메뉴 건너뛰기




Volumn 15, Issue 10, 2012, Pages 1350-1355

From neuroanatomy to behavior: Central integration of peripheral signals regulating feeding behavior

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; CHOLECYSTOKININ; GHRELIN; GLUCAGON LIKE PEPTIDE 1; INSULIN; LEPTIN; MELANOCORTIN; NEUROTRANSMITTER; PROOPIOMELANOCORTIN; VESICULAR GLUTAMATE TRANSPORTER 2; VESICULAR INHIBITORY AMINO ACID TRANSPORTER;

EID: 84866705627     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3217     Document Type: Review
Times cited : (319)

References (100)
  • 1
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • Schwartz, M.W. & Porte, D. Jr. Diabetes, obesity, and the brain. Science 307, 375-379 (2005).
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte, Jr.D.2
  • 3
    • 0032577376 scopus 로고    scopus 로고
    • Signals that regulate food intake and energy homeostasis
    • Woods, S.C., Seeley, R.J., Porte, D. Jr. & Schwartz, M.W. Signals that regulate food intake and energy homeostasis. Science 280, 1378-1383 (1998).
    • (1998) Science , vol.280 , pp. 1378-1383
    • Woods, S.C.1    Seeley, R.J.2    Porte, Jr.D.3    Schwartz, M.W.4
  • 4
    • 79951990905 scopus 로고    scopus 로고
    • Modulation of the central melanocortin system by leptin, insulin, and serotonin: Co-ordinated actions in a dispersed neuronal network
    • Williams, K.W., Scott, M.M. & Elmquist, J.K. Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network. Eur. J. Pharmacol. 660, 2-12 (2011).
    • (2011) Eur. J. Pharmacol. , vol.660 , pp. 2-12
    • Williams, K.W.1    Scott, M.M.2    Elmquist, J.K.3
  • 5
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman, D.L. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9, 294-298 (1973).
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 6
    • 0014608866 scopus 로고
    • Effects of parabiosis of normal with genetically diabetic mice
    • Coleman, D.L. & Hummel, K.P. Effects of parabiosis of normal with genetically diabetic mice. Am. J. Physiol. 217, 1298-1304 (1969).
    • (1969) Am. J. Physiol. , vol.217 , pp. 1298-1304
    • Coleman, D.L.1    Hummel, K.P.2
  • 7
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1
  • 8
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J. & Cone, R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165-168 (1997).
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 9
    • 84866666334 scopus 로고    scopus 로고
    • Unraveling the brain regulation of appetite: Lessons from genetics
    • Yeo, G.S. & Heisler, L.K. Unraveling the brain regulation of appetite: lessons from genetics. Nat. Neurosci. 15, 1343-1349 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 1343-1349
    • Yeo, G.S.1    Heisler, L.K.2
  • 10
    • 27544450765 scopus 로고    scopus 로고
    • Divergence of melanocortin pathways in the control of food intake and energy expenditure
    • Balthasar, N. et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123, 493-505 (2005).
    • (2005) Cell , vol.123 , pp. 493-505
    • Balthasar, N.1
  • 11
    • 0034611681 scopus 로고    scopus 로고
    • Genetics of body-weight regulation
    • Barsh, G.S., Farooqi, I.S. & O'Rahilly, S. Genetics of body-weight regulation. Nature 404, 644-651 (2000).
    • (2000) Nature , vol.404 , pp. 644-651
    • Barsh, G.S.1    Farooqi, I.S.2    O'Rahilly, S.3
  • 12
    • 0034456398 scopus 로고    scopus 로고
    • A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-defcient mouse
    • Butler, A.A. et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-defcient mouse. Endocrinology 141, 3518-3521 (2000).
    • (2000) Endocrinology , vol.141 , pp. 3518-3521
    • Butler, A.A.1
  • 13
    • 0037456768 scopus 로고    scopus 로고
    • Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    • Farooqi, I.S. et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. 348, 1085-1095 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1085-1095
    • Farooqi, I.S.1
  • 14
    • 79551555006 scopus 로고    scopus 로고
    • Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
    • Rossi, J. et al. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab. 13, 195-204 (2011).
