Chemistry and pharmacology of the Citrus bioflavonoid hesperidin

Phytotherapy Research

Volumn 15, Issue 8, 2001, Pages 655-669

  Garg, A ^a   Garg, S ^b   Zaneveld, L J D ^c   Singla, A K ^a  

^a PANJAB UNIVERSITY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Analysis; Bioflavonoid; Hesperetin; Hesperidin; Pharmacology

Indexed keywords

AMPHETAMINE DERIVATIVE; ANGIOPAN; ANTINEOPLASTIC AGENT; ASCORBIC ACID; BIOFLAVONOID; BUPHENINE; CALCIUM CHANNEL BLOCKING AGENT; CARBON 14; CEPEVIT K; DAFLON; DAFLON 500; DAUNORUBICIN; DIOSMIN; FLAVONOID; GUAIAC; HAMAMELIS EXTRACT; HEPANEPHROL; HEPANEPROL; HESPERETIN; HESPERIDIN; HY C; HYALURONIDASE; MIN DETOX C; NITRENDIPINE; ORAL CONTRACEPTIVE AGENT; OSTOCHORT; PERIDIN C; PLANT EXTRACT; PROVENO; RUBUS EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARICOSANOL FORTE; VINCRISTINE;

ANALGESIA; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ASCORBIC ACID DEFICIENCY; BLEEDING; CARDIOVASCULAR EFFECT; CITRUS FRUIT; CLINICAL ARTICLE; CONTRACEPTION; DRUG INDUCED DISEASE; DRUG SAFETY; FEMALE; FOOD DRUG INTERACTION; HEMORRHOID; HOT FLUSH; HUMAN; IMMUNOMODULATION; MALE; NONHUMAN; ONDASCORA; PASSIVE SKIN ANAPHYLAXIS; PHYTOTHERAPY; RADIATION PROTECTION; RAT; REVIEW; RHEUMATIC DISEASE; THROMBOCYTE AGGREGATION INHIBITION; ULCER; VASCULAR DISEASE; WOUND HEALING;

CITRUS; HESPERIDIN; HUMANS; PHYTOTHERAPY;

CITRUS;

EID: 0035667114     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1074     Document Type: Review

References (184)

