Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity

Journal of Biological Chemistry

Volumn 285, Issue 20, 2010, Pages 15538-15547

  Susaki, Etsuo ^a,b   Kaneko Oshikawa, Chie ^a,b   Miyata, Keishi ^c   Tabata, Mitsuhisa ^c   Yamada, Tetsuya ^d   Oike, Yuichi ^c   Katagiri, Hideki ^d   Nakayama, Keiichi I ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEINS; AGGREGATE FORMATION; ANIMAL MODEL; BRAIN REGIONS; CAUSAL RELATIONSHIPS; CHAIN ELONGATION; CULTURED CELL; ENERGY EXPENDITURE; EXPERIMENTAL EVIDENCE; FOOD INTAKE; HYPOTHALAMIC NEURON; METABOLIC DISORDERS; NEURODEGENERATION; NEURODEGENERATIVE DISEASE; PUBLIC HEALTH; TRANSGENIC MICE; TRANSGENICS; UBIQUITIN;

AGGREGATES; DISEASES; MAMMALS; METABOLISM; NEURONS; PROTEINS;

NUTRITION;

ELONGATION FACTOR; ELONGATION FACTOR E4B; PROTEIN P62; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN FUNCTION; CELL AGGREGATION; CELL DEGENERATION; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME ACTIVITY; FEMALE; FOOD INTAKE; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HYPOTHALAMUS; MALE; METABOLIC DISORDER; MOUSE; NERVE DEGENERATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; SATIETY; TRANSGENE; UBIQUITINATION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; HYPOTHALAMUS; MICE; MICE, TRANSGENIC; NEURONS; OBESITY; PEPTIDE ELONGATION FACTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SATIETY RESPONSE; UBIQUITIN; UBIQUITINATION;

ANIMALIA; MAMMALIA; MUS; MUS MUSCULUS;

EID: 77952084417     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.105841     Document Type: Article

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