Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1831, Issue 1, 2013, Pages 228-238

  Pyne, Nigel J ^a   Dubois, Gerald ^b   Pyne, Susan ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Connective tissue growth factor; Fibrosis; Lysophosphatidic acid; Signalling; Sphingosine 1 phosphate; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; AUTOTAXIN; COLONY STIMULATING FACTOR 1; CYCLOOXYGENASE 2; CYTOCHROME C OXIDASE; GAMMA INTERFERON; GELSOLIN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; INTERLEUKIN 1; INTERSTITIAL COLLAGENASE; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; P21 ACTIVATED KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROHIBITIN; PROSTAGLANDIN E2; RAC1 PROTEIN; RHO KINASE; SMAD1 PROTEIN; SMAD3 PROTEIN; SPHINGOSINE 1 PHOSPHATE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; VILLIN;

APOPTOSIS; AUTOPHAGY; CELL DIFFERENTIATION; CELL GROWTH; CELL MIGRATION; CELL SURVIVAL; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; GENE OVEREXPRESSION; HEART MUSCLE FIBROSIS; HUMAN; LIVER FIBROSIS; LUNG FIBROSIS; MITOCHONDRIAL RESPIRATION; MUSCLE DEVELOPMENT; MYOFIBROBLAST; NONHUMAN; OCULAR FIBROSIS; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; SENESCENCE; SKIN FIBROSIS; TUMOR GROWTH;

ANIMALS; FIBROSIS; HUMANS; LYSOPHOSPHOLIPIDS; MODELS, BIOLOGICAL; ORGAN SPECIFICITY; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE;

EID: 84868514607     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2012.07.003     Document Type: Review

References (142)

1. A. Canbay, S. Friedman, and G.J. Gores Apoptosis: the nexus of liver injury and fibrosis Hepatology 39 2004 273 278
2. P.M. Henson Possible roles for apoptosis and apoptotic cell recognition in inflammation and fibrosis Am. J. Respir. Cell Mol. Biol. 29 2003 S70 S76
3. K. Kuwano, N. Hagimoto, and Y. Nakanishi The role of apoptosis in pulmonary fibrosis Histol. Histopathol. 19 2004 867 881
4. B.D. Uhal Epithelial apoptosis in the initiation of lung fibrosis Eur. Respir. J. Suppl. 44 2003 7s 9s
5. J.P. Iredale, R.C. Benyon, J. Pickering, M. McCullen, M. Northrop, S. Pawley, C. Hovell, and M.J. Arthur Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors J. Clin. Invest. 102 1998 538 549
6. G. Grieb, G. Steffens, N. Pallua, J. Bernhagen, and R. Bucala Circulating fibrocytes-biology and mechanisms in wound healing and scar formation Int. Rev. Cell Mol. Biol. 291 2011 1 19
7. R. Kalluri, and E.G. Neilson Epithelial-mesenchymal transition and its implications for fibrosis J. Clin. Invest. 112 2003 1776 1784
8. Z. Wu, L. Yang, L. Cai, M. Zhang, X. Cheng, X. Yang, and J. Xu Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse Respir. Res. 8 2007 1
9. T. Ikegami, Y. Zhang, and Y. Matsuzaki Liver fibrosis: possible involvement of EMT Cells Tissues Organs 185 2007 213 221
10. K. Taura, K. Miura, K. Iwaisako, C.H. Osterreicher, Y. Kodama, M. Penz-Osterreicher, and D.A. Brenner Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice Hepatology 51 2010 1027 1036
11. B.D. Humphreys, S.L. Lin, A. Kobayashi, T.E. Hudson, B.T. Nowlin, J.V. Bonventre, M.T. Valerius, A.P. McMahon, and J.S. Duffield Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis Am. J. Pathol. 176 2010 85 97
12. J.R. Rock, C.E. Barkauskas, M.J. Cronce, Y. Xue, J.R. Harris, J. Liang, P.W. Noble, and B.L. Hogan Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition Proc. Natl. Acad. Sci. U.S.A. 108 2011 E1475 E1483
13. S.L. Lin, T. Kisseleva, D.A. Brenner, and J.S. Duffield Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney Am. J. Pathol. 173 2008 1617 1627
