Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

Nature Protocols

Volumn 5, Issue 9, 2010, Pages 1540-1551

  De Graaf, Inge A M ^a   Olinga, Peter ^a   De Jager, Marina H ^a   Merema, Marjolijn T ^a   De Kanter, Ruben ^a,b   Van De Kerkhof, Esther G ^a   Groothuis, Geny M M ^a,c  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Chemical Design and Synthesis Unit   (Netherlands)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AGAROSE;

ACCURACY; DRUG METABOLISM; DRUG RESEARCH; EXPERIMENTAL DESIGN; HUMAN; INCUBATION TIME; INTERMETHOD COMPARISON; INTESTINE PREPARATION; LIVER PRESERVATION; LIVER SLICE; NONHUMAN; PRIORITY JOURNAL; REVIEW; THICKNESS; TISSUE CULTURE TECHNIQUE; TISSUE FIXATION; TISSUE PREPARATION; TISSUE SECTION; TISSUE SLICE; TISSUE STRUCTURE; TOXICITY TESTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; HUMANS; INTESTINES; LIVER; MICROTOMY; RATS; TISSUE CULTURE TECHNIQUES; XENOBIOTICS;

RATTUS;

EID: 77955914314     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2010.111     Document Type: Review

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