1. An original microhaemorheological approach to the pharmacological effects of Daflon-500 mg in severe chronic venous insufficiency
2. Flavanone absorption after naringin, hesperidin and citrus administration
3. Study of the pharmacodynamic activity of Daflon-500 mg
4. Absolute configuration of (-) hesperetin and (-) liquiritigenin
5. Uber den einfluss von substanzen der flavon gruppe auf die permeabilitat der kapillaren. Vitamin P
6. An examination of the Rutaceae of Hong Kong. Part-I. Flavonoid glycosides from Zanthoxylum species and the occurence of optically active hesperidin
7. Flavanone glucosides(V): Reduction of flavanone and flavonol derivatives
8. In vitro anti-Helicobacter activity of some flavonoids and their metabolites
9. In vitro inhibitory effect of some flavonoids on rotavirus infectivity
10. Radioimmunoassay for the quantitative determination of hesperidin and analysis of its distribution in Citrus sinensis
11. Inhibitory action of vitamin-P compounds on hyaluronidase
12. Inhibition of hyaluronidase action by derivatives of hesperidin
13. Inhibitory effect of hesperidin on tumour initiation and promotion in mouse skin
14. Chemotaxonomy of Indigofera Linn
15. Mutagenic activity of quercetin and related compounds
16. Proprietes antiradicalaires antilipoperoxydantes et antioxydantes de flavonoides
17. Plasma and hepatic cholesterol hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA; Cholesterol transferase are lower in rats fed Citrus peel extract or a mixture of Citrus bioflavonoids
18. Flavonoids as potential protective agents against photo-oxidative skin damage
19. In vitro antioxidant activity and in vivo photoprotective effect of a red orange extract
20. Metabolic fate of hesperidin, eriodictyol, homoeriodictyol and diosmin
21. Effects of oral administration of different doses of purified micronized flavonoid fraction on microvascular reactivity after ischemia/reperfusion in the hamster cheek pouch
22. Effects of oral administration of purified micronised flavonoid fraction on increased microvascular permeability induced by various agents and on ischemia/reperfusion in diabetic hamsters
23. Micronised flavonoid therapy in internal hemorrhoids in pregnancy
24. Inhibition of bacterial mutagenesis by Citrus flavonoids
25. Analytical monitoring of citrus juices by using capillary electrophoresis
26. Liquid chromatographic/mass spectrometric determination of phenolic compounds using a capillary scale particle beam interface
27. Validation of a liquid chromatography ionspray mass spectrometry method for the analysis of flavanones, flavones and flavonols
28. Separation of flavonoids by reversed phase high performance liquid chromatography
29. 14C) hesperidin methylchalcone in the rat
30. Does phosphorylated hesperidin affect fertility?
31. Polyphenolic constituents from the leaves of Cynara species growing in Greece
32. Antimutagenic effects of plant flavonoids in the Salmonella assay system
33. Antihyperlipidemic effect of flavonoids from Prunus davidiana
34. A human model of gastric carcinogenesis
35. Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS
36. Therapeutic activity of micronized flavonoid fraction (Daflon-500 mg) in IUCD-induced bleeding
37. High-performance liquid chromatography of 34 selected flavonoids
38. Skin photosensitising agents and the role of reactive oxygen species in photoaging
39. Effect of chronic treatment with a purified flavonoid fraction on inflammatory granuloma in the rat. Study of prostaglandin E2 and F2 alpha and thromboxane B2 release and histological changes
40. Free radicals in cutaneous biology
41. Flavonoids function as antioxidants: By scavenging reactive oxygen species or by chelating iron?
42. Recovery of hesperidin from orange peel by concentration of extracts on styrene-divinylbenzene resin
43. Quantitative gas chromatographische bestimmung von rutin, hesperidin und naringenin in orangesaft
44. Modified H-point standard addition method and logarithmic function for the spectrometric and spectrodensitometric determination of hesperidin and diosmin in mixtures
45. Pharmacological evaluation of the anti-inflammatory activity of a Citrus bioflavonoid, hesperidin and the isoflavanoids duartin and claussequinone, in rats and mice
46. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice
47. Separation of honey flavonoids by micellar electrokinetic capillary chromatography
48. A HPLC method for the quantification of hesperidin in orange juice
49. Hydrolysis of flavonoid rhamnoglucosides to flavonoid glucosides
50. Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminiscence
51. Inhibition of neoplastic transformation and bioavailability of dietary flavonoid agents
52. Cellular basis of inflammation, edema and the activity of Daflon 500 mg
53. Oral administration of purified micronised flavonoid fraction suppresses leukocyte adhesion in ischemia-reperfusion injury: In-vivo observations in the hamster skin fold
