메뉴 건너뛰기




Volumn 71, Issue 19, 2011, Pages 6184-6194

Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN; WNT5A PROTEIN;

EID: 80053361798     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-1341     Document Type: Article
Times cited : (82)

References (49)
  • 2
    • 70349773104 scopus 로고    scopus 로고
    • Healing and hurting: Molecular mechanisms, functions, and pathologies of cellular senescence
    • Adams PD. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell 2009;36:2-14.
    • (2009) Mol Cell , vol.36 , pp. 2-14
    • Adams, P.D.1
  • 5
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • DOI 10.1038/nature05529, PII NATURE05529
    • Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007;445:656-60. (Pubitemid 46232886)
    • (2007) Nature , vol.445 , Issue.7128 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6    Cordon-Cardo, C.7    Lowe, S.W.8
  • 7
    • 77649291770 scopus 로고    scopus 로고
    • PICS-ure this: Prosenescence therapy?
    • Peeper DS. PICS-ure this: prosenescence therapy? Cancer Cell 2010;17:219-20.
    • (2010) Cancer Cell , vol.17 , pp. 219-220
    • Peeper, D.S.1
  • 9
    • 43049099384 scopus 로고    scopus 로고
    • Genomic analysis of epithelial ovarian cancer. Cell Res 2008;18:538-48. 10. Shih Ie M, Kurman RJ. Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis
    • Farley J, Ozbun LL, Birrer MJ. Genomic analysis of epithelial ovarian cancer. Cell Res 2008;18:538-48. 10. Shih Ie M, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol 2004;164:1511-8.
    • (2004) Am J Pathol , vol.164 , pp. 1511-1518
    • Farley, J.1    Ozbun, L.L.2    Birrer, M.J.3
  • 10
    • 4344584730 scopus 로고    scopus 로고
    • WNT and beta-catenin signalling: Diseases and therapies
    • DOI 10.1038/nrg1427
    • Moon RT, Kohn AD, De Ferrari GV, Kaykas A. WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet 2004;5:691-701. (Pubitemid 39150127)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.9 , pp. 691-701
    • Moon, R.T.1    Kohn, A.D.2    De Ferrari, G.V.3    Kaykas, A.4
  • 11
    • 34547107319 scopus 로고    scopus 로고
    • WNT signaling pathway and stem cell signaling network
    • DOI 10.1158/1078-0432.CCR-06-2316
    • Katoh M.WNT signaling pathway and stem cell signaling network. Clin Cancer Res 2007;13:4042-5. (Pubitemid 47105963)
    • (2007) Clinical Cancer Research , vol.13 , Issue.14 , pp. 4042-4045
    • Katoh, M.1    Katoh, M.2
  • 15
    • 67650594771 scopus 로고    scopus 로고
    • The opposing roles of Wnt-5a in cancer
    • McDonald SL, Silver A. The opposing roles of Wnt-5a in cancer. Br J Cancer 2009;101:209-14.
    • (2009) Br J Cancer , vol.101 , pp. 209-214
    • McDonald, S.L.1    Silver, A.2
  • 16
    • 78650493658 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells
    • Li H, Cai Q, Godwin AK, Zhang R. Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells. Mol Cancer Res 2010;8:1610-8.
    • (2010) Mol Cancer Res , vol.8 , pp. 1610-1618
    • Li, H.1    Cai, Q.2    Godwin, A.K.3    Zhang, R.4
  • 17
    • 33744932953 scopus 로고    scopus 로고
    • Identification of novel target genes by an epigenetic reactivation screen of renal cancer
    • DOI 10.1158/0008-5472.CAN-05-3365
    • Ibanez de Caceres I, Dulaimi E, Hoffman AM, Al-Saleem T, Uzzo RG, Cairns P. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. Cancer Res 2006;66: 5021-8. (Pubitemid 43844922)
    • (2006) Cancer Research , vol.66 , Issue.10 , pp. 5021-5028
    • Ibanez, D.C.I.1    Dulaimi, E.2    Hoffman, A.M.3    Al-Saleem, T.4    Uzzo, R.G.5    Cairns, P.6
  • 18
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • DOI 10.1128/MCB.02019-06
    • Zhang R, Chen W, Adams PD. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol 2007; 27:2343-58. (Pubitemid 46418486)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.6 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 21
    • 34447343780 scopus 로고    scopus 로고
    • Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells
    • DOI 10.1016/j.molcel.2007.05.034, PII S1097276507003589
    • Ye X, Zerlanko B, Kennedy A, Banumathy G, Zhang R, Adams PD. Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell 2007;27:183-96. (Pubitemid 47058300)
    • (2007) Molecular Cell , vol.27 , Issue.2 , pp. 183-196
    • Ye, X.1    Zerlanko, B.2    Kennedy, A.3    Banumathy, G.4    Zhang, R.5    Adams, P.D.6
  • 22
    • 34548799705 scopus 로고    scopus 로고
    • Methods to detect biomarkers of cellular senescence: The senescence-associated beta-galactosidase assay
    • DOI 10.1385/1-59745-361-7:21, Biological Aging: Methods and Protocols
    • Itahana K, Campisi J, Dimri GP. Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol 2007;371:21-31. (Pubitemid 350183415)
    • (2007) Methods in Molecular Biology , vol.371 , pp. 21-31
    • Itahana, K.1    Campisi, J.2    Dimri, G.P.3
  • 23
    • 66849128197 scopus 로고    scopus 로고
    • Xenograft and transgenic mouse models of epithelial ovarian cancer and non invasive imaging modalities to monitor ovarian tumor growth in situ - Applications in evaluating novel therapeutic agents
    • Connolly DC, Hensley HH. Xenograft and transgenic mouse models of epithelial ovarian cancer and non invasive imaging modalities to monitor ovarian tumor growth in situ - applications in evaluating novel therapeutic agents. Curr Protoc Pharmacol 2009;45:14.12.1-26.
