Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue

Cancer Cell

Volumn 4, Issue 5, 2003, Pages 349-360

  Liang, Huiling ^a   Chen, Qin ^b   Coles, Andrew H ^a   Anderson, Stephen J ^c,f   Pihan, German ^a   Bradley, Allan ^d   Gerstein, Rachel ^a   Jurecic, Roland ^e   Jones, Stephen N ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Serono Repro Biology Institute   (United States)

^c BD Technologies   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; INTERLEUKIN 7; UNCLASSIFIED DRUG; WNT PROTEIN; WNT5A PROTEIN;

ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; DOWN REGULATION; GENETIC ANALYSIS; HEMATOPOIESIS; HEMIZYGOSITY; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; MOUSE; MYELOID LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0345356929     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(03)00268-X     Document Type: Article

References (46)

1. Austin T.W., Solar G.P., Ziegler F.C., Liem L., Matthews W. A role for the Wnt gene family in hematopoiesis. expansion of multilineage progenitor cells Blood. 89:1997;3624-3635.
2. Behrens J., von Kries J.P., Kuhl M., Bruhn L., Wedlich D., Grosschedl R., Birchmeier W. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature. 382:1996;638-642.
3. Bouillet P., Oulad-Abdelghani M., Ward S.J., Bronner S., Chambon P., Dolle P. A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid. Mech. Dev. 58:1996;141-152.
4. Fry T.J., Mackall C.L. Interleukin-7. from bench to clinic Blood. 99:2002;3892-3904.
5. He X., Saint-Jeannet J.P., Wang Y., Nathans J., Dawid I., Varmus H. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science. 275:1997;1652-1654.
6. Holmen S.L., Salic A., Zylstra C.R., Kirschner M.W., Williams B.O. A novel set of wnt-frizzled fusion proteins identifies receptor components that activate beta-catenin-dependent signalling. J. Biol. Chem. 277:2002;34727-34735.
7. Iozzo R.V., Eichstetter I., Danielson K.G. Aberrant expression of the growth factor Wnt-5A in human malignancy. Cancer Res. 55:1995;3495-3499.
8. Ishitani T., Kishida S., Hyodo-Miura J., Ueno N., Yasuda J., Waterman M., Shibuya H., Moon R.T., Ninomiya-Tsuji J., Matsumoto K. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signalling. Mol. Cell. Biol. 1:2003;131-139.
9. Jordan C.T., Astle C.M., Zawadzki J., Mackarehtschian K., Lemischka I.R., Harrison D.E. Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation. Exp. Hematol. 23:1995;1011-1015.
10. Kuhl M., Sheldahl L.C., Malbon C.C., Moon R.T. Ca(2+)/calmodulin- dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275:2000;12701-12711.
11. Kuhl M., Geis K., Sheldahl L.C., Pukrop T., Moon R.T., Wedlich D. Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signalling. Mech. Dev. 106:2001;61-76.
12. Lejeune S., Huguet E.L., Hamby A., Poulsom R., Harris A.L. Wnt5a cloning, expression, and up-regulation in human primary breast cancers. Clin. Cancer Res. 1:1995;215-222.
13. Mitsutake N., Namba H., Shklyaev S.S., Tsukazaki T., Ohtsuru A., Ohba M., Kuroki T., Ayabe H., Yamashita S. PKC delta mediates ionizing radiation-induced activation of c-Jun NH(2)-terminal kinase through MKK7 in human thyroid cells. Oncogene. 20:2001;989-996.
14. Miyamoto A., Nakayama K., Imaki H., Hirose S., Jiang Y., Abe M., Tsukiyama T., Nagahama H., Ohno S., Hatakeyama S., Nakayama K.I. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature. 416:2002;865-869.
15. Molenaar M., van de Wetering M., Oosterwegel M., Peterson-Maduro J., Godsave S., Korinek V., Roose J., Destree O., Clevers H. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell. 86:1996;391-399.
16. Murdoch B., Chadwick K., Martin M., Shojaei F., Shah K.V., Gallacher L., Moon R.T., Bhatia M. Wnt-5a augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc. Natl. Acad. Sci. USA. 100:2003;3422-3427.
17. Myers D.C., Sepich D.S., Solnica-Krezel L. Bmp activity gradient regulates convergent extension during zebrafish gastrulation. Dev. Biol. 243:2002;81-98.
18. Nusse R., Varmus H.E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell. 31:1982;99-109.
