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Volumn 6, Issue 1, 2004, Pages 85-100

New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: Introduction of moving pictures into functional genomics and biochemical phenotyping

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA;

EID: 0742323124     PISSN: 10967176     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymben.2003.10.005     Document Type: Article
Times cited : (89)

References (43)
  • 2
    • 15844410399 scopus 로고    scopus 로고
    • Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
    • Bai, Y., Zhang, S., et al., 1996. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J. Biol. Chem. 271 (24), 13939-13942.
    • (1996) J. Biol. Chem. , vol.271 , Issue.24 , pp. 13939-13942
    • Bai, Y.1    Zhang, S.2
  • 3
    • 0025895183 scopus 로고
    • Toward a science of metabolic engineering
    • Bailey, J.E., 1991. Toward a science of metabolic engineering. Science 252 (5013), 1668-1675.
    • (1991) Science , vol.252 , Issue.5013 , pp. 1668-1675
    • Bailey, J.E.1
  • 5
    • 0037840686 scopus 로고    scopus 로고
    • Measurement of mitochondrial DNA synthesis in vivo in rodents and humans using a stable isotope-mass spectrometric technique
    • Collins, M., Eng, S., et al., 2003. Measurement of mitochondrial DNA synthesis in vivo in rodents and humans using a stable isotope-mass spectrometric technique. J. Appl. Phys. 94, 2208-2211.
    • (2003) J. Appl. Phys. , vol.94 , pp. 2208-2211
    • Collins, M.1    Eng, S.2
  • 6
    • 0021676528 scopus 로고
    • Measurement of rates of cholesterol synthesis using tritiated water
    • Dietschy, J.M., Spady, D.K., 1984. Measurement of rates of cholesterol synthesis using tritiated water. J. Lipid Res. 25 (13), 1469-1476.
    • (1984) J. Lipid Res. , vol.25 , Issue.13 , pp. 1469-1476
    • Dietschy, J.M.1    Spady, D.K.2
  • 7
    • 0033214567 scopus 로고    scopus 로고
    • Measurement of T-cell kinetics: Recent methodologic advances
    • Hellerstein, M.K., 1999. Measurement of T-cell kinetics: recent methodologic advances. Immunol. Today 20 (10), 438-441.
    • (1999) Immunol. Today , vol.20 , Issue.10 , pp. 438-441
    • Hellerstein, M.K.1
  • 8
    • 0026448766 scopus 로고
    • Mass isotopomer distribution analysis: A technique for measuring biosynthesis and turnover of polymers
    • Hellerstein, M.K., Neese, R.A., 1992. Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. Am. J. Physiol. 263 (5 Pt 1), E988-E1001.
    • (1992) Am. J. Physiol. , vol.263 , Issue.5 PART 1
    • Hellerstein, M.K.1    Neese, R.A.2
  • 9
    • 0033038503 scopus 로고    scopus 로고
    • Mass isotopomer distribution analysis at eight years: Theoretical, analytic, and experimental considerations
    • Hellerstein, M.K., Neese, R.A., 1999. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am. J. Physiol. 276 (6 Pt 1), E1146-E1170.
    • (1999) Am. J. Physiol. , vol.276 , Issue.6 PART 1
    • Hellerstein, M.K.1    Neese, R.A.2
  • 10
    • 0022525686 scopus 로고
    • Glycoconjugates as noninvasive probes of intrahepatic metabolism: Pathways of glucose entry into compartmentalized hepatic UDP-glucose pools during glycogen accumulation
    • Hellerstein, M.K., Greenblatt, D.J., et al., 1986. Glycoconjugates as noninvasive probes of intrahepatic metabolism: pathways of glucose entry into compartmentalized hepatic UDP-glucose pools during glycogen accumulation. Proc. Natl. Acad. Sci. USA 83 (18), 7044-7048.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , Issue.18 , pp. 7044-7048
    • Hellerstein, M.K.1    Greenblatt, D.J.2
  • 11
    • 0025796935 scopus 로고
    • Measurement of de novo hepatic lipogenesis in humans using stable isotopes
    • Hellerstein, M.K., Christiansen, M., et al., 1991. Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J. Clin. Invest. 87 (5), 1841-1852.
