Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosis

Journal of Biological Chemistry

Volumn 285, Issue 30, 2010, Pages 23398-23409

  Schneider, Jochen G ^a,b   Yang, Zhen ^a   Chakravarthy, Manu V ^a   Lodhi, Irfan J ^a   Wei, Xiaochao ^a   Turk, John ^a   Semenkovich, Clay F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-ATHEROGENIC EFFECTS; ATHEROSCLEROTIC LESIONS; BODY WEIGHT; BONE MARROW; CHOLESTEROL EFFLUX; DOWNSTREAM TARGET; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; FEEDBACK INHIBITION; FOAM CELLS; GLUCOSE METABOLISM; KNOCK OUTS; LESION FORMATION; LIVER X RECEPTORS; NUCLEAR RECEPTORS; OXIDIZED-LOW DENSITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; SCAVENGER RECEPTOR; SERUM LIPID; SYNTHASES; TARGET GENE EXPRESSION; WILD TYPES;

ACIDS; ANIMALS; BLOOD PRESSURE; CELLULAR MANUFACTURING; CYTOLOGY; FATTY ACIDS; GENE EXPRESSION; GLUCOSE; LIPIDS; METABOLISM; NUTRITION; TARGETS;

MACROPHAGES;

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; CD36 ANTIGEN; CHOLESTEROL; FATTY ACID; FATTY ACID SYNTHASE; GLUCOSE; INSULIN; LIPID; LIVER X RECEPTOR ALPHA; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; SCAVENGER RECEPTOR B; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE MEASUREMENT; BODY WEIGHT; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DIETARY INTAKE; ENZYME DEFICIENCY; ENZYME INACTIVATION; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; FEMALE; FOAM CELL; GENE EXPRESSION; GLUCOSE METABOLISM; IMMUNOCYTOCHEMISTRY; KNOCKOUT MOUSE; LIPID BLOOD LEVEL; LIPOPROTEIN DEFICIENCY; MACROPHAGE; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; WILD TYPE;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; DIET; DISEASE SUSCEPTIBILITY; ENZYME ACTIVATION; FATTY ACID SYNTHETASE COMPLEX; GENE DELETION; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; LIPID METABOLISM; MACROPHAGES; MICE; ORPHAN NUCLEAR RECEPTORS; PHENOTYPE; PPAR ALPHA; TRANSPLANTATION;

ANIMALIA; MUS;

EID: 77954943228     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.100321     Document Type: Article

References (56)

