyder W.B., and Subramani S. Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Traffic 3 (2002) 560-574
    • (2002) Traffic , vol.3 , pp. 560-574
    • Hazra, P.P.1    Suriapranata, I.2    Snyder, W.B.3    Subramani, S.4
  • 28
  • 29
    • 0242570685 scopus 로고    scopus 로고
    • Peroxisome homeostasis in Hansenula polymorpha
    • Leão A.N., and Kiel J.A.K.W. Peroxisome homeostasis in Hansenula polymorpha. FEMS Yeast Res. 4 (2003) 131-139
    • (2003) FEMS Yeast Res. , vol.4 , pp. 131-139
    • Leão, A.N.1    Kiel, J.A.K.W.2
  • 30
    • 0037371332 scopus 로고    scopus 로고
    • The Hansenula polymorpha PDD7 gene is essential for both macro- and micropexophagy
    • Komduur J.A., Veenhuis M., and Kiel J.A.K.W. The Hansenula polymorpha PDD7 gene is essential for both macro- and micropexophagy. FEMS Yeast Res. 3 (2003) 27-34
    • (2003) FEMS Yeast Res. , vol.3 , pp. 27-34
    • Komduur, J.A.1    Veenhuis, M.2    Kiel, J.A.K.W.3
  • 31
    • 33845324731 scopus 로고    scopus 로고
    • J.A. Komduur, Molecular aspects of peroxisome degradation in Hansenula polymorpha. PhD thesis, University of Groningen, The Netherlands, 2004.
  • 33
    • 33745964401 scopus 로고    scopus 로고
    • The Hansenula polymorpha ATG25 gene encodes a novel coiled-coil protein that is required for macropexophagy
    • Monastryska I., Kiel J.A.K.W., Krikken A.M., Komduur J.A., Veenhuis M., and van der Klei I.J. The Hansenula polymorpha ATG25 gene encodes a novel coiled-coil protein that is required for macropexophagy. Autophagy 1 (2005) 92-100
    • (2005) Autophagy , vol.1 , pp. 92-100
    • Monastryska, I.1    Kiel, J.A.K.W.2    Krikken, A.M.3    Komduur, J.A.4    Veenhuis, M.5    van der Klei, I.J.6
  • 35
    • 12844250563 scopus 로고    scopus 로고
    • A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate
    • Ano Y., Hattori T., Oku M., Mukaiyama H., Baba M., Ohsumi Y., Kato N., and Sakai Y. A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate. Mol. Biol. Cell 16 (2005) 446-457
    • (2005) Mol. Biol. Cell , vol.16 , pp. 446-457
    • Ano, Y.1    Hattori, T.2    Oku, M.3    Mukaiyama, H.4    Baba, M.5    Ohsumi, Y.6    Kato, N.7    Sakai, Y.8
  • 36
    • 33747402357 scopus 로고    scopus 로고
    • A PI4P-signaling pathway for the synthesis of a nascent membrane structure in selective autophagy
    • Yamashita S., Oku M., Wasada Y., Ano Y., and Sakai Y. A PI4P-signaling pathway for the synthesis of a nascent membrane structure in selective autophagy. J. Cell Biol. 173 (2006) 709-717
    • (2006) J. Cell Biol. , vol.173 , pp. 709-717
    • Yamashita, S.1    Oku, M.2    Wasada, Y.3    Ano, Y.4    Sakai, Y.5
  • 38
    • 27644544004 scopus 로고    scopus 로고
    • Atg9 cycles between mitochondria and the preautophagosomal structure in yeasts
    • Reggiori F., Shintani T., Chong H., Nair U., and Klionsky D.J. Atg9 cycles between mitochondria and the preautophagosomal structure in yeasts. Autophagy 1 (2005) 101-109
    • (2005) Autophagy , vol.1 , pp. 101-109
    • Reggiori, F.1    Shintani, T.2    Chong, H.3    Nair, U.4    Klionsky, D.J.5
  • 39
    • 0036901104 scopus 로고    scopus 로고
    • Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway
    • Shintani T., Huang W.P., Stromhaug P.E., and Klionsky D.J. Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev. Cell. 3 (2002) 825-837
    • (2002) Dev. Cell. , vol.3 , pp. 825-837
