Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices

Chemico-Biological Interactions

Volumn 193, Issue 2, 2011, Pages 109-118

  Ly, Van T ^a   Brock, Barry ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Cytochrome P450 mediated; Hepatotoxicity; Metabolism mediated; Precocene I; Rat liver slices

Indexed keywords

1 AMINOBENZOTRIAZOLE; ADENOSINE TRIPHOSPHATE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; DIETHYLDITHIOCARBAMIC ACID; FURAFYLLINE; GLUTATHIONE; KETOCONAZOLE; LACTATE DEHYDROGENASE; PRECOCENE I; QUINIDINE; SULFAPHENAZOLE; TRANYLCYPROMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GLUCURONIDATION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER NECROSIS; LIVER SLICE; LIVER TOXICITY; LONG TERM EXPOSURE; MALE; MASS SPECTROMETRY; METABOLIC REGULATION; METABOLITE; NONHUMAN; PROTEIN FUNCTION; RAT;

RATTUS;

EID: 79961017208     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.05.011     Document Type: Article

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