1. Stewart, S. T., Cutler, D. M., and Rosen, A. B. (2009) N. Engl. J. Med. 361, 2252-2260
2. Wilson, P. W., D'Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H., and Kannel, W. B. (1998) Circulation 97, 1837-1847
3. Pekkanen, J., Tervahauta, M., Nissinen, A., and Karvonen, M. J. (1993) Cardiology 82, 181-190
4. Kannel, W. B., and Schatzkin, A. (1985) J. Am. Coll. Cardiol. 5, 141B-149B
5. LaRosa, J. C., Grundy, S. M., Waters, D. D., Shear, C., Barter, P., Fruchart, J. C., Gotto, A. M., Greten, H., Kastelein, J. J., Shepherd, J., and Wenger, N. K. (2005) N. Engl. J. Med. 352, 1425-1435
6. Insull, W., Jr., and Bartsch, G. E. (1966) J. Clin. Invest. 45, 513-523
7. Lang, P. D., and Insull, W., Jr. (1970) J. Clin. Invest. 49, 1479-1488
8. Stachowska, E., Dołegowska, B., Chlubek, D., Wesołowska, T., Ciechanowski, K., Gutowski, P., Szumiłowicz, H., and Turowski, R. (2004) Eur. J. Nutr. 43, 313-318
9. Felton, C. V., Crook, D., Davies, M. J., and Oliver, M. F. (1997) Arterioscler. Thromb. Vasc. Biol. 17, 1337-1345
10. Felton, C. V., Crook, D., Davies, M. J., and Oliver, M. F. (1994) Lancet 344, 1195-1196
11. Lofland, H. B., Clarkson, T. B., and Artom, C. (1960) Arch. Biochem. Biophys 88, 105-109
12. Howard, C. F., Jr. (1968) J. Lipid Res. 9, 254-261
13. Whereat, A. F. (1971) Adv. Lipid. Res. 9, 119-159
14. Whereat, A. F. (1964) J. Atheroscler. Res. 4, 272-282
15. Lofland, H. B., Jr., Moury, D. M., Hoffman, C. W., and Clarkson, T. B. (1965) J. Lipid Res. 6, 112-118
16. Semenkovich, C. F. (1997) Prog. Lipid Res. 36, 43-53
17. Semenkovich, C. F., Coleman, T., and Fiedorek, F. T., Jr. (1995) J. Lipid Res. 36, 1507-1521
18. Chirala, S. S., Chang, H., Matzuk, M., Abu-Elheiga, L., Mao, J., Mahon, K., Finegold, M., and Wakil, S. J. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 6358-6363
19. Chakravarthy, M. V., Pan, Z., Zhu, Y., Tordjman, K., Schneider, J. G., Coleman, T., Turk, J., and Semenkovich, C. F. (2005) Cell Metab. 1, 309-322
20. Chakravarthy, M. V., Zhu, Y., López, M., Yin, L., Wozniak, D. F., Coleman, T., Hu, Z., Wolfgang, M., Vidal-Puig, A., Lane, M. D., and Semenkovich, C. F. (2007) J. Clin. Invest. 117, 2539-2552
21. Chakravarthy, M. V., Lodhi, I. J., Yin, L., Malapaka, R. R., Xu, H. E., Turk, J., and Semenkovich, C. F. (2009) Cell 138, 476-488
22. Daugherty, A., Rateri, D. L., and Lu, H. (2008) Circ. Res. 102, 1445-1447
23. Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., and Förster, I. (1999) Transgenic Res. 8, 265-277
24. Li, B., Nolte, L. A., Ju, J. S., Han, D. H., Coleman, T., Holloszy, J. O., and Semenkovich, C. F. (2000) Nat. Med. 6, 1115-1120
25. Schneider, J. G., Finck, B. N., Ren, J., Standley, K. N., Takagi, M., Maclean, K. H., Bernal-Mizrachi, C., Muslin, A. J., Kastan, M. B., and Semenkovich, C. F. (2006) Cell Metab. 4, 377-389
26. Schneider, J. G., Zhu, Y., Coleman, T., and Semenkovich, C. F. (2007) Arterioscler. Thromb. Vasc. Biol. 27, 2699-2706
27. Bernal-Mizrachi, C., Weng, S., Li, B., Nolte, L. A., Feng, C., Coleman, T., Holloszy, J. O., and Semenkovich, C. F. (2002) Arterioscler. Thromb. Vasc. Biol. 22, 961-968
28. Hallberg, A. (1984) Biochim. Biophys. Acta 796, 328-335
29. Traves, P. G., Hortelano, S., Zeini, M., Chao, T. H., Lam, T., Neuteboom, S. T., Theodorakis, E. A., Palladino, M. A., Castrillo, A., and Bosca, L. (2007) Mol. Pharmacol. 71, 1545-1553
30. Huby, T., Doucet, C., Dachet, C., Ouzilleau, B., Ueda, Y., Afzal, V., Rubin, E., Chapman, M. J., and Lesnik, P. (2006) J. Clin. Invest. 116, 2767-2776
31. Taleb, S., Romain, M., Ramkhelawon, B., Uyttenhove, C., Pasterkamp, G., Herbin, O., Esposito, B., Perez, N., Yasukawa, H., Van Snick, J., Yoshimura, A., Tedgui, A., and Mallat, Z. (2009) J. Exp. Med. 206, 2067-2077
32. Chakravarthy, M. V., Zhu, Y., Wice, M. B., Coleman, T., Pappan, K. L., Marshall, C. A., McDaniel, M. L., and Semenkovich, C. F. (2008) Diabetes 57, 2698-2707
33. Arai, H., Nagano, Y., Narumiya, S., and Kita, T. (1992) J. Biochem. 112, 482-487