14. N. Hashimoto, H. Jin, T. Liu, S.W. Chensue, and S.H. Phan Bone marrow derived progenitor cells in pulmonary fibrosis J. Clin. Invest. 113 2004 243 252
15. T. Kisseleva, H. Uchinami, N. Feirt, O. Quintana-Bustamante, J.C. Segovia, R.F. Schwabe, and D.A. Brenner Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis J. Hepatol. 45 2006 429 438
16. M. Schmidt, G. Sun, M.A. Stacey, L. Mori, and S. Mattoli Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma J. Immunol. 171 2003 380 389
17. K.M. Hong, J.A. Belperio, M.P. Keane, M.D. Burdick, and R.M. Strieter Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma J. Biol. Chem. 282 2007 22910 22920
18. J.S. Munger, X. Huang, H. Kawakatsu, M.J. Griffiths, S.L. Dalton, J. Wu, J.F. Pittet, N. Kaminski, C. Garat, M.A. Matthay, D.B. Rifkin, and D. Sheppard The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis Cell 96 3 1999 319 328
19. T.A. Wynn Cellular and molecular mechanisms of fibrosis J. Pathol. 214 2 2008 199 210
20. S. Pyne, and N.J. Pyne Translational aspects of sphingosine 1-phosphate biology Trends Mol. Med. 17 2011 463 472
21. Y.A. Hannun, and L.M. Obeid Principles of bioactive lipid signaling: lessons from sphingolipids Nat. Rev. Mol. Cell Biol. 9 2 2008 139 150
22. N.J. Pyne, and S. Pyne Sphingosine 1-phosphate and cancer Nat. Rev. Cancer 10 2010 489 503
23. Y.A. Hannun, and L.M. Obeid Many ceramides J. Biol. Chem. 286 32 2011 27855 27862
24. S. Pyne, S.C. Lee, J. Long, and N.J. Pyne Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signaling in health and disease Cell. Signal. 21 1 2009 14 21
25. N.C. Hait, C.A. Oskeritzian, S.W. Paugh, S. Milstien, and S. Spiegel Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases Biochim. Biophys. Acta 1758 12 2006 2016 2026
26. A. Kumar, and J.D. Saba Lyase to live by: sphingosine phosphate lyase as a therapeutic target Expert Opin. Ther. Targets 13 8 2009 1013 1025
27. S.E. Alvarez, K.B. Harikumar, N.C. Hait, J. Allegood, G.M. Strub, E.Y. Kim, M. Maceyka, H. Jiang, C. Luo, T. Kordula, S. Milstien, and S. Spiegel Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 Nature 465 7301 2010 1084 1088
28. M. Maceyka, S.E. Alvarez, S. Milstien, and S. Spiegel Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration Mol. Cell. Biol. 28 18 2008 5687 5697
29. G.M. Strub, M. Paillard, J. Liang, L. Gomez, J.C. Allegood, N.C. Hait, M. Maceyka, M.M. Price, Q. Chen, D.C. Simpson, T. Kordula, S. Milstien, E.J. Lesnefsky, and S. Spiegel Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration FASEB J. 25 2 2011 600 612
30. N.C. Hait, J. Allegood, M. Maceyka, G.M. Strub, K.B. Harikumar, S.K. Singh, C. Luo, R. Marmorstein, T. Kordula, S. Milstien, and S. Spiegel Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate Science 325 5945 2009 1254 1257
31. J. Chun, T. Hla, K.R. Lynch, S. Spiegel, and W.H. Moolenaar International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature Pharmacol. Rev. 62 4 2010 579 587
32. M.Z. Ratajczak, H. Lee, M. Wysoczynski, W. Wan, W. Marlicz, M.J. Laughlin, M. Kucia, A. Janowska-Wieczorek, and J. Ratajczak Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex Leukemia 24 2010 976 985
33. K. Takabe, R.H. Kim, J.C. Allegood, P. Mitra, S. Ramachandran, M. Nagahashi, K.B. Harikumar, N.C. Hait, S. Milstien, and S. Spiegel Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2 J. Biol. Chem. 285 2010 10477 10486
34. K. Sato, E. Malchinkhuu, Y. Horiuchi, C. Mogi, H. Tomura, M. Tosaka, Y. Yoshimoto, A. Kuwabara, and F. Okajima Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes J. Neurochem. 103 2007 2610 2619
