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Volumn 54, Issue 8, 2012, Pages 589-602

Tor-centric concept of regulation mitogenic, metabolic and energetic signal processing in cell

Author keywords

MTOR; Rapamycin; Senescence; Tumour growth

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MTOR PROTEIN, HUMAN; PROTEIN KINASE B; PROTEIN P53; TARGET OF RAPAMYCIN KINASE; TP53 PROTEIN, HUMAN;

EID: 84868655826     PISSN: 00413771     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (108)
  • 1
    • 0035865682 scopus 로고    scopus 로고
    • LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505
    • Amano T., Tanabe K., Eto T., Narumiya S., Mizuno K. 2001. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Biochem. J. 354:149-159.
    • (2001) Biochem. J. , vol.354 , pp. 149-159
    • Amano, T.1    Tanabe, K.2    Eto, T.3    Narumiya, S.4    Mizuno, K.5
  • 5
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny M. V. 2006. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 18:2087-2102.
    • (2006) Cell Cycle. , vol.18 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 6
    • 80655140442 scopus 로고    scopus 로고
    • Progeria, rapamycin and normal aging: Recent breakthrouth
    • Blagosklonny M. V. 2011. Progeria, rapamycin and normal aging: recent breakthrouth. Aging. 3:685-691.
    • (2011) Aging. , vol.3 , pp. 685-691
    • Blagosklonny, M.V.1
  • 9
    • 79959776029 scopus 로고    scopus 로고
    • Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
    • Cao K., Graziotto J. J., Blair C. D., MazulliJ. R., Erdos M. R., Krainc D., Collins F. S. 2011. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Science Transl. Med. 3:1-11.
    • (2011) Science Transl. Med. , vol.3 , pp. 1-11
    • Cao, K.1    Graziotto, J.J.2    Blair, C.D.3    MazulliJ, R.4    Erdos, M.R.5    Krainc, D.6    Collins, F.S.7
  • 10
    • 0347318052 scopus 로고    scopus 로고
    • The AMP-activated protein kinase cascade - Unifying system for energy control
    • Carling D. 2004. The AMP-activated protein kinase cascade - unifying system for energy control. Trends Biochem. Sci. 29:18-24.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 18-24
    • Carling, D.1
  • 12
    • 0344668558 scopus 로고    scopus 로고
    • Mitochondrial translocation of cofilin is an early step in apoptosis induction
    • Chua B. T., Volbracht C., Tan K. O., Li R., Yu V. C., Li P. 2003. Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nat. Cell Biol. 12:1083-1089.
    • (2003) Nat. Cell Biol. , vol.12 , pp. 1083-1089
    • Chua, B.T.1    Volbracht, C.2    Tan, K.O.3    Li, R.4    Yu, V.C.5    Li, P.6
  • 13
    • 33646583835 scopus 로고    scopus 로고
    • Stability of p21Wafl/Cipl CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton
    • Coleman M. L., Densham R. M., Croft D. R., Olson M. F. 2006. Stability of p21Wafl/Cipl CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton. Oncogene. 25:2708-2716.
    • (2006) Oncogene. , vol.25 , pp. 2708-2716
    • Coleman, M.L.1    Densham, R.M.2    Croft, D.R.3    Olson, M.F.4
  • 14
    • 33750058023 scopus 로고    scopus 로고
    • Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
    • Corradetti M. N., Guan K.-L. 2006. Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene. 25:6347-6360.
    • (2006) Oncogene. , vol.25 , pp. 6347-6360
    • Corradetti, M.N.1    Guan, K.-L.2
  • 16
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta S. R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M. E. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91:231-241.
    • (1997) Cell. , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 17
    • 0002549377 scopus 로고
    • The lysosome
    • De Duve C. 1963. The lysosome. Sci. Amer. 208:64-72.
    • (1963) Sci. Amer. , vol.208 , pp. 64-72
    • De Duve, C.1
  • 20
    • 0028807085 scopus 로고
    • The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
    • Dorman J. B., Albinder B., Shroyer T., Kenyon C. 1995. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics. 141:1399-1406.
