In vitro detection of differential and cell-specific hepatobiliary toxicity induced by geldanamycin and 17-allylaminogeldanamycin in rats

Toxicology in Vitro

Volumn 19, Issue 8, 2005, Pages 1079-1088

  Behrsing, H P ^a   Amin, K ^a   Ip, C ^a   Jimenez, L ^a   Tyson, C A ^a  

^a SRI INTERNATIONAL   (United States)

Author keywords

17 AAG; BrdU; Cell specific effects; Geldanamycin; Hepatobiliary toxicity; Liver; Tissue slices

Indexed keywords

17 ALLYLAMINOGELDANAMYCIN; ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; GAMMA GLUTAMYLTRANSFERASE; GELDANAMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EPITHELIUM CELL; HEPATOBILIARY SYSTEM; HISTOPATHOLOGY; IN VITRO STUDY; LIVER; LIVER CELL DAMAGE; MALE; NONHUMAN; RAT; RAT STRAIN; TISSUE CULTURE;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ASPARTATE AMINOTRANSFERASES; BENZOQUINONES; BILE DUCTS; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; EPITHELIAL CELLS; GAMMA-GLUTAMYLTRANSFERASE; HEPATOCYTES; L-LACTATE DEHYDROGENASE; LACTAMS, MACROCYCLIC; LIVER; MALE; QUINONES; RATS; RATS, INBRED F344; RIFABUTIN; TOXICITY TESTS;

ANIMALIA;

EID: 27644449187     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2005.06.033     Document Type: Article

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