    • (2011) Cell Metab. , vol.13 , pp. 195-204
    • Rossi, J.1
  • 15
    • 33645839593 scopus 로고    scopus 로고
    • Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or-4 receptors
    • Sutton, G.M. et al. Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or-4 receptors. Endocrinology 147, 2183-2196 (2006).
    • (2006) Endocrinology , vol.147 , pp. 2183-2196
    • Sutton, G.M.1
  • 16
    • 77249146406 scopus 로고    scopus 로고
    • Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    • Williams, K.W. et al. Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J. Neurosci. 30, 2472-2479 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 2472-2479
    • Williams, K.W.1
  • 17
    • 0031919929 scopus 로고    scopus 로고
    • XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors
    • Michel, M.C. et al. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50, 143-150 (1998).
    • (1998) Pharmacol. Rev. , vol.50 , pp. 143-150
    • Michel, M.C.1
  • 18
    • 34547105098 scopus 로고    scopus 로고
    • Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis
    • Baldock, P.A. et al. Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis. J. Biol. Chem. 282, 19092-19102 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 19092-19102
    • Baldock, P.A.1
  • 19
    • 0037173035 scopus 로고    scopus 로고
    • Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice
    • Sainsbury, A. et al. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl. Acad. Sci. USA 99, 8938-8943 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8938-8943
    • Sainsbury, A.1
  • 20
    • 77955331814 scopus 로고    scopus 로고
    • NPY neuron-specifc Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice
    • Shi, Y.C. et al. NPY neuron-specifc Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. PLoS ONE 5, e11361 (2010).
    • (2010) PLoS ONE , vol.5
    • Shi, Y.C.1
  • 21
    • 79951999061 scopus 로고    scopus 로고
    • GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism
    • Wu, Q. & Palmiter, R.D. GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism. Eur. J. Pharmacol. 660, 21-27 (2011).
    • (2011) Eur. J. Pharmacol. , vol.660 , pp. 21-27
    • Wu, Q.1    Palmiter, R.D.2
  • 22
    • 84866686337 scopus 로고    scopus 로고
    • Synaptic plasticity in circuits regulating energy balance
    • Zeltser, L.M., Seeley, R.J. & Tschöp, M. Synaptic plasticity in circuits regulating energy balance. Nat. Neurosci. 15, 1336-1342 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 1336-1342
    • Zeltser, L.M.1    Seeley, R.J.2    Tschöp, M.3
  • 23
    • 0036288345 scopus 로고    scopus 로고
    • Neither agouti-related protein nor neuropeptide y is critically required for the regulation of energy homeostasis in mice
    • Qian, S. et al. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol. Cell. Biol. 22, 5027-5035 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5027-5035
    • Qian, S.1
  • 24
    • 77950547451 scopus 로고    scopus 로고
    • Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits
    • Padilla, S.L., Carmody, J.S. & Zeltser, L.M. Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat. Med. 16, 403-405 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 403-405
    • Padilla, S.L.1    Carmody, J.S.2    Zeltser, L.M.3
  • 25
    • 2442654859 scopus 로고
    • Identifcation and expression cloning of a leptin receptor, OB-R
    • Tartaglia, L.A. et al. Identifcation and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271 (1995).
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1
  • 26
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identifcation of a mutation in the leptin receptor gene in db/db mice
    • Chen, H. et al. Evidence that the diabetes gene encodes the leptin receptor: identifcation of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491-495 (1996).
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1
  • 27
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee, G.-H. et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635 (1996).
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.-H.1
  • 28
    • 84863267488 scopus 로고    scopus 로고
    • Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
    • Berglund, E.D. et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J. Clin. Invest. 122, 1000-1009 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 1000-1009
    • Berglund, E.D.1
  • 29
    • 2942733252 scopus 로고    scopus 로고
    • Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    • Balthasar, N. et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42, 983-991 (2004).
