-
1
-
-
0029027857
-
Prediction of in vivo disposition from in vitro systems: Clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data
-
ASHFORTH, E. I. L., CARLILE, D. J., CHENERY, R. and HOUSTON, J. B., 1995, Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data. Journal of Pharmacology and Experimental Therapeutics, 274, 761-766.
-
(1995)
Journal of Pharmacology and Experimental Therapeutics
, vol.274
, pp. 761-766
-
-
Ashforth, E.I.L.1
Carlile, D.J.2
Chenery, R.3
Houston, J.B.4
-
2
-
-
0000751859
-
The metabolism and activation of benzo(a)pyrene
-
COOPER, C. S., GROVER, P. L. and SIMS, P., 1983, The metabolism and activation of benzo(a)pyrene. Progress in Drug Metabolism, 7, 295-396.
-
(1983)
Progress in Drug Metabolism
, vol.7
, pp. 295-396
-
-
Cooper, C.S.1
Grover, P.L.2
Sims, P.3
-
3
-
-
0343921510
-
-
submitted
-
CARLILE, D. J., ZOMORODI, K. and HOUSTON, J. B., 1996, Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes and the intact liver (submitted).
-
(1996)
Scaling Factors to Relate Drug Metabolic Clearance in Hepatic Microsomes, Isolated Hepatocytes and the Intact Liver
-
-
Carlile, D.J.1
Zomorodi, K.2
Houston, J.B.3
-
4
-
-
0026076770
-
Determination of ondansetron in plasma and its pharmacokinetics in the young and elderly
-
COLTHUP, P. V., FELGATE, C. C., PALMER, J. L. and SCULLY, N. L., 1991, Determination of ondansetron in plasma and its pharmacokinetics in the young and elderly. Journal of Pharmaceutical Sciences, 80, 868-871.
-
(1991)
Journal of Pharmaceutical Sciences
, vol.80
, pp. 868-871
-
-
Colthup, P.V.1
Felgate, C.C.2
Palmer, J.L.3
Scully, N.L.4
-
5
-
-
0028840740
-
Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans
-
DIXON, C. M., COLTHUP, P. V., SERABJIT-SINGH, C. J., KERR, B. M., BOEHLERT, C. C., PARK, G. R. and TARBIT, M. H., 1995, Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. Drug Metabolism and Disposition, 23, 1225-1230.
-
(1995)
Drug Metabolism and Disposition
, vol.23
, pp. 1225-1230
-
-
Dixon, C.M.1
Colthup, P.V.2
Serabjit-Singh, C.J.3
Kerr, B.M.4
Boehlert, C.C.5
Park, G.R.6
Tarbit, M.H.7
-
6
-
-
0028223289
-
The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron
-
FISCHER, V., VICKERS, A. E. M., HEITZ, F., MAHADEVAN, S., BALDECK, J-P., MINEHY, P. and TYNES, R., 1994, The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron. Drug Metabolism and Disposition, 22, 269-274.
-
(1994)
Drug Metabolism and Disposition
, vol.22
, pp. 269-274
-
-
Fischer, V.1
Vickers, A.E.M.2
Heitz, F.3
Mahadevan, S.4
Baldeck, J.-P.5
Minehy, P.6
Tynes, R.7
-
7
-
-
0028903015
-
In vivo disposition of caffeine predicted from hepatic microsomal and hepatocyte data
-
HAYES, K. A., BRENNAN, B., CHENERY, R. and HOUSTON, J. B., 1995, In vivo disposition of caffeine predicted from hepatic microsomal and hepatocyte data. Drug Metabolism and Disposition, 23, 353.
-
(1995)
Drug Metabolism and Disposition
, vol.23
, pp. 353
-
-
Hayes, K.A.1
Brennan, B.2
Chenery, R.3
Houston, J.B.4
-
8
-
-
0028342648
-
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
-
HOUSTON, J. B., 1994, Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochemical Pharmacology, 47, 1469-1479.
-
(1994)
Biochemical Pharmacology
, vol.47
, pp. 1469-1479
-
-
Houston, J.B.1
-
9
-
-
0011368056
-
Cytochrome P450 metabolism of ondansetron by CYP1A2, CYP1A1 and CYP2D6
-
Fifth North American ISSX Meeting, 17-21 October, Tuscon, Arizona (Bethesda: ISSX)
-
KERR, B. M., BOULDING-BROWN, S. Y., LEE, C. A., BOEHLERT, C. C., PRITCHARD, J. F., DIXON, C. M., COLTHUP, P. V., BAYLISS, M. K., TARBIT, M. H. and SERABJIT-SINGH, C. J., 1993, Cytochrome P450 metabolism of ondansetron by CYP1A2, CYP1A1 and CYP2D6. ISSX Proceedings, vol. 4, p. 137. Fifth North American ISSX Meeting, 17-21 October, Tuscon, Arizona (Bethesda: ISSX).
-
(1993)
ISSX Proceedings
, vol.4
, pp. 137
-
-
Kerr, B.M.1
Boulding-Brown, S.Y.2
Lee, C.A.3
Boehlert, C.C.4
Pritchard, J.F.5
Dixon, C.M.6
Colthup, P.V.7
Bayliss, M.K.8
Tarbit, M.H.9
Serabjit-Singh, C.J.10
-
11
-
-
0026801232
-
Ondansetron metabolism and pharmacokinetics
-
PRITCHARD, J. F., 1992, Ondansetron metabolism and pharmacokinetics. Seminars in Oncology, 19, 9-15.
-
(1992)
Seminars in Oncology
, vol.19
, pp. 9-15
-
-
Pritchard, J.F.1
-
14
-
-
0344418493
-
Mechanisms of oxidative functionalization reactions
-
edited by P. Jenner and B. Testa (New York: Marcel Decker)
-
TRAGER, W. F., 1990, Mechanisms of oxidative functionalization reactions. In Concepts in Drug Metabolism. Part A, edited by P. Jenner and B. Testa (New York: Marcel Decker), pp. 177-209.
-
(1990)
Concepts in Drug Metabolism. Part A
, pp. 177-209
-
-
Trager, W.F.1
-
15
-
-
0023132476
-
Clearance approaches in pharmacology
-
WILKINSON, G. R., 1987, Clearance approaches in pharmacology. Pharmacological Reviews, 39, 1-47.
-
(1987)
Pharmacological Reviews
, vol.39
, pp. 1-47
-
-
Wilkinson, G.R.1
-
16
-
-
0028928220
-
Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds
-
WORBOYS, P. D., BRADBURY, A. and HOUSTON, J. B., 1995, Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds. Drug Metabolism and Disposition, 23, 393-397.
-
(1995)
Drug Metabolism and Disposition
, vol.23
, pp. 393-397
-
-
Worboys, P.D.1
Bradbury, A.2
Houston, J.B.3
-
17
-
-
0030024225
-
Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes
-
WORBOYS, P. D., BRADBURY, A. and HOUSTON, J. B., 1996, Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes. Drug Metabolism and Disposition, 24, 676-681.
-
(1996)
Drug Metabolism and Disposition
, vol.24
, pp. 676-681
-
-
Worboys, P.D.1
Bradbury, A.2
Houston, J.B.3
-
18
-
-
0028882361
-
Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance
-
ZOMORODI, K., CARLILE, D. J. and HOUSTON, J. B., 1995, Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance. Xenobiotica, 25, 907-916.
-
(1995)
Xenobiotica
, vol.25
, pp. 907-916
-
-
Zomorodi, K.1
Carlile, D.J.2
Houston, J.B.3
|