    • (1995) Genetics. , vol.141 , pp. 1399-1406
    • Dorman, J.B.1    Albinder, B.2    Shroyer, T.3    Kenyon, C.4
  • 22
    • 0021164348 scopus 로고
    • Activity of rapamycin (AY-22, 989) against transplanted rumors
    • Tokyo
    • Eng C. P., Sehgal S. N., Vézina C. 1984. Activity of rapamycin (AY-22, 989) against transplanted rumors. J. Antibiot. (Tokyo). 37:1231-1237.
    • (1984) J. Antibiot. , vol.37 , pp. 1231-1237
    • Eng, C.P.1    Sehgal, S.N.2    Vézina, C.3
  • 23
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z., Zhang H., Levine A. J., Jin S. 2005. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Nat. Acad. Sci. USA. 102:8204-8209.
    • (2005) Proc. Nat. Acad. Sci. USA , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 25
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) conducting the cellular signaling symphony
    • Foster K. G., Fingar D. C. 2010. Mammalian target of rapamycin (mTOR) conducting the cellular signaling symphony. J. Biol. Chem. 285:14071-14077.
    • (2010) J. Biol. Chem. , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 26
    • 0031887111 scopus 로고    scopus 로고
    • Amino acids stimulate phosphorylation of p70 (S6k) and organization of rat adipocytes into multicellular clusters
    • Fox H. L., Kimball S. R., Jefferson L. S., Lynch C. J. 1998. Amino acids stimulate phosphorylation of p70 (S6k) and organization of rat adipocytes into multicellular clusters. Amer. J. Physiol. Cell Physiol. 274:C206-C213.
    • (1998) Amer. J. Physiol. Cell Physiol. , vol.274
    • Fox, H.L.1    Kimball, S.R.2    Jefferson, L.S.3    Lynch, C.J.4
  • 27
    • 21744445111 scopus 로고    scopus 로고
    • The actin cytoskeleton: A key regulator of apoptosis and ageing?
    • Gourlay C. W., Ayscough K. R. 2005. The actin cytoskeleton: a key regulator of apoptosis and ageing? Nat. Rev. Mol. Cell Biol. 6:583-589.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 583-589
    • Gourlay, C.W.1    Ayscough, K.R.2
  • 28
    • 34848901974 scopus 로고    scopus 로고
    • Therapeutic suppression of translation initiation factor elF-4E expression reduced tumor growth without toxicity
    • Graff J. R., Konicek B. W., Vincent T. M., Lynch R. L., Monteith D., Weir S. N., Schwier P. 2007. Therapeutic suppression of translation initiation factor elF-4E expression reduced tumor growth without toxicity. J. Clin. Invest. 117:2638-2648.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2638-2648
    • Graff, J.R.1    Konicek, B.W.2    Vincent, T.M.3    Lynch, R.L.4    Monteith, D.5    Weir, S.N.6    Schwier, P.7
  • 30
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin D. A., Sabatini D. M. 2007. Defining the role of mTOR in cancer. Cancer Cell. 12:9-22.
    • (2007) Cancer Cell. , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 31
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FO-XO and PKCalpha, but not S6K1
    • Guertin D. A., Stevens D. M., Thoreen C. C., Burds A. A., Kalaany N. Y., Moffat J., Brown M., Fitzgerald K. J., Sabatini D. M. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FO-XO and PKCalpha, but not S6K1. Develop. Cell. 11:859-871.
    • (2006) Develop. Cell. , vol.11 , pp. 859-871
    • Guertin, D.A.1    Stevens, D.M.2    Thoreen, C.C.3    Burds, A.A.4    Kalaany, N.Y.5    Moffat, J.6    Brown, M.7    Fitzgerald, K.J.8    Sabatini, D.M.9
  • 35
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J., Mowa N. R., Hall M. N. 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 253:905-909.
    • (1991) Science. , vol.253 , pp. 905-909
    • Heitman, J.1    Mowa, N.R.2    Hall, M.N.3
  • 38
    • 79958696694 scopus 로고    scopus 로고
    • The mTOR-regulated phosphoproteome reveals a mechanism of mTORCl-mediated inhibition of growth factor signaling
    • Hsu P. P., Kang S. A., Rameseder J., Zhang Yi., Sabatini D. M. 2011. The mTOR-regulated phosphoproteome reveals a mechanism of mTORCl-mediated inhibition of growth factor signaling. Science. 332:1317-1322.
