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Volumn 43, Issue 1, 2013, Pages 15-28

Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices

Author keywords

Cytochromes P450; Enzyme induction; Phase II metabolism; Precision cut tissue slices

Indexed keywords

CYTOCHROME P450; DRUG METABOLIZING ENZYME; EPOXIDE HYDROLASE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; PHASE II ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFOTRANSFERASE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

EID: 84870557207     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.698766     Document Type: Review
Times cited : (25)

References (80)
  • 1
    • 77957876664 scopus 로고    scopus 로고
    • Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables
    • Abdull Razis AF, Bagatta M, De Nicola GR, Iori R, Ioannides C. (2010). Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables. Toxicology 277: 74-85.
    • (2010) Toxicology , vol.277 , pp. 74-85
    • Abdull Razis, A.F.1    Bagatta, M.2    De Nicola, G.R.3    Iori, R.4    Ioannides, C.5
  • 2
    • 79851510819 scopus 로고    scopus 로고
    • Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin
    • Abdull Razis AF, Bagatta M, De Nicola GR, Iori R, Ioannides C. (2011a). Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin. Lung Cancer 71: 298-305.
    • (2011) Lung Cancer , vol.71 , pp. 298-305
    • Abdull Razis, A.F.1    Bagatta, M.2    De Nicola, G.R.3    Iori, R.4    Ioannides, C.5
  • 3
    • 79955416779 scopus 로고    scopus 로고
    • The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer
    • Abdull Razis AF, Iori R, Ioannides C. (2011b). The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer 128: 2775-2782.
    • (2011) Int J Cancer , vol.128 , pp. 2775-2782
    • Abdull Razis, A.F.1    Iori, R.2    Ioannides, C.3
  • 4
    • 80052746485 scopus 로고    scopus 로고
    • Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: Importance of side-chain substituent and chirality
    • Abdull Razis AF, Bagatta M, De Nicola GR, Iori R, Ioannides C. (2011c). Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. Arch Toxicol 85: 919-927.
    • (2011) Arch Toxicol , vol.85 , pp. 919-927
    • Abdull Razis, A.F.1    Bagatta, M.2    De Nicola, G.R.3    Iori, R.4    Ioannides, C.5
  • 5
    • 84856955584 scopus 로고    scopus 로고
    • 4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent
    • Abdull Razis AF, De Nicola GR, Pagnotta E, Iori R, Ioannides C. (2012). 4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent. Arch Toxicol 86: 183-194.
    • (2012) Arch Toxicol , vol.86 , pp. 183-194
    • Abdull Razis, A.F.1    De Nicola, G.R.2    Pagnotta, E.3    Iori, R.4    Ioannides, C.5
  • 7
    • 0024465355 scopus 로고
    • Redox and addition chemistry of quinoid compounds and its biological implications
    • Brunmark A, Cadenas E. (1989). Redox and addition chemistry of quinoid compounds and its biological implications. Free Radic Biol Med 7: 435-477.
    • (1989) Free Radic Biol Med , vol.7 , pp. 435-477
    • Brunmark, A.1    Cadenas, E.2
  • 8
    • 33845188014 scopus 로고    scopus 로고
    • Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium
    • Catania JR, McGarrigle BP, Rittenhouse-Olson K, Olson Jr. A. (2007). Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium. Toxicol In Vitro 21: 109-115.
    • (2007) Toxicol in Vitro , vol.21 , pp. 109-115
    • Catania, J.R.1    McGarrigle, B.P.2    Rittenhouse-Olson, K.3    Olson Jr., A.4
  • 10
    • 23944483436 scopus 로고    scopus 로고
    • Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: Correlation study with induction in vivo
    • Cui X, Thomas A, Han Y, Palamanda J, Montgomery D, White RE, Morrison RA, Cheng KC. (2005). Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo. J Pharmacol Toxicol Methods 52: 234-243.
    • (2005) J Pharmacol Toxicol Methods , vol.52 , pp. 234-243
    • Cui, X.1    Thomas, A.2    Han, Y.3    Palamanda, J.4    Montgomery, D.5    White, R.E.6    Morrison, R.A.7    Cheng, K.C.8
  • 11
    • 10644271665 scopus 로고    scopus 로고
    • Induction of cytochromes P450
    • Dickins M. (2004). Induction of cytochromes P450. Curr Top Med Chem 4: 1745-1766.