    • (2004) Neuron , vol.42 , pp. 983-991
    • Balthasar, N.1
  • 30
    • 17844389670 scopus 로고    scopus 로고
    • The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    • Coppari, R. et al. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 1, 63-72 (2005).
    • (2005) Cell Metab. , vol.1 , pp. 63-72
    • Coppari, R.1
  • 32
    • 30044447631 scopus 로고    scopus 로고
    • Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    • Morton, G.J. et al. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2, 411-420 (2005).
    • (2005) Cell Metab. , vol.2 , pp. 411-420
    • Morton, G.J.1
  • 33
    • 66049133685 scopus 로고    scopus 로고
    • Leptin-dependent control of glucose balance and locomotor activity by POMC neurons
    • Huo, L. et al. Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab. 9, 537-547 (2009).
    • (2009) Cell Metab. , vol.9 , pp. 537-547
    • Huo, L.1
  • 34
    • 79960190012 scopus 로고    scopus 로고
    • Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    • Vong, L. et al. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71, 142-154 (2011).
    • (2011) Neuron , vol.71 , pp. 142-154
    • Vong, L.1
  • 35
    • 77950264425 scopus 로고    scopus 로고
    • Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
    • Hill, J.W. et al. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 11, 286-297 (2010).
    • (2010) Cell Metab. , vol.11 , pp. 286-297
    • Hill, J.W.1
  • 36
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    • Xu, A.W., Ste-Marie, L., Kaelin, C.B. & Barsh, G.S. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 148, 72-80 (2007).
    • (2007) Endocrinology , vol.148 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 37
    • 30644473109 scopus 로고    scopus 로고
    • Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    • Dhillon, H. et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49, 191-203 (2006).
    • (2006) Neuron , vol.49 , pp. 191-203
    • Dhillon, H.1
  • 38
    • 48849100361 scopus 로고    scopus 로고
    • The vagus nerve, food intake and obesity
    • Berthoud, H.R. The vagus nerve, food intake and obesity. Regul. Pept. 149, 15-25 (2008).
    • (2008) Regul. Pept. , vol.149 , pp. 15-25
    • Berthoud, H.R.1
  • 39
    • 72649103549 scopus 로고    scopus 로고
    • Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
    • Hayes, M.R. et al. Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab. 11, 77-83 (2010).
    • (2010) Cell Metab. , vol.11 , pp. 77-83
    • Hayes, M.R.1
  • 40
    • 79957896911 scopus 로고    scopus 로고
    • Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    • Scott, M.M., Williams, K.W., Rossi, J., Lee, C.E. & Elmquist, J.K. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J. Clin. Invest. 121, 2413-2421 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2413-2421
    • Scott, M.M.1    Williams, K.W.2    Rossi, J.3    Lee, C.E.4    Elmquist, J.K.5
  • 41
    • 63849112609 scopus 로고    scopus 로고
    • Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors
    • Skibicka, K.P. & Grill, H.J. Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Endocrinology 150, 1705-1711 (2009).
    • (2009) Endocrinology , vol.150 , pp. 1705-1711
    • Skibicka, K.P.1    Grill, H.J.2
  • 42
    • 41549111593 scopus 로고    scopus 로고
    • Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    • van de Wall, E. et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149, 1773-1785 (2008).
    • (2008) Endocrinology , vol.149 , pp. 1773-1785
    • Van De Wall, E.1
  • 43
    • 42449086900 scopus 로고    scopus 로고
    • Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
    • Bingham, N.C., Anderson, K.K., Reuter, A.L., Stallings, N.R. & Parker, K.L. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149, 2138-2148 (2008).
    • (2008) Endocrinology , vol.149 , pp. 2138-2148
    • Bingham, N.C.1    Anderson, K.K.2    Reuter, A.L.3    Stallings, N.R.4    Parker, K.L.5
  • 44
    • 40449132293 scopus 로고    scopus 로고
    • Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
    • Shi, H. et al. Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am. J. Physiol. Endocrinol. Metab. 294, E630-E639 (2008).