    • (2011) Science , vol.332 , pp. 1317-1322
    • Hsu, P.P.1    Kang, S.A.2    Rameseder, J.3    Yi, Z.4    Sabatini, D.M.5
  • 39
    • 0035744033 scopus 로고    scopus 로고
    • Mechanisms of resistance to rapamycins
    • Huang S., Houghton P. J. 2001. Mechanisms of resistance to rapamycins. Drug Resist. Updat. 4:378-391.
    • (2001) Drug Resist. Updat. , vol.4 , pp. 378-391
    • Huang, S.1    Houghton, P.J.2
  • 40
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
    • Huang J., Manning B. D. 2008. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem. J. 412:179-190.
    • (2008) Biochem. J. , vol.412 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 41
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and two mTOR complexes
    • Huang J., Manning B. D. 2009. A complex interplay between Akt, TSC2 and two mTOR complexes. Biochem. Soc. Transactions. 37:217-222.
    • (2009) Biochem. Soc. Transactions , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 42
    • 68049126433 scopus 로고    scopus 로고
    • Signal events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for tuberous sclerosis complex tumor suppressors
    • Huang J., Wu S., Wu C.-L., Manning B. D. 2009. Signal events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for tuberous sclerosis complex tumor suppressors. Cancer Res. 69:6107-6114.
    • (2009) Cancer Res. , vol.69 , pp. 6107-6114
    • Huang, J.1    Wu, S.2    Wu, C.-L.3    Manning, B.D.4
  • 43
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • Hwangbo D. S., Gershman B., Tu M. P., Palmer M., Tatar M. 2004. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature. 429:562-566.
    • (2004) Nature , vol.429 , pp. 562-566
    • Hwangbo, D.S.1    Gershman, B.2    Tu, M.P.3    Palmer, M.4    Tatar, M.5
  • 44
    • 0037039167 scopus 로고    scopus 로고
    • Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex
    • Ichetovkin I., Grant W., Condeelis J. 2002. Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex. Curr. Biol. 12:79-84.
    • (2002) Curr. Biol. , vol.12 , pp. 79-84
    • Ichetovkin, I.1    Grant, W.2    Condeelis, J.3
  • 45
    • 33748153690 scopus 로고    scopus 로고
    • TSC2 integrate Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
    • Inoki K., Zhu T., Lindvall C., Guan K. L. 2006. TSC2 integrate Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 126:955-968.
    • (2006) Cell , vol.126 , pp. 955-968
    • Inoki, K.1    Zhu, T.2    Lindvall, C.3    Guan, K.L.4
  • 47
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • Jia K., Chen D., Riddle D. L. 2004. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development. 131:3897-3906.
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 48
    • 75749105049 scopus 로고    scopus 로고
    • MTORC 1-activated S6K1 phosphorylates rictor on threonine 1135 and regulates mTORC2 signaling
    • Julien L.-A., Carriere A., Moreau J., Roux P. P. 2010. mTORC 1-activated S6K1 phosphorylates rictor on threonine 1135 and regulates mTORC2 signaling. Mol. Cell. Biol. 30:908-921.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 908-921
    • Julien, L.-A.1    Carriere, A.2    Moreau, J.3    Roux, P.P.4
  • 49
    • 0025850837 scopus 로고
    • Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts
    • Jurivich D. A., Chung J., Blenis J. 1991. Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts. J. Cell. Physiol. 148:252-259.
    • (1991) J. Cell. Physiol. , vol.148 , pp. 252-259
    • Jurivich, D.A.1    Chung, J.2    Blenis, J.3
  • 50
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P., Zid B. M., Harper T., Koslover D., Sapin V., Benzer S. 2004. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14:885-890.
