Tissue slices revisited: Evaluation and development of a short-term incubation for integrated drug metabolism

Drug Metabolism and Disposition

Volumn 29, Issue 10, 2001, Pages 1337-1342

  Thohan, Sanjeev ^a   Zurich, Marylynn C ^b   Chung, Ho ^c   Weiner, Myron ^d   Kane, Andrew S ^e   Rosen, Gerald M ^d  

^a ASTRAZENECA   (United Kingdom)

^b Zurich Toxicology Consulting   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

^e UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN DERIVATIVE; LACTATE DEHYDROGENASE; O DEMETHYLASE; OXYGEN; TITANIUM;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOARCHITECTURE; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME ACTIVITY; EXPERIMENTAL MODEL; INCUBATION TIME; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE SLICE;

ANIMALS; COUMARINS; LIVER; MALE; METHODS; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; UMBELLIFERONES;

EID: 0034829036     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Serum lactic dehydrogenase: An analytical assessment of current assays
2. [14C]-Ethoxycoumarin metabolism by precision-cut rat hepatic slices
3. Liver slices in dynamic organ culture. I: An alternative in vitro technique for the study of rat hepatic drug metabolism
4. Liver slices in dynamic organ culture. II: An in vitro cellular technique for the study of integrated drug metabolism using human tissue
5. Comparison of caffeine metabolism by slices, microsomes and hepatocyte cultures from adult human liver
6. A rapid and sensitive method for quantitation of microgram quantities of protein using the principle of protein-dye binding
7. Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity
8. Gender aspects of liver slice incubations with cultures of human liver slices
9. Development of a simple incubation system for metabolism studies with precision-cut liver slices
10. A species comparison of tolbutamide metabolism in precision-cut liver slices from rats and dogs
11. Past, present and future applications of precision-cut liver slices for in vitro xenobiotic metabolism
12. Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes
13. Xenobiotic metabolism in rat dog, and human precision-cut liver slices, freshly isolated hepatocytes and vitrified precision-cut liver slices
14. Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices: Optimization of tissue culture, part 1
15. An improved assay for 7-ethoxycoumarin O-deethylase activity induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin
16. Suicide inactivation of rat liver cytochrome P-450 by chloramphenicol in vivo and in vitro
17. Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: A comparison of the dynamic organ and multiwell plate culture procedures
18. Dynamic culture of fish hepatic tissue slices to assess phase I and phase II biotransformation
19. Biotransformation of coumarin derivatives (2) oxidative metabolism of 7-alkoxycoumarin by microsomal enzymes and a simple assay procedure for 7-alkoxycoumarin O-dealkylase
20. Characterization of olanzapine (LY170053) in human liver slices by liquid chromatography/tandem mass spectrometry
21. Comparison of five incubation systems for rat liver slices using functional and viability parameters
22. In vitro cytotoxicity of allyl alcohol and bromobenzenes in a novel organ culture system
23. Dynamic organic culture of precision cut liver slices for in vitro toxicology
24. Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices
25. Cytotoxicity profiles for a series of investigational compounds using liver slice technology and human derived cell cultures
26. Morphological and functional integrity of precision-cut rat liver slices in rotating organ culture and multiwell plate culture: Effects of oxygen tension
27. In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slices
28. Preparation and properties of partially purified cytochrome P-450 and reduced NADPH P-450 redactase from rabbit liver microsomes
29. An improved HPLC assay for the assessment of liver slice metabolic viability using 7-ethoxycoumarin
30. Kinetics of drug metabolism in rat liver slices: Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds
31. Kinetics of drug metabolism in rat liver slices: Relationship between metabolic clearance and slice uptake rate
32. Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition
33. Comparative metabolism of clenbuterol by rat and bovine liver microsomes and slices