54. Biological effects of hesperidin, a Citrus flavonoid. Part 1. Anti-inflammatory and analgesic activity
55. Biological effects of hesperidin, a Citrus flavonoid. Part 3. Antihypertensive and diuretic activity in the rat
56. Daflon-500 mg: International assessment of therapeutic interest for haemorrhoids
57. A long term treatment with a venotropic drug: Results on efficacy and safety of Daflon-500 mg in chronic venous insufficiency
58. Inhibitors of hyaluronidase
59. Comparative mutagenesis of plant flavonoids in microbial systems
60. Efficacy of micronised flavonoid fraction in healing of clean and infected wounds
61. The chemical nature of hesperidin and its experimental medicinal use as a source of vitamin-P: A review
62. Prospective randomised controlled trial of a micronised flavonoidic fraction to reduce bleeding after haemorrhoidectomy
63. Citrus flavonoids
64. Flavonoids of Citrus- VI
65. Anti-AIDS agents
66. Inhibition of xanthine oxidase by flavonoids
67. Effects of flavonoids on alkaline phosphatase
68. Effect of flavonoids on alpha-glucosidase and beta-fructosidase from yeast
69. Biological activities of the secondary metabolites isolated from Zieria smithi and Zanthoxylum elephantiasis on micro-organisms and brine shrimps
70. Antifertility substances
71. Mediators involved in inflammation: Effects of Daflon-500 mg on their release
72. Inhibition of aromatase activity by flavonoids
73. Flavonoids as anti-oxidants
74. Effect of hyaluronidase, beta-glucuronidase and beta-N-acetyl glucosaminidase inhibitors on sperm penetration of the mouse oocytes
75. Vaginal contraceptive activity of hyaluronidase and cyclooxygenase inhibitors in the rabbit
76. Spectral properties of flavonoid compounds
77. Flavonoid substances of Capsella Bursa Pastoris
78. Fluorimetric determination of hesperidin
79. Phenolic composition of various tissues of Rutaceae species
80. Antiviral effects of flavonoids on human viruses
81. Subchronic toxicity study of methyl hesperidin in mice
82. Colony stimulating factor inducing activity of hesperidin
83. Hesperidin as an inhibitor of lipases from porcine pancreas and Pseudomonas
84. Pharmacological activities of flavonoids (II) - Structure activity relationships of flavonoids in immunosuppression
85. Pharmacological activities of flavonoids (I)- Relationships of chemical structure of flavonoids and their inhibitory activity on hypersensitivities
86. Pharmacological activities of flavonoids. (II) Relationships of anti-inflammatory and anti-granulomatous actions
87. Intestinal bacterial metabolism of flavonoids and its relation to some biological activities
88. Inhibitory effect of herbal medicines on rotavirus infectivity
89. Permeation of hesperidin glycosides across Caco-2 cell monolayers via the paracellular pathway
90. Natural glucosides, Part 3
91. Flavonoids of the arial parts of Acinos suaveolens
92. Synthesis of neohesperidin glycosides and naringin glycosides by cyclodextrin gluconotransferase from an alkalophilic Bacillus Species
93. Transglycosylation of hesperidin by cyclodextrin glucotransferase from an alkalophilic Bacillus species in alkaline pH and properties of hesperidin glycosides
94. Adhesion molecule expression in post ischemic microvascular dysfunction: Activity of a micronised purified flavonoid fraction
95. Preventive effect of hesperidin against inflammation in CD-1 mouse skin caused by tumour promoter
96. Investigation of antifungal effect of flavonoids. Part 1
97. Uber die antioxidative aktivatät von zitrusfruchtschalen
98. Spectrophotometric investigation of the Cu(II)-hesperidin complex
99. Spectrophotometric investigation of the uranil(II)-hesperidin complex in 70% methanol
100. Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilisation in rat adipocytes
101. Hypocholesterolemic effect of hesperetin mediated by inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A: Cholesterol acyltransferase in rats fed high-cholesterol diet
102. Antiviral activity of some flavonoids on Herpes-simplex virus
103. Effects of flavonoids on the release of reactive oxygen species by stimulated human neutrophils
104. Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats
105. Protective effect of a purified flavonoid fraction against reactive oxygen radicals
106. Spectrophotometric determination of hesperidin by Al (III) - Hesperidin complex in water - Methanol solution
107. Inhibitors of 15-lipoxygenase from orange peel
108. 13C NMR of flavonoids-II
109. Effect of phosphorylated hesperidin, a hyaluronidase inhibitor on fertility in the rat
110. Pharmacological study of Citrus fruits (II) Anti-allergic effect of fruit of Citrus unshiu
111. Effect of a purified micronised fraction on in vivo platelet functions in the rat
112. Effects of flavonoids on daunomycin-induced toxicity in cultivated endothelial cells
113. Safety and security of Daflon-500 mg in venous insufficiency and in haemorrhoids disease
114. The flavonoids
115. The relative contributions of ascorbic acid and phenolic antioxidants to the total antioxidant activity of orange and apple fruit juices and blackcurrant drink