    • (2004) Curr. Biol. , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 51
    • 33750233450 scopus 로고    scopus 로고
    • Combination of the mTOR inhibitor Rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG) inhibits proliferation and induces apoptosis in Multiple Myeloma (MM)
    • Part I of II Supplement
    • Kasdan L. A., Lu G., Singha U., Lentzsch S., Roadman G. D., Ghobrial I. M. 2005. Combination of the mTOR inhibitor Rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG) inhibits proliferation and induces apoptosis in Multiple Myeloma (MM). J. Clinical Oncol. ASCO Annual Meeting Proceedings. 23, Part I of II (Supplement): 9609.
    • (2005) J. Clinical Oncol. ASCO Annual Meeting Proceedings , vol.23 , pp. 9609
    • Kasdan, L.A.1    Lu, G.2    Singha, U.3    Lentzsch, S.4    Roadman, G.D.5    Ghobrial, I.M.6
  • 53
    • 51849097348 scopus 로고    scopus 로고
    • The role of PTEN signaling perturbations in cancer and in targeted therapy
    • Keniry M., Parsons R. 2008. The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene. 27:5477-5485.
    • (2008) Oncogene , vol.27 , pp. 5477-5485
    • Keniry, M.1    Parsons, R.2
  • 54
    • 14044277429 scopus 로고    scopus 로고
    • The molecular machinery of autophagy: Unanswered questions
    • Klionsky D. J. 2005. The molecular machinery of autophagy: unanswered questions. J. Cell Sci. 118:7-18.
    • (2005) J. Cell Sci. , vol.118 , pp. 7-18
    • Klionsky, D.J.1
  • 56
    • 0347717882 scopus 로고    scopus 로고
    • Cytoplasmic p21 Cipl is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway
    • Lee S., Helfman D. M. 2004. Cytoplasmic p21 Cipl is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J. Biol. Chem. 279:1885-1891.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1885-1891
    • Lee, S.1    Helfman, D.M.2
  • 57
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    • Levine A. J., Feng Z., Mak T. W., You H., Jin S. 2006. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Develop. 20:267-275.
    • (2006) Genes Develop. , vol.20 , pp. 267-275
    • Levine, A.J.1    Feng, Z.2    Mak, T.W.3    You, H.4    Jin, S.5
  • 58
    • 33846080045 scopus 로고    scopus 로고
    • Hypoxia-induced endothelial proliferation requires both mTORC 1 and mTORC2
    • Li W., Petrimpol M., Molle K. D., Hall M. N., Battegay E. J., Humar R. 2007. Hypoxia-induced endothelial proliferation requires both mTORC 1 and mTORC2. Circ. Res. 100:79-87.
    • (2007) Circ. Res. , vol.100 , pp. 79-87
    • Li, W.1    Petrimpol, M.2    Molle, K.D.3    Hall, M.N.4    Battegay, E.J.5    Humar, R.6
  • 59
    • 0029805324 scopus 로고    scopus 로고
    • Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways
    • Lim L., Manser K., Leung T., Hall C. 1996. Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur. J. Biochem. 242:171-185.
    • (1996) Eur. J. Biochem. , vol.242 , pp. 171-185
    • Lim, L.1    Manser, K.2    Leung, T.3    Hall, C.4
  • 60
    • 50649123206 scopus 로고    scopus 로고
    • Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins
    • Liu L., Chen L., Chung J., Huang S. 2008. Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins. Oncogene. 27:4998-5010.
    • (2008) Oncogene , vol.27 , pp. 4998-5010
    • Liu, L.1    Chen, L.2    Chung, J.3    Huang, S.4
  • 61
    • 78649637235 scopus 로고    scopus 로고
    • Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity
    • Liu L., Luo Y., Chen L., Shen T., Xu B., Chen W., Zhou H., Han X., Huang S. 2010. Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J. Biol. Chem. 285:38362-38372.
    • (2010) J. Biol. Chem. , vol.285 , pp. 38362-38372
    • Liu, L.1    Luo, Y.2    Chen, L.3    Shen, T.4    Xu, B.5    Chen, W.6    Zhou, H.7    Han, X.8    Huang, S.9
  • 62
    • 33947145667 scopus 로고    scopus 로고
    • Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin
    • Liu X., Zheng X. F. 2007. Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin. Mol. Biol. Cell. 18:1073-1082.
