Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Trends in Endocrinology and Metabolism

Volumn 24, Issue 1, 2013, Pages 40-47

  Cai, Dongsheng ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Brain; Diabetes; Hypothalamus; Inflammation; Neural stem cells; Neurodegeneration; NF B; Obesity

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

CELL REGENERATION; DISEASE ASSOCIATION; ENERGY BALANCE; HUMAN; HYPOTHALAMUS; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NEURAL STEM CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OVERNUTRITION; PRIORITY JOURNAL; REVIEW;

EID: 84871650203     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2012.11.003     Document Type: Review

References (108)

1. Belgardt B.F., Bruning J.C. CNS leptin and insulin action in the control of energy homeostasis. Ann. N. Y. Acad. Sci. 2010, 1212:97-113.
2. Myers M.G., et al. Mechanisms of leptin action and leptin resistance. Annu. Rev. Physiol. 2008, 70:537-556.
3. Myers M.G., et al. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol. Metab. 2010, 21:643-651.
4. Elmquist J.K., Flier J.S. Neuroscience. The fat-brain axis enters a new dimension. Science 2004, 304:63-64.
5. Rahmouni K., et al. Obesity-associated hypertension: new insights into mechanisms. Hypertension 2005, 45:9-14.
6. Elmquist J.K., et al. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J. Comp. Neurol. 2005, 493:63-71.
7. Williams K.W., Elmquist J.K. From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior. Nat. Neurosci. 2012, 15:1350-1355.
8. Yi C.X., et al. A role for astrocytes in the central control of metabolism. Neuroendocrinology 2011, 93:143-149.
9. Dietrich M.O., Horvath T.L. Feeding signals and brain circuitry. Eur. J. Neurosci. 2009, 30:1688-1696.
10. Cai D., Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB. Aging (Albany, NY) 2012, 4:98-115.
11. Cai D., Liu T. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann. N. Y. Acad. Sci. 2011, 1243:E1-E39.
12. Cai D. NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system. Cell Cycle 2009, 8:2542-2548.
13. Cai D. One step from prediabetes to diabetes: hypothalamic inflammation?. Endocrinology 2012, 153:1010-1013.
14. Thaler J.P., Schwartz M.W. Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 2010, 151:4109-4115.
15. Thaler J.P., et al. Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 2012, 122:153-162.
16. Li J., et al. IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat. Cell Biol. 2012, 14:999-1012.
17. McNay D.E., et al. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J. Clin. Invest. 2012, 122:142-152.
18. Pierce A.A., Xu A.W. De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J. Neurosci. 2010, 30:723-730.
19. Ballard C., et al. Alzheimer's disease. Lancet 2011, 377:1019-1031.
20. Lees A.J., et al. Parkinson's disease. Lancet 2009, 373:2055-2066.
21. Beydoun M.A., et al. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes. Rev. 2008, 9:204-218.
22. Lu F.P., et al. Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis. PLoS ONE 2009, 4:e4144.
23. Hamer M., Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol. Med. 2009, 39:3-11.
24. Gregor M.F., Hotamisligil G.S. Inflammatory mechanisms in obesity. Annu. Rev. Immunol. 2011, 29:415-445.
25. Lumeng C.N., Saltiel A.R. Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 2011, 121:2111-2117.
26. Shoelson S.E., Goldfine A.B. Getting away from glucose: fanning the flames of obesity-induced inflammation. Nat. Med. 2009, 15:373-374.
27. Schenk S., et al. Insulin sensitivity: modulation by nutrients and inflammation. J. Clin. Invest. 2008, 118:2992-3002.
28. Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 2011, 11:98-107.
29. Glass C.K., Olefsky J.M. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012, 15:635-645.
30. Ferrante A.W. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J. Intern. Med. 2007, 262:408-414.
31. Marino J.S., et al. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol. Metab. 2011, 22:275-285.
32. Sandoval D., et al. The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation. Annu. Rev. Physiol. 2008, 70:513-535.
