메뉴 건너뛰기




Volumn 131, Issue 2, 2011, Pages 242-253

AMPK and vasculoprotection

Author keywords

AMPK; Atherosclerosis; Endothelium; Nitric oxide; Vascular smooth muscle; Vasculoprotection

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ATORVASTATIN; BERBERINE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; METFORMIN; PIOGLITAZONE; PRAVASTATIN; ROSIGLITAZONE; SIMVASTATIN; TELMISARTAN; TROGLITAZONE;

EID: 79959714887     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2010.11.002     Document Type: Review
Times cited : (100)

References (167)
  • 2
    • 33947526130 scopus 로고    scopus 로고
    • AMP-activated protein kinase in the heart: Role during health and disease
    • DOI 10.1161/01.RES.0000258446.23525.37, PII 0000301220070302000007
    • M. Arad, C.E. Seidman, and J.G. Seidman AMP-activated protein kinase in the heart: role during health and disease Circ Res 100 4 2007 474 488 (Pubitemid 46673257)
    • (2007) Circulation Research , vol.100 , Issue.4 , pp. 474-488
    • Arad, M.1    Seidman, C.E.2    Seidman, J.G.3
  • 3
    • 77951208745 scopus 로고    scopus 로고
    • Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel
    • Q. Aziz, A. Thomas, T. Khambra, and A. Tinker Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channel Eur J Pharmacol 634 1-3 2010 26 32
    • (2010) Eur J Pharmacol , vol.634 , Issue.13 , pp. 26-32
    • Aziz, Q.1    Thomas, A.2    Khambra, T.3    Tinker, A.4
  • 5
    • 0031016272 scopus 로고    scopus 로고
    • The structure of a domain common to archaebacteria and the homocystinuria disease protein
    • DOI 10.1016/S0968-0004(96)30046-7, PII S0968000496300467
    • A. Bateman The structure of a domain common to archaebacteria and the homocystinuria disease protein TIBS 22 1 1997 12 13 (Pubitemid 27056090)
    • (1997) Trends in Biochemical Sciences , vol.22 , Issue.1 , pp. 12-13
    • Bateman, A.1
  • 6
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • J.S. Beckman, T.W. Beckman, J. Chen, P.A. Marshall, and B.A. Freeman Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide Proc Natl Acad Sci USA 87 4 1990 1620 1624
    • (1990) Proc Natl Acad Sci USA , vol.87 , Issue.4 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 8
  • 10
    • 0141753981 scopus 로고    scopus 로고
    • MO25 isoforms interact with the STE20-related pseudokinase STRADalpha/beta and enhance their ability to bind, activate and localise the LKB1 tumour suppressor in the cytoplasm
    • J. Boudeau, A.F. Baas, M. Deak, N.A. Morrice, A. Kieloch, and M. Schutkowski MO25 isoforms interact with the STE20-related pseudokinase STRADalpha/beta and enhance their ability to bind, activate and localise the LKB1 tumour suppressor in the cytoplasm EMBO J 22 2003 5102 5114
    • (2003) EMBO J , vol.22 , pp. 5102-5114
    • Boudeau, J.1    Baas, A.F.2    Deak, M.3    Morrice, N.A.4    Kieloch, A.5    Schutkowski, M.6
  • 11
    • 45549088112 scopus 로고    scopus 로고
    • Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase
    • J.G. Boyle, P.J. Logan, M.A. Ewart, J.A. Reihill, S.A. Ritchie, and J.M. Connell Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase J Biol Chem 283 17 2008 11210 11217
    • (2008) J Biol Chem , vol.283 , Issue.17 , pp. 11210-11217
    • Boyle, J.G.1    Logan, P.J.2    Ewart, M.A.3    Reihill, J.A.4    Ritchie, S.A.5    Connell, J.M.6
  • 12
    • 77952885895 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by 5-aminoimidazole-4- carboxamide-1-beta-d-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion
    • E.A. Bradley, E.C. Eringa, C.D. Stehouwer, I. Korstjens, G.P. van Nieuw Amerongen, and R. Musters Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion Arterioscler Thromb Vasc Biol 30 6 2010 1137 1142
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.6 , pp. 1137-1142
    • Bradley, E.A.1    Eringa, E.C.2    Stehouwer, C.D.3    Korstjens, I.4    Van Nieuw Amerongen, G.P.5    Musters, R.6
  • 14
    • 0023642627 scopus 로고    scopus 로고
    • A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
    • D. Carling, V.A. Zammit, and D.G. Hardie A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis FEBS Lett 223 2 2007 217 222
    • (2007) FEBS Lett , vol.223 , Issue.2 , pp. 217-222
    • Carling, D.1    Zammit, V.A.2    Hardie, D.G.3
  • 15
    • 77949493599 scopus 로고    scopus 로고
    • Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
    • P.W. Caton, N.K. Nayuni, J. Kieswich, N.Q. Khan, M.M. Yaqoob, and R. Corder Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5 J Endocrinol 205 1 2010 97 106
    • (2010) J Endocrinol , vol.205 , Issue.1 , pp. 97-106
    • Caton, P.W.1    Nayuni, N.K.2    Kieswich, J.3    Khan, N.Q.4    Yaqoob, M.M.5    Corder, R.6
  • 17
    • 77956229580 scopus 로고    scopus 로고
    • AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway
    • M.Y. Chang, F.M. Ho, J.S. Wang, H.C. Kang, Y. Chang, and Z.X. Ye AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway Biochem Pharmacol 80 8 2010 1210 1220
    • (2010) Biochem Pharmacol , vol.80 , Issue.8 , pp. 1210-1220
    • Chang, M.Y.1    Ho, F.M.2    Wang, J.S.3    Kang, H.C.4    Chang, Y.5    Ye, Z.X.6
  • 19
    • 61949165795 scopus 로고    scopus 로고
    • AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
    • Z. Chen, I.C. Peng, W. Sun, M.I. Su, P.H. Hsu, and Y. Fu AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633 Circ Res 104 4 2009 496 505
    • (2009) Circ Res , vol.104 , Issue.4 , pp. 496-505
    • Chen, Z.1    Peng, I.C.2    Sun, W.3    Su, M.I.4    Hsu, P.H.5    Fu, Y.6
  • 20
    • 0034654362 scopus 로고    scopus 로고
    • Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
    • DOI 10.1042/0264-6021:3460659
    • P.C. Cheung, I.P. Salt, S.P. Davies, D.G. Hardie, and D. Carling Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding Biochem J 346 Pt 3 2000 659 669 (Pubitemid 30171026)
    • (2000) Biochemical Journal , vol.346 , Issue.3 , pp. 659-669
    • Cheung, P.C.F.1    Salt, I.P.2    Davies, S.P.3    Hardie, D.G.4    Carling, D.5
  • 21
    • 50649108650 scopus 로고    scopus 로고
    • Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo
    • H.C. Choi, P. Song, Z. Xie, Y. Wu, J. Xu, and M. Zhang Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo J Biol Chem 283 29 2008 20186 20197
    • (2008) J Biol Chem , vol.283 , Issue.29 , pp. 20186-20197
    • Choi, H.C.1    Song, P.2    Xie, Z.3    Wu, Y.4    Xu, J.5    Zhang, M.6
  • 22
    • 67650882500 scopus 로고    scopus 로고
    • AMPKalpha1 regulates the antioxidant status of vascular endothelial cells
    • S.L. Colombo, and S. Moncada AMPKalpha1 regulates the antioxidant status of vascular endothelial cells Biochem J 421 2 2009 163 169
    • (2009) Biochem J , vol.421 , Issue.2 , pp. 163-169
    • Colombo, S.L.1    Moncada, S.2
  • 24
    • 85047689953 scopus 로고
    • 5-Aminoimidazole-4-carboxamide ribonucleoside: A specific method for activating AMP-activated protein kinase in intact cells?