35. Y. Hisano, N. Kobayashi, A. Kawahara, A. Yamaguchi, and T. Nishi The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720 J. Biol. Chem. 286 2011 1758 1766
36. K. Takabe, S.W. Paugh, S. Milstien, and S. Spiegel Inside-out signaling of sphingosine-1 phosphate: therapeutic targets Pharmacol. Rev. 60 2 2008 181 195
37. M.A. Hanson, C.B. Roth, E. Jo, M.T. Griffith, F.L. Scott, G. Reinhart, H. Desale, B. Clemons, S.M. Cahalan, S.C. Schuerer, M.G. Sanna, G.W. Han, P. Kuhn, H. Rosen, and R.C. Stevens Crystal structure of a lipid G protein-coupled receptor Science 335 6070 2012 851 855
38. G. Tigyi Aiming drug discovery and lysophosphatidic acid targets Br. J. Pharmacol. 161 2011 241 270
39. J. Aoki, A. Inoue, and S. Okudaira Two pathways for lysophosphatidic acid production Biochim. Biophys. Acta 1781 2008 513 518
40. M. Umezu-Goto, Y. Kishi, A. Taira, K. Hama, N. Dohmae, K. Takio, T. Yamori, G.B. Mills, K. Inoue, J. Aoki, and H. Arai Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production J. Cell Biol. 158 2002 227 233
41. A. Tokumura, E. Majima, Y. Kariya, K. Tominaga, K. Kogure, K. Yasuda, and K. Fukuzawa Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase J. Biol. Chem. 277 2002 39436 39442
42. H. Sonoda, J. Aoki, T. Hiramatsu, M. Ishida, K. Bandoh, Y. Nagai, R. Taguchi, K. Inoue, and H. Arai A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid J. Biol. Chem. 277 2002 34254 34263
43. T. Hiramatsu, H. Sonoda, Y. Takanezawa, R. Morikawa, M. Ishida, K. Kasahara, Y. Sanai, R. Taguchi, J. Aoki, and H. Arai Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta J. Biol. Chem. 278 2003 49438 49447
44. K.A. Carnevale, and M.K. Cathcart Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1 J. Immunol. 167 6 2001 3414 34121
45. R.S. Mishra, K.A. Carnevale, and M.K. Cathcart iPLA2beta: front and center in human monocyte chemotaxis to MCP-1 J. Exp. Med. 205 2 2008 347 359
46. S. Pyne, J.S. Long, K.T. Ktiskakis, and N.J. Pyne Lipid phosphate phosphatases and lipid phosphate signaling Biochem. Soc. Trans. 33 2005 1370 1374
47. T. Tsukahara, R. Tsukahara, S. Yasuda, N. Makarova, W.J. Valentine, P. Allison, H. Yuan, D.L. Baker, Z. Li, R. Bittman, A. Parrill, and G. Tigyi Different residues mediate recognition of 1-O-oleyllysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor gamma J. Biol. Chem. 281 6 2006 3398 3407
48. K. Meerschaert, V. De Corte, Y. De Ville, J. Vandekerckhove, and J. Gettemans Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid EMBO J. 17 20 1998 5923 5932
49. E. Mintzer, H. Sargsyan, and R. Bittman Lysophosphatidic acid and lipopolysaccharide bind to the PIP2-binding domain of gelsolin Biochim. Biophys. Acta 1758 1 2006 85 89
50. A. Tomar, S.P. George, S. Mathew, and S. Khurana Differential effects of lysophosphatidic acid and phosphatidylinositol 4,5-bisphosphate on actin dynamics by direct association with the actin-binding protein villin J. Biol. Chem. 284 51 2009 35278 35282
51. A. Tokumura, L.D. Carbone, Y. Yoshioka, J. Morishige, M. Kikuchi, A. Postlethwaite, and M.A. Watsky Elevated serum levels of arachidonoyl- lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis Int. J. Med. Sci. 6 4 2009 168 176
52. C. Gallois, J. Davaille, A. Habib, A. Mallat, J. Tao, T. Levade, and S. Lotersztajn Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition Ann. N. Y. Acad. Sci. 905 2000 311 314
53. J. Davaille, C. Gallois, A. Habib, L. Li, A. Mallat, J. Tao, T. Levade, and S. Lotersztajn Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway J. Biol. Chem. 275 44 2000 34628 34633