33. Coll A.P., et al. The hormonal control of food intake. Cell 2007, 129:251-262.
34. Morton G.J., et al. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
35. Cone R.D. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 2005, 8:571-578.
36. Lam T.K., et al. Hypothalamic sensing of fatty acids. Nat. Neurosci. 2005, 8:579-584.
37. Zhang X., et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135:61-73.
38. Milanski M., et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J. Neurosci. 2009, 29:359-370.
39. Kleinridders A., et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 2009, 10:249-259.
40. Posey K.A., et al. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E1003-E1012.
41. De Souza C.T., et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005, 146:4192-4199.
42. Oh I., et al. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Am. J. Physiol. Endocrinol. Metab. 2010, 299:E47-E53.
43. Meng Q., Cai D. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway. J. Biol. Chem. 2011, 286:32324-32332.
44. Purkayastha S., et al. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:2939-2944.
45. Arruda A.P., et al. Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion. Endocrinology 2011, 152:1314-1326.
46. Purkayastha S., et al. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-beta and NF-kappaB. Nat. Med. 2011, 17:883-887.
47. Belgardt B.F., et al. Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc. Natl. Acad. Sci. U.S.A 2010, 107:6028-6033.
48. Sabio G., et al. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 2010, 24:256-264.
49. Hayden M.S., Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008, 132:344-362.
50. Hoffmann A., Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol. Rev. 2006, 210:171-186.
51. Karin M., Lin A. NF-kappaB at the crossroads of life and death. Nat. Immunol. 2002, 3:221-227.
52. Konner A.C., Bruning J.C. Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol. Metab. 2011, 22:16-23.
53. Romanatto T., et al. Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J. Biol. Chem. 2009, 284:36213-36222.
54. Milanski M., et al. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 2012, 61:1455-1462.
55. Thaler J.P., et al. Hypothalamic inflammation and energy homeostasis: resolving the paradox. Front. Neuroendocrinol. 2010, 31:79-84.
56. Zhou R., et al. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 469:221-225.
57. Melov S. Modeling mitochondrial function in aging neurons. Trends Neurosci. 2004, 27:601-606.
58. Sorrells S.F., et al. The stressed CNS: when glucocorticoids aggravate inflammation. Neuron 2009, 64:33-39.
59. Andersen J.K. Oxidative stress in neurodegeneration: cause or consequence?. Nat. Med. 2004, 10(Suppl.):S18-S25.
60. Ozcan L., et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009, 9:35-51.
61. Camacho A., et al. Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response: PGC1 beta coordinates endoplasmic reticulum stress response. Exp. Neurol. 2012, 237:396-406.
62. Nerurkar P.V., et al. Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. J. Neuroinflamm. 2011, 8:64.
63. Charradi K., et al. Grape seed and skin extract prevents high-fat diet-induced brain lipotoxicity in rat. Neurochem. Res. 2012, 37:2004-2013.
64. White C.L., et al. Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol. Dis. 2009, 35:3-13.
65. Morrison C.D., et al. High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. J. Neurochem. 2010, 114:1581-1589.
66. Son S.M., et al. Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions. Autophagy 2012, 8:1842-1844.
67. Singh R.B., et al. Metabolic syndrome: a brain disease. Can. J. Physiol. Pharmacol. 2012, 90:1171-1183.
68. Strowig T., et al. Inflammasomes in health and disease. Nature 2012, 481:278-286.
69. Salminen A., et al. ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J. Neuroinflamm. 2009, 6:41.
70. Galizzi G., et al. Different early ER-stress responses in the CLN8(mnd) mouse model of neuronal ceroid lipofuscinosis. Neurosci. Lett. 2011, 488:258-262.