    • J.M. Corton, J.G. Gillespie, S.A. Hawley, and D.G. Hardie 5-Aminoimidazole-4-carboxamide ribonucleoside: a specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229 1995 558 565
    • (1995) Eur J Biochem , vol.229 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 25
    • 0032567252 scopus 로고    scopus 로고
    • Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase
    • DOI 10.1074/jbc.273.52.35347
    • B.E. Crute, K. Seefeld, J. Gamble, B.E. Kemp, and L.A. Witters Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase J Biol Chem 273 52 1998 35347 35354 (Pubitemid 29028244)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.52 , pp. 35347-35354
    • Crute, B.E.1    Seefeld, K.2    Gamble, J.3    Kemp, B.E.4    Witters, L.A.5
  • 26
    • 0033547339 scopus 로고    scopus 로고
    • The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells
    • Z. Dagher, N. Ruderman, K. Tornheim, and Y. Ido The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells Biochem Biophys Res Commun 265 1 2010 112 115
    • (2010) Biochem Biophys Res Commun , vol.265 , Issue.1 , pp. 112-115
    • Dagher, Z.1    Ruderman, N.2    Tornheim, K.3    Ido, Y.4
  • 27
    • 50949133177 scopus 로고    scopus 로고
    • Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism
    • P. Dallaire, K. Bellmann, M. Laplante, S. Gélinas, C. Centeno-Baez, and P. Penfornis Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism Diabetes 57 8 2008 1999 2011
    • (2008) Diabetes , vol.57 , Issue.8 , pp. 1999-2011
    • Dallaire, P.1    Bellmann, K.2    Laplante, M.3    Gélinas, S.4    Centeno-Baez, C.5    Penfornis, P.6
  • 29
    • 0029561919 scopus 로고
    • 5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2Cα and native bovine protein phosphatase-2A(C)
    • DOI 10.1016/0014-5793(95)01368-7
    • S.P. Davies, N.R. Helps, P.T. Cohen, and D.G. Hardie 5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC FEBS Lett 377 3 1995 421 425 (Pubitemid 26027159)
    • (1995) FEBS Letters , vol.377 , Issue.3 , pp. 421-425
    • Davies, S.P.1    Helps, N.R.2    Cohen, P.T.W.3    Hardie, D.G.4
  • 30
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • DOI 10.2337/diabetes.55.02.06.db05-1064
    • B.J. Davis, Z. Xie, B. Viollet, and M.H. Zou Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase Diabetes 55 2 2006 496 505 (Pubitemid 43343281)
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3    Zou, M.-H.4
  • 31
    • 33847212846 scopus 로고    scopus 로고
    • Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents
    • S.T. de Dios, K.V. Frontanilla, J. Nigro, M.L. Ballinger, M.E. Ivey, and E.A. Cawson Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents J Diab Complications 21 2 2007 108 117
    • (2007) J Diab Complications , vol.21 , Issue.2 , pp. 108-117
    • De Dios, S.T.1    Frontanilla, K.V.2    Nigro, J.3    Ballinger, M.L.4    Ivey, M.E.5    Cawson, E.A.6
  • 33
    • 74249096153 scopus 로고    scopus 로고
    • Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS pathway
    • G. Deng, Y. Long, Y.R. Yu, and M.R. Li Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS pathway Int J Obes Lond 34 1 2010 165 171
    • (2010) Int J Obes Lond , vol.34 , Issue.1 , pp. 165-171
    • Deng, G.1    Long, Y.2    Yu, Y.R.3    Li, M.R.4
  • 34
    • 33845960021 scopus 로고    scopus 로고
    • The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1α(βS*,δS*),2α,6α,8β- (R*),8aα]]-1,2,6,7,8,8a-hexahydro-β,δ, 6-trihydroxy-2-methyl-8- (2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy)butyl ester), reduces splenocyte adhesion and reactive oxygen species generation in normal and atherosclerotic mice
    • DOI 10.1124/jpet.106.109298
    • G. Dever, C.M. Spickett, S. Kennedy, C. Rush, G. Tennant, and A. Monopoli The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S- [1alpha(betaS*, deltaS*), 2alpha,6alpha,8beta-(R*),8a alpha]]-1,2,6,7,8,8a-Hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1- oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy)butyl ester)], reduces splenocyte adhesion and reactive oxygen species generation in normal and atherosclerotic mice J Pharmacol Exp Ther 320 1 2007 419 426 (Pubitemid 46028484)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.1 , pp. 419-426
    • Dever, G.1    Spickett, C.M.2    Kennedy, S.3    Rush, C.4    Tennant, G.5    Monopoli, A.6    Wainwright, C.L.7
  • 35
    • 77149134285 scopus 로고    scopus 로고
    • Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo
    • Y. Dong, M. Zhang, B. Liang, Z. Xie, Z. Zhao, and S. Asfa Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo Circulation 121 6 2010 792 803
    • (2010) Circulation , vol.121 , Issue.6 , pp. 792-803
    • Dong, Y.1    Zhang, M.2    Liang, B.3    Xie, Z.4    Zhao, Z.5    Asfa, S.6
  • 36
    • 77953226963 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo
    • Y. Dong, M. Zhang, S. Wang, B. Liang, Z. Zhao, and C. Liu Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo Diabetes 59 6 2010 1386 1396
    • (2010) Diabetes , vol.59 , Issue.6 , pp. 1386-1396
    • Dong, Y.1    Zhang, M.2    Wang, S.3    Liang, B.4    Zhao, Z.5    Liu, C.6
  • 37
    • 50949114804 scopus 로고    scopus 로고
    • Acadesine, an adenosine-regulating agent with the potential for widespread indications
    • B.G. Drew, and B.A. Kingwell Acadesine, an adenosine-regulating agent with the potential for widespread indications Expert Opin Pharmacother 9 12 2008 2137 2144
    • (2008) Expert Opin Pharmacother , vol.9 , Issue.12 , pp. 2137-2144
    • Drew, B.G.1    Kingwell, B.A.2
  • 38
    • 0000903683 scopus 로고    scopus 로고
    • Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP- dependent protein kinase and 5'-AMP activated protein kinase
    • DOI 10.1046/j.1432-1327.1999.00371.x
    • J.R. Dyck, N. Kudo, A.J. Barr, S.P. Davies, D.G. Hardie, and G.D. Lopaschuk Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5′-AMP activated protein kinase Eur J Biochem 262 1 1999 184 190 (Pubitemid 29242625)
    • (1999) European Journal of Biochemistry , vol.262 , Issue.1 , pp. 184-190
    • Dyck, J.R.B.1    Kudo, N.2    Barr, A.J.3    Davies, S.P.4    Hardie, D.G.5    Lopaschuk, G.D.6
  • 40
    • 57549088860 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase
    • M.A. Ewart, C.F. Kohlhaas, and I.P. Salt Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase Arterioscler Thromb Vasc Biol 28 12 2008 2255 2257
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.12 , pp. 2255-2257
    • Ewart, M.A.1    Kohlhaas, C.F.2    Salt, I.P.3
  • 41
    • 77958108696 scopus 로고    scopus 로고
    • Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR delta/AMPK pathway
    • Feng X., Luo Z., Ma L., Ma S., Yang D., and Zhao Z. Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR delta/AMPK pathway J Cell Mol Med 2010, May 14 [Epub ahead of print]
    • (2010) J Cell Mol Med
    • Feng, X.1    Luo, Z.2    Ma, L.3    Ma, S.4    Yang, D.5    Zhao, Z.6
  • 42
    • 0022371303 scopus 로고
    • Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5'-monophosphate
    • DOI 10.1016/0006-291X(85)91161-1
    • A. Ferrer, C. Caelles, N. Massot, and F.G. Hegardt Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5′-monophosphate Biochem Biophys Res Comm 132 2 1985 497 504 (Pubitemid 16198655)
    • (1985) Biochemical and Biophysical Research Communications , vol.132 , Issue.2 , pp. 497-504
    • Ferrer, A.1    Caelles, C.2    Massot, N.3    Hegardt, F.G.4
  • 43
    • 68049103917 scopus 로고    scopus 로고
    • Activation and signaling by the AMP-activated protein kinase in endothelial cells
    • B. Fisslthaler, and I. Fleming Activation and signaling by the AMP-activated protein kinase in endothelial cells Circ Res 105 2 2009 114 127
    • (2009) Circ Res , vol.105 , Issue.2 , pp. 114-127
