Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: Possible implications for toxicogenomics use of in vitro systems

Toxicological Sciences

Volumn 73, Issue 2, 2003, Pages 386-402

  Boess, Franziska ^a   Kamber, Markus ^b   Romer, Simona ^a   Gasser, Rodolfo ^a   Muller, Dieter ^c   Albertini, Silvio ^a   Suter, Laura ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Hepatic in vitro system; Liver slice; Microarray technology; Monolayer; Rat liver cell line; Sandwich culture

Indexed keywords

CYTOCHROME P450; DNA; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL LINE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DNA MICROARRAY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE TECHNOLOGY; GENETIC ANALYSIS; GENETIC TOXICOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CULTURE; LIVER SLICE; MALE; MONOLAYER CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PROTEIN EXPRESSION; RAT; SAFETY; TIME; UNINDEXED SEQUENCE;

ANIMALS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION PROFILING; GENOMICS; HEPATOCYTES; LIVER; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; SPECIFIC PATHOGEN-FREE ORGANISMS; TIME FACTORS;

ANIMALIA; RODENTIA;

EID: 0038172423     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg064     Document Type: Article

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