    • (2009) Curr Protoc Pharmacol , vol.45
    • Connolly, D.C.1    Hensley, H.H.2
  • 24
    • 77649219639 scopus 로고    scopus 로고
    • The origin and pathogenesis of epithelial ovarian cancer: A proposed unifying theory
    • Kurman RJ, Shih le M. The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol 2010;34:433-43.
    • (2010) Am J Surg Pathol , vol.34 , pp. 433-443
    • Kurman, R.J.1    Shih Le, M.2
  • 25
    • 0022504347 scopus 로고
    • Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors
    • McCarty KS Jr, Szabo E, Flowers JL, Cox EB, Leight GS, Miller L, et al. Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors. Cancer Res 1986;46: 4244s-8s. (Pubitemid 16041242)
    • (1986) Cancer Research , vol.46 , Issue.8 SUPPL.
    • McCarty Jr., K.S.1    Szabo, E.2    Flowers, J.L.3
  • 26
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984;133: 1710-5. (Pubitemid 14035254)
    • (1984) Journal of Immunology , vol.133 , Issue.4 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3
  • 29
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits betacatenin- TCF signaling depending on receptor context
    • Mikels AJ, Nusse R. Purified Wnt5a protein activates or inhibits betacatenin- TCF signaling depending on receptor context. PLoS Biol 2006;4:e115.
    • (2006) PLoS Biol , vol.4
    • Mikels, A.J.1    Nusse, R.2
  • 30
    • 0043234811 scopus 로고    scopus 로고
    • Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    • DOI 10.1083/jcb.200303158
    • Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol 2003;162:899-908. (Pubitemid 37087729)
    • (2003) Journal of Cell Biology , vol.162 , Issue.5 , pp. 899-908
    • Topol, L.1    Jiang, X.2    Choi, H.3    Garrett-Beal, L.4    Carolan, P.J.5    Yang, Y.6
  • 31
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • DOI 10.1038/nature03319
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-50. (Pubitemid 40558990)
    • (2005) Nature , vol.434 , Issue.7035 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 32
    • 36448975490 scopus 로고    scopus 로고
    • Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
    • DOI 10.1038/nrm2277, PII NRM2277
    • Bernardi R, Pandolfi PP. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol 2007;8:1006-16. (Pubitemid 350174636)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.12 , pp. 1006-1016
    • Bernardi, R.1    Pandolfi, P.P.2
  • 33
    • 0942301175 scopus 로고    scopus 로고
    • Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence
    • DOI 10.1038/sj.onc.1206886
    • Mallette FA, Goumard S, Gaumont-Leclerc MF, Moiseeva O, Ferbeyre G. Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence. Oncogene 2004;23:91-9. (Pubitemid 38142243)
    • (2004) Oncogene , vol.23 , Issue.1 , pp. 91-99
    • Mallette, F.A.1    Goumard, S.2    Gaumont-Leclerc, M.-F.3    Moiseeva, O.4    Ferbeyre, G.5
  • 35
    • 0037169341 scopus 로고    scopus 로고
    • The role of PML in tumor suppression
    • DOI 10.1016/S0092-8674(02)00626-8
    • Salomoni P, Pandolfi PP. The role of PML in tumor suppression. Cell 2002;108:165-70. (Pubitemid 34161137)
    • (2002) Cell , vol.108 , Issue.2 , pp. 165-170
    • Salomoni, P.1    Pandolfi, P.P.2
  • 36
    • 34147143631 scopus 로고    scopus 로고
    • Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
    • DOI 10.1128/MCB.01592-06
    • Ye X, Zerlanko B, Zhang R, Somaiah N, Lipinski M, Salomoni P, et al. Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol 2007;27:2452-65. (Pubitemid 46581338)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.7 , pp. 2452-2465
    • Ye, X.1    Zerlanko, B.2    Zhang, R.3    Somaiah, N.4    Lipinski, M.5    Salomoni, P.6    Adams, P.D.7
  • 39
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 1998;18:753-61. (Pubitemid 28063408)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.2 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 40
    • 0026760566 scopus 로고
    • Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines
    • Yaginuma Y, Westphal H. Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res 1992;52:4196-9.