    • Fisslthaler, B.1    Fleming, I.2
  • 44
    • 33846839230 scopus 로고    scopus 로고
    • Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1
    • B. Fisslthaler, I. Fleming, B. Keserü, K. Walsh, and R. Busse Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1 Circ Res 100 2 2007 e12 e21
    • (2007) Circ Res , vol.100 , Issue.2
    • Fisslthaler, B.1    Fleming, I.2    Keserü, B.3    Walsh, K.4    Busse, R.5
  • 45
    • 27144465277 scopus 로고    scopus 로고
    • Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells
    • DOI 10.1242/jcs.02541
    • I. Fleming, B. Fisslthaler, M. Dixit, and R. Busse Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells J Cell Sci 118 Pt 18 2005 4103 4111 (Pubitemid 41488949)
    • (2005) Journal of Cell Science , vol.118 , Issue.18 , pp. 4103-4111
    • Fleming, I.1    Fisslthaler, B.2    Dixit, M.3    Busse, R.4
  • 46
    • 58649116274 scopus 로고    scopus 로고
    • C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest
    • S. Fogarty, and D.G. Hardie C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest J Biol Chem 284 1 2009 77 84
    • (2009) J Biol Chem , vol.284 , Issue.1 , pp. 77-84
    • Fogarty, S.1    Hardie, D.G.2
  • 47
    • 63649110025 scopus 로고    scopus 로고
    • Cardiovascular effects of disturbed insulin activity in metabolic syndrome and in type 2 diabetic patients
    • T. Forst, C. Hohberg, and A. Pfützner Cardiovascular effects of disturbed insulin activity in metabolic syndrome and in type 2 diabetic patients Horm Metab Res 41 2 2009 123 131
    • (2009) Horm Metab Res , vol.41 , Issue.2 , pp. 123-131
    • Forst, T.1    Hohberg, C.2    Pfützner, A.3
  • 49
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • DOI 10.1074/jbc.M202489200
    • L.G. Fryer, A. Parbu-Patel, and D. Carling The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways J Biol Chem 277 2002 25226 25232 (Pubitemid 34951829)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.28 , pp. 25226-25232
    • Fryer, L.G.D.1    Parbu-Patel, A.2    Carling, D.3
  • 50
    • 33846240080 scopus 로고    scopus 로고
    • 5′-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions
    • F.S. Gaskin, K. Kamada, M. Yusof, and R.J. Korthuis 5′-AMP- activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions Am J Physiol Heart Circ Physiol 292 1 2007 H326 H332
    • (2007) Am J Physiol Heart Circ Physiol , vol.292 , Issue.1
    • Gaskin, F.S.1    Kamada, K.2    Yusof, M.3    Korthuis, R.J.4
  • 53
    • 77949834465 scopus 로고    scopus 로고
    • Development of novel adenosine monophosphate-activated protein kinase activators
    • J.H. Guh, W.L. Chang, J. Yang, S.L. Lee, S. Wei, and D. Wang Development of novel adenosine monophosphate-activated protein kinase activators J Med Chem 53 6 2010 2552 2561
    • (2010) J Med Chem , vol.53 , Issue.6 , pp. 2552-2561
    • Guh, J.H.1    Chang, W.L.2    Yang, J.3    Lee, S.L.4    Wei, S.5    Wang, D.6
  • 54
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • DOI 10.1056/NEJM199807233390404
    • S.M. Haffner, S. Lehto, T. Rönnemaa, K. Pyörälä, and M. Laakso Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction N Engl J Med 339 4 1998 229 234 (Pubitemid 28350165)
    • (1998) New England Journal of Medicine , vol.339 , Issue.4 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 55
  • 56
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase
    • D.G. Hardie, and D. Carling The AMP-activated protein kinase Eur J Biochem 246 2 1997 259 273
    • (1997) Eur J Biochem , vol.246 , Issue.2 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 57
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • DOI 10.1146/annurev.biochem.67.1.821
    • D.G. Hardie, D. Carling, and M. Carlson The AMP-activated/snf1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67 1 1998 821 855 (Pubitemid 28411146)
    • (1998) Annual Review of Biochemistry , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 58
    • 43549093962 scopus 로고    scopus 로고
    • High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells
    • Y. Hattori, Y. Nakano, S. Hattori, A. Tomizawa, K. Inukai, and K. Kasai High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells FEBS Lett 582 12 2008 1719 1724
    • (2008) FEBS Lett , vol.582 , Issue.12 , pp. 1719-1724
    • Hattori, Y.1    Nakano, Y.2    Hattori, S.3    Tomizawa, A.4    Inukai, K.5    Kasai, K.6
  • 59
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • S.A. Hawley, J. Boudeau, J.L. Reid, K.J. Mustard, L. Udd, and T.P. Mäkelä Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade J Biol 2 4 2003 28
    • (2003) J Biol , vol.2 , Issue.4 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Mäkelä, T.P.6
  • 60
    • 0029910018 scopus 로고    scopus 로고
    • Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
    • DOI 10.1074/jbc.271.44.27879
    • S.A. Hawley, M. Davison, A. Woods, S.P. Davies, R.K. Beri, and D. Carling Characterization of the AMP-activated protein kinase kinase from rat liver, and identification of threonine-172 as the major site at which it phosphorylates and activates AMP-activated protein kinase J Biol Chem 271 1996 27879 27887 (Pubitemid 26367365)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.44 , pp. 27879-27887
    • Hawley, S.A.1    Davison, M.2    Woods, A.3    Davies, S.P.4    Beri, R.K.5    Carling, D.6    Hardie, D.G.7
  • 61
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
    • DOI 10.1016/j.cmet.2005.05.009, PII S155041310500166X
    • S.A. Hawley, D.A. Pan, K.J. Mustard, L. Ross, J. Bain, and A.M. Edelman Calmodulin-dependent protein kinase kinase-[beta] is an alternative upstream kinase for AMP-activated protein kinase Cell Metab 2 1 2005 9 19 (Pubitemid 43239821)
    • (2005) Cell Metabolism , vol.2 , Issue.1 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 62
    • 77956410464 scopus 로고    scopus 로고
    • Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
    • S.A. Hawley, F.A. Ross, C. Chevtzoff, K.A. Green, A. Evans, and S. Fogarty Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation Cell Metab 11 6 2010 554 565
    • (2010) Cell Metab , vol.11 , Issue.6 , pp. 554-565
    • Hawley, S.A.1    Ross, F.A.2    Chevtzoff, C.3    Green, K.A.4    Evans, A.5    Fogarty, S.6
  • 63
    • 0028845251 scopus 로고
    • 5′-AMP activates the AMP-activated protein kinase cascade, and Ca/calmodulin activates the calmodulin-dependent protein kinase i cascade, via three independent mechanisms
    • S.A. Hawley, M.A. Selbert, E.G. Goldstein, A.M. Edelman, D. Carling, and D.G. Hardie 5′-AMP activates the AMP-activated protein kinase cascade, and Ca/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms J Biol Chem 270 45 1995 27186 27191
    • (1995) J Biol Chem , vol.270 , Issue.45 , pp. 27186-27191
    • Hawley, S.A.1    Selbert, M.A.2    Goldstein, E.G.3    Edelman, A.M.4    Carling, D.5    Hardie, D.G.6
  • 65
    • 49649085586 scopus 로고    scopus 로고
    • AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
    • S. Horman, N. Morel, D. Vertommen, N. Hussain, D. Neumann, and C. Beauloye AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase J Biol Chem 283 27 2008 18505 18512
    • (2008) J Biol Chem , vol.283 , Issue.27 , pp. 18505-18512
    • Horman, S.1    Morel, N.2    Vertommen, D.3    Hussain, N.4    Neumann, D.5    Beauloye, C.6
  • 67
    • 0038814313 scopus 로고    scopus 로고
    • A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias
    • DOI 10.1016/S0960-9822(03)00249-5
    • E.R. Hudson, D.A. Pan, J. James, J.M. Lucocq, S.A. Hawley, and K.A. Green A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias Curr Biol 13 10 2003 861 866 (Pubitemid 36573255)
    • (2003) Current Biology , vol.13 , Issue.10 , pp. 861-866