54. J. Davaille, L. Li, A. Mallat, and S. Lotersztajn Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts J. Biol. Chem. 277 40 2002 37323 37330
55. M. Sato, M. Markiewicz, M. Yamanaka, A. Bielawska, C. Mao, L.M. Obeid, Y.A. Hannun, and M. Trojanowska Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators J. Biol. Chem. 278 11 2003 9276 9282
56. R. Dhami, X. He, and E.H. Schuchman Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice Cell. Physiol. Biochem. 26 4-5 2010 749 760
57. S. Ren, A. Babelova, K. Moreth, C. Xin, W. Eberhardt, A. Doller, H. Pavenstädt, L. Schaefer, J. Pfeilschifter, and A. Huwiler Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression Kidney Int. 76 8 2009 857 867
58. D.V. Messadi, H.S. Doung, Q. Zhang, A.P. Kelly, T.L. Tuan, E. Reichenberger, and A.D. Le Activation of NFkappaB signal pathways in keloid fibroblasts Arch. Dermatol. Res. 296 3 2004 125 133
59. R.F. Schwabe, B. Schnabl, Y.O. Kweon, and B.A. Brenner CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells J. Immunol. 166 11 2001 6812 6819
60. T. Marumo, K. Hishikawa, M. Yoshikawa, J. Hirahashi, S. Kawachi, and T. Fujita Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury Am. J. Physiol. Renal Physiol. J298 1 2010 F133 F141
61. J.C. Wang, C. Chen, T. Dumlao, S. Naik, T. Chang, Y.Y. Xiao, I. Sominsky, and J. Burton Enhanced histone deacetylase enzyme activity in primary myelofibrosis Leuk. Lymphoma 49 12 2008 2321 2327
62. W. Lei, K. Zhang, X. Pan, Y. Hu, D. Wang, X. Yuan, G. Shu, and J. Song Histone deacetylase 1 is required for transforming growth factor-beta1-induced epithelial-mesenchymal transition Int. J. Biochem. Cell Biol. 42 9 2010 1489 1497
63. H. Quan, X. Peng, S. Liu, F. Bo, L. Yang, Z. Huang, H. Li, X. Chen, and W. Di Differentially expressed protein profile of renal tubule cell stimulated by elevated uric acid using SILAC coupled to LC-MS Cell. Physiol. Biochem. 27 1 2011 91 98
64. H. Ikeda, N. Watanabe, I. Ishii, T. Shimosawa, Y. Kume, T. Tomiya, Y. Inoue, T. Nishikawa, N. Ohtomo, Y. Tanoue, S. Iitsuka, R. Fujita, M. Omata, J. Chun, and Y. Yatomi Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2 J. Lipid Res. 50 3 2009 556 564
65. X. Liu, S. Yue, C. Li, L. Yang, H. You, and L. Li Essential roles of sphingosine 1-phosphate receptor type 1 and 3 in human hepatic stellate cells motility and activation J. Cell. Physiol. 226 2011 2370 2377
66. C. Li, S. Zheng, H. You, X. Liu, M. Lin, L. Yang, and L. Li Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility J. Hepatol. 54 6 2011 1205 1213
67. T. Sanchez, T. Estrada-Hernandez, J.H. Paik, M.T. Wu, K. Venkataraman, V. Brinkmann, K. Claffey, and T. Hla Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability J. Biol. Chem. 278 47 2003 47281 47290
68. X. Peng, P.M. Hassoun, S. Sammani, B.J. McVerry, M.J. Burne, H. Rabb, D. Pearse, R.M. Tuder, and J.G. Garcia Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury Am. J. Respir. Crit. Care Med. 169 11 2004 1245 1251
69. B.S. Shea, S.F. Brooks, B.A. Fontaine, J. Chun, A.D. Luster, and A.M. Tager Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury Am. J. Respir. Cell Mol. Biol. 43 6 2010 662 673
70. V. Brinkmnn, A. Billich, T. Baumruker, P. Heining, R. Schmouder, G. Francis, S. Aradhye, and P. Burtin Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis Nat. Rev. Drug Discov. 9 11 2010 883 897
71. M.H. Gräler, and E.J. Goetzl The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors FASEB J. 18 3 2004 551 553
72. J.Y. Kim, S.W. Lim, C. Li, J.S. Kim, K.O. Ahn, H.J. Yang, B.S. Choi, Y.S. Kim, J. Kim, B.K. Bang, and C.W. Yang Effect of FTY720 on chronic cyclosporine nephropathy in rats Transplantation 80 9 2005 1323 1330