    • (1991) J. Clin. Invest. , vol.87 , Issue.5 , pp. 1841-1852
    • Hellerstein, M.K.1    Christiansen, M.2
  • 12
    • 0029846701 scopus 로고    scopus 로고
    • Regulation of hepatic de novo lipogenesis in humans
    • Hellerstein, M.K., Schwarz, J.M., et al., 1996. Regulation of hepatic de novo lipogenesis in humans. Annu. Rev. Nutr. 16, 523-557.
    • (1996) Annu. Rev. Nutr. , vol.16 , pp. 523-557
    • Hellerstein, M.K.1    Schwarz, J.M.2
  • 13
    • 0031014206 scopus 로고    scopus 로고
    • Altered fluxes responsible for reduced hepatic glucose production and gluconeogenesis by exogenous glucose in rats
    • Hellerstein, M.K., Neese, R.A., et al., 1997. Altered fluxes responsible for reduced hepatic glucose production and gluconeogenesis by exogenous glucose in rats. Am. J. Physiol. 272 (1 Pt 1), E163-E172.
    • (1997) Am. J. Physiol. , vol.272 , Issue.1 PART 1
    • Hellerstein, M.K.1    Neese, R.A.2
  • 14
    • 17444379333 scopus 로고    scopus 로고
    • Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
    • Hellerstein, M., Hanley, M.B., et al., 1999. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat. Med. 5 (1), 83-89.
    • (1999) Nat. Med. , vol.5 , Issue.1 , pp. 83-89
    • Hellerstein, M.1    Hanley, M.B.2
  • 15
    • 0041403652 scopus 로고    scopus 로고
    • 2O incorporation into non-essential amino acids (NEAA) and application of mass isotopomer distribution analysis (MIDA)
    • 2O incorporation into non-essential amino acids (NEAA) and application of mass isotopomer distribution analysis (MIDA). FASEB J. 16, A256.
    • (2002) FASEB J. , vol.16
    • Hellerstein, M.1    Neese, R.2
  • 16
    • 0032063076 scopus 로고    scopus 로고
    • The biology of leptin: A review
    • Houseknecht, K.L., Baile, C.A., et al., 1998. The biology of leptin: a review. J. Anim. Sci. 76 (5), 1405-1420.
    • (1998) J. Anim. Sci. , vol.76 , Issue.5 , pp. 1405-1420
    • Houseknecht, K.L.1    Baile, C.A.2
  • 17
    • 0033569441 scopus 로고    scopus 로고
    • Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice
    • Jung, H.R., Turner, S.M., et al., 1999. Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice. Biochem. J. 343 (Pt 2), 473-478.
    • (1999) Biochem. J. , vol.343 , Issue.2 PART , pp. 473-478
    • Jung, H.R.1    Turner, S.M.2
  • 18
    • 0026522051 scopus 로고
    • Model equations for condensation biosynthesis using stable isotopes and radioisotopes
    • Kelleher, J.K., Masterson, T.M., 1992. Model equations for condensation biosynthesis using stable isotopes and radioisotopes. Am. J. Physiol. 262 (1 Pt 1), E118-E125.
    • (1992) Am. J. Physiol. , vol.262 , Issue.1 PART 1
    • Kelleher, J.K.1    Masterson, T.M.2
  • 19
    • 0017284766 scopus 로고
    • Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA-gound valine
    • Khairallah, E.A., Mortimore, G.E., 1976. Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA-gound valine. J. Biol. Chem. 251 (5), 1375-1384.
    • (1976) J. Biol. Chem. , vol.251 , Issue.5 , pp. 1375-1384
    • Khairallah, E.A.1    Mortimore, G.E.2
  • 20
    • 0026794983 scopus 로고
    • Isotopomer spectral analysis of triglyceride fatty acid synthesis in 3T3-L1 cells
    • Kharroubi, A.T., Masterson, T.M., et al., 1992. Isotopomer spectral analysis of triglyceride fatty acid synthesis in 3T3-L1 cells. Am. J. Physiol. 263 (4 Pt 1), E667-E675.
