-
1
-
-
0029156695
-
The use of in vitro metabolism techniques in the planning and interpretation of drug safety studies
-
Wrighton, S A., Ring, B.J. & VandenBranden, M. (1995). The use of in vitro metabolism techniques in the planning and interpretation of drug safety studies Toxicologic Pathology 23, 199-208
-
(1995)
Toxicologic Pathology
, vol.23
, pp. 199-208
-
-
Wrighton, S.A.1
Ring, B.J.2
Vandenbranden, M.3
-
3
-
-
0001726653
-
Precision-cut liver slices, an in vitro system for profiling potential hepatotoxicants
-
Azri, S., Gandolfi, A J. & Brendel, K (1990) Precision-cut liver slices, an in vitro system for profiling potential hepatotoxicants In Vitro Toxicology 3, 309-320
-
(1990)
In Vitro Toxicology
, vol.3
, pp. 309-320
-
-
Azri, S.1
Gandolfi, A.J.2
Brendel, K.3
-
4
-
-
0028818410
-
Precision-cut tissue slices applications in pharmacology and toxicology
-
Parrish, A R., Gandolfi, A.J. & Brendel, K (1995) Precision-cut tissue slices applications in pharmacology and toxicology Life Sciences 57, 1887-1901.
-
(1995)
Life Sciences
, vol.57
, pp. 1887-1901
-
-
Parrish, A.R.1
Gandolfi, A.J.2
Brendel, K.3
-
5
-
-
2842541622
-
The use of tissue slices for pharmacotoxicology studies the report and recommendations of ECVAM workshop 20
-
Bach. P.H , Vickers, A E M , Fisher, R., Baumann, A , Brittebo, E , Carlile, D.J., Koster, H J , Lake, B G., Salmon, F., Sawyer, T W & Skibinski, G. (1996) The use of tissue slices for pharmacotoxicology studies The report and recommendations of ECVAM workshop 20 ATLA 24, 893-923.
-
(1996)
ATLA
, vol.24
, pp. 893-923
-
-
Bach, P.H.1
Vickers, A.E.M.2
Fisher, R.3
Baumann, A.4
Brittebo, E.5
Carlile, D.J.6
Koster, H.J.7
Lake, B.G.8
Salmon, F.9
Sawyer, T.W.10
Skibinski, G.11
-
6
-
-
0029903866
-
Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism
-
Ekins, S (1996) Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism Drug Metabolism Reviews 28, 591-623
-
(1996)
Drug Metabolism Reviews
, vol.28
, pp. 591-623
-
-
Ekins, S.1
-
7
-
-
0029865614
-
Biotransformtion of a somatostatin analogue in precision-cut liver and kidney slices from rat, dog and man
-
Connors, M.S , Larrauri, A., Dannecker, R , Nufer, R , Brendel. K & Vickers, AEM (1996) Biotransformtion of a somatostatin analogue in precision-cut liver and kidney slices from rat, dog and man Xenobiotica 26, 133-141
-
(1996)
Xenobiotica
, vol.26
, pp. 133-141
-
-
Connors, M.S.1
Larrauri, A.2
Dannecker, R.3
Nufer, R.4
Brendel, K.5
Vickers, A.E.M.6
-
8
-
-
0027168407
-
The biotransformation of the ergot derivative CQA 206-291 in human, dog and rat liver slice cultures and prediction of in vitro plasma clearance
-
Vickers, A E.M , Connors, S , Zollinger, M , Biggi, W A , Larrauri, A , Vogelaar, J P W. & Brendel. K (1993) The biotransformation of the ergot derivative CQA 206-291 in human, dog and rat liver slice cultures and prediction of in vitro plasma clearance. Drug Metabolism and Disposition 21, 454-459.
-
(1993)
Drug Metabolism and Disposition
, vol.21
, pp. 454-459
-
-
Vickers, A.E.M.1
Connors, S.2
Zollinger, M.3
Biggi, W.A.4
Larrauri, A.5
Vogelaar, J.P.W.6
Brendel, K.7
-
9
-
-
0028109342
-
Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea-pig, Cynomolgus monkey and human liver slices
-
Steensma, A., Beamand, J.A., Walters, D.G., Price, R.J. & Lake, B.G. (1994). Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea-pig, Cynomolgus monkey and human liver slices. Xenobiotica 24, 893-907.