73. C. Xin, S. Ren, W. Eberhardt, J. Pfeilschifter, and A. Huwiler The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signaling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells Br. J. Pharmacol. 147 2 2006 164 174
74. 3 and Smad3 signaling Am. J. Pathol. 170 1 2007 281 292
75. M.M. Giacomini, M.A. Travis, M. Kudo, and D. Sheppard Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force Exp. Cell Res. 318 6 2012 716 722
76. J. Igarashi, K. Shoji, T. Hashimoto, T. Moriue, K. Yoneda, T. Takamura, T. Yamashita, Y. Kubota, and H. Kosaka Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells Am. J. Physiol. Cell Physiol. 297 5 2009 C1263 C1274
77. Y. Kono, T. Nishiuma, Y. Nishimura, Y. Kotani, T. Okada, S. Nakamura, and M. Yokoyama Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1 Am. J. Respir. Cell Mol. Biol. 37 4 2007 395 404
78. N. Gellings Lowe, J.S. Swaney, K.M. Moreno, and R.A. Sabbadini Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts Cardiovasc. Res. 82 2 2009 303 312
79. 3 axis Mol. Biol. Cell 21 6 2010 1111 1124
80. A.J. Ammit, A.T. Hastie, L.C. Edsall, R.K. Hoffman, Y. Amrani, V.P. Krymskaya, S.A. Kane, S.P. Peters, R.B. Penn, S. Spiegel, and R.A. Panettieri Jr. Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma FASEB J. 15 7 2001 1212 1214
81. L. Huang, P. Fu, W. Ma, D. He, B. Mathew, J.G. Garcia, and V. Natarajan Sphingosine kinase 1 deficiency protects bleomycin induced mouse lung fibrosis Am. J. Respir. Crit. Care Med. 183 2011 A2152
82. J. Milara, R. Navarro, G. Juan, T. Peiro, A. Serrano, M. Ramon, E. Mocillo, and J. Cartijo Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition Thorax 67 2012 147 156
83. T.E. King Jr., A. Pardo, and M. Selman Idiopathic pulmonary fibrosis Lancet 378 2011 1949 1961
84. I. Gorshkova, T. Zhou, B. Mathew, J.R. Jacobson, D. Takekoshi, P. Bhattacharya, B. Smith, B. Aydogan, R.R. Weichselbaum, V. Natarajan, J.G. Garcia, and E.V. Berdyshev Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression J. Lipid Res. 53 8 2012 1553 1568
85. M. Yamanaka, D. Shegogue, H. Pei, S. Bu, A. Bielawska, J. Bielawski, B. Pettus, Y.A. Hannun, L.M. Obeid, and M. Trojanowska Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation J. Biol. Chem. 279 52 2004 53994 54001
86. S. Bu, M. Yamanaka, H. Pei, A. Bielawska, J. Bielawski, Y.A. Hannun, L.M. Obeid, and M. Trojanowska Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts FASEB J. 20 1 2006 184 186
87. S. Bu, B. Kapanadze, T. Hsu, and M. Trojanowska Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway J. Biol. Chem. 283 28 2008 19593 19602
88. S. Bu, Y. Asano, A. Bujor, K. Highland, F. Hant, and M. Trojanowska Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels Arthritis Rheum. 62 7 2010 2117 2126
89. 3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Cardiovasc. Res. 85 3 2010 484 493
90. S.L. Pitkin, J.J. Maguire, T.I. Bonner, and A.P. Davenport International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function Pharmacol. Rev. 62 3 2010 331 342
91. D. Pchejetski, C. Foussal, C. Alfarano, O. Lairez, D. Calise, C. Guilbeau-Frugier, S. Schaak, M.H. Seguelas, E. Wanecq, P. Valet, A. Parini, and O. Kunduzova Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1 Eur. Heart J. 2011 10.1093/eurheartj/ehr389
92. C. Li, Y. Kong, H. Wang, S. Wang, H. Yu, X. Liu, L. Yang, X. Jiang, L. Li, and L. Li Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis J. Hepatol. 50 6 2009 1174 1183