    • Hudson, E.R.1    Pan, D.A.2    James, J.3    Lucocq, J.M.4    Hawley, S.A.5    Green, K.A.6    Baba, O.7    Terashima, T.8    Hardie, D.G.9
  • 68
    • 33845972272 scopus 로고    scopus 로고
    • Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP
    • DOI 10.1074/jbc.M606676200
    • R.L. Hurley, L.K. Barré, S.D. Wood, K.A. Anderson, B.E. Kemp, and A.R. Means Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP J Biol Chem 281 48 2006 36662 36672 (Pubitemid 46042133)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.48 , pp. 36662-36672
    • Hurley, R.L.1    Barre, L.K.2    Wood, S.D.3    Anderson, K.A.4    Kemp, B.E.5    Means, A.R.6    Witters, L.A.7
  • 69
    • 0030953974 scopus 로고    scopus 로고
    • The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex
    • R. Jiang, and M. Carlson The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex Mol Cell Biol 17 4 1997 2099 2106 (Pubitemid 27133295)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.4 , pp. 2099-2106
    • Jiang, R.1    Carlson, M.2
  • 70
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
    • B.B. Kahn, T. Alquier, D. Carling, and D.G. Hardie AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism Cell Metab 1 1 2005 15 25 (Pubitemid 43960587)
    • (2005) Cell Metabolism , vol.1 , Issue.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 71
    • 34548407362 scopus 로고    scopus 로고
    • Nitric oxide generation by NO donors is enhanced following balloon injury in the porcine coronary artery
    • DOI 10.1080/10623320701347039, PII 778553069
    • S. Kennedy, S.G. Burke, A.A. Preston, and A.R. McPhaden Nitric oxide generation by NO donors is enhanced following balloon injury in the porcine coronary artery Endothelium 14 2 2007 105 113 (Pubitemid 47386389)
    • (2007) Endothelium: Journal of Endothelial Cell Research , vol.14 , Issue.2 , pp. 105-113
    • Kennedy, S.1    Burke, S.G.2    Preston, A.A.3    McPhaden, A.R.4
  • 73
    • 65249124172 scopus 로고    scopus 로고
    • Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation
    • S.Y. Kim, N.H. Jeoung, C.J. Oh, Y.K. Choi, H.J. Lee, and H.J. Kim Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation Circ Res 104 7 2009 842 850
    • (2009) Circ Res , vol.104 , Issue.7 , pp. 842-850
    • Kim, S.Y.1    Jeoung, N.H.2    Oh, C.J.3    Choi, Y.K.4    Lee, H.J.5    Kim, H.J.6
  • 74
    • 77951167843 scopus 로고    scopus 로고
    • Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells
    • T. Kimura, H. Tomura, K. Sato, M. Ito, I. Matsuoka, and D.S. Im Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells J Biol Chem 285 7 2010 4387 4397
    • (2010) J Biol Chem , vol.285 , Issue.7 , pp. 4387-4397
    • Kimura, T.1    Tomura, H.2    Sato, K.3    Ito, M.4    Matsuoka, I.5    Im, D.S.6
  • 75
    • 61849127277 scopus 로고    scopus 로고
    • Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardium
    • M.J. Kohr, J.P. Davis, and M.T. Ziolo Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardium Nitric Oxide 20 2009 217 221
    • (2009) Nitric Oxide , vol.20 , pp. 217-221
    • Kohr, M.J.1    Davis, J.P.2    Ziolo, M.T.3
  • 76
    • 0029093341 scopus 로고
    • High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′AMP-activated protein kinase inhibition of acetyl-CoA carboxylase
    • N. Kudo, A.J. Barr, R.L. Barr, S. Desai, and G.D. Lopaschuk High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′AMP-activated protein kinase inhibition of acetyl-CoA carboxylase J Biol Chem 270 29 1995 17513 17520
    • (1995) J Biol Chem , vol.270 , Issue.29 , pp. 17513-17520
    • Kudo, N.1    Barr, A.J.2    Barr, R.L.3    Desai, S.4    Lopaschuk, G.D.5
  • 77
    • 33644749330 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
    • DOI 10.2337/diabetes.55.1.120
    • D. Kukidome, T. Nishikawa, K. Sonoda, K. Imoto, K. Fujisawa, and M. Yano Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells Diabetes 55 1 2006 120 127 (Pubitemid 43343306)
    • (2006) Diabetes , vol.55 , Issue.1 , pp. 120-127
    • Kukidome, D.1    Nishikawa, T.2    Sonoda, K.3    Imoto, K.4    Fujisawa, K.5    Yano, M.6    Motoshima, H.7    Taguchi, T.8    Matsumura, T.9    Araki, E.10
  • 79
    • 0020490359 scopus 로고
    • Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase
    • B. Lent, and K.H. Kim Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase J Biol Chem 257 4 1982 1897 1901
    • (1982) J Biol Chem , vol.257 , Issue.4 , pp. 1897-1901
    • Lent, B.1    Kim, K.H.2
  • 80
    • 53449093439 scopus 로고    scopus 로고
    • AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells
    • X. Li, Y. Han, W. Pang, C. Li, X. Xie, and J.Y. Shyy AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells Arterioscler Thromb Vasc Biol 28 10 2008 1789 1795
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.10 , pp. 1789-1795
    • Li, X.1    Han, Y.2    Pang, W.3    Li, C.4    Xie, X.5    Shyy, J.Y.6
  • 81
    • 68949135307 scopus 로고    scopus 로고
    • The protease inhibitor UCF-101 ameliorates streptozotocin-induced mouse cardiomyocyte contractile dysfunction in vitro: Role of AMP-activated protein kinase
    • Q. Li, L.K. Hueckstaedt, and J. Ren The protease inhibitor UCF-101 ameliorates streptozotocin-induced mouse cardiomyocyte contractile dysfunction in vitro: role of AMP-activated protein kinase Exp Physiol 94 9 2009 984 994
    • (2009) Exp Physiol , vol.94 , Issue.9 , pp. 984-994
    • Li, Q.1    Hueckstaedt, L.K.2    Ren, J.3
  • 82
    • 70349633673 scopus 로고    scopus 로고
    • Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin
    • X.N. Li, J. Song, L. Zhang, S.A. LeMaire, X. Hou, and C. Zhang Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin Diabetes 58 10 2009 2246 2257
    • (2009) Diabetes , vol.58 , Issue.10 , pp. 2246-2257
    • Li, X.N.1    Song, J.2    Zhang, L.3    Lemaire, S.A.4    Hou, X.5    Zhang, C.6
  • 83
    • 77958465082 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice
    • D. Li, D. Wang, Y. Wang, W. Ling, X. Feng, and M. Xia Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice J Biol Chem 285 43 2010 33499 33509
    • (2010) J Biol Chem , vol.285 , Issue.43 , pp. 33499-33509
    • Li, D.1    Wang, D.2    Wang, Y.3    Ling, W.4    Feng, X.5    Xia, M.6
  • 84
    • 77953960882 scopus 로고    scopus 로고
    • Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction
    • D. Li, Y. Zhang, J. Ma, W. Ling, and M. Xia Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction Arterioscler Thromb Vasc Biol 30 7 2010 1354 1362
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.7 , pp. 1354-1362
    • Li, D.1    Zhang, Y.2    Ma, J.3    Ling, W.4    Xia, M.5
  • 85
    • 71649112618 scopus 로고    scopus 로고
    • Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products
    • C. Liang, Y. Ren, H. Tan, Z. He, Q. Jiang, and J. Wu Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products Br J Pharmacol 158 8 2009 1865 1873
    • (2009) Br J Pharmacol , vol.158 , Issue.8 , pp. 1865-1873
    • Liang, C.1    Ren, Y.2    Tan, H.3    He, Z.4    Jiang, Q.5    Wu, J.6
  • 86
    • 0038177982 scopus 로고    scopus 로고
    • Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats
    • K.T. Lida, Y. Kawakami, M. Suzuki, H. Shimano, H. Toyoshima, and H. Sone Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats Am J Physiol Endocrinol Metab 284 6 2003 E1125 E1130
    • (2003) Am J Physiol Endocrinol Metab , vol.284 , Issue.6
    • Lida, K.T.1    Kawakami, Y.2    Suzuki, M.3    Shimano, H.4    Toyoshima, H.5    Sone, H.6
  • 88
    • 77952016579 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin
    • C. Liu, B. Liang, Q. Wang, J. Wu, and M.H. Zou Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin J Biol Chem 285 20 2010 15346 15355
    • (2010) J Biol Chem , vol.285 , Issue.20 , pp. 15346-15355