-
(1994)
Xenobiotica
, vol.24
, pp. 893-907
-
-
Steensma, A.1
Beamand, J.A.2
Walters, D.G.3
Price, R.J.4
Lake, B.G.5
-
10
-
-
0028342648
-
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
-
Houston, J.B. (1994) Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochemical Pharmacology 47, 1469-1479.
-
(1994)
Biochemical Pharmacology
, vol.47
, pp. 1469-1479
-
-
Houston, J.B.1
-
11
-
-
0029027857
-
Prediction of in vivo disposition from in vitro systems: Clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data
-
Ashforth, E.I L., Carlile, D J , Chenery, R. & Houston, J.B. (1995). Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data. Journal of Pharmacology and Experimental Therapeutics 274, 761-766.
-
(1995)
Journal of Pharmacology and Experimental Therapeutics
, vol.274
, pp. 761-766
-
-
Ashforth, E.I.L.1
Carlile, D.J.2
Chenery, R.3
Houston, J.B.4
-
12
-
-
0030850023
-
Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes and the intact liver: Studies with induced livers involving diazepam
-
Carlile, D J., Zomorodi, K & Houston, J.B. (1997). Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes and the intact liver: studies with induced livers involving diazepam. Drug Metabolism and Disposition 25, 903-911.
-
(1997)
Drug Metabolism and Disposition
, vol.25
, pp. 903-911
-
-
Carlile, D.J.1
Zomorodi, K.2
Houston, J.B.3
-
13
-
-
0028928220
-
Kinetics of drug metabolism in rat liver slices Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds
-
Worboys, P D , Bradbury, A & Houston, J.B. (1995) Kinetics of drug metabolism in rat liver slices Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds. Drug Metabolism and Disposition 23, 393-397.
-
(1995)
Drug Metabolism and Disposition
, vol.23
, pp. 393-397
-
-
Worboys, P.D.1
Bradbury, A.2
Houston, J.B.3
-
14
-
-
0029807153
-
Metabolite kinetics of ondansetron in rat: Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition
-
Worboys, P.D., Brennan, B., Bradbury, A. & Houston, J B (1996) Metabolite kinetics of ondansetron in rat: comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition. Xenobiotica 26, 897-907.
-
(1996)
Xenobiotica
, vol.26
, pp. 897-907
-
-
Worboys, P.D.1
Brennan, B.2
Bradbury, A.3
Houston, J.B.4
-
15
-
-
0030024225
-
Kinetics of drug metabolism in rat liver slices II. Comparison of clearance by liver slices and freshly isolated hepatocytes
-
Worboys, P.D., Bradbury, A & Houston, J.B. (1996). Kinetics of drug metabolism in rat liver slices II. Comparison of clearance by liver slices and freshly isolated hepatocytes Drug Metabolism and Disposition 24, 676-681
-
(1996)
Drug Metabolism and Disposition
, vol.24
, pp. 676-681
-
-
Worboys, P.D.1
Bradbury, A.2
Houston, J.B.3
-
16
-
-
0030940186
-
Kinetics of drug metabolism in rat liver slices. III Relationship between metabolic clearance and slice uptake rate
-
Worboys, P.D., Bradbury, A. & Houston, J.B. (1997) Kinetics of drug metabolism in rat liver slices. III Relationship between metabolic clearance and slice uptake rate. Drug Metabolism and Disposition 25, 460-467.
-
(1997)
Drug Metabolism and Disposition
, vol.25
, pp. 460-467
-
-
Worboys, P.D.1
Bradbury, A.2
Houston, J.B.3
-
17
-
-
0031919720
-
Effect of human liver source on the functionality of isolated hepatocytes and liver slices
-
Olinga, P , Merema, M , Hof, I.H , de Jong, K.P , Slooff, M J H., Meijer, D.K F & Groothuis, G M M (1998) Effect of human liver source on the functionality of isolated hepatocytes and liver slices Drug Metabolism and Disposition 26, 5-11.