    • Shintani, T.1    Huang, W.P.2    Stromhaug, P.E.3    Klionsky, D.J.4
  • 42
    • 0036180245 scopus 로고    scopus 로고
    • Vacuole fusion at a ring of vertex docking sites leaves membrane fragments within the organelle
    • Wang L., Seeley E.S., Wickner W., and Merz A.J. Vacuole fusion at a ring of vertex docking sites leaves membrane fragments within the organelle. Cell 108 (2002) 357-369
    • (2002) Cell , vol.108 , pp. 357-369
    • Wang, L.1    Seeley, E.S.2    Wickner, W.3    Merz, A.J.4
  • 43
    • 0037119448 scopus 로고    scopus 로고
    • Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy
    • Nice D.C., Sato T.K., Stromhaug P.E., Emr S.D., and Klionsky D.J. Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J. Biol. Chem. 277 (2002) 30198-30207
    • (2002) J. Biol. Chem. , vol.277 , pp. 30198-30207
    • Nice, D.C.1    Sato, T.K.2    Stromhaug, P.E.3    Emr, S.D.4    Klionsky, D.J.5
  • 44
    • 0028855325 scopus 로고
    • Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris
    • Tuttle D.L., and Dunn Jr. W.A. Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris. J. Cell Sci. 108 (1995) 25-35
    • (1995) J. Cell Sci. , vol.108 , pp. 25-35
    • Tuttle, D.L.1    Dunn Jr., W.A.2
  • 45
    • 0032482219 scopus 로고    scopus 로고
    • Peroxisome degradation by microautophagy in Pichia pastoris: identification of specific steps and morphological intermediates
    • Sakai Y., Koller A., Rangell L.K., Keller G.A., and Subramani S. Peroxisome degradation by microautophagy in Pichia pastoris: identification of specific steps and morphological intermediates. J. Cell Biol. 141 (1998) 625-636
    • (1998) J. Cell Biol. , vol.141 , pp. 625-636
    • Sakai, Y.1    Koller, A.2    Rangell, L.K.3    Keller, G.A.4    Subramani, S.5
  • 46
    • 0036163982 scopus 로고    scopus 로고
    • Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy
    • Mukaiyama H., Oku M., Baba M., Samizo T., Hammond A.T., Glick B.S., Kato N., and Sakai Y. Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy. Genes Cells 7 (2003) 75-90
    • (2003) Genes Cells , vol.7 , pp. 75-90
    • Mukaiyama, H.1    Oku, M.2    Baba, M.3    Samizo, T.4    Hammond, A.T.5    Glick, B.S.6    Kato, N.7    Sakai, Y.8
  • 47
    • 26244457185 scopus 로고    scopus 로고
    • PpATG9 encodes a novel membrane protein that traffics to vacuolar membranes, which sequester peroxisomes during pexophagy in Pichia pastoris
    • Chang T., Schroder L.A., Thomson J.M., Klocman A.S., Tomasini A.J., Stromhaug P.E., and Dunn Jr. W.A. PpATG9 encodes a novel membrane protein that traffics to vacuolar membranes, which sequester peroxisomes during pexophagy in Pichia pastoris. Mol. Biol. Cell 16 (2005) 4941-4953
    • (2005) Mol. Biol. Cell , vol.16 , pp. 4941-4953
    • Chang, T.1    Schroder, L.A.2    Thomson, J.M.3    Klocman, A.S.4    Tomasini, A.J.5    Stromhaug, P.E.6    Dunn Jr., W.A.7
  • 49
    • 0035661648 scopus 로고    scopus 로고
    • Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris
    • Guan J., Stromhaug P.E., George M.D., Habibzadegah-Tari P., Bevan A., Dunn Jr. W.A., and Klionsky D.J. Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol. Biol. Cell 12 (2001) 3821-3838
    • (2001) Mol. Biol. Cell , vol.12 , pp. 3821-3838
    • Guan, J.1    Stromhaug, P.E.2    George, M.D.3    Habibzadegah-Tari, P.4    Bevan, A.5    Dunn Jr., W.A.6    Klionsky, D.J.7
  • 50
    • 0242695642 scopus 로고    scopus 로고