    • (1992) Am. J. Physiol. , vol.263 , Issue.4 PART 1
    • Kharroubi, A.T.1    Masterson, T.M.2
  • 21
    • 0006866473 scopus 로고    scopus 로고
    • A new method to measure proliferation rates of colon epithelial cells
    • Kim, J., Neese, R., et al., 2000. A new method to measure proliferation rates of colon epithelial cells. FASEB J. 14, A718.
    • (2000) FASEB J. , vol.14
    • Kim, J.1    Neese, R.2
  • 22
    • 0017030928 scopus 로고
    • Aspects of the regulation of the metabolism of branched-chain amino acids
    • Krebs, H.A., Lund, P., 1976. Aspects of the regulation of the metabolism of branched-chain amino acids. Adv. Enzyme Regul. 15, 375-394.
    • (1976) Adv. Enzyme Regul. , vol.15 , pp. 375-394
    • Krebs, H.A.1    Lund, P.2
  • 23
    • 0031906044 scopus 로고    scopus 로고
    • Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies in vitro, in animals, and in humans
    • Macallan, D.C., Fullerton, C.A., et al., 1998. Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: studies in vitro, in animals, and in humans. Proc. Natl. Acad. Sci. USA 95 (2), 708-713.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , Issue.2 , pp. 708-713
    • Macallan, D.C.1    Fullerton, C.A.2
  • 24
    • 0034060982 scopus 로고    scopus 로고
    • Factors influencing T-cell turnover in HIV-1-seropositive patients
    • McCune, J.M., Hanley, M.B., et al., 2000. Factors influencing T-cell turnover in HIV-1-seropositive patients. J. Clin. Invest. 105 (5), R1-R8.
    • (2000) J. Clin. Invest. , vol.105 , Issue.5
    • McCune, J.M.1    Hanley, M.B.2
  • 26
    • 0000358623 scopus 로고    scopus 로고
    • 2O for measuring mammary epithelial cell proliferation
    • 2O for measuring mammary epithelial cell proliferation. FASEB J. 14, A1003.
    • (2000) FASEB J. , vol.14
    • Misell, L.1    Thompson, J.2
  • 28
    • 0028980981 scopus 로고
    • Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. Application of the mass isotopomer distribution analysis technique with testing of assumptions and potential problems
    • Neese, R.A., Schwarz, J.M., et al., 1995. Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. Application of the mass isotopomer distribution analysis technique with testing of assumptions and potential problems. J. Biol. Chem. 270 (24), 14452-14466.
    • (1995) J. Biol. Chem. , vol.270 , Issue.24 , pp. 14452-14466
    • Neese, R.A.1    Schwarz, J.M.2
  • 29
  • 30
    • 0033139847 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia. Current strategy and new perspectives of treatment
    • Rai, K.R., 1999. Chronic lymphocytic leukaemia. Current strategy and new perspectives of treatment. Haematologica 84 (Suppl. EHA-4), 94-95.
    • (1999) Haematologica , vol.84 , Issue.SUPPL. EHA-4 , pp. 94-95
    • Rai, K.R.1
  • 31
    • 0023925454 scopus 로고
    • Interactions between deoxyribonucleotide and DNA synthesis
    • Reichard, P., 1988. Interactions between deoxyribonucleotide and DNA synthesis. Annu. Rev. Biochem. 57, 349-374.
    • (1988) Annu. Rev. Biochem. , vol.57 , pp. 349-374
    • Reichard, P.1
  • 32
    • 0028881816 scopus 로고
    • Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection
    • Schwarz, J.M., Neese, R.A., et al., 1995. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J. Clin. Invest. 96 (6), 2735-2743.