    • (2004) Curr Top Med Chem , vol.4 , pp. 1745-1766
    • Dickins, M.1
  • 12
    • 0030273433 scopus 로고    scopus 로고
    • Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction
    • Drahushuk AT, McGarrigle BP, Tai HL, Kitareewan S, Goldstein JA, Olson Jr. (1996). Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction. Toxicol Appl Pharmacol 140: 393-403.
    • (1996) Toxicol Appl Pharmacol , vol.140 , pp. 393-403
    • Drahushuk, A.T.1    McGarrigle, B.P.2    Tai, H.L.3    Kitareewan, S.4    Goldstein, J.A.5    Olson, J.R.6
  • 13
    • 0031679527 scopus 로고    scopus 로고
    • Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture
    • Drahushuk AT, McGarrigle BP, Larsen KE, Stegeman JJ, Olson Jr. (1998). Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture. Carcinogenesis 19: 1361-1368.
    • (1998) Carcinogenesis , vol.19 , pp. 1361-1368
    • Drahushuk, A.T.1    McGarrigle, B.P.2    Larsen, K.E.3    Stegeman, J.J.4    Olson, J.R.5
  • 14
    • 0033105881 scopus 로고    scopus 로고
    • Time- and concentration-dependent induction of CYP1A1 and CYP1A2 in precision-cut rat liver slices incubated in dynamic organ culture in the presence of 2,3,7,8-tetrachlorodibenzo-pdioxin
    • Drahushuk AT, McGarrigle BP, Slezak BP, Stegeman JJ, Olson Jr. (1999). Time- and concentration-dependent induction of CYP1A1 and CYP1A2 in precision-cut rat liver slices incubated in dynamic organ culture in the presence of 2,3,7,8-tetrachlorodibenzo-pdioxin. Toxicol Appl Pharmacol 155: 127-138.
    • (1999) Toxicol Appl Pharmacol , vol.155 , pp. 127-138
    • Drahushuk, A.T.1    McGarrigle, B.P.2    Slezak, B.P.3    Stegeman, J.J.4    Olson, J.R.5
  • 17
    • 0029147940 scopus 로고
    • Ethoxycoumarin O-deethylation (ECOD) activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitro
    • Glockner R, Muller D. (1995). Ethoxycoumarin O-deethylation (ECOD) activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitro. Exp Toxicol Pathol 47: 319-324.
    • (1995) Exp Toxicol Pathol , vol.47 , pp. 319-324
    • Glockner, R.1    Muller, D.2
  • 18
    • 0031654545 scopus 로고    scopus 로고
    • Application of cryopreserved precision-cut liver slices in pharmacotoxicology- principles, literature data and own investigations with special reference to CYP1A1-mRNA induction
    • Glöckner R, Steinmetzer P, Drobner C, Müller D. (1998). Application of cryopreserved precision-cut liver slices in pharmacotoxicology- principles, literature data and own investigations with special reference to CYP1A1-mRNA induction. Exp Toxicol Pathol 50: 440-449.
    • (1998) Exp Toxicol Pathol , vol.50 , pp. 440-449
    • Glöckner, R.1    Steinmetzer, P.2    Drobner, C.3    Müller, D.4
  • 19
    • 0008792569 scopus 로고    scopus 로고
    • Use of fresh and cryopreserved human liver slices in toxicology with special reference to in vitro induction of cytochrome P450
    • Glöckner R, Steinmetzer P, Drobner C, Müller D. (1999). Use of fresh and cryopreserved human liver slices in toxicology with special reference to in vitro induction of cytochrome P450. Toxicol In Vitro 13: 531-535.
    • (1999) Toxicol in Vitro , vol.13 , pp. 531-535
    • Glöckner, R.1    Steinmetzer, P.2    Drobner, C.3    Müller, D.4
  • 20
    • 0035925663 scopus 로고    scopus 로고
    • Monooxygenation, conjugation and other functions in cryopreserved rat liver slices until 24 h after thawing
    • Glöckner R, Rost M, Pissowotzki K, Müller D. (2001). Monooxygenation, conjugation and other functions in cryopreserved rat liver slices until 24 h after thawing. Toxicology 161: 103-109.