    • (2007) Mol. Biol. Cell. , vol.18 , pp. 1073-1082
    • Liu, X.1    Zheng, X.F.2
  • 63
    • 9744221185 scopus 로고    scopus 로고
    • Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    • Majewski N., Nogueira V., Bhaskar P., Coy P. E., Hay N. 2004. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell. 16:819-830.
    • (2004) Mol. Cell. , vol.16 , pp. 819-830
    • Majewski, N.1    Nogueira, V.2    Bhaskar, P.3    Coy, P.E.4    Hay, N.5
  • 66
    • 0017362502 scopus 로고
    • Inhibition of the immune response by rapamycin, a new antifungal antibiotic
    • Martel R. R., Klicius J., Galet S. 1977. Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can. J. Physiol. Pharmacol. 55:48-51.
    • (1977) Can. J. Physiol. Pharmacol. , vol.55 , pp. 48-51
    • Martel, R.R.1    Klicius, J.2    Galet, S.3
  • 69
    • 45849110311 scopus 로고    scopus 로고
    • Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC 1 and Akt signaling lead to improved survival and function
    • Meikle L., Pollizzi K., Egnor A., Kramvis I., Lane H., Sahin M., Kwiatkowski D. J. 2008. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC 1 and Akt signaling lead to improved survival and function. J. Neurosci. 28:5422-5432.
    • (2008) J. Neurosci. , vol.28 , pp. 5422-5432
    • Meikle, L.1    Pollizzi, K.2    Egnor, A.3    Kramvis, I.4    Lane, H.5    Sahin, M.6    Kwiatkowski, D.J.7
  • 70
    • 50249103834 scopus 로고    scopus 로고
    • The cell biology of autophagy in metazoans: A developing story
    • Melendez A., Neufeld T. P. 2008. The cell biology of autophagy in metazoans: a developing story. Development. 135:2347-2360.
    • (2008) Development , vol.135 , pp. 2347-2360
    • Melendez, A.1    Neufeld, T.P.2
  • 71
    • 70349644004 scopus 로고    scopus 로고
    • Autophagy facilitates oncogen-induced senescence
    • Narita M., Young A. R., Narita M. 2009. Autophagy facilitates oncogen-induced senescence. Autophagy. 7:1046-1047.
    • (2009) Autophagy , vol.7 , pp. 1046-1047
    • Narita, M.1    Young, A.R.2    Narita, M.3
  • 72
    • 0034312279 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    • Oldham S., Montagne J., Radimerski T., Thomas G., Hafen E. 2000. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Develop. 14:2689-2694.
    • (2000) Genes Develop. , vol.14 , pp. 2689-2694
    • Oldham, S.1    Montagne, J.2    Radimerski, T.3    Thomas, G.4    Hafen, E.5
  • 74
    • 77956260496 scopus 로고    scopus 로고
    • MTORC 1 links protein quality and quantity control by sensing chaperone availability
    • QianS. B., Zhang X., Sun J., Bennink J. R., Yewdell J. W., Patterson C. 2010. mTORC 1 links protein quality and quantity control by sensing chaperone availability. J. Biol. Chem. 285:27 385-27 395.
    • (2010) J. Biol. Chem. , vol.285 , pp. 27385-27395
    • QianS, B.1    Zhang, X.2    Sun, J.3    Bennink, J.R.4    Yewdell, J.W.5    Patterson, C.6
  • 76
    • 79960841377 scopus 로고    scopus 로고
    • P21 Wafl is required for complete oncogenic transformation of mouse embryo fibroblasts by Elad5 and c-Ha-ras oncogenes
    • Romanov V. S., Bardin A. A., Zubova S. G., Bykova T. V., Pospelov V. A., Pospelova T. V. 2011. p21 Wafl is required for complete oncogenic transformation of mouse embryo fibroblasts by Elad5 and c-Ha-ras oncogenes. Biochimie. 93:1408-1414.
    • (2011) Biochimie , vol.93 , pp. 1408-1414
    • Romanov, V.S.1    Bardin, A.A.2    Zubova, S.G.3    Bykova, T.V.4    Pospelov, V.A.5    Pospelova, T.V.6
  • 79
    • 33750624967 scopus 로고    scopus 로고
    • Mitochondrial signaling, TOR and life span
    • Schieke S. M., Finkel T. 2006. Mitochondrial signaling, TOR and life span. Biol. Chem. 387:1357-1361.
