The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells

British Journal of Pharmacology

Volumn 147, Issue 2, 2006, Pages 164-174

  Xin, Cuiyan ^a   Ren, Shuyu ^a   Eberhardt, Wolfgang ^a   Pfeilschifter, Josef ^a   Huwiler, Andrea ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Collagen; CTGF; FTY720; Mesangial cell; Smad; TGF 2

Indexed keywords

COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; CYTOKINE; FINGOLIMOD; GELATINASE B; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOMODULATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PROTEIN KINASE; SMAD PROTEIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SURAMIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DOWN REGULATION; DRUG POTENCY; ENZYME PHOSPHORYLATION; FIBROSIS; GENETIC TRANSFECTION; KIDNEY CELL; MALE; MESANGIUM CELL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; CELLS, CULTURED; COLLAGEN TYPE IV; CONNECTIVE TISSUE GROWTH FACTOR; FIBROSIS; GLOMERULAR MESANGIUM; IMMEDIATE-EARLY PROTEINS; IMMUNOSUPPRESSIVE AGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROPYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SPHINGOSINE; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 31444445231     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706452     Document Type: Article

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