34. Tabas, I., and Boykow, G. C. (1987) J. Biol. Chem. 262, 12175-12181
35. Rader, D. J., Alexander, E. T., Weibel, G. L., Billheimer, J., and Rothblat, G. H. (2009) J. Lipid Res. 50, S189-S194
36. Chinetti, G., Zawadski, C., Fruchart, J. C., and Staels, B. (2004) Biochem. Biophys. Res. Commun. 314, 151-158
37. Rudd, J. H., Myers, K. S., Bansilal, S., Machac, J., Pinto, C. A., Tong, C., Rafique, A., Hargeaves, R., Farkouh, M., Fuster, V., and Fayad, Z. A. (2008) J. Nucl. Med. 49, 871-878
38. Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J. K., Beck, F. X., Müller, D. N., Derer, W., Goss, J., Ziomber, A., Dietsch, P., Wagner, H., van Rooijen, N., Kurtz, A., Hilgers, K. F., Alitalo, K., Eckardt, K. U., Luft, F. C., Kerjaschki, D., and Titze, J. (2009) Nat. Med. 15, 545-552
39. Beyea, M. M., Heslop, C. L., Sawyez, C. G., Edwards, J. Y., Markle, J. G., Hegele, R. A., and Huff, M. W. (2007) J. Biol. Chem. 282, 5207-5216
40. Joseph, S. B., Laffitte, B. A., Patel, P. H., Watson, M. A., Matsukuma, K. E., Walczak, R., Collins, J. L., Osborne, T. F., and Tontonoz, P. (2002) J. Biol. Chem. 277, 11019-11025
41. Tordjman, K., Bernal-Mizrachi, C., Zemany, L., Weng, S., Feng, C., Zhang, F., Leone, T. C., Coleman, T., Kelly, D. P., and Semenkovich, C. F. (2001) J. Clin. Invest. 107, 1025-1034
42. Kalinowska, A., Górski, J., Harasim, E., Harasiuk, D., Bonen, A., and Chabowski, A. (2009) FEBS Lett. 583, 2527-2534
43. Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., and Silverstein, R. L. (2000) J. Clin. Invest. 105, 1049-1056
44. Moore, K. J., Kunjathoor, V. V., Koehn, S. L., Manning, J. J., Tseng, A. A., Silver, J. M., McKee, M., and Freeman, M. W. (2005) J. Clin. Invest. 115, 2192-2201
45. Manning-Tobin, J. J., Moore, K. J., Seimon, T. A., Bell, S. A., Sharuk, M., Alvarez-Leite, J. I., de Winther, M. P., Tabas, I., and Freeman, M. W. (2009) Arterioscler. Thromb. Vasc. Biol. 29, 19-26
46. Park, Y. M., Febbraio, M., and Silverstein, R. L. (2009) J. Clin. Invest. 119, 136-145
47. Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A., Collins, A. R., Laffitte, B. A., Chen, M., Noh, G., Goodman, J., Hagger, G. N., Tran, J., Tippin, T. K., Wang, X., Lusis, A. J., Hsueh, W. A., Law, R. E., Collins, J. L., Willson, T. M., and Tontonoz, P. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 7604-7609
48. Tangirala, R. K., Bischoff, E. D., Joseph, S. B., Wagner, B. L., Walczak, R., Laffitte, B. A., Daige, C. L., Thomas, D., Heyman, R. A., Mangelsdorf, D. J., Wang, X., Lusis, A. J., Tontonoz, P., and Schulman, I. G. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 11896-11901
49. Teupser, D., Kretzschmar, D., Tennert, C., Burkhardt, R., Wilfert, W., Fengler, D., Naumann, R., Sippel, A. E., and Thiery, J. (2008) Arterioscler. Thromb. Vasc. Biol. 28, 2009-2015
50. Brunham, L. R., Singaraja, R. R., Duong, M., Timmins, J. M., Fievet, C., Bissada, N., Kang, M. H., Samra, A., Fruchart, J. C., McManus, B., Staels, B., Parks, J. S., and Hayden, M. R. (2009) Arterioscler. Thromb. Vasc. Biol. 29, 548-554
51. Van Eck, M., Singaraja, R. R., Ye, D., Hildebrand, R. B., James, E. R., Hayden, M. R., and Van Berkel, T. J. (2006) Arterioscler. Thromb. Vasc. Biol. 26, 929-934
52. Chawla, A., Boisvert, W. A., Lee, C. H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., Evans, R. M., and Tontonoz, P. (2001) Mol. Cell 7, 161-171
53. Ide, T., Shimano, H., Yoshikawa, T., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Nakakuki, M., Yatoh, S., Iizuka, Y., Tomita, S., Ohashi, K., Takahashi, A., Sone, H., Gotoda, T., Osuga, J., Ishibashi, S., and Yamada, N. (2003) Mol. Endocrinol. 17, 1255-1267
54. Maier, T., Leibundgut, M., and Ban, N. (2008) Science 321, 1315-1322
55. Kridel, S. J., Lowther, W. T., and Pemble, C. W., 4th (2007) Expert Opin. Investig. Drugs 16, 1817-1829
56. Ecker, J., Liebisch, G., Englmaier, M., Grandl, M., Robenek, H., and Schmitz, G. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 7817-7822