-
(1998)
Drug Metabolism and Disposition
, vol.26
, pp. 5-11
-
-
Olinga, P.1
Merema, M.2
Hof, I.H.3
De Jong, K.P.4
Slooff, M.J.H.5
Meijer, D.K.F.6
Groothuis, G.M.M.7
-
18
-
-
0027478959
-
Culture of precision-cut liver slices effect of some peroxisome proliferators
-
Beamand, J A , Price, R.J., Cunninghame, M E. & Lake, B G (1993) Culture of precision-cut liver slices effect of some peroxisome proliferators. Food and Chemical Toxicology 31, 137-147.
-
(1993)
Food and Chemical Toxicology
, vol.31
, pp. 137-147
-
-
Beamand, J.A.1
Price, R.J.2
Cunninghame, M.E.3
Lake, B.G.4
-
19
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
Lowry, O H , Rosebrough, N.J , Farr, A.L. & Randall, R J (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265-275
-
(1951)
Journal of Biological Chemistry
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
-
20
-
-
0027327501
-
Development of a simple incubation system for metabolism studies with precision-cut liver slices
-
Dogterom, P (1993) Development of a simple incubation system for metabolism studies with precision-cut liver slices Drug Metabolism and Disposition 21, 699-704
-
(1993)
Drug Metabolism and Disposition
, vol.21
, pp. 699-704
-
-
Dogterom, P.1
-
21
-
-
0001983466
-
Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices. I: Optimization of tissue slice culture
-
Fisher, R L , Shaughnessy, R P , Jenkins, P M., Austin, M L , Roth, G L , Gandolfi, A J. & Brendel. K (1995) Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices. I: Optimization of tissue slice culture. Toxicology Methods 5, 99-113
-
(1995)
Toxicology Methods
, vol.5
, pp. 99-113
-
-
Fisher, R.L.1
Shaughnessy, R.P.2
Jenkins, P.M.3
Austin, M.L.4
Roth, G.L.5
Gandolfi, A.J.6
Brendel, K.7
-
22
-
-
0000919194
-
Determination of optimal incubation media and suitable slice diameters in precision-cut liver slices II Optimization of tissue slice culture
-
Fisher, R L , Hasal, S.J., Sanuik, J T , Gandolfi, A J & Brendel, K. (1995) Determination of optimal incubation media and suitable slice diameters in precision-cut liver slices II Optimization of tissue slice culture Toxicology Methods 5, 115-130
-
(1995)
Toxicology Methods
, vol.5
, pp. 115-130
-
-
Fisher, R.L.1
Hasal, S.J.2
Sanuik, J.T.3
Gandolfi, A.J.4
Brendel, K.5
-
23
-
-
0031967151
-
Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: Comparison of the Krumdieck and Brendel tissue slicers
-
Price, R.J., Ball, S E, Renwick, A.B., Barton, P T., Beamand, J A & Lake, B.G. (1998). Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicers. Xenobiotica 28, 361-371.
-
(1998)
Xenobiotica
, vol.28
, pp. 361-371
-
-
Price, R.J.1
Ball, S.E.2
Renwick, A.B.3
Barton, P.T.4
Beamand, J.A.5
Lake, B.G.6
-
24
-
-
0001736713
-
Human liver slices express the same lidocaine biotransformation rate as isolated hepatocytes
-
Olinga, P., Merema, M.T., Meijer, D.K.F , Slooff, M J.H. & Groothuis, G.M.M. (1993). Human liver slices express the same lidocaine biotransformation rate as isolated hepatocytes. ATLA 21, 466-468.
-
(1993)
ATLA
, vol.21
, pp. 466-468
-
-
Olinga, P.1
Merema, M.T.2
Meijer, D.K.F.3
Slooff, M.J.H.4
Groothuis, G.M.M.5
-
25
-
-
0031968984
-
Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver
-
Olinga, P., Merema, M.T., Hof, I.H., de Jager, M.H., de Jong, K.P., Slooff, M.J.H , Meijer, D.K.F. & Groothuis, G.M.M. (1998). Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver. Xenobiotica 28, 349-360.
-
(1998)
Xenobiotica
, vol.28
, pp. 349-360
-
-
Olinga, P.1
Merema, M.T.2
Hof, I.H.3
De Jager, M.H.4
De Jong, K.P.5
Slooff, M.J.H.6
Meijer, D.K.F.7
Groothuis, G.M.M.8
|