    • (2001) Toxicology , vol.161 , pp. 103-109
    • Glöckner, R.1    Rost, M.2    Pissowotzki, K.3    Müller, D.4
  • 21
    • 0037100093 scopus 로고    scopus 로고
    • In vitro induction of cytochrome P450 2B1- and 3A1-mRNA and enzyme immunostaining in cryopreserved precision-cut rat liver slices
    • Glöckner R, Steinmetzer P, Lupp A, Danz M, Müller D. (2002). In vitro induction of cytochrome P450 2B1- and 3A1-mRNA and enzyme immunostaining in cryopreserved precision-cut rat liver slices. Toxicology 176: 187-193.
    • (2002) Toxicology , vol.176 , pp. 187-193
    • Glöckner, R.1    Steinmetzer, P.2    Lupp, A.3    Danz, M.4    Müller, D.5
  • 22
    • 0037963570 scopus 로고    scopus 로고
    • In vitro induction of cytochrome P4503A1-mRNA and testosterone hydroxylation in precision-cut liver slices from male and female rats
    • Glöckner R, Wagener J, Lieder A, Müller D. (2003). In vitro induction of cytochrome P4503A1-mRNA and testosterone hydroxylation in precision-cut liver slices from male and female rats. Exp Toxicol Pathol 54: 411-415.
    • (2003) Exp Toxicol Pathol , vol.54 , pp. 411-415
    • Glöckner, R.1    Wagener, J.2    Lieder, A.3    Müller, D.4
  • 23
    • 54949088993 scopus 로고    scopus 로고
    • Determination of CYP activity in precision-cut liver slices: Whether to use intact slices or slice homogenate
    • Glöckner R, Lieder A, Lupp A. (2008). Determination of CYP activity in precision-cut liver slices: whether to use intact slices or slice homogenate. Anal Bioanal Chem 392: 1167-1172.
    • (2008) Anal Bioanal Chem , vol.392 , pp. 1167-1172
    • Glöckner, R.1    Lieder, A.2    Lupp, A.3
  • 24
    • 0030966935 scopus 로고    scopus 로고
    • Cytochrome P450 isoenzyme activities in cultured rat and mouse liver slices
    • Gokhale MS, Bunton TE, Zurlo J, Yager JD. (1997). Cytochrome P450 isoenzyme activities in cultured rat and mouse liver slices. Xenobiotica 27: 341-355.
    • (1997) Xenobiotica , vol.27 , pp. 341-355
    • Gokhale, M.S.1    Bunton, T.E.2    Zurlo, J.3    Yager, J.D.4
  • 25
    • 56749175044 scopus 로고    scopus 로고
    • Induction of drug metabolism: Species differences and toxicological relevance
    • Graham MJ, Lake BG. (2008). Induction of drug metabolism: species differences and toxicological relevance. Toxicology 254: 184-191.
    • (2008) Toxicology , vol.254 , pp. 184-191
    • Graham, M.J.1    Lake, B.G.2
  • 26
    • 53249140296 scopus 로고    scopus 로고
    • Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane
    • Hanlon N, Coldham N, Sauer MJ, Ioannides C. (2008). Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane. Toxicology 252: 92-98.
    • (2008) Toxicology , vol.252 , pp. 92-98
    • Hanlon, N.1    Coldham, N.2    Sauer, M.J.3    Ioannides, C.4
  • 27
    • 57649184041 scopus 로고    scopus 로고
    • Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane
    • Hanlon N, Coldham N, Sauer MJ, Ioannides C. (2009a). Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane. Chem Biol Interact 177: 115-120.