    • (2006) Biol. Chem. , vol.387 , pp. 1357-1361
    • Schieke, S.M.1    Finkel, T.2
  • 80
    • 33748752151 scopus 로고    scopus 로고
    • The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    • Schieke S. M., Phillips D., McCoy J. P., Aponte A. M., Shen R. F., Balaban R. S., Finkel T. 2006. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. Biol. Chem. 281:27643-27652.
    • (2006) Biol. Chem. , vol.281 , pp. 27643-27652
    • Schieke, S.M.1    Phillips, D.2    McCoy, J.P.3    Aponte, A.M.4    Shen, R.F.5    Balaban, R.S.6    Finkel, T.7
  • 81
    • 33845874899 scopus 로고    scopus 로고
    • Direct induction of autophagy by Atgl inhibits cell growth and induces apoptotic cell death
    • Scott R. C., Juhasz G., Neufeld T. P. 2007. Direct induction of autophagy by Atgl inhibits cell growth and induces apoptotic cell death. Curr. Biol. 17:1-11.
    • (2007) Curr. Biol. , vol.17 , pp. 1-11
    • Scott, R.C.1    Juhasz, G.2    Neufeld, T.P.3
  • 82
    • 0038299000 scopus 로고    scopus 로고
    • Sirolimus: Its discovery, biological properties, and mechanism of action
    • Sehgal S. N. 2003. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc. 35:7S-14S.
    • (2003) Transplant Proc. , vol.35
    • Sehgal, S.N.1
  • 83
    • 84875701943 scopus 로고    scopus 로고
    • Aging in IGF-1 hypomorphic mice. Current directions in studying mechanisms of aging
    • Sell C., Lorenzini S. 2007. Aging in IGF-1 hypomorphic mice. Current directions in studying mechanisms of aging. Age. 29:105-106.
    • (2007) Age , vol.29 , pp. 105-106
    • Sell, C.1    Lorenzini, S.2
  • 85
    • 33747808579 scopus 로고    scopus 로고
    • Turnover of the active fraction of IRS1 involves Raptor-mTOR and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis
    • Shah O. J., Hunter T. 2006. Turnover of the active fraction of IRS1 involves Raptor-mTOR and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol. Cell. Biol. 26:6425-6434.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 6425-6434
    • Shah, O.J.1    Hunter, T.2
  • 86
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI (3) K and mTOR signaling controls tumour cell growth
    • Shaw R. J., Cantley L. S. 2006. Ras, PI (3) K and mTOR signaling controls tumour cell growth. Nature. 441:424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.S.2
  • 87
    • 27644534999 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade
    • Shi Y., Yan H., Frost P., Gera J., Lichtenstein A. 2005. Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade. Mol. Cancer Ther. 4:1533-1540.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1533-1540
    • Shi, Y.1    Yan, H.2    Frost, P.3    Gera, J.4    Lichtenstein, A.5
  • 91
    • 0030886015 scopus 로고    scopus 로고
    • Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
    • Sugrue M. M., Shin D. Y., Lee S. W., Aaronson S. A. 1997. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc. Nat. Acad. Sci. USA. 94:9648-9653.
    • (1997) Proc. Nat. Acad. Sci. USA , vol.94 , pp. 9648-9653
    • Sugrue, M.M.1    Shin, D.Y.2    Lee, S.W.3    Aaronson, S.A.4
  • 93
    • 0016724057 scopus 로고
    • Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina C., Kudelski A., Sehgal S. N. 1975. Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo). 28:721-726.