93. 3 signaling in cholestasis-induced liver fibrosis Am. J. Pathol. 175 4 2009 1464 1472
94. J.S. Swaney, K.M. Moreno, A.M. Gentile, R.A. Sabbadini, and G.L. Stoller Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye Exp. Eye Res. 87 4 2008 367 375
95. S. Caballero, J. Swaney, K. Moreno, A. Afzal, J. Kielczewski, G. Stoller, A. Cavalli, W. Garland, G. Hansen, R. Sabbadini, and M.B. Grant Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularisation Exp. Eye Res. 88 3 2009 367 377
96. M.H. Li, T. Sanchez, A. Pappalardo, K.R. Lynch, T. Hla, and F. Ferrer Induction of anti-proliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2 Mol. Cancer Res. 6 10 2008 1649 1656
97. J.S. Long, Y. Fujiwara, J. Edwards, C.L. Tannahill, G. Tigyi, S. Pyne, and N.J. Pyne Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular regulated kinase-1/2 in MDA-MB-453 breast cancer cells J. Biol. Chem. 285 2010 35957 35966
98. M.D. Davis, J.J. Clemens, T.L. Macdonald, and K.R. Lynch Sphingosine 1-phosphate analogs as receptor antagonists J. Biol. Chem. 280 11 2005 9833 9841
99. M. Osada, Y. Yatomi, T. Ohmori, H. Ikeda, and Y. Ozaki Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist Biochem. Biophys. Res. Commun. 299 3 2002 483 487
100. T. Sanchez, A. Skoura, M.T. Wu, B. Casserly, E.O. Harrington, and T. Hla Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN Arterioscler. Thromb. Vasc. Biol. 27 6 2007 1312 1318
101. Y. Koide, K. Uemoto, T. Hasegawa, T. Sada, A. Murakami, H. Takasugi, A. Sakurai, N. Mochizuki, A. Takahashi, and A. Nishida Pharmacophore-based design of sphingosine 1-phosphate-3 receptor antagonists that include a 3,4-dialkoxybenzophenone scaffold J. Med. Chem. 50 3 2007 442 454
102. D. Kapitonov, J.C. Allegood, C. Mitchell, N.C. Hait, J.A. Almenara, J.K. Adams, R.E. Zipkin, P. Dent, T. Kordula, S. Milstien, and S. Spiegel Targeting sphingosine kinase 1 inhibits AKT signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts Cancer Res. 69 2009 6915 6923
103. K.J. French, R.S. Schrecengost, B.D. Lee, Y. Zhuang, S.N. Smith, J.L.M. Eberly, J.K. Yun, and C.D. Smith Discovery and evaluation of inhibitors of human sphingosine kinase Cancer Res. 63 2003 5962 5969
104. K. Kono, M. Tanaka, T. Ogita, and T. Kohama Characterisation of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium J. Antibiot. (Tokyo) 53 2000 759 764
105. K. Kono, M. Tanaka, T. Ogita, T. Hosoya, and T. Koyama F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete J. Antibiot. (Tokyo) 53 2000 459 466
106. K. Kono, M. Tanaka, Y. Ono, T. Hosoya, T. Ogita, and T. Kohama S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus J. Antibiot. (Tokyo) 54 2001 415 420
107. F. Tonelli, K.G. Lim, C. Loveridge, J. Long, S.M. Pitson, G. Tigyi, R. Bittman, S. Pyne, and N.J. Pyne FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells Cell. Signal. 22 2010 1536 1542
108. K.G. Lim, F. Tonelli, Z. Li, X. Lu, R. Bittman, S. Pyne, and N.J. Pyne FTY720 analogues as sphingosine kinase 1 inhibitors: Enzyme inhibition kinetics, allosterism, proteasomal degradation and actin rearrangement in MCF-7 breast cancer cells J. Biol. Chem. 286 2011 18633 18640
109. C. Loveridge, F. Tonelli, T. Leclercq, K.G. Lim, J. Long, E. Berdyshev, R.J. Tate, V. Natarajan, S.M. Pitson, N.J. Pyne, and S. Pyne The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells J. Biol. Chem. 285 2010 38841 38852
110. W.J. Valentine, G.N. Kiss, J. Liu, S.E., M. Gotoh, K. Murakami-Murofushi, T.C. Pham, D.L. Baker, A.L. Parrill, X. Lu, C. Sun, R. Bittman, N.J. Pyne, and G. Tigyi (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, signals as a pan-antagonist of sphingosine 1-phosphate GPCR and inhibits autotaxin activity Cell. Signal. 22 2010 1543 1553