    • (2009) Chem Biol Interact , vol.177 , pp. 115-120
    • Hanlon, N.1    Coldham, N.2    Sauer, M.J.3    Ioannides, C.4
  • 28
    • 68149167105 scopus 로고    scopus 로고
    • The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H: Quinone oxidoreductase (NQO1) in human liver compared with rat
    • Hanlon N, Poynton CL, Coldham N, Sauer MJ, Ioannides C. (2009b). The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H: quinone oxidoreductase (NQO1) in human liver compared with rat. Mol Nutr Food Res 53: 836-844.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 836-844
    • Hanlon, N.1    Poynton, C.L.2    Coldham, N.3    Sauer, M.J.4    Ioannides, C.5
  • 29
    • 33645240574 scopus 로고    scopus 로고
    • Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene
    • Harrigan JA, McGarrigle BP, Sutter TR, Olson Jr. (2006). Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. Toxicol In Vitro 20: 426-438.
    • (2006) Toxicol in Vitro , vol.20 , pp. 426-438
    • Harrigan, J.A.1    McGarrigle, B.P.2    Sutter, T.R.3    Olson, J.R.4
  • 31
    • 0032973226 scopus 로고    scopus 로고
    • Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: A comparison of the dynamic organ and multiwell plate culture procedures
    • Hashemi E, Dobrota M, Till C, Ioannides C. (1999a). Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: a comparison of the dynamic organ and multiwell plate culture procedures. Xenobiotica 29: 11-25.
    • (1999) Xenobiotica , vol.29 , pp. 11-25
    • Hashemi, E.1    Dobrota, M.2    Till, C.3    Ioannides, C.4
  • 32
    • 0032866860 scopus 로고    scopus 로고
    • Stability of phase II conjugation systems in cultured precision-cut rat hepatic slices
    • Hashemi E, Till C, Ioannides C. (1999b). Stability of Phase II Conjugation Systems in Cultured Precision-cut Rat Hepatic Slices. Toxicol In Vitro 13: 459-466.
    • (1999) Toxicol in Vitro , vol.13 , pp. 459-466
    • Hashemi, E.1    Till, C.2    Ioannides, C.3
  • 33
    • 0034699048 scopus 로고    scopus 로고
    • Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices
    • Hashemi E, Till C, Ioannides C. (2000). Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices. Toxicology 149: 51-61.
    • (2000) Toxicology , vol.149 , pp. 51-61
    • Hashemi, E.1    Till, C.2    Ioannides, C.3
  • 34
    • 0030904341 scopus 로고    scopus 로고
    • In vitro modulation of the P450 activities of hamster and human lung slices
    • Hoet PH, Demedts M, Nemery B. (1997). In vitro modulation of the P450 activities of hamster and human lung slices. Cell Biol Toxicol 13: 185-192.
    • (1997) Cell Biol Toxicol , vol.13 , pp. 185-192
    • Hoet, P.H.1    Demedts, M.2    Nemery, B.3
  • 35
    • 0036401287 scopus 로고    scopus 로고
    • Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung
    • Hukkanen J, Pelkonen O, Hakkola J, Raunio H. (2002). Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung. Crit Rev Toxicol 32: 391-411.
    • (2002) Crit Rev Toxicol , vol.32 , pp. 391-411
    • Hukkanen, J.1    Pelkonen, O.2    Hakkola, J.3    Raunio, H.4
  • 36
    • 0036304016 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between herbal remedies and medicinal drugs
    • Ioannides C. (2002a). Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 32: 451-478.
    • (2002) Xenobiotica , vol.32 , pp. 451-478
    • Ioannides, C.1
  • 38
    • 10844224317 scopus 로고    scopus 로고
    • Cytochromes P450 in the bioactivation of chemicals
    • Ioannides C, Lewis DF. (2004). Cytochromes P450 in the bioactivation of chemicals. Curr Top Med Chem 4: 1767-1788.
    • (2004) Curr Top Med Chem , vol.4 , pp. 1767-1788
    • Ioannides, C.1    Lewis, D.F.2
  • 39
    • 84870519807 scopus 로고    scopus 로고
    • Precision-cut tissue slicers: A suitable in vitro system for the study of induction of drug-metabolizing enzyme systems
    • Lyubinov AV, ed. John Wiley & Sons, In press
    • Ioannides C, Lake BG. (2012). Precision-cut tissue slicers: A suitable in vitro system for the study of induction of drug-metabolizing enzyme systems. In: Lyubinov AV, ed. Encyclopedia of Drug Metabolism and Interactions. John Wiley & Sons, In press.