    • (1992) Cancer Res , vol.52 , pp. 4196-4199
    • Yaginuma, Y.1    Westphal, H.2
  • 41
    • 77949737971 scopus 로고    scopus 로고
    • A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
    • Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest 2010;120:681-93.
    • (2010) J Clin Invest , vol.120 , pp. 681-693
    • Alimonti, A.1    Nardella, C.2    Chen, Z.3    Clohessy, J.G.4    Carracedo, A.5    Trotman, L.C.6
  • 42
    • 77952493135 scopus 로고    scopus 로고
    • Exploring a 'pro-senescence' approach for prostate cancer therapy by targeting PTEN
    • Collado M. Exploring a 'pro-senescence' approach for prostate cancer therapy by targeting PTEN. Future Oncol 2010;6:687-9.
    • (2010) Future Oncol , vol.6 , pp. 687-689
    • Collado, M.1
  • 43
    • 58149190789 scopus 로고    scopus 로고
    • The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility
    • Safholm A, Tuomela J, Rosenkvist J, Dejmek J, Harkonen P, Andersson T. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res 2008;14:6556-63.
    • (2008) Clin Cancer Res , vol.14 , pp. 6556-6563
    • Safholm, A.1    Tuomela, J.2    Rosenkvist, J.3    Dejmek, J.4    Harkonen, P.5    Andersson, T.6
  • 44
    • 39749108763 scopus 로고    scopus 로고
    • The complex pathways of Wnt 5a in cancer progression
    • DOI 10.1007/s00109-007-0266-2
    • Pukrop T, Binder C. The complex pathways of Wnt 5a in cancer progression. J Mol Med 2008;86:259-66. (Pubitemid 351311422)
    • (2008) Journal of Molecular Medicine , vol.86 , Issue.3 , pp. 259-266
    • Pukrop, T.1    Binder, C.2
  • 45
    • 77957141708 scopus 로고    scopus 로고
    • WNT5A antagonizes WNT/beta-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma
    • Li J, Ying J, Fan Y, Wu L, Ying Y, Chan AT, et al. WNT5A antagonizes WNT/beta-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma. Cancer Biol Ther 2007;10:617-24.
    • (2007) Cancer Biol Ther , vol.10 , pp. 617-624
    • Li, J.1    Ying, J.2    Fan, Y.3    Wu, L.4    Ying, Y.5    Chan, A.T.6
  • 46
    • 77953539908 scopus 로고    scopus 로고
    • Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells
    • Nishita M, Enomoto M, Yamagata K, Minami Y. Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells. Trends Cell Biol 2010;20:346-54.
    • (2010) Trends Cell Biol , vol.20 , pp. 346-354
    • Nishita, M.1    Enomoto, M.2    Yamagata, K.3    Minami, Y.4
  • 48
    • 79956116022 scopus 로고    scopus 로고
    • Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer
    • Peng C, Zhang X, Yu H, Wu D, Zheng J. Wnt5a as a predictor in poor clinical outcome of patients and a mediator in chemoresistance of ovarian cancer. Int J Gynecol Cancer 2011;21:280-8.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 280-288
    • Peng, C.1    Zhang, X.2    Yu, H.3    Wu, D.4    Zheng, J.5
  • 49
    • 70749118578 scopus 로고    scopus 로고
    • A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: Microfibril-associated glycoprotein 2
    • Mok SC, Bonome T, Vathipadiekal V, Bell A, Johnson ME, Wong KK, et al. A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2. Cancer Cell 2009;16:521-32.
    • (2009) Cancer Cell , vol.16 , pp. 521-532
    • Mok, S.C.1    Bonome, T.2    Vathipadiekal, V.3    Bell, A.4    Johnson, M.E.5    Wong, K.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.