    • Liu, C.1    Liang, B.2    Wang, Q.3    Wu, J.4    Zou, M.H.5
  • 89
    • 79959766207 scopus 로고    scopus 로고
    • Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivo
    • Lotz C., Fisslthaler B., Redel A., Smul T.M., Stumpner J., and Pociej J. Activation of adenosine-monophosphate-activated protein kinase abolishes desflurane-induced preconditioning against myocardial infarction in vivo J Cardiothorac Vasc Anesth 2010, Apr 22 [Epub ahead of print]
    • (2010) J Cardiothorac Vasc Anesth
    • Lotz, C.1    Fisslthaler, B.2    Redel, A.3    Smul, T.M.4    Stumpner, J.5    Pociej, J.6
  • 91
    • 33646070557 scopus 로고    scopus 로고
    • Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats
    • J.B. Majithiya, and R. Balaraman Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats Life Sci 78 22 2006 2615 2624
    • (2006) Life Sci , vol.78 , Issue.22 , pp. 2615-2624
    • Majithiya, J.B.1    Balaraman, R.2
  • 92
    • 77954902957 scopus 로고    scopus 로고
    • Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase
    • J. Mankouri, P.R. Tedbury, S. Gretton, M.E. Hughes, S.D. Griffin, and M.L. Dallas Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase Proc Natl Acad Sci USA 107 25 2010 11549 11554
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.25 , pp. 11549-11554
    • Mankouri, J.1    Tedbury, P.R.2    Gretton, S.3    Hughes, M.E.4    Griffin, S.D.5    Dallas, M.L.6
  • 94
    • 2442711384 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and atherogenesis: Regulators of gene expression in vascular cells
    • DOI 10.1161/01.RES.0000127122.22685.0A
    • N. Marx, H. Duez, J.C. Fruchart, and B. Staels Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells Circ Res 94 9 2004 1168 1178 (Pubitemid 38656403)
    • (2004) Circulation Research , vol.94 , Issue.9 , pp. 1168-1178
    • Marx, N.1    Duez, H.2    Fruchart, J.-C.3    Staels, B.4
  • 95
    • 54049100065 scopus 로고    scopus 로고
    • Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes
    • T. Matsumoto, E. Noguchi, K. Ishida, T. Kobayashi, N. Yamada, and K. Kamata Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes Am J Physiol Heart Circ Physiol 295 3 2008 H1165 H1176
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , Issue.3
    • Matsumoto, T.1    Noguchi, E.2    Ishida, K.3    Kobayashi, T.4    Yamada, N.5    Kamata, K.6
  • 96
    • 60449117423 scopus 로고    scopus 로고
    • AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues
    • M.F. McCarty, J. Barroso-Aranda, and F. Contreras AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues Med Hypotheses 72 4 2009 468 470
    • (2009) Med Hypotheses , vol.72 , Issue.4 , pp. 468-470
    • McCarty, M.F.1    Barroso-Aranda, J.2    Contreras, F.3
  • 97
    • 3242811250 scopus 로고    scopus 로고
    • Potential role for AMPA-ativated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus
    • DOI 10.2337/diabetes.53.8.1953
    • R.J. McCrimmon, X. Fan, Y. Ding, W. Zhu, R.J. Jacob, and R.S. Sherwin Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus Diabetes 53 8 2004 1953 1958 (Pubitemid 38970741)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 1953-1958
    • McCrimmon, R.J.1    Fan, X.2    Ding, Y.3    Zhu, W.4    Jacob, R.J.5    Sherwin, R.S.6
  • 98
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • G.F. Merrill, E.J. Kurth, D.G. Hardie, and W.W. Winder AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle Am J Physiol 273 6 Pt 1 1997 E1107 E1112
    • (1997) Am J Physiol , vol.273 , Issue.6 PART 1
    • Merrill, G.F.1    Kurth, E.J.2    Hardie, D.G.3    Winder, W.W.4
  • 99
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • DOI 10.1038/415339a
    • Y. Minokoshi, Y.B. Kim, O.D. Peroni, L.G. Fryer, C. Müller, and D. Carling Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase Nature 415 6869 2002 339 343 (Pubitemid 34087557)
    • (2002) Nature , vol.415 , Issue.6869 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.-B.2    Peroni, O.D.3    Fryer, L.G.D.4    Muller, C.5    Carling, D.6    Kahn, B.B.7
  • 100
    • 33748747706 scopus 로고    scopus 로고
    • Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
    • DOI 10.1074/jbc.M604399200
    • M. Momcilovic, S.-P. Hong, and M. Carlson Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro J Biol Chem 281 35 2006 25336 25343 (Pubitemid 44401921)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.35 , pp. 25336-25343
    • Momcilovic, M.1    Hong, S.-P.2    Carlson, M.3
  • 101
    • 0041355355 scopus 로고    scopus 로고
    • Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells
    • DOI 10.1074/jbc.M212831200
    • V.A. Morrow, F. Foufelle, J.M. Connell, J.R. Petrie, G.W. Gould, and I.P. Salt Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells J Biol Chem 278 34 2003 31629 31639 (Pubitemid 37048341)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.34 , pp. 31629-31639
    • Morrow, V.A.1    Foufelle, F.2    Connell, J.M.C.3    Petrie, J.R.4    Gould, G.W.5    Salt, I.P.6
  • 102
    • 33745213627 scopus 로고    scopus 로고
    • AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer
    • DOI 10.1113/jphysiol.2006.108324
    • H. Motoshima, B.J. Goldstein, M. Igata, and E. Araki AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer J Physiol 574 Pt 1 2006 63 71 (Pubitemid 43905797)
    • (2006) Journal of Physiology , vol.574 , Issue.1 , pp. 63-71
    • Motoshima, H.1    Goldstein, B.J.2    Igata, M.3    Araki, E.4
  • 103
    • 49749111558 scopus 로고    scopus 로고
    • Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK
    • P.F. Mount, N. Lane, S. Venkatesan, G.R. Steinberg, S.A. Fraser, and B.E. Kemp Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK Atherosclerosis 200 1 2008 28 36
    • (2008) Atherosclerosis , vol.200 , Issue.1 , pp. 28-36
    • Mount, P.F.1    Lane, N.2    Venkatesan, S.3    Steinberg, G.R.4    Fraser, S.A.5    Kemp, B.E.6
  • 104
    • 0035947235 scopus 로고    scopus 로고
    • A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle
    • DOI 10.1016/S1097-2765(01)00251-9
    • J. Mu, J.T. Brozinick Jr., O. Valladares, M. Bucan, and M.J. Birnbaum A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle Mol Cell 7 5 2001 1085 1094 (Pubitemid 32525754)
    • (2001) Molecular Cell , vol.7 , Issue.5 , pp. 1085-1094
    • Mu, J.1    Brozinick Jr., J.T.2    Valladares, O.3    Bucan, M.4    Birnbaum, M.J.5
  • 105
    • 74349090643 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the cardiovascular system
    • D. Nagata, and Y. Hirata The role of AMP-activated protein kinase in the cardiovascular system Hypertens Res 33 1 2010 22 28
    • (2010) Hypertens Res , vol.33 , Issue.1 , pp. 22-28
    • Nagata, D.1    Hirata, Y.2
  • 106
    • 0042733154 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
    • DOI 10.1074/jbc.M300643200
    • D. Nagata, M. Mogi, and K. Walsh AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress J Biol Chem 278 33 2003 31000 31006 (Pubitemid 36994613)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.33 , pp. 31000-31006
    • Nagata, D.1    Mogi, M.2    Walsh, K.3
  • 107
    • 47549102964 scopus 로고    scopus 로고
    • The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells
    • DOI 10.1080/13813450802181013, PII 794966407
    • J. Nigro, S. Potter-Perigo, M.E. Ivey, S.T. de Dios, S.P. Evanko, and T.N. Wight The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells Arch Physiol Biochem 114 3 2008 171 177 (Pubitemid 352009302)
    • (2008) Archives of Physiology and Biochemistry , vol.114 , Issue.3 , pp. 171-177
    • Nigro, J.1    Potter-Perigo, S.2    Ivey, M.E.3    De Dios, S.T.4    Evanko, S.P.5    Wight, T.N.6    Little, P.J.7
  • 108
    • 77954831536 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation
    • J. Ning, and D.R. Clemmons AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation Mol Endocrinol 24 6 2010 1218 1229
    • (2010) Mol Endocrinol , vol.24 , Issue.6 , pp. 1218-1229
    • Ning, J.1    Clemmons, D.R.2
  • 109
    • 63849261100 scopus 로고    scopus 로고
    • Structure and function of AMP-activated protein kinase
    • J.S. Oakhill, J.W. Scott, and B.E. Kemp Structure and function of AMP-activated protein kinase Acta Physiol (Oxf) 196 1 2009 3 14
    • (2009) Acta Physiol (Oxf) , vol.196 , Issue.1 , pp. 3-14
    • Oakhill, J.S.1    Scott, J.W.2    Kemp, B.E.3
  • 110
    • 69249222515 scopus 로고    scopus 로고
    • Metformin suppresses glucose-6-phosphatase expression by a complex i inhibition and AMPK activation-independent mechanism
    • S. Ota, K. Horigome, T. Ishii, M. Nakai, K. Hayashi, and T. Kawamura Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism Biochem Biophys Res Commun 388 2 2009 311 316
    • (2009) Biochem Biophys Res Commun , vol.388 , Issue.2 , pp. 311-316
    • Ota, S.1    Horigome, K.2    Ishii, T.3    Nakai, M.4    Hayashi, K.5    Kawamura, T.6
  • 111
    • 0346463030 scopus 로고    scopus 로고
    • Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells
    • DOI 10.1074/jbc.M310389200
    • N. Ouchi, H. Kobayashi, S. Kihara, M. Kumada, K. Sato, and T. Inoue Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells J Biol Chem 279 2 2004 1304 1309 (Pubitemid 38082655)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.2 , pp. 1304-1309
    • Ouchi, N.1    Kobayashi, H.2    Kihara, S.3    Kumada, M.4    Sato, K.5    Inoue, T.6    Funahashi, T.7    Walsh, K.8
  • 112
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • DOI 10.1042/0264-6021:3480607
    • M.R. Owen, E. Doran, and A.P. Halestrap Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochem J 348 Pt 3 2000 607 614 (Pubitemid 30410251)
    • (2000) Biochemical Journal , vol.348 , Issue.3 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 114
    • 25144453937 scopus 로고    scopus 로고
    • NADPH oxidase and endothelial cell function
    • DOI 10.1042/CS20050067
    • R. Ray, and A.M. Shah NADPH oxidase and endothelial cell function Clin Sci Lond 109 3 2005 217 226 (Pubitemid 41337126)
    • (2005) Clinical Science , vol.109 , Issue.3 , pp. 217-226
    • Ray, R.1    Shah, A.M.2
  • 115
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • R. Ross Atherosclerosis-an inflammatory disease N Engl J Med 340 2 1999 115 126
    • (1999) N Engl J Med , vol.340 , Issue.2 , pp. 115-126
    • Ross, R.1
  • 116
    • 20344394410 scopus 로고    scopus 로고
    • A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II)
    • DOI 10.1016/j.jacc.2005.02.061, PII S073510970500536X
    • A.M. Ross, R.J. Gibbons, G.W. Stone, R.A. Kloner, R.W. Alexander, and A.M.I.S.T.A.D.-I.I. Investigators A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II) J Am Coll Cardiol 45 11 2005 1775 1780 (Pubitemid 40779856)
    • (2005) Journal of the American College of Cardiology , vol.45 , Issue.11 , pp. 1775-1780
    • Ross, A.M.1    Gibbons, R.J.2    Stone, G.W.3    Kloner, R.A.4    Alexander, R.W.5
  • 117
    • 11144283703 scopus 로고    scopus 로고
    • Metabolic activation of AMP kinase in vascular smooth muscle
    • DOI 10.1152/japplphysiol.00075.2004
    • L.J. Rubin, L. Magliola, X. Feng, A.W. Jones, and C.C. Hale Metabolic activation of AMP kinase in vascular smooth muscle J Appl Physiol 98 1 2005 296 306 (Pubitemid 40041260)
    • (2005) Journal of Applied Physiology , vol.98 , Issue.1 , pp. 296-306
    • Rubin, L.J.1    Magliola, L.2    Feng, X.3    Jones, A.W.4    Hale, C.C.5
  • 118
    • 0032529139 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
    • I. Salt, J.W. Celler, S.A. Hawley, A. Prescott, A. Woods, and D. Carling AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform Biochem J 334 1 1998 177 187 (Pubitemid 28420987)
    • (1998) Biochemical Journal , vol.334 , Issue.1 , pp. 177-187
    • Salt, I.1    Celler, J.W.2    Hawley, S.A.3    Prescott, A.4    Woods, A.5    Carling, D.6    Hardie, D.G.7
  • 119
    • 36348978499 scopus 로고    scopus 로고
    • Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
    • DOI 10.1074/jbc.M706543200
    • M.J. Sanders, Z.S. Ali, B.D. Hegarty, R. Heath, M.A. Snowden, and D. Carling Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family J Biol Chem 282 45 2007 32539 32548 (Pubitemid 350159309)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.45 , pp. 32539-32548
    • Sanders, M.J.1    Ali, Z.S.2    Hegarty, B.D.3    Heath, R.4    Snowden, M.A.5    Carling, D.6
  • 120
    • 33749479230 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Role in metabolism and therapeutic implications
    • DOI 10.1111/j.1463-1326.2005.00561.x
    • G. Schimmack, R.A. Defronzo, and N. Musi AMP-activated protein kinase: role in metabolism and therapeutic implications Diab Obes Metab 8 6 2006 591 602 (Pubitemid 44515556)
    • (2006) Diabetes, Obesity and Metabolism , vol.8 , Issue.6 , pp. 591-602
    • Schimmack, G.1    DeFronzo, R.A.2    Musi, N.3
  • 121
    • 0034681773 scopus 로고    scopus 로고
    • Thiazolidinediones: An update
    • K. Schoonjans, and J. Auwerx Thiazolidinediones: an update Lancet 355 9208 2000 1008 1010 (Pubitemid 30148273)
    • (2000) Lancet , vol.355 , Issue.9208 , pp. 1008-1010
    • Schoonjans, K.1    Auwerx, J.2
  • 123
    • 56049112796 scopus 로고    scopus 로고
    • Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes
    • J.W. Scott, B.J. van Denderen, S.B. Jorgensen, J.E. Honeyman, G.R. Steinberg, and J.S. Oakhill Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes Chem Biol 15 11 2008 1220 1230
    • (2008) Chem Biol , vol.15 , Issue.11 , pp. 1220-1230
    • Scott, J.W.1    Van Denderen, B.J.2    Jorgensen, S.B.3    Honeyman, J.E.4    Steinberg, G.R.5    Oakhill, J.S.6
  • 124
    • 34548495791 scopus 로고    scopus 로고
    • Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-γ activation in + db/+ m and + db/+ db mice
    • DOI 10.1016/j.ejphar.2007.05.070, PII S001429990700670X
    • S.W. Seto, T.Y. Lam, G.P. Leung, A.L. Au, S.M. Ngai, and S.W. Chan Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice Eur J Pharmacol 572 1 2010 40 48 (Pubitemid 47374678)
    • (2007) European Journal of Pharmacology , vol.572 , Issue.1 , pp. 40-48
    • Seto, S.W.1    Lam, T.Y.2    Leung, G.P.H.3    Au, A.L.S.4    Ngai, S.M.5    Chan, S.W.6    Kwan, Y.W.7
  • 125
    • 28844433635 scopus 로고    scopus 로고
    • Medicine: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • DOI 10.1126/science.1120781
    • R.J. Shaw, K.A. Lamia, D. Vasquez, S.H. Koo, N. Bardeesy, and R.A. Depinho The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310 5754 2005 1642 1646 (Pubitemid 41780780)
    • (2005) Science , vol.310 , Issue.5754 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.-H.4    Bardeesy, N.5    DePinho, R.A.6    Montminy, M.7    Cantley, L.C.8
  • 126
    • 77953691004 scopus 로고    scopus 로고
    • Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
    • M. Shimano, N. Ouchi, R. Shibata, K. Ohashi, D.R. Pimentel, and T. Murohara Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response J Mol Cell Cardiol 49 2 2010 210 220
    • (2010) J Mol Cell Cardiol , vol.49 , Issue.2 , pp. 210-220
    • Shimano, M.1    Ouchi, N.2    Shibata, R.3    Ohashi, K.4    Pimentel, D.R.5    Murohara, T.6
  • 127
    • 0023896220 scopus 로고
    • The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase
    • A.T.R. Sim, and D.G. Hardie The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase FEBS Lett 233 2 1988 294 298
    • (1988) FEBS Lett , vol.233 , Issue.2 , pp. 294-298
    • Sim, A.T.R.1    Hardie, D.G.2
  • 128
    • 36849092777 scopus 로고    scopus 로고