111. B. Visentin, J.A. Vekich, B.J. Sibbald, A.L. Cavalli, K.M. Moreno, R.G. Matteo, W.A. Garland, Y. Lu, S. Yu, H.S. Hall, V. Kundra, G.B. Mills, and R.A. Sabbadini Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages Cancer Cell 9 3 2006 225 238
112. A. Huwiler, F. Bourquin, N. Kotelevets, O. Pastukhov, G. Capitani, M.G. Grütter, and U. Zangemeister-Wittke A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders PLoS One 6 8 2011 e22436
113. H. Ikeda, Y. Yatomi, M. Yanase, H. Satoh, A. Nishihara, M. Kawabata, and K. Fujiwara Effects of lysophosphatidic acid on proliferation of stellate cells and hepatocytes in culture Biochem. Biophys. Res. Commun. 248 2 1998 436 440
114. H. Ikeda, K. Nagashima, M. Yanase, T. Tomiya, M. Arai, Y. Inoue, K. Tejima, T. Nishikawa, M. Omata, S. Kimura, and K. Fujiwara Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells Am. J. Physiol. Gastrointest. Liver Physiol. 285 5 2003 G880 G886
115. P. Tangkijvanich, A.C. Melton, T. Chitapanarux, J. Han, and H.F. Yee Platelet-derived growth factor-BB and lysophosphatidic acid distinctly regulate hepatic myofibroblast migration through focal adhesion kinase Exp. Cell Res. 281 1 2002 140 147
116. N. Watanabe, H. Ikeda, K. Nakamura, R. Ohkawa, Y. Kume, J. Aoki, K. Hama, S. Okudaira, M. Tanaka, T. Tomiya, M. Yanase, K. Tejima, T. Nishikawa, M. Arai, H. Arai, M. Omata, K. Fujiwara, and Y. Yatomi Both plasma lysophosphatidic acid and serum autotoxin levels are increased in chronic hepatitis C J. Clin. Gastroenterol. 41 6 2007 616 623
117. N. Watanabe, H. Ikeda, K. Nakamura, R. Ohkawa, Y. Kume, T. Tomiya, K. Tejima, T. Nishikawa, M. Arai, M. Yanase, J. Aoki, H. Arai, M. Omata, K. Fujiwara, and Y. Yatomi Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity Life Sci. 81 12 2007 1009 1015
118. H. Nakagawa, H. Ikeda, K. Nakamura, R. Ohkawa, R. Masuzaki, R. Tateishi, H. Yoshida, N. Watanabe, K. Tejima, Y. Kume, T. Iwai, A. Suzuki, T. Tomiya, Y. Inoue, T. Nishikawa, N. Ohtomo, Y. Tanoue, M. Omata, K. Igarashi, J. Aoki, K. Koike, and Y. Yatomi Autotaxin as a novel serum marker of liver fibrosis Clin. Chim. Acta 412 13-14 2011 1201 1206
119. M. Goppelt-Struebe, A. Hahn, D. Iwanciw, M. Rehm, and B. Banas Regulation of connective tissue growth factor (CCN2; CTGF) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins) Mol. Pathol. 54 3 2001 176 179
120. C. Vial, L.M. Zúñiga, C. Cabello-Verrugio, P. Cañón, R. Fadic, and E. Brandan Skeletal muscle cells express the pro-fibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation J. Cell. Physiol. 215 2 2008 410 421
121. C. Cabello-Verrugio, G. Córdova, C. Vial, L.M. Zúñiga, and E. Brandan Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type β receptors and the JNK pathway Cell. Signal. 23 2 2011 449 457
122. 2 receptor and the small G protein G alpha(q) Am. J. Pathol. 174 4 2009 1264 1279
123. Z. Yin, Y. Tong, H. Zhu, and M.A. Watsky ClC-3 is required for LPA-activated Cl-current activity and fibroblast-to-myofibroblast differentiation Am. J. Physiol. Cell Physiol. 294 2 2008 C535 C542
124. A. Graness, I. Cicha, and M. Goppelt-Struebe Contribution of Src-FAK signaling to the induction of connective tissue growth factor in renal fibroblasts Kidney Int. 69 8 2006 1341 1349
125. Y. Iwazu, S. Muto, I. Hirahara, G. Fujisawa, S. Takeda, and E. Kusano Matrix metalloproteinase 2 induces epithelial-mesenchymal transition in proximal tubules from the luminal side and progresses fibrosis in mineralocorticoid/ salt-induced hypertensive rats J. Hypertens. 29 12 2011 2440 2453