    • (2012) Encyclopedia of Drug Metabolism and Interactions
    • Ioannides, C.1    Lake, B.G.2
  • 40
    • 62949110630 scopus 로고    scopus 로고
    • Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver
    • Khan AA, Chow EC, van Loenen-Weemaes AM, Porte RJ, Pang KS, Groothuis GM. (2009). Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. Eur J Pharm Sci 37: 115-125.
    • (2009) Eur J Pharm Sci , vol.37 , pp. 115-125
    • Khan, A.A.1    Chow, E.C.2    Van Loenen-Weemaes, A.M.3    Porte, R.J.4    Pang, K.S.5    Groothuis, G.M.6
  • 41
    • 59149090185 scopus 로고    scopus 로고
    • Coordinate regulation of human drugmetabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor
    • Köhle C, Bock KW. (2009). Coordinate regulation of human drugmetabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor. Biochem Pharmacol 77: 689-699.
    • (2009) Biochem Pharmacol , vol.77 , pp. 689-699
    • Köhle, C.1    Bock, K.W.2
  • 42
    • 79952196644 scopus 로고    scopus 로고
    • Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate
    • Konsue N, Ioannides C. (2010). Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate. Mol Nutr Food Res 54: 1477-1485.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 1477-1485
    • Konsue, N.1    Ioannides, C.2
  • 43
    • 0031678607 scopus 로고    scopus 로고
    • Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin
    • Kuhn UD, Splinter FK, Rost M, Müller D. (1998). Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin. Exp Toxicol Pathol 50: 491-496.
    • (1998) Exp Toxicol Pathol , vol.50 , pp. 491-496
    • Kuhn, U.D.1    Splinter, F.K.2    Rost, M.3    Müller, D.4
  • 44
    • 0035029783 scopus 로고    scopus 로고
    • Para-nitrophenol glucuronidation and sulfation in rat and human liver slices
    • Kuhn UD, Rost M, Müller D. (2001). Para-nitrophenol glucuronidation and sulfation in rat and human liver slices. Exp Toxicol Pathol 53: 81-87.
    • (2001) Exp Toxicol Pathol , vol.53 , pp. 81-87
    • Kuhn, U.D.1    Rost, M.2    Müller, D.3
  • 46
    • 0030009552 scopus 로고    scopus 로고
    • Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices
    • Lake BG, Charzat C, Tredger JM, Renwick AB, Beamand JA, Price RJ. (1996). Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices. Xenobiotica 26: 297-306.
    • (1996) Xenobiotica , vol.26 , pp. 297-306
    • Lake, B.G.1    Charzat, C.2    Tredger, J.M.3    Renwick, A.B.4    Beamand, J.A.5    Price, R.J.6
  • 47
    • 0043166499 scopus 로고    scopus 로고
    • Use of cultured precision-cut rat lung slices to study the in vitro induction of pulmonary cytochrome P450 forms
    • Lake BG, Meredith C, Scott MP, Renwick AB, Price RJ. (2003). Use of cultured precision-cut rat lung slices to study the in vitro induction of pulmonary cytochrome P450 forms. Xenobiotica 33: 691-702.
    • (2003) Xenobiotica , vol.33 , pp. 691-702
    • Lake, B.G.1    Meredith, C.2    Scott, M.P.3    Renwick, A.B.4    Price, R.J.5
  • 48
    • 0035925660 scopus 로고    scopus 로고
    • Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices
    • Lupp A, Danz M, Müller D. (2001). Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices. Toxicology 161: 53-66.
    • (2001) Toxicology , vol.161 , pp. 53-66
    • Lupp, A.1    Danz, M.2    Müller, D.3
  • 49
    • 0036890447 scopus 로고    scopus 로고
    • Cryopreserved precision-cut rat liver slices: Morphology and cytochrome P450 isoforms expression after prolonged incubation
    • Lupp A, Glöckner R, Danz M, Müller D. (2002). Cryopreserved precision-cut rat liver slices: morphology and cytochrome P450 isoforms expression after prolonged incubation. Toxicol In Vitro 16: 749-758.