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294
    • Shi, H.1
  • 45
    • 0036142589 scopus 로고    scopus 로고
    • Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake
    • Grill, H.J. et al. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143, 239-246 (2002).
    • (2002) Endocrinology , vol.143 , pp. 239-246
    • Grill, H.J.1
  • 46
    • 0033780625 scopus 로고    scopus 로고
    • The role of gastrointestinal vagal afferents in the control of food intake: Current prospects
    • Schwartz, G.J. The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 16, 866-873 (2000).
    • (2000) Nutrition , vol.16 , pp. 866-873
    • Schwartz, G.J.1
  • 47
    • 0028878347 scopus 로고
    • Vagovagal refex control of digestion: Afferent modulation by neural and "endoneurocrine" factors
    • Rogers, R.C., McTigue, D.M. & Hermann, G.E. Vagovagal refex control of digestion: afferent modulation by neural and "endoneurocrine" factors. Am. J. Physiol. 268, G1-G10 (1995).
    • (1995) Am. J. Physiol. , vol.268
    • Rogers, R.C.1    McTigue, D.M.2    Hermann, G.E.3
  • 48
    • 77749316808 scopus 로고    scopus 로고
    • A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake
    • Zheng, H. et al. A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R720-R728 (2010).
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.298
    • Zheng, H.1
  • 49
    • 66049102943 scopus 로고    scopus 로고
    • The control of food intake: Behavioral versus molecular perspectives
    • Woods, S.C. The control of food intake: behavioral versus molecular perspectives. Cell Metab. 9, 489-498 (2009).
    • (2009) Cell Metab. , vol.9 , pp. 489-498
    • Woods, S.C.1
  • 50
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • Woods, S.C., Lotter, E.C., McKay, L.D. & Porte, D. Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282, 503-505 (1979).
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, L.D.3    Porte, Jr.D.4
  • 51
    • 34249651956 scopus 로고    scopus 로고
    • Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    • Könner, A.C. et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab. 5, 438-449 (2007).
    • (2007) Cell Metab. , vol.5 , pp. 438-449
    • Könner, A.C.1
  • 52
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning, J.C. et al. Role of brain insulin receptor in control of body weight and reproduction. Science 289, 2122-2125 (2000).
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1
  • 53
    • 0031440266 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    • Spanswick, D., Smith, M.A., Groppi, V.E., Logan, S.D. & Ashford, M.L. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390, 521-525 (1997).
    • (1997) Nature , vol.390 , pp. 521-525
    • Spanswick, D.1    Smith, M.A.2    Groppi, V.E.3    Logan, S.D.4    Ashford, M.L.5
  • 55
    • 43049116846 scopus 로고    scopus 로고
    • Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    • Hill, J.W. et al. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J. Clin. Invest. 118, 1796-1805 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1796-1805
    • Hill, J.W.1
  • 56
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • Bates, S.H. et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421, 856-859 (2003).
    • (2003) Nature , vol.421 , pp. 856-859
    • Bates, S.H.1
  • 57
    • 75349092316 scopus 로고    scopus 로고
    • Leptin excites proopiomelanocortin neurons via activation of TRPC channels
    • Qiu, J., Fang, Y., Ronnekleiv, O.K. & Kelly, M.J. Leptin excites proopiomelanocortin neurons via activation of TRPC channels. J. Neurosci. 30, 1560-1565 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 1560-1565
    • Qiu, J.1    Fang, Y.2    Ronnekleiv, O.K.3    Kelly, M.J.4
  • 58
    • 79959652223 scopus 로고    scopus 로고
    • High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
    • Klöckener, T. et al. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat. Neurosci. 14, 911-918 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 911-918
    • Klöckener, T.1
  • 59
    • 13344277357 scopus 로고    scopus 로고
    • Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    • Accili, D. et al. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat. Genet. 12, 106-109 (1996).
    • (1996) Nat. Genet. , vol.12 , pp. 106-109
    • Accili, D.1
  • 60
    • 0029879127 scopus 로고    scopus 로고
    • Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality
    • Joshi, R.L. et al. Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J. 15, 1542-1547 (1996).