126. N. Oikonomou, A. Thanasopoulou, A. Tzouvelekis, V. Harokopos, T. Paparountas, I. Nikitopoulou, W. Witke, A. Karameris, A. Kotanidou, D. Bouros, and V. Aidinis Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis Thorax 64 6 2009 467 475
127. P.J. Sime The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis J. Investig. Med. 56 2 2008 534 538
128. F. Zhang, Y. Lu, and S. Zheng Peroxisome proliferator-activated receptor-γ cross-regulation of signaling events implicated in liver fibrogenesis Cell. Signal. 24 3 2012 596 605
129. K. Lakota, J. Wei, M. Carns, M. Hinchcliff, J. Lee, M.L. Whitfield, S. Sodin-Semrl, and J. Varga Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker? Arthritis Res. Ther. 14 3 2012 R102
130. 1 receptor activation promotes renal interstitial fibrosis J. Am. Soc. Nephrol. 18 12 2007 3110 3118
131. 1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak Nat. Med. 14 1 2008 45 54
132. J.S. Swaney, C. Chapman, L.D. Correa, K.J. Stebbins, R.A. Bundey, P.C. Prodanovich, P. Fagan, C.S. Baccei, A.M. Santini, J.H. Hutchinson, T.J. Seiders, T.A. Parr, P. Prasit, J.F. Evans, and D.S. Lorrain A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model Br. J. Pharmacol. 160 2010 1699 1713
133. J.S. Swaney, C. Chapman, L.D. Correa, K.J. Stebbins, A.R. Broadhead, G. Bain, A.M. Santini, J. Darlington, C.D. King, C.S. Baccei, C. Lee, T.A. Parr, J.R. Roppe, T.J. Seiders, J. Ziff, P. Prasit, J.H. Hutchinson, J.F. Evans, and D.S. Lorrain Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist J. Pharmacol. Exp. Ther. 336 3 2011 693 700
134. Amira Pharmaceuticals receives orphan drug status for a novel LPA1 antagonist, AM152, for the treatment of idiopathic pulmonary fibrosis http://www.amirapharm.com/articles/AM152%20Orphan%20Drug.html
135. F.V. Castelino, J. Seiders, G. Bain, S.F. Brooks, C.D. King, J.S. Swaney, D.S. Lorrain, J. Chun, A.D. Luster, and A.M. Tager Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma Arthritis Rheum. 63 5 2011 1405 1415
136. Z. Yin, L.D. Carbone, M. Gotoh, A. Postlethwaite, A.L. Bolen, G.J. Tigyi,
137. C.E. Heise, W.L. Santos, A.M. Schreihofer, B.H. Heasley, Y.V. Mukhin, T.L. Macdonald, and K.R. Lynch Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist Mol. Pharmacol. 60 6 2001 1173 1180
138. 1/3 ameliorates lung fibrosis induced by irradiation Biochem. Biophys. Res. Commun. 409 1 2011 7 13
139. J. Hausmann, S. Kamtekar, E. Christodoulou, J.E. Day, T. Wu, Z. Fulkerson, H.M. Albers, L.A. van Meeteren, A.J. Houben, L. van Zeijl, S. Jansen, M. Andries, T. Hall, L.E. Pegg, T.E. Benson, M. Kasiem, K. Harlos, C.W. Kooi, S.S. Smyth, H. Ovaa, M. Bollen, A.J. Morris, W.H. Moolenaar, and A. Perrakis Structural basis of substrate discrimination and integrin binding by autotaxin Nat. Struct. Mol. Biol. 18 2 2011 198 204
140. H. Nishimasu, S. Okudaira, K. Hama, E. Mihara, N. Dohmae, A. Inoue, R. Ishitani, J. Takagi, J. Aoki, and O. Nureki Crystal structure of autotaxin and insight into GPCR activation by lipid mediators Nat. Struct. Mol. Biol. 18 2 2011 205 212
141. H.M. Albers, L.J. Hendrickx, R.J. van Tol, J. Hausmann, A. Perrakis, and H. Ovaa Structure-based design of novel boronic acid-based inhibitors of autotaxin J. Med. Chem. 54 13 2011 4619 4626
142. H.M. Albers, A. Dong, L.A. van Meeteren, D.A. Egan, M. Sunkara, E.W. van Tilburg, K. Schuurman, O. van Tellingen, A.J. Morris, S.S. Smyth, W.H. Moolenaar, and H. Ovaa Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation Proc. Natl. Acad. Sci. U. S. A. 107 16 2010 7257 7262