    • (2002) Toxicol in Vitro , vol.16 , pp. 749-758
    • Lupp, A.1    Glöckner, R.2    Danz, M.3    Müller, D.4
  • 50
    • 10044256659 scopus 로고    scopus 로고
    • Histomorphological changes and cytochrome P450 isoforms expression and activities in precisioncut liver slices from neonatal rats
    • Lupp A, Danz M, Müller D. (2005). Histomorphological changes and cytochrome P450 isoforms expression and activities in precisioncut liver slices from neonatal rats. Toxicology 206: 427-438.
    • (2005) Toxicology , vol.206 , pp. 427-438
    • Lupp, A.1    Danz, M.2    Müller, D.3
  • 51
    • 54949138787 scopus 로고    scopus 로고
    • Precision-cut liver slices from rats of different ages: Basal cytochrome P450-dependent monooxygenase activities and inducibility
    • Lupp A, Glöckner R, Etzrodt J, Müller D. (2008). Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility. Anal Bioanal Chem 392: 1173-1184.
    • (2008) Anal Bioanal Chem , vol.392 , pp. 1173-1184
    • Lupp, A.1    Glöckner, R.2    Etzrodt, J.3    Müller, D.4
  • 52
    • 0242657450 scopus 로고    scopus 로고
    • Phase i and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation
    • Martignoni M, Monshouwer M, de Kanter R, Pezzetta D, Moscone A, Grossi P. (2004). Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation. Toxicol In Vitro 18: 121-128.
    • (2004) Toxicol in Vitro , vol.18 , pp. 121-128
    • Martignoni, M.1    Monshouwer, M.2    De Kanter, R.3    Pezzetta, D.4    Moscone, A.5    Grossi, P.6
  • 53
    • 29144489368 scopus 로고    scopus 로고
    • An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR
    • Martignoni M, de Kanter R, Grossi P, Saturno G, Barbaria E, Monshouwer M. (2006). An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR. Toxicol In Vitro 20: 125-131.
    • (2006) Toxicol in Vitro , vol.20 , pp. 125-131
    • Martignoni, M.1    De Kanter, R.2    Grossi, P.3    Saturno, G.4    Barbaria, E.5    Monshouwer, M.6
  • 55
    • 0038509963 scopus 로고    scopus 로고
    • Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices
    • Meredith C, Scott MP, Renwick AB, Price RJ, Lake BG. (2003). Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices. Xenobiotica 33: 511-527.
    • (2003) Xenobiotica , vol.33 , pp. 511-527
    • Meredith, C.1    Scott, M.P.2    Renwick, A.B.3    Price, R.J.4    Lake, B.G.5
  • 56
    • 0342656975 scopus 로고    scopus 로고
    • Induction of cytochrome P450 2B1-mRNA and pentoxyresorufin O-depentylation after exposure of precision-cut rat liver slices to phenobarbital
    • Müller D, Steinmetzer P, Pissowotzki K, Glöckner R. (2000). Induction of cytochrome P450 2B1-mRNA and pentoxyresorufin O-depentylation after exposure of precision-cut rat liver slices to phenobarbital. Toxicology 144: 93-97.
    • (2000) Toxicology , vol.144 , pp. 93-97
    • Müller, D.1    Steinmetzer, P.2    Pissowotzki, K.3    Glöckner, R.4
  • 57
    • 19444379050 scopus 로고    scopus 로고
    • Interaction of St. John's Wort with oral contraceptives: Effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding
    • Murphy PA, Kern SE, Stanczyk FZ, WesthoffCL. (2005). Interaction of St. John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. Contraception 71: 402-408.
    • (2005) Contraception , vol.71 , pp. 402-408
    • Murphy, P.A.1    Kern, S.E.2    Stanczyk, F.Z.3    Westhoff, C.L.4
  • 59
    • 0036746796 scopus 로고    scopus 로고
    • Use of a quantitative real-time reverse transcriptionpolymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices
    • Pan J, Xiang Q, Renwick AB, Price RJ, Ball SE, Kao J, Scatina JA, Lake BG. (2002). Use of a quantitative real-time reverse transcriptionpolymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. Xenobiotica 32: 739-747.