    • (1996) EMBO J. , vol.15 , pp. 1542-1547
    • Joshi, R.L.1
  • 61
    • 0033805978 scopus 로고    scopus 로고
    • Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans
    • Arvat, E. et al. Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J. Endocrinol. Invest. 23, 493-495 (2000).
    • (2000) J. Endocrinol. Invest. , vol.23 , pp. 493-495
    • Arvat, E.1
  • 62
    • 0034802108 scopus 로고    scopus 로고
    • Minireview: Ghrelin and the regulation of energy balance-a hypothalamic perspective
    • Horvath, T.L., Diano, S., Sotonyi, P., Heiman, M. & Tschöp, M. Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology 142, 4163-4169 (2001).
    • (2001) Endocrinology , vol.142 , pp. 4163-4169
    • Horvath, T.L.1    Diano, S.2    Sotonyi, P.3    Heiman, M.4    Tschöp, M.5
  • 63
    • 0043030280 scopus 로고    scopus 로고
    • Minireview: From anorexia to obesity-the yin and yang of body weight control
    • Zigman, J.M. & Elmquist, J.K. Minireview: from anorexia to obesity-the yin and yang of body weight control. Endocrinology 144, 3749-3756 (2003).
    • (2003) Endocrinology , vol.144 , pp. 3749-3756
    • Zigman, J.M.1    Elmquist, J.K.2
  • 64
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet-induced obesity
    • Zigman, J.M. et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J. Clin. Invest. 115, 3564-3572 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 3564-3572
    • Zigman, J.M.1
  • 65
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst, J.J. The physiology of glucagon-like peptide 1. Physiol. Rev. 87, 1409-1439 (2007).
    • (2007) Physiol. Rev. , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 66
    • 80052049014 scopus 로고    scopus 로고
    • GLP-1 and energy balance: An integrated model of short-term and long-term control
    • Barrera, J.G., Sandoval, D.A., D'Alessio, D.A. & Seeley, R.J. GLP-1 and energy balance: an integrated model of short-term and long-term control. Nat. Rev. Endocrinol. 7, 507-516 (2011).
    • (2011) Nat. Rev. Endocrinol. , vol.7 , pp. 507-516
    • Barrera, J.G.1    Sandoval, D.A.2    D'Alessio, D.A.3    Seeley, R.J.4
  • 67
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • Merchenthaler, I., Lane, M. & Shughrue, P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J. Comp. Neurol. 403, 261-280 (1999).
    • (1999) J. Comp. Neurol. , vol.403 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 68
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton, M.D. et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379, 69-72 (1996).
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1
  • 69
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • Scrocchi, L.A. et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat. Med. 2, 1254-1258 (1996).
    • (1996) Nat. Med. , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1
  • 70
    • 33845997750 scopus 로고    scopus 로고
    • Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure
    • Hansotia, T. et al. Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. J. Clin. Invest. 117, 143-152 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 143-152
    • Hansotia, T.1
  • 71
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • Göke, R., Larsen, P.J., Mikkelsen, J.D. & Sheikh, S.P. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur. J. Neurosci. 7, 2294-2300 (1995).
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 2294-2300
    • Göke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3    Sheikh, S.P.4
  • 72
    • 0034710310 scopus 로고    scopus 로고
    • Chemical characterization of leptin-activated neurons in the rat brain
    • Elias, C.F. et al. Chemical characterization of leptin-activated neurons in the rat brain. J. Comp. Neurol. 423, 261-281 (2000).
    • (2000) J. Comp. Neurol. , vol.423 , pp. 261-281
    • Elias, C.F.1
  • 74
    • 33749019714 scopus 로고    scopus 로고
    • Cholecystokinin and treatment of meal size: Proof of principle
    • Smith, G.P. Cholecystokinin and treatment of meal size: proof of principle. Obesity (Silver Spring) 14 (suppl. 4), S168-S170 (2006).