19. Olson D.J., Gibo D.M. Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial cell transformation. Exp. Cell Res. 241:1998;134-141.
20. Olson D.J., Gibo D.M., Saggers G., Debinski W., Kumar R. Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a. Cell Growth Differ. 8:1997;417-423.
21. Petrenko O., Beavis A., Klaine M., Kittappa R., Godin I., Lemischka I.R. The molecular characterization of the fetal stem cell marker AA4. Immunity. 10:1999;691-700.
22. Phillips R.L., Ernst R.E., Brunk B., Ivanova N., Mahan M.A., Deanehan J.K., Moore K.A., Overton G.C., Lemischka I.R. The genetic program of hematopoietic stem cells. Science. 288:2000;1635-1640.
23. Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., Davis R.J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:1995;7420-7426.
24. Rolink A., Haasner D., Nishikawa S.-I., Melchers F. Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice. Blood. 81:1993;2290-2300.
25. Saitoh T., Katoh M. Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region. Int. J. Oncol. 19:2001;347-351.
26. Saneyoshi T., Kume S., Amasaki Y., Mikoshiba K. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature. 417:2002;295-299.
27. Sheldahl L.C., Park M., Malbon C.C., Moon R.T. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr. Biol. 9:1999;695-698.
28. Slusarski D.C., Yang-Snyder J., Busa W.B., Moon R.T. Modulation of embryonic intracellular Ca2+ signalling by Wnt-5A. Dev. Biol. 182:1997;114-120. a.
29. Slusarski D.C., Corces V.G., Moon R.T. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature. 390:1997;410-413. b.
30. Stark K., Vainio S., Vassileva G., McMahon A.P. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 372:1994;679-683.
31. Sun P., Enslen H., Myung P.S., Maurer R.A. Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev. 8:1994;2527-2539.
32. Takada S., Stark K.L., Shea M.J., Vassileva G., McMahon J.A., McMahon A.P. Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 8:1994;174-189.
33. Torres M.A., Yang-Snyder J.A., Purcell S.M., DeMarais A.A., McGrew L.L., Moon R.T. Activities of the Wnt-1 class of secreted signalling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J. Cell Biol. 133:1996;1123-1137.
34. Toyofuku T., Hong Z., Kuzuya T., Tada M., Hori M. Wnt/frizzled-2 signalling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J. Cell Biol. 150:2000;225-241.
35. Van Den Berg D.J., Sharma A.K., Bruno E., Hoffman R. Role of members of the Wnt gene family in human hematopoiesis. Blood. 92:1998;3189-3202.
36. van Gijn M.E., Daemen M.J., Smits J.F., Blankesteijn W.M. The wnt-frizzled cascade in cardiovascular disease. Cardiovasc. Res. 55:2002;16-24.
37. Wallingford J.B., Vogeli K.M., Harland R.M. Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway. Int. J. Dev. Biol. 45:2001;225-227.
38. Weeraratna A.T., Jiang Y., Hostetter G., Rosenblatt K., Duray P., Bittner M., Trent J.M. Wnt5a signalling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell. 1:2002;279-288.
39. Whitlock C.A., Robertson D., Witte O.N. Murine B cell lymphopoiesis in long term culture. J. Immunol. Methods. 67:1984;353-369.
40. Wodarz A., Nusse R. Mechanisms of Wnt signalling in development. Annu. Rev. Cell Dev. Biol. 14:1998;59-88.
41. Wolda S.L., Moody C.J., Moon R.T. Overlapping expression of Xwnt-3A and Xwnt-1 in neural tissue of Xenopus laevis embryos. Dev. Biol. 155:1993;46-57.
42. Wong G.T., Gavin B.J., McMahon A.P. Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 14:1994;6278-6286.
43. Wu X., McMurray C.T. Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein. J. Biol. Chem. 276:2001;1735-1741.
44. Yamaguchi T.P. Heads or tails. Wnts and anterior-posterior patterning Curr. Biol. 11:2001;R713-R724.
45. Yamaguchi T.P., Bradley A., McMahon A.P., Jones S. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development. 126:1999;1211-1223.
46. Yamanaka H., Moriguchi T., Masuyama N., Kusakabe M., Hanafusa H., Takada R., Takada S., Nishida E. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep. 3:2002;69-75.