    • (2002) Xenobiotica , vol.32 , pp. 739-747
    • Pan, J.1    Xiang, Q.2    Renwick, A.B.3    Price, R.J.4    Ball, S.E.5    Kao, J.6    Scatina, J.A.7    Lake, B.G.8
  • 61
    • 32244447844 scopus 로고    scopus 로고
    • Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans
    • Persson KP, Ekehed S, Otter C, Lutz ES, McPheat J, Masimirembwa CM, Andersson TB. (2006). Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans. Pharm Res 23: 56-69.
    • (2006) Pharm Res , vol.23 , pp. 56-69
    • Persson, K.P.1    Ekehed, S.2    Otter, C.3    Lutz, E.S.4    McPheat, J.5    Masimirembwa, C.M.6    Andersson, T.B.7
  • 62
    • 0038573535 scopus 로고    scopus 로고
    • Glucuronidation of 4-methylumbelliferone and 4-hydroxybiphenyl and in vitro induction of UDP-glucuronosyltransferase 2B12-mRNA in precision-cut rat liver slices
    • Pissowotzki K, Glöckner R, Müller D. (2003). Glucuronidation of 4-methylumbelliferone and 4-hydroxybiphenyl and in vitro induction of UDP-glucuronosyltransferase 2B12-mRNA in precision-cut rat liver slices. Exp Toxicol Pathol 54: 489-492.
    • (2003) Exp Toxicol Pathol , vol.54 , pp. 489-492
    • Pissowotzki, K.1    Glöckner, R.2    Müller, D.3
  • 63
    • 1642493711 scopus 로고    scopus 로고
    • Metabolism of nicotine and induction of CYP1A forms in precision-cut rat liver and lung slices
    • Price RJ, Renwick AB, Walters DG, Young PJ, Lake BG. (2004). Metabolism of nicotine and induction of CYP1A forms in precision-cut rat liver and lung slices. Toxicol In Vitro 18: 179-185.
    • (2004) Toxicol in Vitro , vol.18 , pp. 179-185
    • Price, R.J.1    Renwick, A.B.2    Walters, D.G.3    Young, P.J.4    Lake, B.G.5
  • 64
    • 33846844804 scopus 로고    scopus 로고
    • Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities
    • Pushparajah DS, Umachandran M, Plant KE, Plant N, Ioannides C. (2007). Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities. Toxicology 231: 68-80.
    • (2007) Toxicology , vol.231 , pp. 68-80
    • Pushparajah, D.S.1    Umachandran, M.2    Plant, K.E.3    Plant, N.4    Ioannides, C.5
  • 65
    • 37249077516 scopus 로고    scopus 로고
    • Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; Association with the Ah locus and importance of molecular size
    • Pushparajah DS, Umachandran M, Nazir T, Plant KE, Plant N, Lewis DF, Ioannides C. (2008a). Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. Toxicol In Vitro 22: 128-145.
    • (2008) Toxicol in Vitro , vol.22 , pp. 128-145
    • Pushparajah, D.S.1    Umachandran, M.2    Nazir, T.3    Plant, K.E.4    Plant, N.5    Lewis, D.F.6    Ioannides, C.7
  • 66
    • 46349100716 scopus 로고    scopus 로고
    • Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; Comparison with rat liver and lung
    • Pushparajah DS, Umachandran M, Plant KE, Plant N, Ioannides C. (2008b). Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung. Mutagenesis 23: 299-308.
    • (2008) Mutagenesis , vol.23 , pp. 299-308
    • Pushparajah, D.S.1    Umachandran, M.2    Plant, K.E.3    Plant, N.4    Ioannides, C.5
  • 67
    • 40649116713 scopus 로고    scopus 로고
    • Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: Studies using precision-cut tissue slices
    • Pushparajah DS, Umachandran M, Plant KE, Plant N, Ioannides C. (2008c). Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices. Mutat Res 640: 153-161.