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.SUPPL. 4
    • Smith, G.P.1
  • 75
    • 0032708056 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors
    • Noble, F. et al. International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol. Rev. 51, 745-781 (1999).
    • (1999) Pharmacol. Rev. , vol.51 , pp. 745-781
    • Noble, F.1
  • 76
    • 0024162579 scopus 로고
    • Capsaicin application to central or peripheral vagal fbers attenuates CCK satiety
    • South, E.H. & Ritter, R.C. Capsaicin application to central or peripheral vagal fbers attenuates CCK satiety. Peptides 9, 601-612 (1988).
    • (1988) Peptides , vol.9 , pp. 601-612
    • South, E.H.1    Ritter, R.C.2
  • 77
    • 0019890231 scopus 로고
    • Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat
    • Smith, G.P., Jerome, C., Cushin, B.J., Eterno, R. & Simansky, K.J. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science 213, 1036-1037 (1981).
    • (1981) Science , vol.213 , pp. 1036-1037
    • Smith, G.P.1    Jerome, C.2    Cushin, B.J.3    Eterno, R.4    Simansky, K.J.5
  • 79
    • 0032830989 scopus 로고    scopus 로고
    • Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus
    • Rinaman, L. Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus. Am. J. Physiol. 277, R582-R590 (1999).
    • (1999) Am. J. Physiol. , vol.277
    • Rinaman, L.1
  • 80
    • 24944570025 scopus 로고    scopus 로고
    • Cholecystokinin octapeptide increases spontaneous glutamatergic synaptic transmission to neurons of the nucleus tractus solitarius centralis
    • Baptista, V., Zheng, Z.L., Coleman, F.H., Rogers, R.C. & Travagli, R.A. Cholecystokinin octapeptide increases spontaneous glutamatergic synaptic transmission to neurons of the nucleus tractus solitarius centralis. J. Neurophysiol. 94, 2763-2771 (2005).
    • (2005) J. Neurophysiol. , vol.94 , pp. 2763-2771
    • Baptista, V.1    Zheng, Z.L.2    Coleman, F.H.3    Rogers, R.C.4    Travagli, R.A.5
  • 81
    • 1842560331 scopus 로고    scopus 로고
    • Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
    • Fan, W. et al. Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Nat. Neurosci. 7, 335-336 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 335-336
    • Fan, W.1
  • 82
    • 0347993676 scopus 로고    scopus 로고
    • Weighing the role of hypothalamic feeding neurotransmitters
    • van den Pol, A.N. Weighing the role of hypothalamic feeding neurotransmitters. Neuron 40, 1059-1061 (2003).
    • (2003) Neuron , vol.40 , pp. 1059-1061
    • Van Den Pol, A.N.1
  • 83
    • 79951992387 scopus 로고    scopus 로고
    • AGRP neurons are suffcient to orchestrate feeding behavior rapidly and without training
    • Aponte, Y., Atasoy, D. & Sternson, S.M. AGRP neurons are suffcient to orchestrate feeding behavior rapidly and without training. Nat. Neurosci. 14, 351-355 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 351-355
    • Aponte, Y.1    Atasoy, D.2    Sternson, S.M.3
  • 84
    • 50249120768 scopus 로고    scopus 로고
    • Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    • Tong, Q., Ye, C.P., Jones, J.E., Elmquist, J.K. & Lowell, B.B. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat. Neurosci. 11, 998-1000 (2008).
    • (2008) Nat. Neurosci. , vol.11 , pp. 998-1000
    • Tong, Q.1    Ye, C.P.2    Jones, J.E.3    Elmquist, J.K.4    Lowell, B.B.5
  • 85
    • 1842529267 scopus 로고    scopus 로고
    • Rapid rewiring of arcuate nucleus feeding circuits by leptin
    • Pinto, S. et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304, 110-115 (2004).
    • (2004) Science , vol.304 , pp. 110-115
    • Pinto, S.1
  • 86
    • 84863012024 scopus 로고    scopus 로고
    • Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone
    • Liu, T. et al. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron 73, 511-522 (2012).