    • Tumor necrosis factor-∥augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-β-activated kinase 1 (TAK1)-dependent signaling pathway
    • DOI 10.1074/jbc.M705329200
    • A.K. Srivastava, X. Qin, N. Wedhas, M. Arnush, T.A. Linkhart, and R.B. Chadwick Tumor necrosis factor-α augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-β-activated kinase 1 (TAK1)-dependent signaling pathway J Biol Chem 282 48 2007 35113 35124 (Pubitemid 350232481)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.48 , pp. 35113-35124
    • Srivastava, A.K.1    Qin, X.2    Wedhas, N.3    Arnush, M.4    Linkhart, T.A.5    Chadwick, R.B.6    Kumar, A.7
  • 129
    • 77951251172 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase
    • N. Stahmann, A. Woods, K. Spengler, A. Heslegrave, R. Bauer, and S. Krause Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase J Biol Chem 285 14 2010 10638 10652
    • (2010) J Biol Chem , vol.285 , Issue.14 , pp. 10638-10652
    • Stahmann, N.1    Woods, A.2    Spengler, K.3    Heslegrave, A.4    Bauer, R.5    Krause, S.6
  • 131
    • 0034141355 scopus 로고    scopus 로고
    • The regulation of AMP-activated protein kinase by phosphorylation
    • DOI 10.1042/0264-6021:3450437
    • S.C. Stein, A. Woods, N.A. Jones, M.D. Davison, and D. Carling The regulation of AMP-activated protein kinase by phosphorylation Biochem J 345 3 2000 437 443 (Pubitemid 30099070)
    • (2000) Biochemical Journal , vol.345 , Issue.3 , pp. 437-443
    • Stein, S.C.1    Woods, A.2    Jones, N.A.3    Davison, M.D.4    Cabling, D.5
  • 132
    • 57749083482 scopus 로고    scopus 로고
    • Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase
    • B.J. Stuck, M. Lenski, M. Böhm, and U. Laufs Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase J Biol Chem 283 47 2008 32562 32569
    • (2008) J Biol Chem , vol.283 , Issue.47 , pp. 32562-32569
    • Stuck, B.J.1    Lenski, M.2    Böhm, M.3    Laufs, U.4
  • 133
    • 33845707278 scopus 로고    scopus 로고
    • Statins activate AMP-activated protein kinase in vitro and in vivo
    • DOI 10.1161/CIRCULATIONAHA.106.630194, PII 0000301720061212000015
    • W. Sun, T.S. Lee, M. Zhu, C. Gu, Y. Wang, and Y. Zhu Statins activate AMP-activated protein kinase in vitro and in vivo Circulation 114 24 2006 2655 2662 (Pubitemid 44967349)
    • (2006) Circulation , vol.114 , Issue.24 , pp. 2655-2662
    • Sun, W.1    Lee, T.-S.2    Zhu, M.3    Gu, C.4    Wang, Y.5    Zhu, Y.6    Shyy, J.Y.-J.7
  • 134
    • 33845949733 scopus 로고    scopus 로고
    • Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
    • DOI 10.1074/jbc.M606357200
    • M. Suter, U. Riek, R. Tuerk, U. Schlattner, T. Wallimann, and D. Neumann Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase J Biol Chem 281 43 2006 32207 32216 (Pubitemid 46036775)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.43 , pp. 32207-32216
    • Suter, M.1    Riek, U.2    Tuerk, R.3    Schlattner, U.4    Wallimann, T.5    Neumann, D.6
  • 135
    • 41349090413 scopus 로고    scopus 로고
    • Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetes
    • DOI 10.1038/ajh.2008.6, PII AJH20086
    • K. Suzuki, K. Uchida, N. Nakanishi, and Y. Hattori Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetes Am J Hypertens 21 4 2008 451 457 (Pubitemid 351450872)
    • (2008) American Journal of Hypertension , vol.21 , Issue.4 , pp. 451-457
    • Suzuki, K.1    Uchida, K.2    Nakanishi, N.3    Hattori, Y.4
  • 136
    • 0032524622 scopus 로고    scopus 로고
    • Identification of a novel AMP-activated protein kinase β subunit isoform that is highly expressed in skeletal muscle
    • DOI 10.1074/jbc.273.20.12443
    • C. Thornton, M.A. Snowden, and D. Carling Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle J Biol Chem 273 20 1998 12443 12450 (Pubitemid 28240617)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.20 , pp. 12443-12450
    • Thornton, C.1    Snowden, M.A.2    Carling, D.3
  • 137
    • 4344628605 scopus 로고    scopus 로고
    • Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt
    • DOI 10.1016/j.febslet.2004.07.078, PII S0014579304009548
    • B. Thors, H. Halldórsson, and G. Thorgeirsson Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt FEBS Lett 573 1-3 2004 175 180 (Pubitemid 39141054)
    • (2004) FEBS Letters , vol.573 , Issue.1-3 , pp. 175-180
    • Thors, B.1    Halldorsson, H.2    Thorgeirsson, G.3
  • 138
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • M.C. Towler, and D.G. Hardie AMP-activated protein kinase in metabolic control and insulin signaling Circ Res 100 3 2007 328 341
    • (2007) Circ Res , vol.100 , Issue.3 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 139
    • 70349921265 scopus 로고    scopus 로고
    • A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle
    • J.T. Treebak, J.B. Birk, B.F. Hansen, G.S. Olsen, and J.F. Wojtaszewski A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle Am J Physiol Cell Physiol 297 4 2009 C1041 C1052
    • (2009) Am J Physiol Cell Physiol , vol.297 , Issue.4
    • Treebak, J.T.1    Birk, J.B.2    Hansen, B.F.3    Olsen, G.S.4    Wojtaszewski, J.F.5
  • 140
    • 48449084609 scopus 로고    scopus 로고
    • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
    • N. Turner, J.Y. Li, A. Gosby, S.W. To, Z. Cheng, and H. Miyoshi Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action Diabetes 57 5 2008 1414 1418
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1414-1418
    • Turner, N.1    Li, J.Y.2    Gosby, A.3    To, S.W.4    Cheng, Z.5    Miyoshi, H.6
  • 142
    • 0037178764 scopus 로고    scopus 로고
    • Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice
    • DOI 10.1161/01.RES.0000028004.76218.B8
    • C. Vecchione, and R.P. Brandes Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice Circ Res 91 2 2002 173 179 (Pubitemid 34827229)
    • (2002) Circulation Research , vol.91 , Issue.2 , pp. 173-179
    • Vecchione, C.1    Brandes, R.P.2
  • 144
    • 66249092436 scopus 로고    scopus 로고
    • Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase
    • Y. Wang, Y. Huang, K.S. Lam, Y. Li, W.T. Wong, and H. Ye Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase Cardiovasc Res 82 3 2009 484 492
    • (2009) Cardiovasc Res , vol.82 , Issue.3 , pp. 484-492
    • Wang, Y.1    Huang, Y.2    Lam, K.S.3    Li, Y.4    Wong, W.T.5    Ye, H.6
  • 145
    • 68049129864 scopus 로고    scopus 로고
    • In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase i
    • S. Wang, J. Xu, P. Song, B. Viollet, and M.H. Zou In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I Diabetes 58 8 2009 1893 1901
    • (2009) Diabetes , vol.58 , Issue.8 , pp. 1893-1901
    • Wang, S.1    Xu, J.2    Song, P.3    Viollet, B.4    Zou, M.H.5
  • 146
    • 77950989801 scopus 로고    scopus 로고
    • AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: Role of 26S proteasomes
    • S. Wang, M. Zhang, B. Liang, J. Xu, Z. Xie, and C. Liu AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes Circ Res 106 6 2010 1117 1128
    • (2010) Circ Res , vol.106 , Issue.6 , pp. 1117-1128
    • Wang, S.1    Zhang, M.2    Liang, B.3    Xu, J.4    Xie, Z.5    Liu, C.6
  • 147
    • 0035282062 scopus 로고    scopus 로고
    • Post-translational modifications of the β-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization
    • DOI 10.1042/0264-6021:3540275
    • S.M. Warden, C. Richardson, J. O'Donnell Jr., D. Stapleton, B.E. Kemp, and L.A. Witters Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization Biochem J 354 2 2001 275 283 (Pubitemid 32209863)
    • (2001) Biochemical Journal , vol.354 , Issue.2 , pp. 275-283
    • Warden, S.M.1    Richardson, C.2    O'Donnell Jr., J.3    Stapleton, D.4    Kemp, B.E.5    Witters, L.A.6
  • 148
    • 38949168973 scopus 로고    scopus 로고
    • Pro-healing drug-eluting stents: A role for antioxidants?
