Carbamazepine: A 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems

Xenobiotica

Volumn 31, Issue 6, 2001, Pages 321-343

  Pelkonen, O ^a   Myllynen, P ^a   Taavitsainen, P ^a   Boobis, A R ^a   Watts, P ^a   Lake, B G ^a   Price, R J ^a   Renwick, A B ^a   Gomez Lechon M J ^a   Castell, J V ^a   Ingelman Sundberg, M ^a   Hidestrand, M ^a   Guillouzo, A ^a   Corcos, L ^a   Goldfarb, P S ^a   Lewis, D F V ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; CARBAMAZEPINE; CYTOCHROME B5; CYTOCHROME P450 3A4; RECOMBINANT ENZYME;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; DRUG POTENCY; ENZYME ACTIVITY; EPOXIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL; LIVER METABOLISM; LIVER MICROSOME; LIVER SLICE; PREDICTION;

ANTICONVULSANTS; CARBAMAZEPINE; CELLS, CULTURED; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; EPOXY COMPOUNDS; HEPATOCYTES; HUMANS; KINETICS; LIVER; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; RECOMBINANT PROTEINS;

EID: 17844407393     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250110055479     Document Type: Article

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