    • (2012) Neuron , vol.73 , pp. 511-522
    • Liu, T.1
  • 87
    • 0028909857 scopus 로고
    • Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    • Tecott, L.H. et al. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374, 542-546 (1995).
    • (1995) Nature , vol.374 , pp. 542-546
    • Tecott, L.H.1
  • 88
    • 0031721271 scopus 로고    scopus 로고
    • Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    • Nonogaki, K., Strack, A.M., Dallman, M.F. & Tecott, L.H. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med. 4, 1152-1156 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 1152-1156
    • Nonogaki, K.1    Strack, A.M.2    Dallman, M.F.3    Tecott, L.H.4
  • 89
    • 78650191226 scopus 로고    scopus 로고
    • 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    • Xu, Y. et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat. Neurosci. 13, 1457-1459 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 1457-1459
    • Xu, Y.1
  • 90
    • 56349145180 scopus 로고    scopus 로고
    • 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
    • Xu, Y. et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 60, 582-589 (2008).
    • (2008) Neuron , vol.60 , pp. 582-589
    • Xu, Y.1
  • 91
    • 79961180328 scopus 로고    scopus 로고
    • Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels
    • Sohn, J.W. et al. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron 71, 488-497 (2011).
    • (2011) Neuron , vol.71 , pp. 488-497
    • Sohn, J.W.1
  • 93
    • 77950930288 scopus 로고    scopus 로고
    • Molecular and cellular approaches for diversifying and extending optogenetics
    • Gradinaru, V. et al. Molecular and cellular approaches for diversifying and extending optogenetics. Cell 141, 154-165 (2010).
    • (2010) Cell , vol.141 , pp. 154-165
    • Gradinaru, V.1
  • 94
    • 79953307878 scopus 로고    scopus 로고
    • Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
    • Krashes, M.J. et al. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J. Clin. Invest. 121, 1424-1428 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 1424-1428
    • Krashes, M.J.1
  • 95
    • 84864711337 scopus 로고    scopus 로고
    • Deconstruction of a neural circuit for hunger
    • Atasoy, D., Betley, J.N., Su, H.H. & Sternson, S.M. Deconstruction of a neural circuit for hunger. Nature 488, 172-177 (2012).
    • (2012) Nature , vol.488 , pp. 172-177
    • Atasoy, D.1    Betley, J.N.2    Su, H.H.3    Sternson, S.M.4
  • 96
    • 84859215897 scopus 로고    scopus 로고
    • Deciphering a neuronal circuit that mediates appetite
    • Wu, Q., Clark, M.S. & Palmiter, R.D. Deciphering a neuronal circuit that mediates appetite. Nature 483, 594-597 (2012).
    • (2012) Nature , vol.483 , pp. 594-597
    • Wu, Q.1    Clark, M.S.2    Palmiter, R.D.3
  • 97
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • Luquet, S., Perez, F.A., Hnasko, T.S. & Palmiter, R.D. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310, 683-685 (2005).
    • (2005) Science , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 98
    • 33846597193 scopus 로고    scopus 로고
    • NPY/AgRP neurons are not essential for feeding responses to glucoprivation
    • Luquet, S., Phillips, C.T. & Palmiter, R.D. NPY/AgRP neurons are not essential for feeding responses to glucoprivation. Peptides 28, 214-225 (2007).
    • (2007) Peptides , vol.28 , pp. 214-225
    • Luquet, S.1    Phillips, C.T.2    Palmiter, R.D.3
  • 99
    • 84860435420 scopus 로고    scopus 로고
    • Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production
    • Ramnanan, C.J., Edgerton, D.S. & Cherrington, A.D. Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production. Cell Metab. 15, 656-664 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 656-664
    • Ramnanan, C.J.1    Edgerton, D.S.2    Cherrington, A.D.3
  • 100
    • 84856442945 scopus 로고    scopus 로고
    • A guide to analysis of mouse energy metabolism
    • Tschöp, M.H. et al. A guide to analysis of mouse energy metabolism. Nat. Methods 9, 57-63 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 57-63
    • Tschöp, M.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.