    • (1995) J. Clin. Invest. , vol.96 , Issue.6 , pp. 2735-2743
    • Schwarz, J.M.1    Neese, R.A.2
  • 33
    • 0032716189 scopus 로고    scopus 로고
    • De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption
    • Siler, S.Q., Neese, R.A., et al., 1999. De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption. Am. J. Clin. Nutr. 70 (5), 928-936.
    • (1999) Am. J. Clin. Nutr. , vol.70 , Issue.5 , pp. 928-936
    • Siler, S.Q.1    Neese, R.A.2
  • 34
    • 0032549874 scopus 로고    scopus 로고
    • Metabolic engineering
    • Stephanopoulos, G., 1998. Metabolic engineering. Biotechnol. Bioeng. 58 (2-3), 119-120.
    • (1998) Biotechnol. Bioeng. , vol.58 , Issue.2-3 , pp. 119-120
    • Stephanopoulos, G.1
  • 35
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos, G., Vallino, J.J., 1991. Network rigidity and metabolic engineering in metabolite overproduction. Science 252 (5013), 1675-1681.
    • (1991) Science , vol.252 , Issue.5013 , pp. 1675-1681
    • Stephanopoulos, G.1    Vallino, J.J.2
  • 36
    • 0004155427 scopus 로고
    • W.H. Freeman and Co., New York
    • Stryer, L., 1995. Biochemistry. W.H. Freeman and Co., New York.
    • (1995) Biochemistry
    • Stryer, L.1
  • 37
    • 0026509089 scopus 로고
    • The effect of ethanol on fat storage in healthy subjects
    • Suter, P.M., Schutz, Y., et al., 1992. The effect of ethanol on fat storage in healthy subjects. N. Engl. J. Med. 326 (15), 983-987.
    • (1992) N. Engl. J. Med. , vol.326 , Issue.15 , pp. 983-987
    • Suter, P.M.1    Schutz, Y.2
  • 38
    • 0042406002 scopus 로고    scopus 로고
    • Independent effects of leptin and caloric intake on adipose metabolism in the ob/ob Mouse
    • Turner, S., Samady, W., et al., 2002. Independent effects of leptin and caloric intake on adipose metabolism in the ob/ob Mouse. FASEB J. 16, A987.
    • (2002) FASEB J. , vol.16
    • Turner, S.1    Samady, W.2
  • 39
    • 0141839083 scopus 로고    scopus 로고
    • 2O incorporation into the glycerol moiety and application of MIDA
    • 2O incorporation into the glycerol moiety and application of MIDA. Am. J. Phys. 285, E790-E803.
    • (2003) Am. J. Phys. , vol.285
    • Turner, S.1    Murphy, E.2
  • 41
    • 0031549576 scopus 로고    scopus 로고
    • Seminars in medicine of the Beth Israel Deaconess medical center. Caloric intake and aging
    • Weindruch, R., Sohal, R.S., 1997. Seminars in medicine of the Beth Israel Deaconess medical center. Caloric intake and aging. N. Engl. J. Med. 337 (14), 986-994.
    • (1997) N. Engl. J. Med. , vol.337 , Issue.14 , pp. 986-994
    • Weindruch, R.1    Sohal, R.S.2
  • 42
    • 0028821841 scopus 로고
    • A genetic model for absent chylomicron formation: Mice producing apolipoprotein B in the liver, but not in the intestine
    • Young, S.G., Cham, C.M., et al., 1995. A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine. J. Clin. Invest. 96 (6), 2932-2946.
    • (1995) J. Clin. Invest. , vol.96 , Issue.6 , pp. 2932-2946
    • Young, S.G.1    Cham, C.M.2
  • 43
    • 0033514948 scopus 로고    scopus 로고
    • Reversing adipocyte differentiation: Implications for treatment of obesity
    • Zhou, Y.T., Wang, Z.W., et al., 1999. Reversing adipocyte differentiation: implications for treatment of obesity. Proc. Natl. Acad. Sci. USA 96 (5), 2391-2395.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , Issue.5 , pp. 2391-2395
    • Zhou, Y.T.1    Wang, Z.W.2


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