    • DOI 10.1042/CS20070207
    • J. Watt, R. Wadsworth, S. Kennedy, and K.G. Oldroyd Pro-healing drug-eluting stents: a role for antioxidants? Clin Sci Lond 114 4 2008 265 273 (Pubitemid 351294002)
    • (2008) Clinical Science , vol.114 , Issue.3-4 , pp. 265-273
    • Watt, J.1    Wadsworth, R.2    Kennedy, S.3    Oldroyd, K.G.4
  • 149
    • 33846030181 scopus 로고    scopus 로고
    • A revised model for AMP-activated protein kinase structure: The α-subunit binds to both the β- and γ-subunits although there is no direct binding between the β- and γ-subunits
    • DOI 10.1074/jbc.M607410200
    • K.A. Wong, and H.F. Lodish A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits J Biol Chem 281 47 2006 36434 36442 (Pubitemid 46041377)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.47 , pp. 36434-36442
    • Wong, K.A.1    Lodish, H.F.2
  • 150
    • 66949121471 scopus 로고    scopus 로고
    • AMP-activated protein kinase pathway: A potential therapeutic target in cardiometabolic disease
    • A.K. Wong, J. Howie, J.R. Petrie, and C.C. Lang AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease Clin Sci Lond 116 8 2009 607 620
    • (2009) Clin Sci Lond , vol.116 , Issue.8 , pp. 607-620
    • Wong, A.K.1    Howie, J.2    Petrie, J.R.3    Lang, C.C.4
  • 153
    • 0030592623 scopus 로고    scopus 로고
    • The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
    • DOI 10.1016/S0014-5793(96)01209-4, PII S0014579396012094
    • A. Woods, I. Salt, J. Scott, D.G. Hardie, and D. Carling The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro FEBS Lett 397 2-3 1996 347 351 (Pubitemid 26414047)
    • (1996) FEBS Letters , vol.397 , Issue.2-3 , pp. 347-351
    • Woods, A.1    Salt, I.2    Scott, J.3    Hardie, D.G.4    Carling, D.5
  • 155
    • 34248199965 scopus 로고    scopus 로고
    • Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase
    • DOI 10.1074/jbc.M608310200
    • Y. Wu, P. Song, J. Xu, M. Zhang, and M.H. Zou Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase J Biol Chem 282 13 2007 9777 9788 (Pubitemid 47104626)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.13 , pp. 9777-9788
    • Wu, Y.1    Song, P.2    Xu, J.3    Zhang, M.4    Zou, M.-H.5
  • 156
    • 21244472282 scopus 로고    scopus 로고
    • Nitric oxide mediates the effect of fluvastatin on intercellular adhesion molecule-1 and platelet endothelialcell adhesion molecule-1 expressionon human endothelial cells
    • DOI 10.1007/s10016-005-0011-7
    • E.S. Xenos, S.L. Stevens, M.B. Freeman, D.C. Cassada, and M.H. Goldman Nitric oxide mediates the effect of fluvastatin on intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression on human endothelial cells Ann Vasc Surg 19 3 2005 386 392 (Pubitemid 40884094)
    • (2005) Annals of Vascular Surgery , vol.19 , Issue.3 , pp. 386-392
    • Xenos, E.S.1    Stevens, S.L.2    Freeman, M.B.3    Cassada, D.C.4    Goldman, M.H.5
  • 157
    • 33646573080 scopus 로고    scopus 로고
    • Activation of protein kinase Cζ by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells
    • DOI 10.1074/jbc.M511178200
    • Z. Xie, Y. Dong, M. Zhang, M.Z. Cui, R.A. Cohen, and U. Riek Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells J Biol Chem 281 10 2006 6366 6375 (Pubitemid 43847568)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.10 , pp. 6366-6375
    • Xie, Z.1    Dong, Y.2    Zhang, M.3    Cui, M.-Z.4    Cohen, R.A.5    Riek, U.6    Neumann, D.7    Schlattner, U.8    Zou, M.-H.9
  • 159
    • 58149358854 scopus 로고    scopus 로고
    • Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes
    • Z. Xie, J. Zhang, J. Wu, B. Viollet, and M.H. Zou Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes Diabetes 57 12 2008 3222 3230
    • (2008) Diabetes , vol.57 , Issue.12 , pp. 3222-3230
    • Xie, Z.1    Zhang, J.2    Wu, J.3    Viollet, B.4    Zou, M.H.5
  • 160
    • 0029551805 scopus 로고
    • Identification of a member of the MAPKKK family as a potential Mediator of TGF-β signal transduction
    • K. Yamaguchi, K. Shirakabe, H. Shibuya, K. Irie, I. Oishi, N. Ueno, T. Taniguchi, E. Nishida, and K. Matsumoto Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction Science 270 5244 1995 2008 2011 (Pubitemid 26097194)
    • (1995) Science , vol.270 , Issue.5244 , pp. 2008-2011
    • Yamaguchi, K.1    Shirakabe, K.2    Shibuya, H.3    Irie, K.4    Oishi, I.5    Ueno, N.6    Taniguchi, T.7    Nishida, E.8    Matsumoto, K.9
  • 162
    • 0028804791 scopus 로고
    • Acadesine reduces the frequency of coronary artery reocclusion following rt-PA induced thrombolysis in the dog
    • M.A. Young, C. Henry, S. Wong, D. Bullough, and K. Mullane Acadesine reduces the frequency of coronary artery reocclusion following rt-PA induced thrombolysis in the dog Thromb Haemost 74 5 1995 1348 1352
    • (1995) Thromb Haemost , vol.74 , Issue.5 , pp. 1348-1352
    • Young, M.A.1    Henry, C.2    Wong, S.3    Bullough, D.4    Mullane, K.5
  • 163
    • 55549135363 scopus 로고    scopus 로고
    • Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells
    • J. Zhang, Z. Xie, Y. Dong, S. Wang, C. Liu, and M.H. Zou Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells J Biol Chem 283 41 2008 27452 27461
    • (2008) J Biol Chem , vol.283 , Issue.41 , pp. 27452-27461
    • Zhang, J.1    Xie, Z.2    Dong, Y.3    Wang, S.4    Liu, C.5    Zou, M.H.6
  • 165
    • 0037031892 scopus 로고    scopus 로고
    • 1179 phosphorylation of endothelial nitric oxide synthase
    • DOI 10.1074/jbc.M204512200
    • M.H. Zou, X.Y. Hou, C.M. Shi, D. Nagata, K. Walsh, and R.A. Cohen Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase J Biol Chem 277 36 2002 32552 32557 (Pubitemid 34984758)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 32552-32557
    • Zou, M.-H.1    Hou, X.-Y.2    Shi, C.-M.3    Nagata, D.4    Walsh, K.5    Cohen, R.A.6
  • 167
    • 41749120541 scopus 로고    scopus 로고
    • AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function
    • DOI 10.1111/j.1440-1681.2007.04851.x
    • M.H. Zou, and Y. Wu AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function Clin Exp Pharmacol Physiol 35 5-6 2008 535 545 (Pubitemid 351490095)
    • (2008) Clinical and Experimental Pharmacology and Physiology , vol.35 , Issue.5-6 , pp. 535-545
    • Zou, M.-H.1    Wu, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.