    • GSA11 encodes a unique 208-kDa protein required for pexophagy and autophagy in Pichia pastoris
    • Stromhaug P.E., Bevan A., and Dunn Jr. W.A. GSA11 encodes a unique 208-kDa protein required for pexophagy and autophagy in Pichia pastoris. J. Biol. Chem. 276 (2001) 42422-42435
    • (2001) J. Biol. Chem. , vol.276 , pp. 42422-42435
    • Stromhaug, P.E.1    Bevan, A.2    Dunn Jr., W.A.3
  • 51
    • 0035860689 scopus 로고    scopus 로고
    • Fusion of docked membranes requires the armadillo repeat protein Vac8p
    • Wang Y.X., Kauffman E.J., Duex J.E., and Weisman L.S. Fusion of docked membranes requires the armadillo repeat protein Vac8p. J. Biol. Chem. 276 (2001) 35133-35140
    • (2001) J. Biol. Chem. , vol.276 , pp. 35133-35140
    • Wang, Y.X.1    Kauffman, E.J.2    Duex, J.E.3    Weisman, L.S.4
  • 52
    • 0035876373 scopus 로고    scopus 로고
    • Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion
    • Veit M., Laage R., Dietrich L., Wang L., and Ungermann C. Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion. EMBO J. 20 (2001) 3145-3155
    • (2001) EMBO J. , vol.20 , pp. 3145-3155
    • Veit, M.1    Laage, R.2    Dietrich, L.3    Wang, L.4    Ungermann, C.5
  • 53
    • 0032498794 scopus 로고    scopus 로고
    • Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole
    • Wang Y.X., Catlett N.L., and Weisman L.S. Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. J. Cell Biol. 140 (1998) 1063-1074
    • (1998) J. Cell Biol. , vol.140 , pp. 1063-1074
    • Wang, Y.X.1    Catlett, N.L.2    Weisman, L.S.3
  • 55
    • 0036544561 scopus 로고    scopus 로고
    • A cycle of Vam7p release from and PtdIns 3-P-dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion
    • Boeddinghaus C., Merz A.J., Laage R., and Ungermann C. A cycle of Vam7p release from and PtdIns 3-P-dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion. J. Cell Biol. 157 (2002) 79-89
    • (2002) J. Cell Biol. , vol.157 , pp. 79-89
    • Boeddinghaus, C.1    Merz, A.J.2    Laage, R.3    Ungermann, C.4
  • 56
    • 0030883562 scopus 로고    scopus 로고
    • Glucose-induced microautophagy in Pichia pastoris requires the alpha-subunit of phosphofructokinase
    • Yuan W., Tuttle D.L., Shi Y.J., Ralph G.S., and Dunn Jr. W.A. Glucose-induced microautophagy in Pichia pastoris requires the alpha-subunit of phosphofructokinase. J. Cell Sci. 110 (1997) 1935-1945
    • (1997) J. Cell Sci. , vol.110 , pp. 1935-1945
    • Yuan, W.1    Tuttle, D.L.2    Shi, Y.J.3    Ralph, G.S.4    Dunn Jr., W.A.5
  • 58
    • 28644447348 scopus 로고    scopus 로고
    • The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae
    • Reggiori F., Monastyrska I., Shintani T., and Klionsky D.J. The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae. Mol. Biol. Cell 16 (2005) 5843-5856
    • (2005) Mol. Biol. Cell , vol.16 , pp. 5843-5856
    • Reggiori, F.1    Monastyrska, I.2    Shintani, T.3    Klionsky, D.J.4
  • 59
    • 33645920963 scopus 로고    scopus 로고
    • Atg11 directs autophagosome cargoes to the PAS along actin cables
    • Monastyrska I., Shintani T., Klionsky D.J., and Reggiori F. Atg11 directs autophagosome cargoes to the PAS along actin cables. Autophagy 2 (2006) 119-121
    • (2006) Autophagy , vol.2 , pp. 119-121
    • Monastyrska, I.1    Shintani, T.2    Klionsky, D.J.3    Reggiori, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.