116. Effect of bioflavonoids on vincristine transport across blood-brain barrier
117. Isolation of glucosylflavone from lemon peel and antioxidative activity of flavonoid compounds in lemon fruit
118. Biological effects of hesperidin, a Citrus flavonoid. Part 2. Hypolipidemic activity on experimental hypercholesterolemia in the rat
119. Research for vitamin-P
120. Therapy approaches for lymphedema
121. Simultaneous separation of flavanone glycosides and polymethoxylated flavones in citrus juices using liquid chromatography
122. Column liquid chromatographic determination of flavanone glycosides in Citrus. Application to grapefruit and sour orange juice adulterations
123. Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids
124. Phenolics from Larix needles
125. 1H NMR spectra at 360 MHz of diosmin and hesperidin in DMSO solution
126. Determination of hesperidin by cathode stripping voltammetry in orange juice and helopyrin, a phytopharmaceutical preparation
127. Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases
128. Influence of flavonoids on combined experimental infections with EMC virus and Staphylococcus aureus in mice
129. Flavonoids of B. pendula Roth and B. obscura Kot leaves
130. Spectrofluorimetric determination of hesperidin by manual and flow injection methods
131. In-vivo and in-vitro inhibition of hyaluronidase by organic phosphates
132. Spectrophotometric determination of hesperidin by Zr(IV)-hesperidin complexation
133. Effects of flavonoids on nonenzymatic lipid peroxidation: Structure activity relationship
134. Effect of flavonoids on survival time of rats fed thrombogenic or atherogenic regimens
135. Effects of phenyl-benzo-gamma-pyrone derivatives (flavonoids) on blood cell aggregation: Basis for a concept of mode of action
136. Variance of common flavonoids by brand of grapefruit juice
137. Liquid chromatographic determination of naringin and neohesperidin as a detector of grapefruit juice and orange juice
138. Solid-phase extraction and HPLC determination of 4-vinyl guaicol and its precursor, ferulic acid, in orange juice
139. Influence of different penetration enhancers on in vitro skin permeation and in vivo photoprotective effects of flavonoids
140. Deficiency of vitamin-C and vitamin-P in man
141. Vitamins
142. Treatment of erythropoetic protoporphyria with hydroxyethylrutinosides
143. Determination of eight constituents of Hsia-cheng-chi-tang by high performance liquid chromatography
144. A new antifertility factor
145. Non hormonal control of vasomotor flushing in menopausal patients
146. Effects of rutin and hesperidin on total cholesterol concentration, transaminase and alkaline phosphatase activity in carbon tetrachloride treated rats
147. The hyaluronidase inhibiting and permeability reducing properties of hesperidin in isolated connective tissue membranes
148. Flavonoids: A review of the pharmacology and therapeutic efficacy of Daflon-500 mg in patients with chronic venous insufficiency and related disorders
149. Hesperidin and neohesperidin dihydrochalcone on different experimental models of induced gastric ulcer
150. In vitro scavenger and antioxidant properties of hesperidin and neohesperidin dihydrochalcone
151. Preparation of citrin
152. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin
153. Modulation of N- methyl-N-amylnitrosamine induced tumorigenesis by dietary feeding of diosmin and hesperidin, alone and in combination
154. Chemoprevention of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: Comparison with protective effects of beta carotene
155. Chemoprevention of 4-nitroquinoline-1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination
156. Antiviral activity of natural occurring flavonoids in vitro
157. Inhibition of lens aldose reductase by flavonoids - Their possible role in the prevention of diabetic cataracts
158. Determination of rutin and other flavonoids by flow-injection/adsorptive stripping voltammetry using nujol-graphite and diphenylether-graphite paste electrodes
159. Virus inhibition by hesperidin
160. Antiviral activity of plant components
161. Inhibition of the autooxidation of linoleic acid by flavonoids in micelles
162. Determination of hesperidin in Pericarpium Citri- Reticulatae by HPLC
163. Metabolism of phenolics in animals
164. A simultaneous determination of various main components in oriental pharmaceutical decoction "Heii-san" by ion-pair high-performance liquid chromatography
165. Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice
166. Flavonoids as superoxide scavengers and antioxidants
167. New natural inhibitors of platelet aggregation in vivo. Part I. Citroflavonoids and hesperidin
168. Effect of the citroflavonoids on platelet aggregation
169. Constituents from the roots of Acanthopanax setchuenensis
170. Preconcentration at a carbon-paste electrode and determination by adsorptive-stripping voltammetry of rutin and other flavonoids