메뉴 건너뛰기




Volumn 153, Issue 3, 2012, Pages 1010-1013

One step from prediabetes to diabetes: Hypothalamic inflammation?

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 6; LEPTIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SH2; STRESS ACTIVATED PROTEIN KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; TYROSINE;

EID: 84857419560     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-2183     Document Type: Short Survey
Times cited : (25)

References (31)
  • 3
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling
    • DOI 10.1038/12631
    • Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF 1999 Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet 23:32-40 (Pubitemid 29418784)
    • (1999) Nature Genetics , vol.23 , Issue.1 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5    White, M.F.6
  • 5
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • DOI 10.1126/science.1142179
    • Taguchi A, Wartschow LM, White MF 2007 Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317:369-372 (Pubitemid 47106376)
    • (2007) Science , vol.317 , Issue.5836 , pp. 369-372
    • Taguchi, A.1    Wartschow, L.M.2    White, M.F.3
  • 6
    • 33646553059 scopus 로고    scopus 로고
    • Regulating energy balance: The substrate strikes back
    • DOI 10.1126/science.1127971
    • Flier JS 2006 Neuroscience. Regulating energy balance: the substrate strikes back. Science 312:861-864 (Pubitemid 43727307)
    • (2006) Science , vol.312 , Issue.5775 , pp. 861-864
    • Flier, J.S.1
  • 7
    • 34147119799 scopus 로고    scopus 로고
    • The Hormonal Control of Food Intake
    • DOI 10.1016/j.cell.2007.04.001, PII S0092867407004473
    • Coll AP, Farooqi IS, O'Rahilly S 2007 The hormonal control of food intake. Cell 129:251-262 (Pubitemid 46574977)
    • (2007) Cell , vol.129 , Issue.2 , pp. 251-262
    • Coll, A.P.1    Farooqi, I.S.2    O'Rahilly, S.3
  • 9
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • DOI 10.1038/nm798
    • Obici S, Zhang BB, Karkanias G, Rossetti L 2002 Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8:1376-1382 (Pubitemid 36019422)
    • (2002) Nature Medicine , vol.8 , Issue.12 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 10
    • 27744436291 scopus 로고    scopus 로고
    • Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
    • DOI 10.1002/cne.20786
    • Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB 2005 Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 493:63-71 (Pubitemid 41636188)
    • (2005) Journal of Comparative Neurology , vol.493 , Issue.1 , pp. 63-71
    • Elmquist, J.K.1    Coppari, R.2    Balthasar, N.3    Ichinose, M.4    Lowell, B.B.5
  • 11
    • 34548362074 scopus 로고    scopus 로고
    • Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
    • DOI 10.1113/jphysiol.2007.135590
    • Morton GJ 2007 Hypothalamic leptin regulation of energy homeostasis and glucose metabolism. J Physiol 583:437-443 (Pubitemid 47343482)
    • (2007) Journal of Physiology , vol.583 , Issue.2 , pp. 437-443
    • Morton, G.J.1
  • 12
    • 79551665635 scopus 로고    scopus 로고
    • Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance
    • Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q, CaiD2011 Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron 69:523-535
    • (2011) Neuron , vol.69 , pp. 523-535
    • Zhang, G.1    Bai, H.2    Zhang, H.3    Dean, C.4    Wu, Q.5    Li, J.6    Guariglia, S.7    Meng, Q.8    Cai, D.9
  • 14
    • 79951834732 scopus 로고    scopus 로고
    • Study on establishment of congenic strains and screening of characteristics in IRS-2 deficient mice to support translational research on type 2 diabetes
    • Hashimoto H 2011 Study on establishment of congenic strains and screening of characteristics in IRS-2 deficient mice to support translational research on type 2 diabetes. Exp Anim 60:21-32
    • (2011) Exp Anim , vol.60 , pp. 21-32
    • Hashimoto, H.1
  • 15
    • 69249211226 scopus 로고    scopus 로고
    • NFκB-mediated metabolic inflammation in peripheral tissues versus central nervous system
    • Cai D 2009 NFκB-mediated metabolic inflammation in peripheral tissues versus central nervous system. Cell Cycle 8:2542-2548
    • (2009) Cell Cycle , vol.8 , pp. 2542-2548
    • Cai, D.1
  • 16
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng CN, Saltiel AR 2011 Inflammatory links between obesity and metabolic disease. J Clin Invest 121:2111-2117
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 17
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D 2008 Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61-73
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 20
    • 79952595599 scopus 로고    scopus 로고
    • Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
    • Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y, Cai D 2011 Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc Natl Acad Sci USA 108: 2939-2944
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2939-2944
    • Purkayastha, S.1    Zhang, H.2    Zhang, G.3    Ahmed, Z.4    Wang, Y.5    Cai, D.6
  • 21
    • 80052712323 scopus 로고    scopus 로고
    • Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway
    • Meng Q, Cai D 2011 Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway. J Biol Chem 286:32324-32332
    • (2011) J Biol Chem , vol.286 , pp. 32324-32332
    • Meng, Q.1    Cai, D.2
  • 24
    • 74949093168 scopus 로고    scopus 로고
    • XuAW2010 Functional role of c-Jun-N-terminal kinase in feeding regulation
    • Unger EK, Piper ML, Olofsson LE, XuAW2010 Functional role of c-Jun-N-terminal kinase in feeding regulation. Endocrinology 151: 671-682
    • Endocrinology , vol.151 , pp. 671-682
    • Unger, E.K.1    Piper, M.L.2    Olofsson, L.E.3
  • 25
    • 33746537247 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
    • DOI 10.1016/j.cmet.2006.06.010, PII S1550413106002427
    • Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS 2006 Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab 4:123-132 (Pubitemid 44138722)
    • (2006) Cell Metabolism , vol.4 , Issue.2 , pp. 123-132
    • Kievit, P.1    Howard, J.K.2    Badman, M.K.3    Balthasar, N.4    Coppari, R.5    Mori, H.6    Lee, C.E.7    Elmquist, J.K.8    Yoshimura, A.9    Flier, J.S.10
  • 27
    • 77951194676 scopus 로고    scopus 로고
    • Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis
    • Reed AS, Unger EK, Olofsson LE, Piper ML, Myers Jr MG, Xu AW 2010 Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes 59:894-906
    • (2010) Diabetes , vol.59 , pp. 894-906
    • Reed, A.S.1    Unger, E.K.2    Olofsson, L.E.3    Piper, M.L.4    Myers Jr., M.G.5    Xu, A.W.6
  • 28
    • 79960117277 scopus 로고    scopus 로고
    • Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB
    • Purkayastha S, Zhang G, Cai D 2011 Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nat Med 17:883-887
    • (2011) Nat Med , vol.17 , pp. 883-887
    • Purkayastha, S.1    Zhang, G.2    Cai, D.3
  • 30
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • DOI 10.1038/nature05485, PII NATURE05485
    • Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867 (Pubitemid 46024993)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.