    • (2008) Mutat Res , vol.640 , pp. 153-161
    • Pushparajah, D.S.1    Umachandran, M.2    Plant, K.E.3    Plant, N.4    Ioannides, C.5
  • 70
    • 0034764793 scopus 로고    scopus 로고
    • Contribution of CYP1A2 in the hepatic metabolism of melatonin: Studies with isolated microsomal preparations and liver slices
    • Skene DJ, Papagiannidou E, Hashemi E, Snelling J, Lewis DF, Fernandez M, Ioannides C. (2001). Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices. J Pineal Res 31: 333-342.
    • (2001) J Pineal Res , vol.31 , pp. 333-342
    • Skene, D.J.1    Papagiannidou, E.2    Hashemi, E.3    Snelling, J.4    Lewis, D.F.5    Fernandez, M.6    Ioannides, C.7
  • 71
    • 58149327483 scopus 로고    scopus 로고
    • Glucosinolates, isothiocyanates and human health
    • Traka M, Mithen R. (2009). Glucosinolates, isothiocyanates and human health. Phytochem Rev 8: 269-282.
    • (2009) Phytochem Rev , vol.8 , pp. 269-282
    • Traka, M.1    Mithen, R.2
  • 72
    • 8444237430 scopus 로고    scopus 로고
    • Metabolic and structural viability of precision-cut rat lung slices in culture
    • Umachandran M, Howarth J, Ioannides C. (2004). Metabolic and structural viability of precision-cut rat lung slices in culture. Xenobiotica 34: 771-780.
    • (2004) Xenobiotica , vol.34 , pp. 771-780
    • Umachandran, M.1    Howarth, J.2    Ioannides, C.3
  • 73
    • 33745203083 scopus 로고    scopus 로고
    • Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72 h
    • Umachandran M, Ioannides C. (2006). Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72 h. Toxicology 224: 14-21.
    • (2006) Toxicology , vol.224 , pp. 14-21
    • Umachandran, M.1    Ioannides, C.2
  • 74
    • 27544446645 scopus 로고    scopus 로고
    • Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies
    • van de Kerkhof EG, de Graaf IAM, de Jager MH, Meijer DKF, Groothuis GMM. (2005). Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. Drug Met Disp 33: 1613-1620.
    • (2005) Drug Met Disp , vol.33 , pp. 1613-1620
    • Van De Kerkhof, E.G.1    De Graaf, I.A.M.2    De Jager, M.H.3    Meijer, D.K.F.4    Groothuis, G.M.M.5
  • 75
    • 34249034398 scopus 로고    scopus 로고
    • Induction of Phase i and Phase II drug metabolism in rat and small intestine and colon in vitro
    • van de Kerkhof EG, de Graaf IAM, de Jager MH, Groothuis GMM. (2007). Induction of Phase I and Phase II drug metabolism in rat and small intestine and colon in vitro. Drug Met Disp 35: 898-907.
    • (2007) Drug Met Disp , vol.35 , pp. 898-907
    • Van De Kerkhof, E.G.1    De Graaf, I.A.M.2    De Jager, M.H.3    Groothuis, G.M.M.4
  • 76
    • 40849104960 scopus 로고    scopus 로고
    • Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro
    • van de Kerkhof EG, de Graaf IAM, Ungell A-LB, Groothuis GMM. (2008). Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Met Disp 36: 604-613.
    • (2008) Drug Met Disp , vol.36 , pp. 604-613
    • Van De Kerkhof, E.G.1    De Graaf, I.A.M.2    A-Lb, U.3    Groothuis, G.M.M.4
  • 78
    • 4744361539 scopus 로고    scopus 로고
    • The use of precisioncut liver slices from male Wistar rats as a tool to study age related changes in CYP3A induction and in formation of paracetamol conjugates
    • Wauthier V, Verbeeck RK, Buc Calderon P. (2004). The use of precisioncut liver slices from male Wistar rats as a tool to study age related changes in CYP3A induction and in formation of paracetamol conjugates. Toxicol In Vitro 18: 879-885.
    • (2004) Toxicol in Vitro , vol.18 , pp. 879-885
    • Wauthier, V.1    Verbeeck, R.K.2    Buc Calderon, P.3
  • 80
    • 45249121177 scopus 로고    scopus 로고
    • Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
    • Zhou SF. (2008). Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab 9: 310-322.
    • (2008) Curr Drug Metab , vol.9 , pp. 310-322
    • Zhou, S.F.1


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