    • (1975) J. Antibiot. (Tokyo) , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 94
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I., Sawyers C. L. 2002. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer. 2:489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 95
    • 0031439105 scopus 로고    scopus 로고
    • Heat shock increases the association of binding protein-1 with initiation factor 4E
    • Vries R. G., Flynn A., Patel J. C., Wang X., Denton R. M., Proud C. G. 1997. Heat shock increases the association of binding protein-1 with initiation factor 4E. J. Biol. Chem. 272:32779-32784.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32779-32784
    • Vries, R.G.1    Flynn, A.2    Patel, J.C.3    Wang, X.4    Denton, R.M.5    Proud, C.G.6
  • 96
    • 84875753483 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR signaling pathway: Implications for human cancer
    • New York: Nova Sci. Publ., Inc
    • Wan X., Helman L. J. 2008. PI3K/Akt/mTOR signaling pathway: implications for human cancer. In: Oncogene proteins: structure, functions and analyses. New York: Nova Sci. Publ., Inc. 87-115.
    • (2008) Oncogene Proteins: Structure, Functions and Analyses , pp. 87-115
    • Wan, X.1    Helman, L.J.2
  • 97
    • 17044408768 scopus 로고    scopus 로고
    • JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
    • Wang M. C., Bohmann D., Jasper H. 2005. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell. 121:115-125.
    • (2005) Cell , vol.121 , pp. 115-125
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 98
    • 0000459772 scopus 로고
    • Uber den stoffwechsel der carcinom zelle
    • Warburg O. 1924. Uber den stoffwechsel der carcinom zelle. Biochem. Z. 152:309-344.
    • (1924) Biochem. Z. , vol.152 , pp. 309-344
    • Warburg, O.1
  • 99
    • 63149114250 scopus 로고    scopus 로고
    • Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse
    • Way S. W., McKenna J., 3rd, Mietzsch U., Reith R. M., Wu H. C., Gambello M. J. 2009. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum. Mol. Genet. 18:1252-1265.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1252-1265
    • Way, S.W.1    McKenna III, J.2    Mietzsch, U.3    Reith, R.M.4    Wu, H.C.5    Gambello, M.J.6
  • 100
    • 0029154954 scopus 로고
    • The molecular basis of oncogenes and tumor suppressor genes
    • Weinberg R. A. 1995. The molecular basis of oncogenes and tumor suppressor genes. Ann. N. Y. Acad. Sci. 758:331-338.
    • (1995) Ann. N. Y. Acad. Sci. , vol.758 , pp. 331-338
    • Weinberg, R.A.1
  • 102
    • 79958696336 scopus 로고    scopus 로고
    • Phosphoproteomic analysis identifies GrblO as an mTORCl substrate that negatively regulates insulin signaling
    • Yonghao Yu., Yoon S.-O., Poulogiannis G., Yang Q., Blenis J. 2011. Phosphoproteomic analysis identifies GrblO as an mTORCl substrate that negatively regulates insulin signaling. Science. 332:1322-1326.
    • (2011) Science , vol.332 , pp. 1322-1326
    • Yonghao, Yu.1    Yoon, S.-O.2    Poulogiannis, G.3    Yang, Q.4    Blenis, J.5
  • 103
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng L. H., Xu L., Gutmann D. H., Wong M. 2008. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol. 63:444-453.
    • (2008) Ann Neurol. , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 105
    • 0034312315 scopus 로고    scopus 로고
    • Regulation of cellular growth by the Drosophila target of rapamycin dTOR
    • Zhang H., Stallock J. P., Ng J. C., Reinhard C., Neufeld T. P. 2000. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Develop. 14:2712-2724.
    • (2000) Genes Develop. , vol.14 , pp. 2712-2724
    • Zhang, H.1    Stallock, J.P.2    Ng, J.C.3    Reinhard, C.4    Neufeld, T.P.5
  • 106
    • 84863116501 scopus 로고    scopus 로고
    • MTOR-independent 4E-BPl phosphorylation is associated with cancer resistance to mTOR kinase inhibitors
    • Zang Y., Zheng S. 2012. mTOR-independent 4E-BPl phosphorylation is associated with cancer resistance to mTOR kinase inhibitors. Cell Cycle. 11:594-603.
    • (2012) Cell Cycle. , vol.11 , pp. 594-603
    • Zang, Y.1    Zheng, S.2
  • 108
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • Zhou B. P., Liao Y., Xia W., Zou Y., Spohn B., Hung M. C. 2001. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 3:973-982.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6


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