Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues

Toxicology and Applied Pharmacology

Volumn 244, Issue 3, 2010, Pages 354-365

  Vickers, Alison E M ^a   Sinclair, John R ^a   Fisher, Robyn L ^b   Morris, Stephen R ^a   Way, William ^a  

^a ALLERGAN INC   (United States)

^b NONE

Author keywords

Dog and human tissue; Oxidative stress and in vitro hemolysis model with rat

Indexed keywords

CELL PROTEIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HAPTOGLOBIN; HEMOGLOBIN; IMIDAZOLE; INTERLEUKIN 6; INTERLEUKIN 8; LECTIN; LIVER PROTEIN; PEROXIREDOXIN 1; PROTEIN GCLC; PROTEIN HMOX1; PROTEIN LGALS3; PROTEIN SLC40A1; THIAMAZOLE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CATION TRANSPORT PROTEIN; HEME OXYGENASE 1; HMOX1 PROTEIN, HUMAN; METAL TRANSPORTING PROTEIN 1; PEROXIREDOXIN; PRDX1 PROTEIN, HUMAN;

ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BLOOD TOXICITY; CELL TRANSPORT; COCULTURE; CONTROLLED STUDY; CYTOTOXICITY; DOG; ERYTHROCYTE; FEMALE; GENE EXPRESSION REGULATION; HEMOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IRON TRANSPORT; KUPFFER CELL; LIVER; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN DEGRADATION; RAT; TISSUE CULTURE; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DONOR; DRUG EFFECT; GENE EXPRESSION; METABOLISM; SPRAGUE DAWLEY RAT;

CANIS FAMILIARIS; RATTUS;

ANIMALS; BIOLOGICAL MARKERS; CATION TRANSPORT PROTEINS; COCULTURE TECHNIQUES; DOGS; ERYTHROCYTES; FEMALE; GENE EXPRESSION; HEME OXYGENASE-1; HEMOLYSIS; HUMANS; LIVER; MALE; METHIMAZOLE; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PEROXIREDOXINS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DONORS; UP-REGULATION;

EID: 77950501295     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.01.017     Document Type: Article

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