71. Valenzuela V., et al. Activation of the unfolded protein response enhances motor recovery after spinal cord injury. Cell Death Dis. 2012, 3:e272.
72. Alirezaei M., et al. Disruption of neuronal autophagy by infected microglia results in neurodegeneration. PLoS ONE 2008, 3:e2906.
73. Meissner F., et al. Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Proc. Natl. Acad. Sci. U.S.A 2010, 107:13046-13050.
74. Alirezaei M., et al. Autophagy, inflammation and neurodegenerative disease. Eur. J. Neurosci. 2011, 33:197-204.
75. Won J.C., et al. Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin. Obesity (Silver Spring) 2009, 17:1861-1865.
76. Howard J.K., Flier J.S. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol. Metab. 2006, 17:365-371.
77. Reed A.S., et al. Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes 2010, 59:894-906.
78. Kievit P., et al. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab. 2006, 4:123-132.
79. Mori H., et al. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat. Med. 2004, 10:739-743.
80. Zabolotny J.M., et al. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J. Biol. Chem. 2008, 283:14230-14241.
81. Banno R., et al. PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. J. Clin. Invest. 2010, 120:720-734.
82. Picardi P.K., et al. Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology 2008, 149:3870-3880.
83. Bence K.K., et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat. Med. 2006, 12:917-924.
84. Liao G., et al. Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brain. Brain Res. 2009, 1270:140-151.
85. Loh K., et al. Elevated hypothalamic TCPTP in bbesity contributes to cellular leptin resistance. Cell Metab. 2011, 14:684-699.
86. King B.M. The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol. Behav. 2006, 87:221-244.
87. Moraes J.C., et al. High-fat diet induces apoptosis of hypothalamic neurons. PLoS ONE 2009, 4:e5045.
88. Susaki E., et al. Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. J. Biol. Chem. 2010, 285:15538-15547.
89. Ryu K.Y., et al. Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene. Proc. Natl. Acad. Sci. U.S.A 2008, 105:4016-4021.
90. Ramesh B.J., et al. Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. J. Neurochem. 2008, 106:107-120.
91. Gage F.H. Mammalian neural stem cells. Science 2000, 287:1433-1438.
92. Cameron H.A., McKay R. Stem cells and neurogenesis in the adult brain. Curr. Opin. Neurobiol. 1998, 8:677-680.
93. Emsley J.G., et al. Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells. Prog. Neurobiol. 2005, 75:321-341.
94. Gould E. How widespread is adult neurogenesis in mammals?. Nat. Rev. Neurosci. 2007, 8:481-488.
95. Kokoeva M.V., et al. Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 2005, 310:679-683.
96. Kokoeva M.V., et al. Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J. Comp. Neurol. 2007, 505:209-220.
97. Lee D.A., et al. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat. Neurosci. 2012, 15:700-702.
98. Rolls A., et al. Toll-like receptors modulate adult hippocampal neurogenesis. Nat. Cell Biol. 2007, 9:1081-1088.
99. Koo J.W., et al. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. U.S.A 2010, 107:2669-2674.
100. Schapira A.H. Mitochondrial diseases. Lancet 2012, 379:1825-1834.
101. Dinarello C.A. Anti-inflammatory agents: present and future. Cell 2010, 140:935-950.
102. Bousquet M., et al. High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice. Neurobiol. Dis. 2012, 45:529-538.
103. Sadagurski M., et al. IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. J. Clin. Invest. 2011, 121:4070-4081.
104. Petit A., et al. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J. Biol. Chem. 2005, 280:34025-34032.
105. Scheele C., et al. Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?. FASEB J. 2007, 21:3653-3665.
106. Dugan L.L., et al. IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase. PLoS ONE 2009, 4:e5518.
107. Bruce-Keller A.J., et al. Obesity and vulnerability of the CNS. Biochim. Biophys. Acta 2009, 1792:395-400.
108. de la Monte S.M., et al. Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis. Curr. Opin. Investig. Drugs 2009, 10:1049-1060.