Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β(IKKβ)/NF-κB pathway

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32324-32332

  Meng, Qingyuan ^a   Cai, Dongsheng ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY; BODY WEIGHT; CENTRAL CONTROL; CENTRAL NERVOUS SYSTEMS; CONTROL-CELL; ENERGY INTAKE; HIGH-FAT DIET; INSULIN RESISTANCE; KNOCKOUT MICE; METABOLIC CHANGES; METABOLIC REGULATIONS; METABOLIC TISSUES; MOUSE MODELS; PROINFLAMMATORY; REDUCED ENERGY; SITE-SPECIFIC; TISSUE HOMEOSTASIS; UNDERLYING MECHANISM; WHOLE-BODY;

ANTHROPOMETRY; BRAIN; ENZYMES; FEEDING; MAMMALS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TISSUE;

NUTRITION;

BIOLOGICAL MARKER; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; PROTEIN ATG7; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN FUNCTION; BRAIN REGION; CALORIC INTAKE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE COURSE; ENERGY EXPENDITURE; ENZYME ACTIVATION; FEEDING BEHAVIOR; HYPOTHALAMUS; INFLAMMATION; INSULIN RESISTANCE; LIPID DIET; MOUSE; NONHUMAN; OBESITY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; TISSUE DISTRIBUTION; WEIGHT GAIN;

ANIMALS; AUTOPHAGY; DIETARY FATS; DISEASE MODELS, ANIMAL; ENERGY INTAKE; ENERGY METABOLISM; HYPOTHALAMUS; I-KAPPA B KINASE; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NF-KAPPA B; OBESITY;

MUS;

EID: 80052712323     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.254417     Document Type: Article

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