Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38362-38373

  Liu, Lei ^a   Luo, Yan ^a   Chen, Long ^a   Shen, Tao ^a   Xu, Baoshan ^a   Chen, Wenxing ^a   Zhou, Hongyu ^a   Han, Xiuzhen ^a   Huang, Shile ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MIGRATION; CELL MOTILITY; CONSTITUTIVELY ACTIVES; CYTOSKELETONS; DOWN-REGULATION; ECTOPIC EXPRESSIONS; GTPASES; IN-CELL; INSULIN-LIKE GROWTH FACTOR; LAMELLIPODIA; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); PROTEIN EXPRESSIONS; PROTEIN SYNTHESIS; RAPAMYCIN; REGULATORY PROTEIN; RNA INTERFERENCE; SIGNALING PATHWAYS; UNDERLYING MECHANISM;

ANTIBIOTICS; CELL PROLIFERATION; LAWS AND LEGISLATION; MAMMALS; RNA;

PROTEINS;

GUANOSINE TRIPHOSPHATASE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN CDC42; RAC1 PROTEIN; RAPAMYCIN; REGULATOR PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SOMATOMEDIN C;

ARTICLE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIBIOTICS, ANTINEOPLASTIC; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CELL SURVIVAL; CYTOSKELETON; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEINS; RAC1 GTP-BINDING PROTEIN; RHOA GTP-BINDING PROTEIN; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION FACTORS;

MAMMALIA; RAPTORES;

EID: 78649637235     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.141168     Document Type: Article

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